Rtn4 (reticulon 4) - Rat Genome Database

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Gene: Rtn4 (reticulon 4) Ictidomys tridecemlineatus
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Symbol: Rtn4
Name: reticulon 4
RGD ID: 12454151
Description: ENCODES a protein that exhibits cadherin binding (ortholog); protein homodimerization activity (ortholog); protein-containing complex binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis (ortholog); axonal fasciculation (ortholog); ASSOCIATED WITH Experimental Liver Cirrhosis (ortholog); schizophrenia (ortholog); visual epilepsy (ortholog); FOUND IN axon (ortholog); cell junction (ortholog); cell projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: reticulon 4, transcript variant X1; reticulon 4, transcript variant X2; reticulon 4, transcript variant X3; reticulon-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629227,097,303 - 27,163,878 (+)NCBI
SpeTri2.0NW_0049364911,407,414 - 1,474,031 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
axonal fasciculation  (ISO)
blastocyst formation  (ISO)
cardiac epithelial to mesenchymal transition  (ISO)
cell adhesion involved in sprouting angiogenesis  (ISO)
cell migration involved in vasculogenesis  (ISO)
cellular response to hypoxia  (ISO)
cellular sphingolipid homeostasis  (ISO)
central nervous system vasculogenesis  (ISO)
cerebral cortex radial glia-guided migration  (ISO)
endoplasmic reticulum organization  (ISO)
endoplasmic reticulum tubular network formation  (ISO)
endoplasmic reticulum tubular network membrane organization  (ISO)
endoplasmic reticulum tubular network organization  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of axonogenesis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of formation of growth cone in injured axon  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of neuron projection regeneration  (ISO)
negative regulation of vasculogenesis  (ISO)
nervous system development  (ISO)
nuclear pore complex assembly  (ISO)
olfactory nerve development  (ISO)
oligodendrocyte differentiation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of artery morphogenesis  (ISO)
positive regulation of collateral sprouting of injured axon  (ISO)
positive regulation of dopamine secretion  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERBB3 signaling pathway  (ISO)
positive regulation of glial cell differentiation  (ISO)
positive regulation of hepatocyte proliferation  (ISO)
positive regulation of macrophage cytokine production  (ISO)
positive regulation of macrophage migration  (ISO)
positive regulation of mammary gland epithelial cell proliferation  (ISO)
positive regulation of neutrophil migration  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein localization to endoplasmic reticulum  (ISO)
positive regulation of Rac protein signal transduction  (ISO)
positive regulation of toll-like receptor 9 signaling pathway  (ISO)
protein localization to lysosome  (ISO)
protein stabilization  (ISO)
regulation of branching morphogenesis of a nerve  (ISO)
regulation of cell migration  (ISO)
regulation of nervous system development  (ISO)
regulation of sensory perception of pain  (ISO)
response to activity  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
Rtn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629227,097,303 - 27,163,878 (+)NCBI
SpeTri2.0NW_0049364911,407,414 - 1,474,031 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl254,972,187 - 55,112,621 (-)EnsemblGRCh38hg38GRCh38
GRCh38254,972,189 - 55,137,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37255,199,325 - 55,364,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36255,052,829 - 55,131,238 (-)NCBINCBI36hg18NCBI36
Build 34255,110,979 - 55,187,977NCBI
Celera255,039,812 - 55,118,248 (-)NCBI
Cytogenetic Map2p16.1NCBI
HuRef254,934,258 - 55,012,692 (-)NCBIHuRef
CHM1_1255,129,380 - 55,207,793 (-)NCBICHM1_1
Rtn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391129,642,898 - 29,694,414 (+)NCBIGRCm39mm39
GRCm39 Ensembl1129,642,947 - 29,694,331 (+)Ensembl
GRCm381129,692,898 - 29,744,414 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1129,692,947 - 29,744,331 (+)EnsemblGRCm38mm10GRCm38
MGSCv371129,592,898 - 29,644,414 (+)NCBIGRCm37mm9NCBIm37
MGSCv361129,592,947 - 29,642,916 (+)NCBImm8
Celera1132,055,366 - 32,110,540 (+)NCBICelera
Cytogenetic Map11A3.3NCBI
Rtn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.214103,450,074 - 103,497,687 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl14103,449,930 - 103,497,686 (+)Ensembl
Rnor_6.014114,126,931 - 114,174,459 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14114,126,943 - 114,174,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014113,792,257 - 113,839,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.414110,725,089 - 110,772,578 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.114110,751,435 - 110,798,925 (+)NCBI
Celera14102,325,054 - 102,372,199 (+)NCBICelera
Cytogenetic Map14q22NCBI
Rtn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542428,061,346 - 28,125,838 (+)NCBIChiLan1.0ChiLan1.0
RTN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A56,271,214 - 56,348,117 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A55,129,272 - 55,207,031 (-)NCBIMhudiblu_PPA_v0panPan3
RTN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11055,884,452 - 55,954,476 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1055,885,125 - 55,936,574 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1055,839,508 - 55,910,109 (-)NCBI
ROS_Cfam_1.01056,886,721 - 56,957,194 (-)NCBI
UMICH_Zoey_3.11056,588,329 - 56,658,758 (-)NCBI
UNSW_CanFamBas_1.01056,866,767 - 56,937,240 (-)NCBI
UU_Cfam_GSD_1.01057,157,709 - 57,228,145 (-)NCBI
RTN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl386,180,047 - 86,252,122 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1386,180,022 - 86,252,126 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2391,013,117 - 91,202,777 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RTN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11451,876,697 - 51,955,788 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604559,766,791 - 59,846,774 (-)NCBIVero_WHO_p1.0
Rtn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248336,514,409 - 6,584,061 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005322006   ⟹   XP_005322063
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629227,097,307 - 27,163,878 (+)NCBI
SpeTri2.0NW_0049364911,407,414 - 1,473,948 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005322009   ⟹   XP_005322066
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629227,097,313 - 27,163,878 (+)NCBI
SpeTri2.0NW_0049364911,407,414 - 1,474,031 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005322010   ⟹   XP_005322067
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629227,129,957 - 27,163,878 (+)NCBI
SpeTri2.0NW_0049364911,407,414 - 1,441,335 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040271562   ⟹   XP_040127496
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440629227,097,303 - 27,163,878 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005322066   ⟸   XM_005322009
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_005322063   ⟸   XM_005322006
- Peptide Label: isoform X2
- UniProtKB: I3LWP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005322067   ⟸   XM_005322010
- Peptide Label: isoform X4
- UniProtKB: A0A287CYH3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040127496   ⟸   XM_040271562
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000472 ENTREZGENE
Ensembl Protein ENSSTOP00000000423 ENTREZGENE
  ENSSTOP00000026304 ENTREZGENE
Ensembl Transcript ENSSTOT00000039958 ENTREZGENE
NCBI Gene Rtn4 ENTREZGENE
UniProt A0A287CYH3 ENTREZGENE
  I3LWP8 ENTREZGENE