Slc30a10 (solute carrier family 30, member 10) - Rat Genome Database

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Gene: Slc30a10 (solute carrier family 30, member 10) Rattus norvegicus
Analyze
Symbol: Slc30a10
Name: solute carrier family 30, member 10
RGD ID: 1305098
Description: Predicted to enable calcium:manganese antiporter activity and zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including detoxification of zinc ion; intracellular monoatomic cation homeostasis; and monoatomic cation transmembrane transport. Predicted to act upstream of or within epidermal growth factor receptor signaling pathway. Predicted to be located in Golgi apparatus; endosome membrane; and plasma membrane. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium/manganese antiporter SLC30A10; LOC289353; RGD1305098; similar to hypothetical protein DKFZp547M236; zinc transporter 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Slc30a10em1Sommu  
Genetic Models: CD-Slc30a10em1Sommu
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81399,529,664 - 99,584,442 (+)NCBIGRCr8
mRatBN7.21396,998,143 - 97,048,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,998,143 - 97,009,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1399,497,741 - 99,509,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,903,238 - 100,914,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01398,080,008 - 98,091,280 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013103,396,295 - 103,406,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13103,396,314 - 103,410,363 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013108,048,948 - 108,083,821 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,474,867 - 101,492,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,664,109 - 101,681,195 (+)NCBI
Celera1396,511,232 - 96,522,472 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3-Iodothyronamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
ciglitazone  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
dibenz[a,h]anthracene  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
folic acid  (ISO)
furan  (ISO)
GW 501516  (ISO)
isotretinoin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
ritodrine  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thyroxine  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22341972   PMID:22427991   PMID:25319704   PMID:26728129  


Genomics

Comparative Map Data
Slc30a10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81399,529,664 - 99,584,442 (+)NCBIGRCr8
mRatBN7.21396,998,143 - 97,048,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,998,143 - 97,009,103 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1399,497,741 - 99,509,009 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,903,238 - 100,914,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01398,080,008 - 98,091,280 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013103,396,295 - 103,406,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13103,396,314 - 103,410,363 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013108,048,948 - 108,083,821 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,474,867 - 101,492,180 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,664,109 - 101,681,195 (+)NCBI
Celera1396,511,232 - 96,522,472 (+)NCBICelera
Cytogenetic Map13q26NCBI
SLC30A10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381219,910,445 - 219,959,098 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1219,685,427 - 219,959,018 (-)EnsemblGRCh38hg38GRCh38
GRCh371220,083,787 - 220,132,440 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,154,229 - 218,168,616 (-)NCBINCBI36Build 36hg18NCBI36
Celera1193,307,088 - 193,321,437 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1190,762,978 - 190,777,364 (-)NCBIHuRef
CHM1_11221,360,934 - 221,375,280 (-)NCBICHM1_1
T2T-CHM13v2.01219,148,333 - 219,196,857 (-)NCBIT2T-CHM13v2.0
Slc30a10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,187,045 - 185,200,959 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,187,045 - 185,200,959 (+)EnsemblGRCm39 Ensembl
GRCm381185,454,848 - 185,468,762 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,454,848 - 185,468,762 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,278,727 - 187,292,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,155,636 - 187,169,550 (+)NCBIMGSCv36mm8
Celera1192,408,431 - 192,422,120 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.53NCBI
Slc30a10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555203,631,192 - 3,641,595 (+)NCBIChiLan1.0ChiLan1.0
SLC30A10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2129,456,860 - 29,505,242 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,419,410 - 29,464,618 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01195,480,707 - 195,528,243 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11200,521,746 - 200,536,317 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1200,522,554 - 200,566,228 (-)Ensemblpanpan1.1panPan2
SLC30A10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13814,705,517 - 14,746,835 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3814,709,866 - 14,747,540 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3814,748,635 - 14,789,627 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03814,742,854 - 14,784,066 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3814,734,379 - 14,784,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13814,752,051 - 14,793,083 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,096,305 - 15,111,010 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,407,944 - 15,427,303 (-)NCBIUU_Cfam_GSD_1.0
SLC30A10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1109,527,523 - 9,545,493 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21011,611,255 - 11,651,498 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC30A10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,654,846 - 9,671,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,655,129 - 9,668,280 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,932,951 - 9,979,601 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc30a10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248353,598,260 - 3,611,307 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248353,598,375 - 3,612,165 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc30a10
296 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:159
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000049499
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat

