Map2k5 (mitogen activated protein kinase kinase 5) - Rat Genome Database

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Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus
Analyze
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
RGD ID: 61890
Description: Exhibits ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Localizes to cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2,4-trimethylbenzene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Map2k5Tn(sb-T2/Bart3)2.150Mcwi  
Genetic Models: F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2863,625,220 - 63,852,090 (-)NCBI
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Celera863,038,974 - 63,262,592 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
butanal  (ISO)
carbamazepine  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
clofibrate  (ISO)
clozapine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
dorsomorphin  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
methamphetamine  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
oxytocin  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
platycodin D  (EXP)
potassium chromate  (ISO)
resveratrol  (ISO)
rutin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium dichromate  (ISO)
sulfates  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thapsigargin  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
troglitazone  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IDA,TAS)
membrane  (IEA)
nucleus  (IDA)
spindle  (ISO)

References

Additional References at PubMed
PMID:11544482   PMID:12477932   PMID:15489334   PMID:15509711   PMID:15601854   PMID:16415348   PMID:17947239   PMID:19103177   PMID:19484198   PMID:20607863   PMID:25666619  


Genomics

Comparative Map Data
Map2k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2863,625,220 - 63,852,090 (-)NCBI
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Celera863,038,974 - 63,262,592 (-)NCBICelera
Cytogenetic Map8q24NCBI
MAP2K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1567,542,703 - 67,807,117 (+)EnsemblGRCh38hg38GRCh38
GRCh381567,542,685 - 67,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371567,835,041 - 68,099,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,622,075 - 65,886,506 (+)NCBINCBI36hg18NCBI36
Build 341565,719,944 - 65,886,505NCBI
Celera1544,722,555 - 44,987,508 (+)NCBI
Cytogenetic Map15q23NCBI
HuRef1544,669,592 - 44,933,408 (+)NCBIHuRef
CHM1_11567,952,970 - 68,217,538 (+)NCBICHM1_1
Map2k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,071,050 - 63,288,964 (-)NCBIGRCm39mm39
GRCm39 Ensembl963,071,050 - 63,285,184 (-)Ensembl
GRCm38963,163,768 - 63,381,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,163,768 - 63,377,902 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,011,577 - 63,225,659 (-)NCBIGRCm37mm9NCBIm37
MGSCv36962,961,776 - 63,175,858 (-)NCBImm8
Celera960,383,063 - 60,597,534 (-)NCBICelera
Cytogenetic Map9B- CNCBI
Map2k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,203,569 - 8,458,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,207,577 - 8,458,258 (-)NCBIChiLan1.0ChiLan1.0
MAP2K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11564,761,465 - 65,029,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,761,394 - 65,029,655 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01546,493,139 - 46,760,271 (+)NCBIMhudiblu_PPA_v0panPan3
MAP2K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,665,032 - 31,920,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,664,564 - 31,920,751 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,599,952 - 31,856,489 (+)NCBI
ROS_Cfam_1.03031,860,861 - 32,117,463 (+)NCBI
UMICH_Zoey_3.13031,790,015 - 32,045,842 (+)NCBI
UNSW_CanFamBas_1.03031,850,721 - 32,107,484 (+)NCBI
UU_Cfam_GSD_1.03032,096,413 - 32,353,048 (+)NCBI
Map2k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,643,236 - 109,880,510 (+)NCBI
SpeTri2.0NW_00493647127,491,255 - 27,728,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,458,258 - 165,740,319 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11165,458,263 - 165,733,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21183,148,368 - 183,197,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12615,694,760 - 15,956,814 (-)NCBI
ChlSab1.1 Ensembl2615,693,811 - 15,956,918 (-)Ensembl
Vero_WHO_p1.0NW_023666048125,513,002 - 125,773,972 (+)NCBI
Map2k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247815,224,722 - 5,489,517 (-)NCBI

Position Markers
D8Got101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,634,971 - 63,635,232 (+)MAPPER
Rnor_6.0868,065,730 - 68,065,988NCBIRnor6.0
Rnor_5.0867,794,622 - 67,794,880UniSTSRnor5.0
RGSC_v3.4867,323,225 - 67,323,484RGDRGSC3.4
RGSC_v3.4867,323,226 - 67,323,484UniSTSRGSC3.4
RGSC_v3.1867,342,280 - 67,342,538RGD
Celera863,048,725 - 63,048,983UniSTS
RH 3.4 Map8799.2UniSTS
RH 3.4 Map8799.2RGD
RH 2.0 Map8593.8RGD
Cytogenetic Map8q24UniSTS
D8Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25147,440,770 - 147,441,022 (+)MAPPER
mRatBN7.2863,713,366 - 63,714,054 (+)MAPPER
Rnor_6.0868,145,077 - 68,145,764NCBIRnor6.0
Rnor_6.05153,552,704 - 153,552,955NCBIRnor6.0
Rnor_5.0867,872,683 - 67,873,370UniSTSRnor5.0
Rnor_5.05157,322,066 - 157,322,317UniSTSRnor5.0
RGSC_v3.45153,989,202 - 153,989,453UniSTSRGSC3.4
RGSC_v3.4867,401,029 - 67,401,716UniSTSRGSC3.4
Celera863,126,644 - 63,127,331UniSTS
Celera5145,850,612 - 145,850,863UniSTS
Cytogenetic Map8q24UniSTS
BF394715  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,660,375 - 63,660,475 (+)MAPPER
Rnor_6.0868,091,216 - 68,091,315NCBIRnor6.0
Rnor_5.0867,820,108 - 67,820,207UniSTSRnor5.0
RGSC_v3.4867,348,566 - 67,348,665UniSTSRGSC3.4
Celera863,074,061 - 63,074,160UniSTS
RH 3.4 Map8801.1UniSTS
Cytogenetic Map8q24UniSTS
RH138128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,667,592 - 63,667,801 (+)MAPPER
Rnor_6.0868,099,307 - 68,099,515NCBIRnor6.0
Rnor_5.0867,826,913 - 67,827,121UniSTSRnor5.0
RGSC_v3.4867,355,258 - 67,355,466UniSTSRGSC3.4
Celera863,080,873 - 63,081,081UniSTS
Cytogenetic Map8q24UniSTS
RH138410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,625,307 - 63,625,557 (+)MAPPER
Rnor_6.0868,056,064 - 68,056,313NCBIRnor6.0
Rnor_5.0867,784,956 - 67,785,205UniSTSRnor5.0
RGSC_v3.4867,313,560 - 67,313,809UniSTSRGSC3.4
Celera863,039,062 - 63,039,311UniSTS
RH 3.4 Map8802.9UniSTS
Cytogenetic Map8q24UniSTS
UniSTS:469815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2863,625,330 - 63,625,553 (+)MAPPER
Rnor_6.0868,056,087 - 68,056,309NCBIRnor6.0
Rnor_5.0867,784,979 - 67,785,201UniSTSRnor5.0
RGSC_v3.4867,313,583 - 67,313,805UniSTSRGSC3.4
Celera863,039,085 - 63,039,307UniSTS
Cytogenetic Map8q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84571247575971259Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85406504489058369Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85406504489058369Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85406504489058369Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)855435004115812386Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)855659105100659105Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)858230766106394378Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)85842551091990535Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)85842551091990535Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)858425510106526740Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)859234112108068306Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)861394378106394378Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)865717449128033050Rat


