Map2k5 (mitogen activated protein kinase kinase 5)

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Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus

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Symbol:

Map2k5

Name:

mitogen activated protein kinase kinase 5

RGD ID:

61890

Description:

Enables ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Predicted to be located in spindle. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2,4-trimethylbenzene; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

Genetic Models:

F344-Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	72,520,616 - 72,748,395 (-)	NCBI		GRCr8
mRatBN7.2	8	63,625,220 - 63,852,090 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	63,625,221 - 63,851,983 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	69,140,369 - 69,367,101 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	67,412,831 - 67,639,556 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	65,282,951 - 65,509,687 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	68,055,972 - 68,282,590 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	67,332,521 - 67,559,107 (-)	NCBI
Celera	8	63,038,974 - 63,262,592 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amphetamine abuse (ISO)

Bloom syndrome (ISO)

Body Weight (ISO)

Cardiomegaly (ISO)

colorectal cancer (ISO)

dilated cardiomyopathy (ISO)

neuronal ceroid lipofuscinosis (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Sudden Death (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (EXP)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetylsalicylic acid (ISO)

afimoxifene (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

arecoline (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cis-caffeic acid (ISO)

clofibrate (ISO)

clozapine (EXP)

copper atom (ISO)

copper(0) (ISO)

dexamethasone (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

fipronil (EXP)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP)

haloperidol (EXP)

hesperidin (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (ISO)

methamphetamine (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

N(4)-hydroxycytidine (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

oxaliplatin (EXP)

oxytocin (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

platycodin D (EXP)

potassium chromate (ISO)

resveratrol (ISO)

rutin (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium dichromate (ISO)

sodium fluoride (EXP)

sulfates (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

trans-caffeic acid (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

undecane (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to growth factor stimulus (IMP)

ERK5 cascade (IMP)

heart development (ISO)

insulin-like growth factor receptor signaling pathway (ISO)

MAPK cascade (IBA,IC,IMP,ISO)

negative regulation of canonical NF-kappaB signal transduction (IMP)

negative regulation of cell migration involved in sprouting angiogenesis (IMP)

negative regulation of chemokine (C-X-C motif) ligand 2 production (IMP)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IMP)

negative regulation of heterotypic cell-cell adhesion (IMP)

negative regulation of interleukin-8 production (IMP)

negative regulation of response to cytokine stimulus (IMP)

negative regulation of smooth muscle cell apoptotic process (IMP)

negative regulation of transcription by RNA polymerase II (IMP)

positive regulation of cell growth (IMP)

positive regulation of epithelial cell proliferation (IDA)

positive regulation of protein metabolic process (IMP)

positive regulation of transcription by RNA polymerase II (IMP)

protein phosphorylation (IDA,IEA)

signal transduction (IEA)

Cellular Component

cytosol (TAS)

membrane (IEA)

spindle (ISO)

Molecular Function

ATP binding (IDA,IEA)

MAP kinase activity (TAS)

MAP kinase kinase activity (IBA,IC,ISO)

metal ion binding (IEA)

protein binding (ISO)

protein kinase activity (IDA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IEA)

protein tyrosine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Erk5 MAPK signaling pathway (ISO)

Erk5 MAPK signaling pathway (IMP,ISO)

mitogen activated protein kinase signaling pathway (IEA)

neurotrophic factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Isolation of MEK5 and differential expression of alternatively spliced forms.	English JM, etal., J Biol Chem 1995 Dec 1;270(48):28897-902.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.	Mehta PB, etal., Oncogene. 2003 Mar 6;22(9):1381-9.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.	Nicol RL, etal., EMBO J. 2001 Jun 1;20(11):2757-67.
8.	Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).	Ohnesorge N, etal., J Biol Chem. 2010 Aug 20;285(34):26199-210. doi: 10.1074/jbc.M110.103127. Epub 2010 Jun 15.
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.	Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease.	Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60.
14.	Hypertrophic responses to cardiotrophin-1 are not mediated by STAT3, but via a MEK5-ERK5 pathway in cultured cardiomyocytes.	Takahashi N, etal., J Mol Cell Cardiol. 2005 Jan;38(1):185-92. Epub 2004 Dec 10.
15.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction.	Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606.
17.	Regulation of cellular functions by the ERK5 signalling pathway.	Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
18.	Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.	Woo CH, etal., FASEB J. 2010 Dec;24(12):4917-28. doi: 10.1096/fj.10-162636. Epub 2010 Aug 19.

