(R)-lipoic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 1,2-dimethylhydrazine increases expression EXP 6480464 1, 2-Dimethylhydrazine results in increased expression of MMP12 mRNA CTD PMID:27840820 1-chloro-2,4-dinitrobenzene increases expression ISO RGD:732694 6480464 Dinitrochlorobenzene results in increased expression of MMP12 mRNA CTD PMID:10216232 17alpha-ethynylestradiol multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein CTD PMID:22085904 17beta-estradiol multiple interactions ISO RGD:1350336 6480464 ESR2 protein affects the reaction [Estradiol results in increased expression of MMP12 mRNA] CTD PMID:14699072 17beta-estradiol affects expression ISO RGD:1350336 6480464 Estradiol affects the expression of MMP12 mRNA CTD PMID:14699072 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1350336 6480464 Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA, Tetrachlorodibenzodioxin results in increased expression of MMP12 protein CTD PMID:15531779 , PMID:21441140 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732694 6480464 Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA CTD PMID:18606429 more ... 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732694 6480464 Tetrachlorodibenzodioxin affects the expression of MMP12 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA CTD PMID:20959002 , PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1350336 6480464 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP12 mRNA] CTD PMID:21441140 2,4,6-trinitrobenzenesulfonic acid increases expression ISO RGD:732694 6480464 Trinitrobenzenesulfonic Acid results in increased expression of MMP12 mRNA CTD PMID:17982090 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of MMP12 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP12 mRNA] CTD PMID:17109745 2-amino-2-deoxy-D-glucopyranose increases expression EXP 6480464 Glucosamine results in increased expression of MMP12 mRNA CTD PMID:17109745 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:20959002 4,4'-sulfonyldiphenol increases expression ISO RGD:732694 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of MMP12 mRNA CTD PMID:30951980 4-nitroquinoline N-oxide decreases expression ISO RGD:732694 6480464 4-Nitroquinoline-1-oxide results in decreased expression of MMP12 mRNA CTD PMID:22561872 4-nitroquinoline N-oxide increases expression ISO RGD:732694 6480464 4-Nitroquinoline-1-oxide results in increased expression of MMP12 mRNA CTD PMID:22561872 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of MMP12 mRNA CTD PMID:24780913 6alpha-methylprednisolone decreases expression ISO RGD:1350336 6480464 Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 7,12-dimethyltetraphene increases expression EXP 6480464 9 more ... CTD PMID:19480007 acetamide increases expression EXP 6480464 acetamide results in increased expression of MMP12 mRNA CTD PMID:31881176 acetohydroxamic acid multiple interactions ISO RGD:1350336 6480464 acetohydroxamic acid binds to and results in decreased activity of MMP12 protein CTD PMID:17269766 acrolein increases secretion ISO RGD:1350336 6480464 Acrolein results in increased secretion of MMP12 protein CTD PMID:30204913 afimoxifene decreases expression ISO RGD:732694 6480464 afimoxifene results in decreased expression of MMP12 mRNA CTD PMID:17640349 aflatoxin B1 increases expression ISO RGD:1350336 6480464 Aflatoxin B1 results in increased expression of MMP12 mRNA CTD PMID:22100608 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 results in increased expression of MMP12 mRNA CTD PMID:23630614 , PMID:25378103 aldehydo-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of MMP12 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP12 mRNA] CTD PMID:17109745 aldehydo-D-glucosamine increases expression EXP 6480464 Glucosamine results in increased expression of MMP12 mRNA CTD PMID:17109745 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of MMP12 mRNA CTD PMID:16483693 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:1350336 6480464 pyrazolanthrone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein], pyrazolanthrone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 aprepitant multiple interactions ISO RGD:732694 6480464 aprepitant inhibits the reaction [TAC1 protein results in increased expression of MMP12 mRNA] CTD PMID:18441096 arsenous acid decreases expression ISO RGD:1350336 6480464 Arsenic Trioxide results in decreased expression of MMP12 mRNA CTD PMID:19128835 azathioprine decreases