Genetic Models
This gene Map2k5 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:232
Count of miRNA genes:88
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000010991, ENSRNOT00000051558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 28 21 11 19 11 1 74 31 41 11
Low 1 15 36 30 30 8 10 4 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_017246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006243229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017595502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010991   ⟹   ENSRNOP00000010991
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl868,055,977 - 68,282,590 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000051558   ⟹   ENSRNOP00000050528
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl868,055,977 - 68,282,590 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079122   ⟹   ENSRNOP00000070803
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl868,055,972 - 68,275,720 (-)Ensembl
RefSeq Acc Id: NM_001033987   ⟹   NP_001029159
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,851,983 (-)NCBI
Rnor_6.0868,055,976 - 68,282,590 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
RGSC_v3.4867,313,472 - 67,542,723 (-)RGD
Celera863,038,974 - 63,262,592 (-)RGD
Sequence:
RefSeq Acc Id: NM_017246   ⟹   NP_058942
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,851,983 (-)NCBI
Rnor_6.0868,055,976 - 68,282,590 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
RGSC_v3.4867,313,472 - 67,542,723 (-)RGD
Celera863,038,974 - 63,262,592 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243229   ⟹   XP_006243291
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,852,084 (-)NCBI
Rnor_6.0868,055,976 - 68,282,656 (-)NCBI
Rnor_5.0867,784,868 - 68,010,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595501   ⟹   XP_017450990
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,852,085 (-)NCBI
Rnor_6.0868,055,976 - 68,282,655 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595502   ⟹   XP_017450991
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,851,329 (-)NCBI
Rnor_6.0868,055,976 - 68,281,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080953   ⟹   XP_038936881
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,660,201 - 63,852,089 (-)NCBI
RefSeq Acc Id: XM_039080954   ⟹   XP_038936882
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080955   ⟹   XP_038936883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080956   ⟹   XP_038936884
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,660,201 - 63,852,090 (-)NCBI
RefSeq Acc Id: XM_039080957   ⟹   XP_038936885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,654,803 - 63,852,086 (-)NCBI
RefSeq Acc Id: XM_039080958   ⟹   XP_038936886
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,852,085 (-)NCBI
RefSeq Acc Id: XM_039080959   ⟹   XP_038936887
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,625,220 - 63,852,086 (-)NCBI
RefSeq Acc Id: XM_039080960   ⟹   XP_038936888
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,660,201 - 63,851,329 (-)NCBI
RefSeq Acc Id: XM_039080961   ⟹   XP_038936889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,663,749 - 63,852,086 (-)NCBI
RefSeq Acc Id: XM_039080962   ⟹   XP_038936890
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2863,663,749 - 63,852,086 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001029159   ⟸   NM_001033987
- Peptide Label: isoform a
- UniProtKB: Q62862 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_058942   ⟸   NM_017246
- Peptide Label: isoform b
- UniProtKB: Q62862 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006243291   ⟸   XM_006243229
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017450990   ⟸   XM_017595501
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017450991   ⟸   XM_017595502
- Peptide Label: isoform X13
- UniProtKB: Q62862 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070803   ⟸   ENSRNOT00000079122
RefSeq Acc Id: ENSRNOP00000050528   ⟸   ENSRNOT00000051558
RefSeq Acc Id: ENSRNOP00000010991   ⟸   ENSRNOT00000010991
RefSeq Acc Id: XP_038936887   ⟸   XM_039080959
- Peptide Label: isoform X9
RefSeq Acc Id: XP_038936886   ⟸   XM_039080958
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038936885   ⟸   XM_039080957
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038936883   ⟸   XM_039080955
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936884   ⟸   XM_039080956
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936882   ⟸   XM_039080954
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936881   ⟸   XM_039080953
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936888   ⟸   XM_039080960
- Peptide Label: isoform X10
RefSeq Acc Id: XP_038936890   ⟸   XM_039080962
- Peptide Label: isoform X12
RefSeq Acc Id: XP_038936889   ⟸   XM_039080961
- Peptide Label: isoform X11
Protein Domains
PB1   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696058
Promoter ID:EPDNEW_R6583
Type:initiation region
Name:Map2k5_1
Description:mitogen activated protein kinase kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0868,282,594 - 68,282,654EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61890 AgrOrtholog
Ensembl Genes ENSRNOG00000007926 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000010991 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000050528 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070803 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010991 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000051558 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000079122 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7122708 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PB1_dom UniProtKB/Swiss-Prot
  PB1_MAP2K5 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:29568 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93521 IMAGE-MGC_LOAD
NCBI Gene 29568 ENTREZGENE
Pfam PB1 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Map2k5 PhenoGen
PROSITE PB1 UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART PB1 UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC216643
UniProt MP2K5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q62863 UniProtKB/Swiss-Prot
  Q62864 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Map2k5  mitogen activated protein kinase kinase 5       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function does not phosphorylate ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1 61658