Additional References at PubMed

PMID:11544482	PMID:12477932	PMID:15489334	PMID:15509711	PMID:15601854	PMID:16415348	PMID:17947239	PMID:19103177	PMID:19484198	PMID:20607863	PMID:25666619

Genomics

Comparative Map Data

Map2k5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	72,520,616 - 72,748,395 (-)	NCBI		GRCr8
mRatBN7.2	8	63,625,220 - 63,852,090 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	63,625,221 - 63,851,983 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	69,140,369 - 69,367,101 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	67,412,831 - 67,639,556 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	65,282,951 - 65,509,687 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	68,055,972 - 68,282,590 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	67,332,521 - 67,559,107 (-)	NCBI
Celera	8	63,038,974 - 63,262,592 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

MAP2K5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	67,542,703 - 67,807,114 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	67,542,703 - 67,807,117 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	67,835,041 - 68,099,452 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	65,622,075 - 65,886,506 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	65,719,944 - 65,886,505	NCBI
Celera	15	44,722,555 - 44,987,508 (+)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	44,669,592 - 44,933,408 (+)	NCBI		HuRef
CHM1_1	15	67,952,970 - 68,217,538 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	65,364,709 - 65,628,974 (+)	NCBI		T2T-CHM13v2.0

Map2k5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	63,071,050 - 63,288,964 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	63,071,050 - 63,285,184 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	63,163,768 - 63,381,682 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	63,163,768 - 63,377,902 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	63,011,577 - 63,225,659 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	62,961,776 - 63,175,858 (-)	NCBI		MGSCv36	mm8
Celera	9	60,383,063 - 60,597,534 (-)	NCBI		Celera
Cytogenetic Map	9	B- C	NCBI
cM Map	9	33.96	NCBI

Map2k5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	8,203,569 - 8,458,258 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	8,207,577 - 8,458,258 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAP2K5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	56,797,445 - 57,064,491 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	60,970,950 - 61,238,196 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	46,493,139 - 46,760,271 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	64,761,465 - 65,029,655 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	64,761,394 - 65,029,655 (+)	Ensembl	panpan1.1		panPan2

MAP2K5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	31,665,032 - 31,920,792 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	31,664,564 - 31,920,751 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	31,599,952 - 31,856,489 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	31,860,861 - 32,117,463 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	31,861,062 - 32,117,422 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	31,790,015 - 32,045,842 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	31,850,721 - 32,107,484 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	32,096,413 - 32,353,048 (+)	NCBI		UU_Cfam_GSD_1.0

Map2k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	109,643,236 - 109,880,510 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	27,491,342 - 27,728,607 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	27,491,255 - 27,728,572 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP2K5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	165,458,258 - 165,740,297 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	165,458,263 - 165,733,452 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	183,148,368 - 183,197,101 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP2K5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	15,694,760 - 15,956,814 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	15,693,811 - 15,956,918 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	125,513,002 - 125,773,972 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map2k5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	5,224,724 - 5,489,488 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	5,224,722 - 5,489,517 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Map2k5
725 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	232
Count of miRNA genes:	88
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000010991, ENSRNOT00000051558
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30856404	75856404	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	30848154	101699754	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	41866876	86866876	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	42692684	90165460	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	30848154	101699754	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	31737729	76737729	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	35582032	80582032	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	50095249	82460899	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	30848154	101699754	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	28242912	73242912	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	28242912	99525068	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	30848154	82460899	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	27205715	99103503	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	19331152	93965294	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	29502665	70386295	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	22662330	67662330	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	40713066	82925667	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	41866876	75097878	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	35551938	80551938	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	40713066	93965294	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	27205715	99103503	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	30848259	105647037	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	54237644	85365202	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	27205715	99103503	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	41867010	70386132	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	50095249	82460899	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	54237644	85365202	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	30848154	82460899	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	43296169	98968765	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	54259986	100382532	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	30188867	94457446	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	43296169	98968765	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	30848154	82460899	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	43296169	98968765	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	43296169	98968765	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	43296169	98968765	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	43296169	98968765	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	51351728	107062046	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	50095249	82460899	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	54043744	98968765	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	46531722	99083736	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	36469535	99083736	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	8462195	110921472	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	18984168	84531599	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	26130187	71130187	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	49805831	94805831	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	30848154	82460899	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	26130187	71130187	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	53968765	98968765	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	54237644	99103503	Rat

