Gene: Mmp12 (matrix metallopeptidase 12) Rattus norvegicus
Symbol: Mmp12
Name: matrix metallopeptidase 12
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); collagen binding (ortholog); core promoter binding (ortholog); INVOLVED IN positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; response to drug; ASSOCIATED WITH abnormal uterine spiral artery remodeling; ASSOCIATED WITH anti-basement membrane glomerulonephritis; Cerebral Hemorrhage; crescentic glomerulonephritis; FOUND IN cytoplasm (ortholog); extracellular space (ortholog); nucleus (ortholog); INTERACTS WITH (R)-lipoic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: macrophage metalloelastase; matrix metalloproteinase 12; matrix metalloproteinase-12; Mme; MMP-12
Homo sapiens (human) : MMP12 (matrix metallopeptidase 12)  HGNC  Alliance
Mus musculus (house mouse) : Mmp12 (matrix metallopeptidase 12)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
Sus scrofa (pig) : MMP12 (matrix metallopeptidase 12)
more info ...
Allele / Splice: Mmp12em1Soar   Mmp12em2Soar  
Genetic Models: SD-Mmp12em2Soar SD-Mmp12em1Soar
Is Marker For: Strains:   SD-Mmp12em1Soar  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.085,594,717 - 5,616,494 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.085,610,392 - 5,620,294 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,249,938 - 4,259,675 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.184,249,937 - 4,259,675 (+)NCBI
Celera86,141,589 - 6,151,491 (+)NCBICelera
Cytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mmp12
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620195
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE