Map2k5 (mitogen activated protein kinase kinase 5)

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Gene: Map2k5 (mitogen activated protein kinase kinase 5) Rattus norvegicus

Analyze

Symbol:

Map2k5

Name:

mitogen activated protein kinase kinase 5

RGD ID:

61890

Description:

Exhibits ATP binding activity and protein kinase activity. Involved in several processes, including ERK5 cascade; negative regulation of apoptotic process; and regulation of gene expression. Localizes to cytosol and nucleus. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5); PARTICIPATES IN Erk5 MAPK signaling pathway; altered Erk5 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,1-dichloroethene; 1,2,4-trimethylbenzene; ammonium chloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; MAPK/ERK kinase 5; MAPKK 5; MEK 5; Mek5; mitogen-activated protein kinase kinase 5

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

Genetic Models:

F344-Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	63,625,220 - 63,852,090 (-)	NCBI
Rnor_6.0 Ensembl	8	68,055,972 - 68,282,590 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	67,332,521 - 67,559,107 (-)	NCBI
Celera	8	63,038,974 - 63,262,592 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amphetamine abuse (ISO)

Bloom syndrome (ISO)

Body Weight (ISO)

Cardiomegaly (ISO)

colon cancer (ISO)

dilated cardiomyopathy (ISO)

prostate cancer (ISO)

Prostatic Neoplasms (ISO)

Sudden Death (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (EXP)

1,2,4-trimethylbenzene (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetylsalicylic acid (ISO)

afimoxifene (ISO)

ammonium chloride (EXP)

aristolochic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-chloroethyl) sulfide (EXP)

bisphenol A (EXP,ISO)

butanal (ISO)

carbamazepine (ISO)

choline (ISO)

cis-caffeic acid (ISO)

clofibrate (ISO)

clozapine (EXP)

copper atom (ISO)

copper(0) (ISO)

dexamethasone (ISO)

diclofenac (ISO)

dorsomorphin (ISO)

fipronil (EXP)

flavonoids (EXP)

folic acid (ISO)

formaldehyde (ISO)

genistein (EXP)

haloperidol (EXP)

hydrogen peroxide (ISO)

indometacin (ISO)

L-methionine (ISO)

methamphetamine (ISO)

methoxychlor (EXP)

methylmercury chloride (ISO)

methylseleninic acid (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

oxaliplatin (EXP)

oxytocin (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

platycodin D (EXP)

potassium chromate (ISO)

resveratrol (ISO)

rutin (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium dichromate (ISO)

sulfates (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP)

thapsigargin (ISO)

topotecan (EXP)

trans-caffeic acid (ISO)

troglitazone (ISO)

undecane (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to growth factor stimulus (IMP)

ERK5 cascade (IMP)

heart development (ISO)

MAPK cascade (IC,ISO)

negative regulation of cell migration involved in sprouting angiogenesis (IMP)

negative regulation of chemokine (C-X-C motif) ligand 2 production (IMP)

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process (IMP)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IMP)

negative regulation of heterotypic cell-cell adhesion (IMP)

negative regulation of interleukin-8 production (IMP)

negative regulation of NF-kappaB transcription factor activity (IMP)

negative regulation of response to cytokine stimulus (IMP)

negative regulation of transcription by RNA polymerase II (IMP)

obsolete activation of MAPK activity (IBA,IMP)

peptidyl-tyrosine phosphorylation (IEA)

positive regulation of cell growth (IMP)

positive regulation of epithelial cell proliferation (IDA)

positive regulation of protein metabolic process (IMP)

positive regulation of transcription by RNA polymerase II (IMP)

protein phosphorylation (IDA)

Cellular Component

cytosol (IDA,TAS)

membrane (IEA)

nucleus (IDA)

spindle (ISO)

Molecular Function

ATP binding (IDA)

MAP kinase kinase activity (IBA,IC)

metal ion binding (IEA)

protein binding (ISO)

protein kinase activity (IDA)

protein serine kinase activity (IEA)

protein threonine kinase activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Erk5 MAPK signaling pathway (ISO)

Erk5 MAPK signaling pathway (IMP,ISO)

mitogen activated protein kinase signaling pathway (IEA)

neurotrophic factor signaling pathway (IEA)

References

References - curated


1.	English JM, etal., J Biol Chem 1995 Dec 1;270(48):28897-902.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Mehta PB, etal., Oncogene. 2003 Mar 6;22(9):1381-9.
5.	MGD data from the GO Consortium
6.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Nicol RL, etal., EMBO J. 2001 Jun 1;20(11):2757-67.
8.	Ohnesorge N, etal., J Biol Chem. 2010 Aug 20;285(34):26199-210. doi: 10.1074/jbc.M110.103127. Epub 2010 Jun 15.
9.	Pipeline to import KEGG annotations from KEGG into RGD
10.	Raviv Z, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1773-84. Epub 2004 Mar 16.
11.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	RGD automated import pipeline for gene-chemical interactions
13.	Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60.
14.	Takahashi N, etal., J Mol Cell Cardiol. 2005 Jan;38(1):185-92. Epub 2004 Dec 10.
15.	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16.	Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606.
17.	Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.