Markers in Region

D8Got101

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,634,971 - 63,635,232 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,065,730 - 68,065,988	NCBI	Rnor6.0
Rnor_5.0	8	67,794,622 - 67,794,880	UniSTS	Rnor5.0
RGSC_v3.4	8	67,323,226 - 67,323,484	UniSTS	RGSC3.4
RGSC_v3.4	8	67,323,225 - 67,323,484	RGD	RGSC3.4
RGSC_v3.1	8	67,342,280 - 67,342,538	RGD
Celera	8	63,048,725 - 63,048,983	UniSTS
RH 3.4 Map	8	799.2	RGD
RH 3.4 Map	8	799.2	UniSTS
RH 2.0 Map	8	593.8	RGD
Cytogenetic Map	8	q24	UniSTS

D8Mco2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	147,440,770 - 147,441,022 (+)	MAPPER	mRatBN7.2
mRatBN7.2	8	63,713,366 - 63,714,054 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,145,077 - 68,145,764	NCBI	Rnor6.0
Rnor_6.0	5	153,552,704 - 153,552,955	NCBI	Rnor6.0
Rnor_5.0	8	67,872,683 - 67,873,370	UniSTS	Rnor5.0
Rnor_5.0	5	157,322,066 - 157,322,317	UniSTS	Rnor5.0
RGSC_v3.4	5	153,989,202 - 153,989,453	UniSTS	RGSC3.4
RGSC_v3.4	8	67,401,029 - 67,401,716	UniSTS	RGSC3.4
Celera	8	63,126,644 - 63,127,331	UniSTS
Celera	5	145,850,612 - 145,850,863	UniSTS
Cytogenetic Map	8	q24	UniSTS

BF394715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,660,375 - 63,660,475 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,091,216 - 68,091,315	NCBI	Rnor6.0
Rnor_5.0	8	67,820,108 - 67,820,207	UniSTS	Rnor5.0
RGSC_v3.4	8	67,348,566 - 67,348,665	UniSTS	RGSC3.4
Celera	8	63,074,061 - 63,074,160	UniSTS
RH 3.4 Map	8	801.1	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH138128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,667,592 - 63,667,801 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,099,307 - 68,099,515	NCBI	Rnor6.0
Rnor_5.0	8	67,826,913 - 67,827,121	UniSTS	Rnor5.0
RGSC_v3.4	8	67,355,258 - 67,355,466	UniSTS	RGSC3.4
Celera	8	63,080,873 - 63,081,081	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH138410

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,625,307 - 63,625,557 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,056,064 - 68,056,313	NCBI	Rnor6.0
Rnor_5.0	8	67,784,956 - 67,785,205	UniSTS	Rnor5.0
RGSC_v3.4	8	67,313,560 - 67,313,809	UniSTS	RGSC3.4
Celera	8	63,039,062 - 63,039,311	UniSTS
RH 3.4 Map	8	802.9	UniSTS
Cytogenetic Map	8	q24	UniSTS

