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Gene: RTN4 (reticulon 4) Homo sapiens
Symbol: RTN4
Name: reticulon 4
Description: Exhibits cadherin binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cell adhesion involved in sprouting angiogenesis; endoplasmic reticulum tubular network organization; and positive regulation of signal transduction. Localizes to several cellular components, including the endoplasmic reticulum tubular network; endoplasmic reticulum tubular network membrane; and integral component of endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ASY; foocen; Human NogoA; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; neurite outgrowth inhibitor; neuroendocrine-specific protein C homolog; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; reticulon 5; reticulon-4; reticulon-5; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
Mus musculus (house mouse) : Rtn4 (reticulon 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rtn4 (reticulon 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rtn4 (reticulon 4)
Pan paniscus (bonobo/pygmy chimpanzee) : RTN4 (reticulon 4)
Canis lupus familiaris (dog) : RTN4 (reticulon 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rtn4 (reticulon 4)
Sus scrofa (pig) : RTN4 (reticulon 4)
Chlorocebus sabaeus (green monkey) : RTN4 (reticulon 4)
Heterocephalus glaber (naked mole-rat) : Rtn4 (reticulon 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl254,972,187 - 55,112,621 (-)Ensembl
GRCh38254,972,189 - 55,137,831 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37255,199,325 - 55,307,770 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36255,052,829 - 55,131,238 (-)NCBINCBI36hg18NCBI36
Build 34255,110,979 - 55,187,977NCBI
Celera255,039,812 - 55,118,248 (-)NCBI
Cytogenetic Map2p16.1NCBI
HuRef254,934,258 - 55,012,692 (-)NCBIHuRef
CHM1_1255,129,380 - 55,295,030 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on RTN4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730919
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.