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Gene: Mmp12 (matrix metallopeptidase 12) Rattus norvegicus
Symbol: Mmp12
Name: matrix metallopeptidase 12
Description: Predicted to have several functions, including core promoter sequence-specific DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; and response to hypoxia. Predicted to localize to cytoplasm; extracellular space; and nucleus. Used to study crescentic glomerulonephritis. Biomarker of anti-basement membrane glomerulonephritis and crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Orthologous to human MMP12 (matrix metallopeptidase 12); INTERACTS WITH (R)-lipoic acid; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: macrophage metalloelastase; matrix metalloproteinase 12; matrix metalloproteinase-12; Mme; MMP-12
Homo sapiens (human) : MMP12 (matrix metallopeptidase 12)  HGNC  Alliance
Mus musculus (house mouse) : Mmp12 (matrix metallopeptidase 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
Sus scrofa (pig) : MMP12 (matrix metallopeptidase 12)
Chlorocebus sabaeus (African green monkey) : MMP12 (matrix metallopeptidase 12)
Heterocephalus glaber (naked mole-rat) : Mmp12 (matrix metallopeptidase 12)
more info ...
Allele / Splice: Mmp12em1Soar   Mmp12em2Soar  
Genetic Models: SD-Mmp12em2Soar SD-Mmp12em1Soar
Is Marker For: Strains:   SD-Mmp12em1Soar  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.085,594,717 - 5,616,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,606,592 - 5,616,493 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,610,392 - 5,620,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,249,938 - 4,259,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,249,937 - 4,259,675 (+)NCBI
Celera86,141,589 - 6,151,491 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mmp12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620195
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.