UniSTS:469815

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,625,330 - 63,625,553 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	68,056,087 - 68,056,309	NCBI	Rnor6.0
Rnor_5.0	8	67,784,979 - 67,785,201	UniSTS	Rnor5.0
RGSC_v3.4	8	67,313,583 - 67,313,805	UniSTS	RGSC3.4
Celera	8	63,039,085 - 63,039,307	UniSTS
Cytogenetic Map	8	q24	UniSTS

Genetic Models

This gene Map2k5 is modified in the following models/strains:

F344-Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system

circulatory system

endocrine system

exocrine system

hemolymphoid system

hepatobiliary system

integumental system

musculoskeletal system

nervous system

renal system

reproductive system

respiratory system

appendage

High

Medium

250

103

131

Low

130

102

Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_017246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063265018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000010991 ⟹ ENSRNOP00000010991

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	63,625,221 - 63,851,983 (-)	Ensembl
Rnor_6.0 Ensembl	8	68,055,977 - 68,282,590 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000051558 ⟹ ENSRNOP00000050528

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	63,625,221 - 63,851,983 (-)	Ensembl
Rnor_6.0 Ensembl	8	68,055,977 - 68,282,590 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079122 ⟹ ENSRNOP00000070803

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	63,625,221 - 63,851,983 (-)	Ensembl
Rnor_6.0 Ensembl	8	68,055,972 - 68,275,720 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114643 ⟹ ENSRNOP00000083354

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	63,625,242 - 63,851,983 (-)	Ensembl

RefSeq Acc Id:

NM_001033987 ⟹ NP_001029159

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,520,616 - 72,747,373 (-)	NCBI
mRatBN7.2	8	63,625,220 - 63,851,983 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,590 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	RGD
Celera	8	63,038,974 - 63,262,592 (-)	RGD

Sequence:

show sequence

CGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCTC
CGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGTG
GAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCACG
CTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACCA
GGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTTG
TCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCCC
CAGTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTGCAAGCTCCC
TCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTGTCTTCTGTC
TATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCCTTGCCGCAG
GATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGCCATGGAGAA
CCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACCGTGCACTCC
GGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACGA
CGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGACGAAGAGAT
GAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGCCAGCTAATA
GAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGA
AGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTCACTTCCAAG
CAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAGATGAATGAA
CAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATC
ATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACTGGAGCTTCA
GAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATCATAGGATTT
TACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATGGGGGGTCTT
TGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGTTGTTAAAGG
CCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAACATGCTTGTA
AACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGAATTCTATAG
CCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGAGCAGTATGG
GATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGGGAGGTTTCCA
TATCCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTG
ATGAGGATTCGCCGGTCCTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTACATTTCATCACTCA
GTGCATGAGGAAGCAGCCCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGGTCACCCATTCATC
GTGCAGTTCAATGACGGAAACGCCACTGTGGTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGA
GACGGAGCCAGCAGGGGCCCCCATGAGACCTCAGCAGGACACTGACCACCCAGGACCAGGCATC
AAGGTCACAACAAGCCGTGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGATGTACTGGGCACA
GCCTCCTGCTTTCACCTTCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCC
CTCACCACTGGTAGGGAGGAGGCACTGACAATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGAT
GAGGTTATGGAACCTCCTCTGGCCCCACCCTCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTA
TCAGCAGCACTGATGGGAATAAAGTATTACTGCTTTGGAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_017246 ⟹ NP_058942

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,520,616 - 72,747,373 (-)	NCBI
mRatBN7.2	8	63,625,220 - 63,851,983 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,590 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	RGD
Celera	8	63,038,974 - 63,262,592 (-)	RGD