expression ISO RGD:1350336 6480464 Azathioprine results in decreased expression of MMP12 mRNA CTD PMID:19192274 barium sulfate increases expression EXP 6480464 Barium Sulfate results in increased expression of MMP12 mRNA, Barium Sulfate results in increased expression of MMP12 protein CTD PMID:29463257 benzalkonium chloride increases expression ISO RGD:732694 6480464 Benzalkonium Compounds results in increased expression of MMP12 mRNA CTD PMID:30171875 benzo[a]pyrene increases expression ISO RGD:732694 6480464 Benzo(a)pyrene results in increased expression of MMP12 mRNA CTD PMID:22228805 benzo[a]pyrene increases expression ISO RGD:1350336 6480464 Benzo(a)pyrene results in increased expression of MMP12 mRNA CTD PMID:32234424 beta-D-glucosamine multiple interactions EXP 6480464 Glucosamine inhibits the reaction [IL1B results in increased expression of MMP12 mRNA], IL1B promotes the reaction [Glucosamine results in increased expression of MMP12 mRNA] CTD PMID:17109745 beta-D-glucosamine increases expression EXP 6480464 Glucosamine results in increased expression of MMP12 mRNA CTD PMID:17109745 beta-hexachlorocyclohexane increases expression ISO RGD:732694 6480464 beta-hexachlorocyclohexane results in increased expression of MMP12 mRNA CTD PMID:17640349 beta-naphthoflavone increases expression EXP 6480464 beta-Naphthoflavone results in increased expression of MMP12 mRNA CTD PMID:22687991 bis(2-chloroethyl) sulfide increases expression ISO RGD:732694 6480464 Mustard Gas results in increased expression of MMP12 mRNA CTD PMID:29935281 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of MMP12 mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:732694 6480464 bisphenol F results in increased expression of MMP12 mRNA CTD PMID:30951980 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of MMP12 mRNA CTD PMID:20471445 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of MMP12 mRNA CTD PMID:25993096 cadmium dichloride increases secretion ISO RGD:1350336 6480464 Cadmium Chloride results in increased secretion of MMP12 protein CTD PMID:30572105 calcitriol increases expression ISO RGD:1350336 6480464 Calcitriol results in increased expression of MMP12 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1350336 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of MMP12 mRNA CTD PMID:21592394 capsaicin decreases expression ISO RGD:732694 6480464 Capsaicin results in decreased expression of MMP12 mRNA, Capsaicin results in decreased expression of MMP12 protein CTD PMID:18441096 carbon atom increases expression ISO RGD:1350336 6480464 Carbon results in increased expression of MMP12 mRNA CTD PMID:26880698 carbon atom multiple interactions ISO RGD:1350336 6480464 [Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP12 mRNA, lipopolysaccharide, E coli O55-B5 promotes the reaction [Carbon results in increased expression of MMP12 mRNA] CTD PMID:26880698 carbon nanotube affects expression ISO RGD:732694 6480464 Nanotubes, Carbon affects the expression of MMP12 mRNA CTD PMID:23845593 carbon nanotube increases expression EXP 6480464 Nanotubes, Carbon results in increased expression of MMP12 mRNA, Nanotubes, Carbon results in increased expression of MMP12 protein CTD PMID:19836432 , PMID:24911292 carbon nanotube increases expression ISO RGD:732694 6480464 Nanotubes, Carbon analog results in increased expression of MMP12 mRNA, Nanotubes, Carbon results in increased expression of MMP12 mRNA CTD PMID:25554681 catechol increases expression ISO RGD:732694 6480464 catechol results in increased expression of MMP12 mRNA CTD PMID:10216232 cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of MMP12 mRNA CTD PMID:18500788 ceric oxide multiple interactions ISO RGD:732694 6480464 ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of MMP12 mRNA] CTD PMID:29792201 ceric oxide increases expression EXP 6480464 ceric oxide results in increased expression of MMP12 mRNA, ceric oxide results in increased expression of MMP12 protein CTD PMID:29463257 choline multiple interactions ISO RGD:732694 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA CTD PMID:20938992 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of MMP12 mRNA CTD PMID:22023808 cisplatin decreases expression ISO RGD:732694 6480464 Cisplatin results in decreased expression of MMP12 mRNA CTD PMID:29148169 copper atom increases expression EXP 6480464 Copper deficiency results in increased expression of MMP12 mRNA, Copper results in increased expression of MMP12 mRNA CTD