Additional References at PubMed

PMID:11544482	PMID:12477932	PMID:15489334	PMID:15509711	PMID:15601854	PMID:16415348	PMID:17947239	PMID:19103177	PMID:19484198	PMID:20607863	PMID:25666619

Genomics

Comparative Map Data

Map2k5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	8	63,625,220 - 63,852,090 (-)	NCBI
Rnor_6.0 Ensembl	8	68,055,972 - 68,282,590 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	8	67,332,521 - 67,559,107 (-)	NCBI
Celera	8	63,038,974 - 63,262,592 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

MAP2K5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	67,542,703 - 67,807,117 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	67,542,685 - 67,807,114 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	67,835,041 - 68,099,452 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	65,622,075 - 65,886,506 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	15	65,719,944 - 65,886,505	NCBI
Celera	15	44,722,555 - 44,987,508 (+)	NCBI
Cytogenetic Map	15	q23	NCBI
HuRef	15	44,669,592 - 44,933,408 (+)	NCBI		HuRef
CHM1_1	15	67,952,970 - 68,217,538 (+)	NCBI		CHM1_1

Map2k5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	63,071,050 - 63,288,964 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	9	63,071,050 - 63,285,184 (-)	Ensembl
GRCm38	9	63,163,768 - 63,381,682 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	63,163,768 - 63,377,902 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	63,011,577 - 63,225,659 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	9	62,961,776 - 63,175,858 (-)	NCBI			mm8
Celera	9	60,383,063 - 60,597,534 (-)	NCBI		Celera
Cytogenetic Map	9	B- C	NCBI

Map2k5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	8,203,569 - 8,458,258 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	8,207,577 - 8,458,258 (-)	NCBI	ChiLan1.0	ChiLan1.0

MAP2K5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	64,761,465 - 65,029,655 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	64,761,394 - 65,029,655 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	46,493,139 - 46,760,271 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

MAP2K5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	31,665,032 - 31,920,792 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	31,664,564 - 31,920,751 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	31,599,952 - 31,856,489 (+)	NCBI
ROS_Cfam_1.0	30	31,860,861 - 32,117,463 (+)	NCBI
UMICH_Zoey_3.1	30	31,790,015 - 32,045,842 (+)	NCBI
UNSW_CanFamBas_1.0	30	31,850,721 - 32,107,484 (+)	NCBI
UU_Cfam_GSD_1.0	30	32,096,413 - 32,353,048 (+)	NCBI

Map2k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	109,643,236 - 109,880,510 (+)	NCBI
SpeTri2.0	NW_004936471	27,491,255 - 27,728,572 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP2K5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	165,458,258 - 165,740,319 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	165,458,263 - 165,733,452 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	183,148,368 - 183,197,101 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP2K5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	15,694,760 - 15,956,814 (-)	NCBI
ChlSab1.1 Ensembl	26	15,693,811 - 15,956,918 (-)	Ensembl
Vero_WHO_p1.0	NW_023666048	125,513,002 - 125,773,972 (+)	NCBI

Map2k5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624781	5,224,722 - 5,489,517 (-)	NCBI

Position Markers

D8Got101

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,634,971 - 63,635,232 (+)	MAPPER
Rnor_6.0	8	68,065,730 - 68,065,988	NCBI	Rnor6.0
Rnor_5.0	8	67,794,622 - 67,794,880	UniSTS	Rnor5.0
RGSC_v3.4	8	67,323,225 - 67,323,484	RGD	RGSC3.4
RGSC_v3.4	8	67,323,226 - 67,323,484	UniSTS	RGSC3.4
RGSC_v3.1	8	67,342,280 - 67,342,538	RGD
Celera	8	63,048,725 - 63,048,983	UniSTS
RH 3.4 Map	8	799.2	UniSTS
RH 3.4 Map	8	799.2	RGD
RH 2.0 Map	8	593.8	RGD
Cytogenetic Map	8	q24	UniSTS

D8Mco2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	147,440,770 - 147,441,022 (+)	MAPPER
mRatBN7.2	8	63,713,366 - 63,714,054 (+)	MAPPER
Rnor_6.0	8	68,145,077 - 68,145,764	NCBI	Rnor6.0
Rnor_6.0	5	153,552,704 - 153,552,955	NCBI	Rnor6.0
Rnor_5.0	8	67,872,683 - 67,873,370	UniSTS	Rnor5.0
Rnor_5.0	5	157,322,066 - 157,322,317	UniSTS	Rnor5.0
RGSC_v3.4	5	153,989,202 - 153,989,453	UniSTS	RGSC3.4
RGSC_v3.4	8	67,401,029 - 67,401,716	UniSTS	RGSC3.4
Celera	8	63,126,644 - 63,127,331	UniSTS
Celera	5	145,850,612 - 145,850,863	UniSTS
Cytogenetic Map	8	q24	UniSTS

