RGD Reference Report - A class of dynamin-like GTPases involved in the generation of the tubular ER network. - Rat Genome Database

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A class of dynamin-like GTPases involved in the generation of the tubular ER network.

Authors: Hu, J  Shibata, Y  Zhu, PP  Voss, C  Rismanchi, N  Prinz, WA  Rapoport, TA  Blackstone, C 
Citation: Hu J, etal., Cell. 2009 Aug 7;138(3):549-61. doi: 10.1016/j.cell.2009.05.025.
RGD ID: 8554793
Pubmed: PMID:19665976   (View Abstract at PubMed)
PMCID: PMC2746359   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cell.2009.05.025   (Journal Full-text)

The endoplasmic reticulum (ER) consists of tubules that are shaped by the reticulons and DP1/Yop1p, but how the tubules form an interconnected network is unknown. Here, we show that mammalian atlastins, which are dynamin-like, integral membrane GTPases, interact with the tubule-shaping proteins. The atlastins localize to the tubular ER and are required for proper network formation in vivo and in vitro. Depletion of the atlastins or overexpression of dominant-negative forms inhibits tubule interconnections. The Sey1p GTPase in S. cerevisiae is likely a functional ortholog of the atlastins; it shares the same signature motifs and membrane topology and interacts genetically and physically with the tubule-shaping proteins. Cells simultaneously lacking Sey1p and a tubule-shaping protein have ER morphology defects. These results indicate that formation of the tubular ER network depends on conserved dynamin-like GTPases. Since atlastin-1 mutations cause a common form of hereditary spastic paraplegia, we suggest ER-shaping defects as a neuropathogenic mechanism.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Atl1  (atlastin GTPase 1)
Rtn4  (reticulon 4)


Additional Information