Markers in Region
AW522618  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.013108,068,398 - 108,068,488UniSTSRnor5.0
RGSC_v3.413101,471,485 - 101,471,575UniSTSRGSC3.4
Celera1396,507,686 - 96,507,776UniSTS
RH 3.4 Map13657.9UniSTS
Cytogenetic Map13q26UniSTS
UniSTS:547077  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1396,511,185 - 96,512,753UniSTS
Cytogenetic Map13q26UniSTS


Genetic Models
This gene Slc30a10 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 6 41 41 1 41 58
Low 1 8 10 16 1 1 16 2 18 2 1
Below cutoff 16 6 2 4 4 26 20 8 4

Sequence


RefSeq Acc Id: ENSRNOT00000049499   ⟹   ENSRNOP00000050013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1396,998,143 - 97,009,103 (+)Ensembl
Rnor_6.0 Ensembl13103,396,314 - 103,410,363 (+)Ensembl
RefSeq Acc Id: NM_001105985   ⟹   NP_001099455
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81399,529,681 - 99,540,641 (+)NCBI
mRatBN7.21396,998,143 - 97,009,103 (+)NCBI
Rnor_6.013103,396,295 - 103,406,759 (+)NCBI
Rnor_5.013108,048,948 - 108,083,821 (+)NCBI
RGSC_v3.413101,474,867 - 101,492,180 (+)RGD
Celera1396,511,232 - 96,522,472 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090583   ⟹   XP_038946511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81399,529,664 - 99,568,677 (+)NCBI
mRatBN7.21396,998,263 - 97,033,527 (+)NCBI
RefSeq Acc Id: XM_039090584   ⟹   XP_038946512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81399,529,664 - 99,584,442 (+)NCBI
mRatBN7.21396,998,263 - 97,048,076 (+)NCBI
RefSeq Acc Id: XM_039090585   ⟹   XP_038946513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81399,529,664 - 99,538,295 (+)NCBI
mRatBN7.21396,998,263 - 97,006,757 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099455 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946511 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946512 (Get FASTA)   NCBI Sequence Viewer  
  XP_038946513 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94925 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000050013
  ENSRNOP00000050013.2
RefSeq Acc Id: NP_001099455   ⟸   NM_001105985
- UniProtKB: D3ZJB7 (UniProtKB/TrEMBL),   A6JGR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050013   ⟸   ENSRNOT00000049499
RefSeq Acc Id: XP_038946512   ⟸   XM_039090584
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946511   ⟸   XM_039090583
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038946513   ⟸   XM_039090585
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJB7-F1-model_v2 AlphaFold D3ZJB7 1-472 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699093
Promoter ID:EPDNEW_R9618
Type:initiation region
Name:Slc30a10_1
Description:solute carrier family 30, member 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013103,396,372 - 103,396,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305098 AgrOrtholog
BioCyc Gene G2FUF-16970 BioCyc
Ensembl Genes ENSRNOG00000002397 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049499 ENTREZGENE
  ENSRNOT00000049499.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1510.10 UniProtKB/TrEMBL
InterPro Cation_efflux UniProtKB/TrEMBL
  Cation_efflux_TMD UniProtKB/TrEMBL
KEGG Report rno:289353 UniProtKB/TrEMBL
NCBI Gene 289353 ENTREZGENE
PANTHER FI23527P1 UniProtKB/TrEMBL
  ZINC TRANSPORTER 10 UniProtKB/TrEMBL
Pfam Cation_efflux UniProtKB/TrEMBL
PhenoGen Slc30a10 PhenoGen
RatGTEx ENSRNOG00000002397 RatGTEx
Superfamily-SCOP SSF161111 UniProtKB/TrEMBL
UniProt A6JGR9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZJB7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Slc30a10  solute carrier family 30, member 10   Slc30a10_predicted  solute carrier family 30, member 10 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Slc30a10_predicted  solute carrier family 30, member 10 (predicted)  RGD1305098_predicted  similar to hypothetical protein DKFZp547M236 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1305098_predicted  similar to hypothetical protein DKFZp547M236 (predicted)  LOC289353_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289353_predicted  similar to hypothetical protein DKFZp547M236 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL