Kank1 (KN motif and ankyrin repeat domains 1) - Rat Genome Database

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Gene: Kank1 (KN motif and ankyrin repeat domains 1) Rattus norvegicus
Analyze
Symbol: Kank1
Name: KN motif and ankyrin repeat domains 1
RGD ID: 1307714
Description: Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of cellular component organization; negative regulation of substrate adhesion-dependent cell spreading; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ankrd15; ankyrin repeat domain 15; KN motif and ankyrin repeat domain-containing protein 1; LOC309429; MGC125169
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21222,877,962 - 223,074,514 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,877,622 - 223,074,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,405,112 - 231,522,079 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01238,335,228 - 238,452,173 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01231,155,957 - 231,272,929 (+)NCBIRnor_WKY
Rnor_6.01243,201,073 - 243,398,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1243,276,403 - 243,398,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,464,788 - 250,659,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,748,121 - 228,868,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,953,941 - 229,032,270 (+)NCBI
Celera1220,157,106 - 220,275,618 (+)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
glafenine  (EXP)
hydralazine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
ochratoxin A  (ISO)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
6. A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma. Sarkar S, etal., J Biol Chem. 2002 Sep 27;277(39):36585-91. Epub 2002 Jul 19.
Additional References at PubMed
PMID:12477932   PMID:16968744   PMID:17996375   PMID:18458160   PMID:19171758   PMID:19559006   PMID:22084092   PMID:25961457  


Genomics

Comparative Map Data
Kank1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21222,877,962 - 223,074,514 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1222,877,622 - 223,074,514 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1231,405,112 - 231,522,079 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01238,335,228 - 238,452,173 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01231,155,957 - 231,272,929 (+)NCBIRnor_WKY
Rnor_6.01243,201,073 - 243,398,531 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1243,276,403 - 243,398,536 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,464,788 - 250,659,569 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,748,121 - 228,868,261 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,953,941 - 229,032,270 (+)NCBI
Celera1220,157,106 - 220,275,618 (+)NCBICelera
Cytogenetic Map1q51NCBI
KANK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389470,295 - 746,103 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl9470,291 - 746,105 (+)EnsemblGRCh38hg38GRCh38
GRCh379470,295 - 746,103 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369494,703 - 736,103 (+)NCBINCBI36Build 36hg18NCBI36
Celera9421,697 - 662,617 (+)NCBICelera
Cytogenetic Map9p24.3NCBI
HuRef9422,063 - 697,776 (+)NCBIHuRef
CHM1_19469,730 - 745,633 (+)NCBICHM1_1
T2T-CHM13v2.09469,752 - 745,414 (+)NCBIT2T-CHM13v2.0
Kank1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391925,214,091 - 25,411,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1925,214,339 - 25,411,860 (+)EnsemblGRCm39 Ensembl
GRCm381925,236,732 - 25,434,498 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1925,236,975 - 25,434,496 (+)EnsemblGRCm38mm10GRCm38
MGSCv371925,311,692 - 25,508,986 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361925,304,299 - 25,501,593 (+)NCBIMGSCv36mm8
Celera1926,023,481 - 26,224,832 (+)NCBICelera
Cytogenetic Map19BNCBI
Kank1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554345,191,846 - 5,279,739 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554345,247,278 - 5,279,043 (+)NCBIChiLan1.0ChiLan1.0
KANK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v09550,713 - 556,230 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KANK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1189,446,340 - 89,618,716 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl189,480,399 - 89,618,143 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha189,881,037 - 90,088,470 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0189,960,930 - 90,168,925 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl189,960,543 - 90,168,925 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1189,606,742 - 89,814,600 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0189,319,249 - 89,527,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0190,086,221 - 90,294,502 (+)NCBIUU_Cfam_GSD_1.0
Kank1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947136,917,110 - 137,047,718 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365034,122,204 - 4,246,680 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365034,125,302 - 4,255,880 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KANK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,015,046 - 221,078,245 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,015,042 - 221,218,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21247,300,636 - 247,477,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KANK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11278,775,214 - 79,015,538 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1278,774,788 - 78,973,851 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603867,163,360 - 67,410,180 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kank1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247365,379,728 - 5,444,234 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247365,260,761 - 5,444,234 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kank1
1327 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:92
Count of miRNA genes:70
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000021496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1214537555226660468Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1218108584224054420Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat

Markers in Region
D1Rat223  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,987,545 - 222,987,745 (+)MAPPERmRatBN7.2
Rnor_6.01243,311,415 - 243,311,614NCBIRnor6.0
Rnor_5.01250,572,809 - 250,573,008UniSTSRnor5.0
RGSC_v3.41228,780,913 - 228,781,113RGDRGSC3.4
RGSC_v3.41228,780,914 - 228,781,113UniSTSRGSC3.4
RGSC_v3.11228,944,937 - 228,945,136RGD
Celera1220,189,134 - 220,189,333UniSTS
RH 3.4 Map11611.9UniSTS
RH 3.4 Map11611.9RGD
SHRSP x BN Map1118.6299UniSTS
SHRSP x BN Map1118.6299RGD
Cytogenetic Map1q51UniSTS
RH133058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21222,928,444 - 222,928,630 (+)MAPPERmRatBN7.2
Rnor_6.01243,249,590 - 243,249,775NCBIRnor6.0
Rnor_5.01250,513,715 - 250,513,900UniSTSRnor5.0
RGSC_v3.41228,721,199 - 228,721,384UniSTSRGSC3.4
Celera1220,130,192 - 220,130,377UniSTS
RH 3.4 Map11615.51UniSTS
Cytogenetic Map1q51UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 50 35 18 35 7 7 45 35 40 11 7
Low 1 7 6 1 6 1 4 29 1 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001037197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006231220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC107446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000021496   ⟹   ENSRNOP00000021496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1223,049,303 - 223,074,514 (+)Ensembl
Rnor_6.0 Ensembl1243,276,403 - 243,398,536 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080689   ⟹   ENSRNOP00000071999
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1223,051,965 - 223,074,511 (+)Ensembl
Rnor_6.0 Ensembl1243,375,981 - 243,398,527 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100961   ⟹   ENSRNOP00000080934
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,877,622 - 223,074,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107412   ⟹   ENSRNOP00000089539
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1222,877,622 - 223,074,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110548   ⟹   ENSRNOP00000097599
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1223,047,034 - 223,074,514 (+)Ensembl
RefSeq Acc Id: NM_001037197   ⟹   NP_001032274
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,955,377 - 223,074,510 (+)NCBI
Rnor_6.01243,276,434 - 243,398,526 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
RGSC_v3.41228,748,121 - 228,868,261 (+)RGD
Celera1220,157,106 - 220,275,618 (+)RGD
Sequence:
RefSeq Acc Id: XM_006231212   ⟹   XP_006231274
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,046,957 - 223,074,514 (+)NCBI
Rnor_6.01243,370,274 - 243,398,531 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231214   ⟹   XP_006231276
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,877,962 - 223,074,514 (+)NCBI
Rnor_6.01243,201,073 - 243,398,530 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231215   ⟹   XP_006231277
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,877,962 - 223,074,514 (+)NCBI
Rnor_6.01243,201,073 - 243,398,530 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231218   ⟹   XP_006231280
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,046,952 - 223,074,514 (+)NCBI
Rnor_6.01243,370,274 - 243,398,531 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231219   ⟹   XP_006231281
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,047,364 - 223,074,514 (+)NCBI
Rnor_6.01243,371,414 - 243,398,531 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006231220   ⟹   XP_006231282
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,023,130 - 223,074,514 (+)NCBI
Rnor_6.01243,346,737 - 243,398,531 (+)NCBI
Rnor_5.01250,464,788 - 250,659,569 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589274   ⟹   XP_017444763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,047,248 - 223,074,514 (+)NCBI
Rnor_6.01243,371,340 - 243,398,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589275   ⟹   XP_017444764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,035,986 - 223,074,514 (+)NCBI
Rnor_6.01243,359,871 - 243,398,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589276   ⟹   XP_017444765
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,035,617 - 223,074,514 (+)NCBI
Rnor_6.01243,358,933 - 243,398,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017589277   ⟹   XP_017444766
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21223,024,243 - 223,074,514 (+)NCBI
Rnor_6.01243,348,784 - 243,398,531 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080248   ⟹   XP_038936176
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,877,962 - 223,074,514 (+)NCBI
RefSeq Acc Id: XM_039080284   ⟹   XP_038936212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21222,877,962 - 223,074,514 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001032274   ⟸   NM_001037197
- Sequence:
RefSeq Acc Id: XP_006231276   ⟸   XM_006231214
- Peptide Label: isoform X2
- UniProtKB: D4AE58 (UniProtKB/TrEMBL),   A0A8I6AL84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231277   ⟸   XM_006231215
- Peptide Label: isoform X2
- UniProtKB: D4AE58 (UniProtKB/TrEMBL),   A0A8I6AL84 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231282   ⟸   XM_006231220
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006231274   ⟸   XM_006231212
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GML0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231280   ⟸   XM_006231218
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006231281   ⟸   XM_006231219
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444766   ⟸   XM_017589277
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444765   ⟸   XM_017589276
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444764   ⟸   XM_017589275
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017444763   ⟸   XM_017589274
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000071999   ⟸   ENSRNOT00000080689
RefSeq Acc Id: ENSRNOP00000021496   ⟸   ENSRNOT00000021496
RefSeq Acc Id: XP_038936176   ⟸   XM_039080248
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AL84 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038936212   ⟸   XM_039080284
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000089539   ⟸   ENSRNOT00000107412
RefSeq Acc Id: ENSRNOP00000097599   ⟸   ENSRNOT00000110548
RefSeq Acc Id: ENSRNOP00000080934   ⟸   ENSRNOT00000100961