Sequence:

show sequence

CGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCTC
CGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGTG
GAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCACG
CTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACCA
GGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTTG
TCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCCC
CAGTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTGCAAGCTCCC
TCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTGTCTTCTGTC
TATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCCTTGCCGCAG
GATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGCCATGGAGAA
CCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACCGTGCACTCC
GGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACGA
CGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGACGAAGAGAT
GAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGCCAGCTAATA
GAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGA
AGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTCACTTCCAAG
CAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAGATGAATGAA
CAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATC
ATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACTGGAGCTTCA
GAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATCATAGGATTT
TACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATGGGGGGTCTT
TGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGTTGTTAAAGG
CCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAACATGCTTGTA
AACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGAATTCTATAG
CCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGAGCAGTATGG
GATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGATTCAGAAAAACCAGGGATCT
TTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCGGTCCTTCCGCTTGGAG
AGTTCTCGGAGCCGTTTGTACATTTCATCACTCAGTGCATGAGGAAGCAGCCCAAGGAAAGACC
AGCGCCCGAGGAGCTGATGGGTCACCCATTCATCGTGCAGTTCAATGACGGAAACGCCACTGTG
GTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGAGACGGAGCCAGCAGGGGCCCCCATGAGACC
TCAGCAGGACACTGACCACCCAGGACCAGGCATCAAGGTCACAACAAGCCGTGACCCCTCTGTC
TGCTGCCTGATTGGGAAGAGATGTACTGGGCACAGCCTCCTGCTTTCACCTTCTACCTTACCTG
GGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCCCTCACCACTGGTAGGGAGGAGGCACTGACA
ATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGATGAGGTTATGGAACCTCCTCTGGCCCCACCC
TCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTATCAGCAGCACTGATGGGAATAAAGTATTAC
TGCTTTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243229 ⟹ XP_006243291

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,520,616 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,625,220 - 63,852,084 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI

Sequence:

show sequence

CCATCGCGTTTTGGTTCCGGAGTAACAGCGGTCTAGCGGCCGCCTTCCTCCTCCTCCTCCTCCT
CTCGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTC
TCCGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGG
TGGAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCA
CGCTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAAC
CAGGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTT
TGTCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTC
CCCAGTATGCTTCTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCT
GCAAGCTCCCTCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCT
GTCTTCTGTCTATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTC
CTTGCCGCAGGATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTG
CCATGGAGAACCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGAC
CGTGCACTCCGGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCT
GAAGCAACGACGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTG
ACGAAGAGATGAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGG
CCAGCTAATAGAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATA
CATGGCCTGAAGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATT
CACTTCCAAGCAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCA
GATGAATGAACAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTAC
AAAGCATATCATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACAC
TGGAGCTTCAGAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATAT
CATAGGATTTTACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGAT
GGGGGGTCTTTGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAG
TTGTTAAAGGCCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAA
CATGCTTGTAAACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTG
AATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAG
AGCAGTATGGGATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGG
GAGGTTTCCATATCCTCAGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCGGTC
CTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTACATTTCATCACTCAGTGCATGAGGAAGCAGC
CCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGGTCACCCATTCATCGTGCAGTTCAATGACGG
AAACGCCACTGTGGTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGAGACGGAGCCAGCAGGGG
CCCCCATGAGACCTCAGCAGGACACTGACCACCCAGGACCAGGCATCAAGGTCACAACAAGCCG
TGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGATGTACTGGGCACAGCCTCCTGCTTTCACCT
TCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCCCTCACCACTGGTAGGGA
GGAGGCACTGACAATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGATGAGGTTATGGAACCTCC
TCTGGCCCCACCCTCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTATCAGCAGCACTGATGGG
AATAAAGTATTACTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_017595501 ⟹ XP_017450990

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,520,616 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,625,220 - 63,852,085 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,655 (-)	NCBI