PMID:17418555 , PMID:30556269 copper(0) increases expression EXP 6480464 Copper deficiency results in increased expression of MMP12 mRNA, Copper results in increased expression of MMP12 mRNA CTD PMID:17418555 , PMID:30556269 copper(II) sulfate increases expression ISO RGD:1350336 6480464 Copper Sulfate results in increased expression of MMP12 mRNA CTD PMID:19549813 corticosterone decreases expression EXP 6480464 Corticosterone results in decreased expression of MMP12 mRNA CTD PMID:15755911 crocidolite asbestos increases expression ISO RGD:732694 6480464 Asbestos, Crocidolite results in increased expression of MMP12 mRNA CTD PMID:16574944 cyclosporin A increases expression ISO RGD:1350336 6480464 Cyclosporine results in increased expression of MMP12 mRNA CTD PMID:20106945 cyclosporin A decreases methylation ISO RGD:1350336 6480464 Cyclosporine results in decreased methylation of MMP12 promoter CTD PMID:27989131 cysteamine increases expression ISO RGD:1350336 6480464 Cysteamine results in increased expression of MMP12 mRNA, Cysteamine results in increased expression of MMP12 protein CTD PMID:22532830 dexamethasone multiple interactions ISO RGD:1350336 6480464 Dexamethasone inhibits the reaction [IL1B protein results in increased activity of MMP12 protein], Dexamethasone inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 dextran sulfate multiple interactions ISO RGD:732694 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of MMP12 mRNA CTD PMID:29950665 diarsenic trioxide decreases expression ISO RGD:1350336 6480464 Arsenic Trioxide results in decreased expression of MMP12 mRNA CTD PMID:19128835 dibenziodolium multiple interactions ISO RGD:732694 6480464 diphenyleneiodonium inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA] CTD PMID:23978445 dibenziodolium decreases expression ISO RGD:732694 6480464 diphenyleneiodonium results in decreased expression of MMP12 mRNA CTD PMID:23978445 diclofenac decreases expression ISO RGD:1350336 6480464 Diclofenac results in decreased expression of MMP12 mRNA CTD PMID:19192274 diethyl maleate increases expression ISO RGD:732694 6480464 diethyl maleate results in increased expression of MMP12 mRNA CTD PMID:10216232 diethylstilbestrol decreases expression EXP 6480464 Diethylstilbestrol results in decreased expression of MMP12 mRNA CTD PMID:21658437 dioxygen multiple interactions ISO RGD:732694 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of MMP12 mRNA CTD PMID:30529165 diuron decreases expression EXP 6480464 Diuron results in decreased expression of MMP12 mRNA CTD PMID:21551480 doxorubicin increases expression ISO RGD:732694 6480464 Doxorubicin results in increased expression of MMP12 mRNA CTD PMID:15033991 doxorubicin decreases expression ISO RGD:1350336 6480464 Doxorubicin results in decreased expression of MMP12 mRNA CTD PMID:29803840 elemental carbon increases expression ISO RGD:1350336 6480464 Carbon results in increased expression of MMP12 mRNA CTD PMID:26880698 elemental carbon multiple interactions ISO RGD:1350336 6480464 [Carbon co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of MMP12 mRNA, lipopolysaccharide, E coli O55-B5 promotes the reaction [Carbon results in increased expression of MMP12 mRNA] CTD PMID:26880698 ethanol increases expression ISO RGD:732694 6480464 Ethanol results in increased expression of MMP12 mRNA, Ethanol results in increased expression of MMP12 protein CTD PMID:23978445 ethanol multiple interactions ISO RGD:732694 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA] more ... CTD PMID:23978445 fenbuconazole increases expression ISO RGD:1350336 6480464 fenbuconazole results in increased expression of MMP12 mRNA CTD PMID:15942997 ferric oxide multiple interactions ISO RGD:732694 6480464 [Magnetite Nanoparticles co-treated with ferric oxide] results in increased expression of MMP12 mRNA CTD PMID:20540983 folic acid multiple interactions ISO RGD:732694 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA CTD PMID:20938992 formaldehyde increases expression ISO RGD:1350336 6480464 Formaldehyde results in increased expression of MMP12 mRNA CTD PMID:27905399 furan increases expression EXP 6480464 furan results in increased expression of MMP12 mRNA CTD PMID:26194646 , PMID:27387713 genistein increases expression ISO RGD:732694 6480464 Genistein results in increased expression of MMP12 mRNA CTD PMID:32186404 graphite increases expression EXP 6480464 Graphite results in increased expression of MMP12 mRNA CTD PMID:29933104 