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Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus
Symbol: Map2k5
Name: mitogen activated protein kinase kinase 5
Description: Exhibits ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of macromolecule biosynthetic process. Localizes to cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2,4-trimethylbenzene; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5
Homo sapiens (human) : MAP2K5 (mitogen-activated protein kinase kinase 5)  HGNC  Alliance
Mus musculus (house mouse) : Map2k5 (mitogen-activated protein kinase kinase 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k5 (mitogen-activated protein kinase kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Canis lupus familiaris (dog) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map2k5 (mitogen-activated protein kinase kinase 5)
Sus scrofa (pig) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Chlorocebus sabaeus (African green monkey) : MAP2K5 (mitogen-activated protein kinase kinase 5)
Heterocephalus glaber (naked mole-rat) : Map2k5 (mitogen-activated protein kinase kinase 5)
more info ...
Allele / Splice: Map2k5Tn(sb-T2/Bart3)2.150Mcwi  
Genetic Models: F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Celera863,038,974 - 63,262,592 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Map2k5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61890
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.