Sequence:

show sequence

CATCGCGTTTTGGTTCCGGAGTAACAGCGGTCTAGCGGCCGCCTTCCTCCTCCTCCTCCTCCTC
TCGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCT
CCGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGT
GGAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCAC
GCTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACC
AGGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTT
GTCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCC
CCAGTATGCTTCTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTG
CAAGCTCCCTCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTG
TCTTCTGTCTATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCC
TTGCCGCAGGATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGC
CATGGAGAACCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACC
GTGCACTCCGGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTG
AAGCAACGACGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGA
CGAAGAGATGAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGC
CAGCTAATAGAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATAC
ATGGCCTGAAGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTC
ACTTCCAAGCAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAG
ATGAATGAACAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACA
AAGCATATCATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACT
GGAGCTTCAGAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATC
ATAGGATTTTACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATG
GGGGGTCTTTGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGT
TGTTAAAGGCCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAAC
ATGCTTGTAAACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGA
ATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGA
GCAGTATGGGATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGGG
AGGTTTCCATATCCTCAGGATTCGCCGGTCCTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTAC
ATTTCATCACTCAGTGCATGAGGAAGCAGCCCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGG
TCACCCATTCATCGTGCAGTTCAATGACGGAAACGCCACTGTGGTGTCCATGTGGGTTTGCCGA
GCTCTGGAGGAGAGACGGAGCCAGCAGGGGCCCCCATGAGACCTCAGCAGGACACTGACCACCC
AGGACCAGGCATCAAGGTCACAACAAGCCGTGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGA
TGTACTGGGCACAGCCTCCTGCTTTCACCTTCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGC
CTCTGCCGAACCCCTCACCACTGGTAGGGAGGAGGCACTGACAATGGCAGGTGGAGATGGTGCA
GGGTTGGGGTGATGAGGTTATGGAACCTCCTCTGGCCCCACCCTCATCTCTCCCTACTGTTGTA
AAGGGTCAGCCTATCAGCAGCACTGATGGGAATAAAGTATTACTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_039080953 ⟹ XP_038936881

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,660,201 - 63,852,089 (-)	NCBI

RefSeq Acc Id:

XM_039080954 ⟹ XP_038936882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080955 ⟹ XP_038936883

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080956 ⟹ XP_038936884

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,748,395 (-)	NCBI
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080960 ⟹ XP_038936888

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,746,730 (-)	NCBI
mRatBN7.2	8	63,660,201 - 63,851,329 (-)	NCBI

RefSeq Acc Id:

XM_063265018 ⟹ XP_063121088

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	72,555,595 - 72,700,832 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001029159	(Get FASTA)	NCBI Sequence Viewer
	NP_058942	(Get FASTA)	NCBI Sequence Viewer
	XP_006243291	(Get FASTA)	NCBI Sequence Viewer
	XP_017450990	(Get FASTA)	NCBI Sequence Viewer
	XP_038936881	(Get FASTA)	NCBI Sequence Viewer
	XP_038936882	(Get FASTA)	NCBI Sequence Viewer
	XP_038936883	(Get FASTA)	NCBI Sequence Viewer
	XP_038936884	(Get FASTA)	NCBI Sequence Viewer
	XP_038936888	(Get FASTA)	NCBI Sequence Viewer
	XP_063121088	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52320	(Get FASTA)	NCBI Sequence Viewer
	AAC52321	(Get FASTA)	NCBI Sequence Viewer
	AAC52322	(Get FASTA)	NCBI Sequence Viewer
	AAH78860	(Get FASTA)	NCBI Sequence Viewer
	EDL95767	(Get FASTA)	NCBI Sequence Viewer
	EDL95768	(Get FASTA)	NCBI Sequence Viewer
	EDL95769	(Get FASTA)	NCBI Sequence Viewer
	EDL95770	(Get FASTA)	NCBI Sequence Viewer
	EDL95771	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000010991.6
	ENSRNOP00000050528.2
	ENSRNOP00000070803.2
	ENSRNOP00000083354.1
	ENSRNOP00055036718
	ENSRNOP00060029691
	ENSRNOP00065009135
GenBank Protein	Q62862	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001029159 ⟸ NM_001033987
- Peptide Label:	isoform a
- UniProtKB:	Q62863 (UniProtKB/Swiss-Prot), Q62864 (UniProtKB/Swiss-Prot), Q62862 (UniProtKB/Swiss-Prot), A6J595 (UniProtKB/TrEMBL), A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLP LGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:	NP_058942 ⟸ NM_017246
- Peptide Label:	isoform b
- UniProtKB:	A6J594 (UniProtKB/TrEMBL), A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVH FITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:	XP_006243291 ⟸ XM_006243229
- Peptide Label:	isoform X5
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQPLQLLQCIVDEDSPVLPLGEFSEPFV HFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:	XP_017450990 ⟸ XM_017595501
- Peptide Label:	isoform X6
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQDSPVLPLGEFSEPFVHFITQCMRKQP KERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