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of MMP12 mRNA CTD PMID:21396975 L-methionine multiple interactions ISO RGD:732694 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of MMP12 mRNA CTD PMID:20938992 lipoic acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA CTD PMID:23830814 lipopolysaccharide increases expression ISO RGD:732694 6480464 Lipopolysaccharides results in increased expression of MMP12 mRNA CTD PMID:25106431 LY294002 multiple interactions ISO RGD:1350336 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein], 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550 LY294002 multiple interactions ISO RGD:732694 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] CTD PMID:16571779 megestrol acetate multiple interactions EXP 6480464 [Ethinyl Estradiol co-treated with Megestrol Acetate] results in increased expression of MMP12 protein CTD PMID:22085904 metacetamol decreases expression ISO RGD:732694 6480464 3-hydroxyacetanilide results in decreased expression of MMP12 mRNA CTD PMID:18544908 methotrexate decreases expression ISO RGD:1350336 6480464 Methotrexate results in decreased expression of MMP12 mRNA CTD PMID:19192274 methylisothiazolinone increases expression ISO RGD:1350336 6480464 2-methyl-4-isothiazolin-3-one results in increased expression of MMP12 mRNA CTD PMID:31629900 N-acetyl-L-cysteine multiple interactions ISO RGD:732694 6480464 Acetylcysteine inhibits the reaction [Ethanol results in increased expression of MMP12 mRNA] CTD PMID:23978445 N-hydroxyacetimidic acid multiple interactions ISO RGD:1350336 6480464 acetohydroxamic acid binds to and results in decreased activity of MMP12 protein CTD PMID:17269766 N-nitrosodiethylamine increases expression ISO RGD:732694 6480464 Diethylnitrosamine results in increased expression of MMP12 mRNA CTD PMID:24535843 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MMP12 mRNA CTD PMID:23830814 N-Nitrosopyrrolidine increases expression ISO RGD:1350336 6480464 N-Nitrosopyrrolidine results in increased expression of MMP12 mRNA CTD PMID:32234424 nickel atom affects expression ISO RGD:1350336 6480464 Nickel affects the expression of MMP12 mRNA CTD PMID:14575637 nickel atom increases expression ISO RGD:1350336 6480464 Nickel results in increased expression of MMP12 mRNA CTD PMID:25583101 nickel atom multiple interactions ISO RGD:1350336 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of MMP12 mRNA] CTD PMID:14575637 nickel sulfate increases expression ISO RGD:732694 6480464 nickel sulfate results in increased expression of MMP12 mRNA CTD PMID:16166746 O-methyleugenol increases expression ISO RGD:1350336 6480464 methyleugenol results in increased expression of MMP12 mRNA CTD PMID:32234424 orphenadrine affects expression EXP 6480464 Orphenadrine affects the expression of MMP12 mRNA CTD PMID:23665939 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MMP12 mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of MMP12 mRNA CTD PMID:25729387 ozone increases expression ISO RGD:732694 6480464 Ozone results in increased expression of MMP12 mRNA CTD PMID:12763052 paracetamol affects expression ISO RGD:732694 6480464 Acetaminophen affects the expression of MMP12 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:732694 6480464 PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of MMP12 mRNA] CTD PMID:29246445 paracetamol affects response to substance EXP 6480464 MMP12 mRNA affects the susceptibility to Acetaminophen CTD PMID:26512990 paracetamol increases expression ISO RGD:732694 6480464 Acetaminophen results in increased expression of MMP12 mRNA CTD PMID:18544908 , PMID:29246445 paraquat increases expression ISO RGD:732694 6480464 Paraquat results in increased expression of MMP12 mRNA CTD PMID:17215068 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of MMP12 mRNA CTD PMID:15059925 pioglitazone multiple interactions ISO RGD:732694 6480464 [N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of MMP12 mRNA CTD PMID:27935865 prednisolone decreases expression ISO RGD:1350336 6480464 Prednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 progesterone affects expression ISO RGD:732694 6480464 Progesterone affects the expression of MMP12 mRNA CTD PMID:17251523 quartz increases expression EXP 6480464 Quartz results in increased expression of MMP12 mRNA CTD PMID:19836432 quercetin increases expression ISO RGD:1350336 6480464 Quercetin results in increased expression of MMP12 mRNA CTD PMID:21632981 raloxifene multiple interactions ISO