BF394715

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,660,375 - 63,660,475 (+)	MAPPER
Rnor_6.0	8	68,091,216 - 68,091,315	NCBI	Rnor6.0
Rnor_5.0	8	67,820,108 - 67,820,207	UniSTS	Rnor5.0
RGSC_v3.4	8	67,348,566 - 67,348,665	UniSTS	RGSC3.4
Celera	8	63,074,061 - 63,074,160	UniSTS
RH 3.4 Map	8	801.1	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH138128

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,667,592 - 63,667,801 (+)	MAPPER
Rnor_6.0	8	68,099,307 - 68,099,515	NCBI	Rnor6.0
Rnor_5.0	8	67,826,913 - 67,827,121	UniSTS	Rnor5.0
RGSC_v3.4	8	67,355,258 - 67,355,466	UniSTS	RGSC3.4
Celera	8	63,080,873 - 63,081,081	UniSTS
Cytogenetic Map	8	q24	UniSTS

RH138410

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,625,307 - 63,625,557 (+)	MAPPER
Rnor_6.0	8	68,056,064 - 68,056,313	NCBI	Rnor6.0
Rnor_5.0	8	67,784,956 - 67,785,205	UniSTS	Rnor5.0
RGSC_v3.4	8	67,313,560 - 67,313,809	UniSTS	RGSC3.4
Celera	8	63,039,062 - 63,039,311	UniSTS
RH 3.4 Map	8	802.9	UniSTS
Cytogenetic Map	8	q24	UniSTS

UniSTS:469815

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	63,625,330 - 63,625,553 (+)	MAPPER
Rnor_6.0	8	68,056,087 - 68,056,309	NCBI	Rnor6.0
Rnor_5.0	8	67,784,979 - 67,785,201	UniSTS	Rnor5.0
RGSC_v3.4	8	67,313,583 - 67,313,805	UniSTS	RGSC3.4
Celera	8	63,039,085 - 63,039,307	UniSTS
Cytogenetic Map	8	q24	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581557	Eae16	Experimental allergic encephalomyelitis QTL 16	3.8		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	8	9531047	119211942	Rat
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10938911	120496129	Rat
631271	Lecl1	Lens clarity QTL 1		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	8	21464919	91140553	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	21813070	100873963	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	27841496	72841496	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	29867983	106526740	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	29867983	106526740	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	29867983	106526740	Rat
2303564	Gluco43	Glucose level QTL 43	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	30144800	75144800	Rat
2303572	Insul13	Insulin level QTL 13	2		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	8	30144800	75144800	Rat
1300146	Rf17	Renal function QTL 17	2.9		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	8	30918112	75918112	Rat
8662823	Vetf5	Vascular elastic tissue fragility QTL 5	1.9		artery integrity trait (VT:0010639)	patent ductus arteriosus score (CMO:0002566)	8	30918112	107206309	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	32201981	75971421	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	32888352	101374135	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	33558660	89058369	Rat
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	33558660	89058369	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	33558660	89058369	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	33558660	89058369	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	33558660	109028082	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	33558660	109028082	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	33558660	109028082	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	33558764	113580387	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	35041414	80041414	Rat
1582222	Epfw2	Epididymal fat weight QTL 2	3.2	0.0005	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	8	35925594	80925594	Rat
1331838	Niddm61	Non-insulin dependent diabetes mellitus QTL 61	3.53	0.0004	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	39230130	106506973	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39927901	84927901	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	39958022	84958022	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	44219197	89542960	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	44219197	100873963	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	44458129	118087517	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	45712344	80003418	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	45712344	90712344	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	45712475	75971259	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46588437	96998640	Rat
12879882	Am8	Aortic mass QTL 8		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	8	47200750	106394378	Rat
12879878	Bw183	Body weight QTL 183		0.001	body mass (VT:0001259)	body weight (CMO:0000012)	8	47200750	106394378	Rat
12879879	Cm99	Cardiac mass QTL 99		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	47200750	106394378	Rat
12879880	Cm100	Cardiac mass QTL 100		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	8	47200750	106394378	Rat
12879881	Cm101	Cardiac mass QTL 101		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	8	47200750	106394378	Rat
12879883	Kidm65	Kidney mass QTL 65		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	47200750	106394378	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	50529480	128036471	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	50529480	128036471	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	50529563	106506973	Rat
2313086	Bss60	Bone structure and strength QTL 60	4.1	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	8	54065044	89058369	Rat
4889938	Bss89	Bone structure and strength QTL 89	3.8		tibia size trait (VT:0100001)	tibia cortical bone volume (CMO:0001725)	8	54065044	89058369	Rat
5684973	Bss100	Bone structure and strength QTL 100	4.7		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	8	54065044	89058369	Rat
1358912	Bw51	Body weight QTL 51	2.95		body mass (VT:0001259)	body weight (CMO:0000012)	8	55435004	115812386	Rat
2303570	Gluco48	Glucose level QTL 48	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	55659105	100659105	Rat
2293697	Bmd39	Bone mineral density QTL 39			femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	8	58230766	106394378	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	58425510	91990535	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	58425510	91990535	Rat
631664	Hcar3	Hepatocarcinoma resistance QTL 3	2.9	0.0005	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	8	58425510	106526740	Rat
1300177	Cm2	Cardiac mass QTL 2	3.65		heart mass (VT:0007028)	heart weight (CMO:0000017)	8	59234112	108068306	Rat
2301402	Bp316	Blood pressure QTL 316		0.005	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	61394378	106394378	Rat
10402857	Bp380	Blood pressure QTL 380		0.95	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	61394378	106394378	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	65717449	128033050	Rat

