Gene: Rtn4 (reticulon 4) Rattus norvegicus
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Symbol: Rtn4
Name: reticulon 4
Description: ENCODES a protein that exhibits protein-containing complex binding; cadherin binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aging; axonal fasciculation; negative regulation of axon extension; ASSOCIATED WITH visual epilepsy; Experimental Liver Cirrhosis (ortholog); schizophrenia (ortholog); FOUND IN cytoplasm; endoplasmic reticulum; glutamatergic synapse; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,6-dinitrotoluene
AGR Description: Predicted to have ubiquitin protein ligase binding activity; involved in several processes, including aging, nervous system development, and positive regulation of dopamine secretion; localizes to several cellular components, including the glutamatergic synapse, integral component of endoplasmic reticulum membrane, and integral component of postsynaptic density membrane; biomarker of visual epilepsy; orthologous to human RTN4 (reticulon 4).
Merged Description: Predicted to have ubiquitin protein ligase binding activity; involved in several processes, including aging, nervous system development, and positive regulation of dopamine secretion; localizes to several cellular components, including the glutamatergic synapse, integral component of endoplasmic reticulum membrane, and integral component of postsynaptic density membrane; biomarker of visual epilepsy; orthologous to human RTN4 (reticulon 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; MGC116054; neurite outgrowth inhibitor; NI-220/250; NI-250; Nogo; Nogo-A; r; rat N; rat NogoA; reticulon-4; Vp20
Orthologs:
Homo sapiens (human) : RTN4 (reticulon 4)  HGNC  Alliance
Mus musculus (house mouse) : Rtn4 (reticulon 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rtn4 (reticulon 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RTN4 (reticulon 4)
Canis lupus familiaris (dog) : RTN4 (reticulon 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rtn4 (reticulon 4)
Sus scrofa (pig) : RTN4 (reticulon 4)
more info ...
Allele / Splice: Rtn4Tn(sb-T2/Bart3)2.316Mcwi  
Genetic Models: F344-Rtn4Tn(sb-T2/Bart3)2.316Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.014114,126,931 - 114,174,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.014113,792,257 - 113,839,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414110,725,089 - 110,772,578 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.114110,751,435 - 110,798,925 (+)NCBI
Celera14102,325,054 - 102,372,199 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rtn4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620989
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.