Ensembl Acc Id:

ENSRNOP00000070803 ⟸ ENSRNOT00000079122

Ensembl Acc Id:

ENSRNOP00000050528 ⟸ ENSRNOT00000051558

Ensembl Acc Id:

ENSRNOP00000010991 ⟸ ENSRNOT00000010991

RefSeq Acc Id:	XP_038936883 ⟸ XM_039080955
- Peptide Label:	isoform X3
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936884 ⟸ XM_039080956
- Peptide Label:	isoform X4
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936882 ⟸ XM_039080954
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936881 ⟸ XM_039080953
- Peptide Label:	isoform X1
- UniProtKB:	A0A8L2R4U8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038936888 ⟸ XM_039080960
- Peptide Label:	isoform X7

Ensembl Acc Id:

ENSRNOP00000083354 ⟸ ENSRNOT00000114643

RefSeq Acc Id:	XP_063121088 ⟸ XM_063265018
- Peptide Label:	isoform X8

Protein Domains

PB1 Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q62862-F1-model_v2	AlphaFold	Q62862	1-448	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696058

Promoter ID:

EPDNEW_R6583

Type:

initiation region

Name:

Map2k5_1

Description:

mitogen activated protein kinase kinase 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	68,282,594 - 68,282,654	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61890	AgrOrtholog
BioCyc Gene	G2FUF-30137	BioCyc
Ensembl Genes	ENSRNOG00000007926	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055025959	UniProtKB/Swiss-Prot
	ENSRNOG00060020809	UniProtKB/Swiss-Prot
	ENSRNOG00065007900	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010991.7	UniProtKB/Swiss-Prot
	ENSRNOT00000051558.5	UniProtKB/Swiss-Prot
	ENSRNOT00000079122.2	UniProtKB/TrEMBL
	ENSRNOT00000114643.1	UniProtKB/TrEMBL
	ENSRNOT00055044816	UniProtKB/Swiss-Prot
	ENSRNOT00060036106	UniProtKB/Swiss-Prot
	ENSRNOT00065012437	UniProtKB/Swiss-Prot
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7122708	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PB1_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PB1_MAP2K5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29568	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93521	IMAGE-MGC_LOAD
NCBI Gene	29568	ENTREZGENE
PANTHER	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Pkinase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Map2k5	PhenoGen
PROSITE	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007926	RatGTEx
	ENSRNOG00055025959	RatGTEx
	ENSRNOG00060020809	RatGTEx
	ENSRNOG00065007900	RatGTEx
SMART	PB1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	CAD & PB1 domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC216643
UniProt	A0A8I5ZZ49_RAT	UniProtKB/TrEMBL
	A0A8L2R4U8	ENTREZGENE, UniProtKB/TrEMBL
	A6J594	ENTREZGENE, UniProtKB/TrEMBL
	A6J595	ENTREZGENE, UniProtKB/TrEMBL
	A6J596_RAT	UniProtKB/TrEMBL
	A6J597_RAT	UniProtKB/TrEMBL
	A6J598_RAT	UniProtKB/TrEMBL
	MP2K5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q62863	ENTREZGENE
	Q62864	ENTREZGENE
UniProt Secondary	Q62863	UniProtKB/Swiss-Prot
	Q62864	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Map2k5	mitogen activated protein kinase kinase 5			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	does not phosphorylate ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1	61658

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)