RGD:1350336 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA CTD PMID:19059307 raloxifene affects expression ISO RGD:1350336 6480464 Raloxifene Hydrochloride affects the expression of MMP12 mRNA CTD PMID:14699072 rottlerin multiple interactions ISO RGD:732694 6480464 rottlerin inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] CTD PMID:16571779 serpentine asbestos multiple interactions ISO RGD:732694 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA] more ... CTD PMID:16571779 serpentine asbestos increases expression ISO RGD:732694 6480464 Asbestos, Serpentine results in increased expression of MMP12 mRNA CTD PMID:16251409 , PMID:16571779 serpentine asbestos increases activity ISO RGD:732694 6480464 Asbestos, Serpentine results in increased activity of MMP12 protein CTD PMID:16571779 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of MMP12 mRNA CTD PMID:22431001 silicon dioxide increases expression ISO RGD:732694 6480464 Silicon Dioxide results in increased expression of MMP12 mRNA CTD PMID:26345256 , PMID:29341224 simvastatin increases expression ISO RGD:1350336 6480464 Simvastatin results in increased expression of MMP12 mRNA CTD PMID:17428261 sodium fluoride decreases expression EXP 6480464 Sodium Fluoride results in decreased expression of MMP12 mRNA CTD PMID:27257137 succimer multiple interactions ISO RGD:732694 6480464 [Succimer binds to Magnetite Nanoparticles] which results in increased expression of MMP12 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of MMP12 mRNA CTD PMID:21641980 , PMID:26378955 T-2 Toxin increases expression ISO RGD:732694 6480464 T-2 Toxin results in increased expression of MMP12 mRNA CTD PMID:22800716 tamoxifen multiple interactions ISO RGD:1350336 6480464 [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA CTD PMID:19059307 Tesaglitazar decreases expression EXP 6480464 tesaglitazar results in decreased expression of MMP12 mRNA CTD PMID:21515302 testosterone increases expression ISO RGD:1350336 6480464 Testosterone results in increased expression of MMP12 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1350336 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of MMP12 mRNA CTD PMID:21592394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of MMP12 mRNA, Carbon Tetrachloride results in increased expression of MMP12 protein CTD PMID:22223197 more ... tetrachloromethane increases expression ISO RGD:732694 6480464 Carbon Tetrachloride results in increased expression of MMP12 mRNA CTD PMID:18038451 more ... tetrachloromethane affects expression EXP 6480464 Carbon Tetrachloride affects the expression of MMP12 mRNA CTD PMID:15963342 , PMID:16239168 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of MMP12 mRNA CTD PMID:17056239 tetrachloromethane multiple interactions ISO RGD:732694 6480464 PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP12 mRNA] CTD PMID:18038451 tetrachloromethane affects expression ISO RGD:732694 6480464 Carbon Tetrachloride affects the expression of MMP12 mRNA CTD PMID:17484886 thioacetamide multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MMP12 mRNA, [Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of MMP12 mRNA CTD PMID:23830814 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of MMP12 mRNA CTD PMID:23411599 titanium dioxide increases expression ISO RGD:732694 6480464 titanium dioxide results in increased expression of MMP12 mRNA CTD PMID:19464567 more ... titanium dioxide multiple interactions ISO RGD:732694 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of MMP12 mRNA CTD PMID:29950665 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of MMP12 mRNA CTD PMID:30012374 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of MMP12 mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of MMP12 mRNA CTD PMID:25729387 tributylstannane decreases expression ISO RGD:732694 6480464 tributyltin results in decreased expression of MMP12 mRNA CTD PMID:31939706 trichostatin A multiple interactions ISO RGD:1350336 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of MMP12 mRNA] CTD PMID:14575637 trimellitic anhydride increases expression ISO RGD:732694 6480464 trimellitic anhydride results in increased expression of MMP12 mRNA CTD PMID:16141432 wortmannin multiple interactions ISO RGD:1350336 6480464 wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein], wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] CTD PMID:16359550