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE58-F1-model_v2 AlphaFold D4AE58 1-1358 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307714 AgrOrtholog
BioCyc Gene G2FUF-56077 BioCyc
Ensembl Genes ENSRNOG00000016023 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000021496 ENTREZGENE
  ENSRNOP00000021496.7 UniProtKB/TrEMBL
  ENSRNOP00000071999.1 UniProtKB/TrEMBL
  ENSRNOP00000080934.1 UniProtKB/TrEMBL
  ENSRNOP00000089539 ENTREZGENE
  ENSRNOP00000089539.1 UniProtKB/TrEMBL
  ENSRNOP00000097599 ENTREZGENE
  ENSRNOP00000097599.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021496 ENTREZGENE
  ENSRNOT00000021496.7 UniProtKB/TrEMBL
  ENSRNOT00000080689.2 UniProtKB/TrEMBL
  ENSRNOT00000100961.1 UniProtKB/TrEMBL
  ENSRNOT00000107412 ENTREZGENE
  ENSRNOT00000107412.1 UniProtKB/TrEMBL
  ENSRNOT00000110548 ENTREZGENE
  ENSRNOT00000110548.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
NCBI Gene 309429 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_5 UniProtKB/TrEMBL
  KN_motif UniProtKB/TrEMBL
PhenoGen Kank1 PhenoGen
PROSITE ANK_REPEAT UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
UniProt A0A8I5ZQY2_RAT UniProtKB/TrEMBL
  A0A8I6AL84 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GML0 ENTREZGENE, UniProtKB/TrEMBL
  D4AE58 ENTREZGENE, UniProtKB/TrEMBL
  Q3B7V4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-01-07 Kank1  KN motif and ankyrin repeat domains 1  Ankrd15  ankyrin repeat domain 15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ankrd15  ankyrin repeat domain 15  Ankrd15_predicted  ankyrin repeat domain 15 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ankrd15_predicted  ankyrin repeat domain 15 (predicted)      Symbol and Name status set to approved 70820 APPROVED