Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dichloroethane | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | ethylene dichloride results in decreased expression of FNDC1 mRNA | CTD | PMID:28960355 | 1,2-dimethylhydrazine | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of FNDC1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Estradiol results in decreased expression of FNDC1 mRNA | CTD | PMID:19484750 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FNDC1 mRNA | CTD | PMID:32741896 | 17beta-estradiol | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of FNDC1 mRNA | CTD | PMID:20660070 | 17beta-estradiol 3-benzoate | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FNDC1 mRNA | CTD | PMID:32741896 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of FNDC1 mRNA | CTD | PMID:32109520 and PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 4,4'-sulfonyldiphenol | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | bisphenol S results in increased expression of FNDC1 mRNA | CTD | PMID:30951980 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Fndc1 (Mus musculus) | 6480464 | bisphenol S affects the methylation of FNDC1 gene | CTD | PMID:31683443 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of FNDC1 mRNA | CTD | PMID:28973697 | acrylamide | affects expression | EXP | | 6480464 | Acrylamide affects the expression of FNDC1 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of FNDC1 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | affects methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | aflatoxin B2 affects the methylation of FNDC1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of FNDC1 mRNA | CTD | PMID:36189433 | all-trans-retinoic acid | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Tretinoin results in increased expression of FNDC1 mRNA | CTD | PMID:36189433 | antirheumatic drug | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of FNDC1 mRNA | CTD | PMID:24449571 | arsenite(3-) | increases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | arsenite results in increased methylation of FNDC1 promoter | CTD | PMID:23974009 | arsenous acid | decreases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of FNDC1 mRNA | CTD | PMID:26705709 | benzo[a]pyrene | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of FNDC1 mRNA | CTD | PMID:22610609 | benzo[a]pyrene | affects methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of FNDC1 exon and Benzo(a)pyrene affects the methylation of FNDC1 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of FNDC1 exon and Benzo(a)pyrene results in increased methylation of FNDC1 promoter | CTD | PMID:27901495 | benzo[a]pyrene | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FNDC1 mRNA | CTD | PMID:27858113 | benzo[b]fluoranthene | affects expression | ISO | Fndc1 (Mus musculus) | 6480464 | benzo(b)fluoranthene affects the expression of FNDC1 mRNA | CTD | PMID:26377693 | benzo[b]fluoranthene | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FNDC1 mRNA | CTD | PMID:27858113 | benzo[e]pyrene | increases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of FNDC1 intron | CTD | PMID:30157460 | beta-naphthoflavone | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FNDC1 mRNA | CTD | PMID:18164116 | bis(2-ethylhexyl) phthalate | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of FNDC1 mRNA | CTD | PMID:31163220 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of FNDC1 mRNA | CTD | PMID:25181051 and PMID:34947998 | bisphenol A | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of FNDC1 mRNA | CTD | PMID:38074096 | bisphenol A | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of FNDC1 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of FNDC1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of FNDC1 mRNA | CTD | PMID:30245210 more ... | bisphenol F | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | bisphenol F results in increased expression of FNDC1 mRNA | CTD | PMID:30951980 | bromobenzene | increases expression | EXP | | 6480464 | bromobenzene results in increased expression of FNDC1 mRNA | CTD | PMID:32479839 | butanal | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | butyraldehyde results in increased expression of FNDC1 mRNA | CTD | PMID:26079696 | cantharidin | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Cantharidin results in decreased expression of FNDC1 mRNA | CTD | PMID:36907384 | carbon nanotube | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to FNDC1 gene] | CTD | PMID:28238834 | chrysene | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | chrysene results in increased expression of FNDC1 mRNA | CTD | PMID:26377693 | chrysene | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FNDC1 mRNA | CTD | PMID:27858113 | cocaine | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Cocaine co-treated with FOS protein mutant form] results in decreased expression of FNDC1 mRNA | CTD | PMID:18355967 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of FNDC1 mRNA | CTD | PMID:22465980 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of FNDC1 mRNA | CTD | PMID:22465980 | dexamethasone | decreases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Dexamethasone results in decreased expression of FNDC1 mRNA | CTD | PMID:25047013 | diarsenic trioxide | decreases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of FNDC1 mRNA | CTD | PMID:26705709 | dioxygen | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of FNDC1 mRNA | CTD | PMID:30529165 | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of FNDC1 mRNA | CTD | PMID:33729688 | diquat | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Diquat results in decreased expression of FNDC1 mRNA | CTD | PMID:36851058 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of FNDC1 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of FNDC1 mRNA | CTD | PMID:29803840 | entinostat | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | entinostat results in increased expression of FNDC1 mRNA | CTD | PMID:26272509 and PMID:27188386 | entinostat | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FNDC1 mRNA | CTD | PMID:27188386 | fulvestrant | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of FNDC1 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of FNDC1 mRNA | CTD | PMID:27387713 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of FNDC1 mRNA | CTD | PMID:33387578 | lead(0) | decreases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Lead results in decreased expression of FNDC1 mRNA | CTD | PMID:19921347 | lipopolysaccharide | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of FNDC1 mRNA | CTD | PMID:35811015 | lipopolysaccharide | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Lipopolysaccharides results in increased expression of FNDC1 mRNA | CTD | PMID:35811015 | methapyrilene | increases methylation | ISO | FNDC1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of FNDC1 intron | CTD | PMID:30157460 | microcystin-LR | increases expression | EXP | | 6480464 | cyanoginosin LR results in increased expression of FNDC1 mRNA | CTD | PMID:34740672 | mono(2-ethylhexyl) phthalate | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [mono-(2-ethylhexyl)phthalate co-treated with Tretinoin] results in increased expression of FNDC1 mRNA | CTD | PMID:36189433 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FNDC1 mRNA | CTD | PMID:18164116 | ozone | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of FNDC1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of FNDC1 mRNA | CTD | PMID:27106289 and PMID:34911549 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of FNDC1 mRNA | CTD | PMID:33387578 | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of FNDC1 mRNA | CTD | PMID:32680482 | PCB138 | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [2 more ... | CTD | PMID:25510870 | phenylmercury acetate | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FNDC1 mRNA | CTD | PMID:27188386 | potassium dichromate | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Potassium Dichromate results in increased expression of FNDC1 mRNA | CTD | PMID:23608068 | progesterone | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Progesterone] results in decreased expression of FNDC1 mRNA | CTD | PMID:20660070 | progesterone | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | Progesterone results in decreased expression of FNDC1 mRNA | CTD | PMID:22238285 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of FNDC1 mRNA | CTD | PMID:28374803 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of FNDC1 mRNA | CTD | PMID:35811015 | SB 431542 | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | testosterone | multiple interactions | EXP | | 6480464 | [estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of FNDC1 mRNA | CTD | PMID:32741896 | tetraphene | multiple interactions | ISO | Fndc1 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of FNDC1 mRNA | CTD | PMID:27858113 | titanium dioxide | decreases expression | ISO | Fndc1 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of FNDC1 mRNA | CTD | PMID:23557971 and PMID:27760801 | toluene | increases expression | EXP | | 6480464 | Toluene results in increased expression of FNDC1 mRNA | CTD | PMID:22967744 | troglitazone | increases expression | ISO | Fndc1 (Mus musculus) | 6480464 | troglitazone results in increased expression of FNDC1 mRNA | CTD | PMID:28973697 | valproic acid | affects expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of FNDC1 mRNA | CTD | PMID:25979313 | valproic acid | increases expression | ISO | FNDC1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of FNDC1 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | FNDC1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FNDC1 mRNA | CTD | PMID:27188386 | |