Biological Process cellular response to virus IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to virus ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 collagen catabolic process IBA MGI:MGI:101900 more ... 13792537 PMID:21873635 GO_Central elastin catabolic process ISO RGD:1350336 1624291 (PMID:29101312) RGD PMID:29101312 elastin catabolic process IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular matrix organization IBA FB:FBgn0033438 more ... 13792537 PMID:21873635 GO_Central negative regulation of endothelial cell-matrix adhesion via fibronectin ISO RGD:1350336 1624291 (PMID:29101312) RGD PMID:29101312 negative regulation of endothelial cell-matrix adhesion via fibronectin IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 negative regulation of type I interferon-mediated signaling pathway IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of type I interferon-mediated signaling pathway ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 positive regulation of epithelial cell proliferation IEP 1582367 RGD positive regulation of epithelial cell proliferation involved in wound healing ISO RGD:1350336 1624291 (PMID:15802269) RGD PMID:15802269 positive regulation of epithelial cell proliferation involved in wound healing IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 positive regulation of interferon-alpha production ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 positive regulation of transcription by RNA polymerase II IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 positive regulation of type I interferon-mediated signaling pathway IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of type I interferon-mediated signaling pathway ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 protein import into nucleus IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein import into nucleus ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 protein import into nucleus ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 protein import into nucleus IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 proteolysis ISO RGD:1350336 1624291 (PMID:19932771), (PMID:24784232) RGD PMID:19932771 , PMID:24784232 regulation of defense response to virus by host IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of defense response to virus by host ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 regulation of trophoblast cell migration IMP 12910498 RGD response to drug IEP 1582362 RGD response to hypoxia IEP 12910498 RGD response to organic cyclic compound IEP 1582369 RGD wound healing, spreading of epidermal cells ISO RGD:1350336 1624291 (PMID:15802269) RGD PMID:15802269 wound healing, spreading of epidermal cells IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component cytoplasm IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytoplasm ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 extracellular matrix IEA InterPro:IPR001818 1600115 GO_REF:0000002 InterPro GO_REF:0000002 extracellular space IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 extracellular space IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 nucleus IEA UniProtKB:P34960 , ensembl:ENSMUSP000000059501600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:732694 1624291 (MGI:MGI:5583923, PMID:24784232) RGD MGI:MGI:5583923 , PMID:24784232 nucleus ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 nucleus IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function calcium ion binding IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium ion binding ISO RGD:1350336 1624291 (PMID:11575928) RGD PMID:11575928 collagen binding IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 collagen binding ISO RGD:1350336 1624291 UniProtKB:P02452 more ... RGD PMID:19932771 core promoter sequence-specific DNA binding ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 metalloendopeptidase activity IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 metalloendopeptidase activity IBA FB:FBgn0033438 more ... 13792537 PMID:21873635 GO_Central metalloendopeptidase activity ISO RGD:1350336 1624291 (PMID:19932771), (PMID:24784232) RGD PMID:19932771 , PMID:24784232 sequence-specific DNA binding IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 sequence-specific DNA binding ISO RGD:1350336 1624291 (PMID:24784232) RGD PMID:24784232 zinc ion binding IEA UniProtKB:P39900 , ensembl:ENSP000004585851600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding ISO RGD:1350336 1624291 (PMID:11575928) RGD PMID:11575928
Gene-Chemical Interaction Annotations