Genetic Models

This gene Map2k5 is modified in the following models/strains

F344-Map2k5^{Tn(sb-T2/Bart3)2.150Mcwi}

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	232
Count of miRNA genes:	88
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000010991, ENSRNOT00000051558
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	28	21	11	19	11		1	74	31	41	11
Low	1	15	36	30		30	8	10		4			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001033987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_017246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243229	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080959	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039080962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC078860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000198	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U37464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000010991 ⟹ ENSRNOP00000010991

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	68,055,977 - 68,282,590 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000051558 ⟹ ENSRNOP00000050528

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	68,055,977 - 68,282,590 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079122 ⟹ ENSRNOP00000070803

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	8	68,055,972 - 68,275,720 (-)	Ensembl

RefSeq Acc Id:

NM_001033987 ⟹ NP_001029159

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,851,983 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,590 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	RGD
Celera	8	63,038,974 - 63,262,592 (-)	RGD

Sequence:

show sequence

CGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCTC
CGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGTG
GAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCACG
CTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACCA
GGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTTG
TCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCCC
CAGTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTGCAAGCTCCC
TCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTGTCTTCTGTC
TATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCCTTGCCGCAG
GATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGCCATGGAGAA
CCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACCGTGCACTCC
GGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACGA
CGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGACGAAGAGAT
GAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGCCAGCTAATA
GAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGA
AGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTCACTTCCAAG
CAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAGATGAATGAA
CAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATC
ATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACTGGAGCTTCA
GAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATCATAGGATTT
TACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATGGGGGGTCTT
TGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGTTGTTAAAGG
CCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAACATGCTTGTA
AACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGAATTCTATAG
CCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGAGCAGTATGG
GATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGGGAGGTTTCCA
TATCCTCAGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTG
ATGAGGATTCGCCGGTCCTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTACATTTCATCACTCA
GTGCATGAGGAAGCAGCCCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGGTCACCCATTCATC
GTGCAGTTCAATGACGGAAACGCCACTGTGGTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGA
GACGGAGCCAGCAGGGGCCCCCATGAGACCTCAGCAGGACACTGACCACCCAGGACCAGGCATC
AAGGTCACAACAAGCCGTGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGATGTACTGGGCACA
GCCTCCTGCTTTCACCTTCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCC
CTCACCACTGGTAGGGAGGAGGCACTGACAATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGAT
GAGGTTATGGAACCTCCTCTGGCCCCACCCTCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTA
TCAGCAGCACTGATGGGAATAAAGTATTACTGCTTTGGAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_017246 ⟹ NP_058942

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,851,983 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,590 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI
RGSC_v3.4	8	67,313,472 - 67,542,723 (-)	RGD
Celera	8	63,038,974 - 63,262,592 (-)	RGD

Sequence:

show sequence

CGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCTC
CGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGTG
GAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCACG
CTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACCA
GGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTTG
TCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCCC
CAGTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTGCAAGCTCCC
TCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTGTCTTCTGTC
TATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCCTTGCCGCAG
GATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGCCATGGAGAA
CCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACCGTGCACTCC
GGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACGA
CGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGACGAAGAGAT
GAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGCCAGCTAATA
GAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGA
AGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTCACTTCCAAG
CAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAGATGAATGAA
CAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATC
ATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACTGGAGCTTCA
GAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATCATAGGATTT
TACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATGGGGGGTCTT
TGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGTTGTTAAAGG
CCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAACATGCTTGTA
AACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGAATTCTATAG
CCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGAGCAGTATGG
GATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGATTCAGAAAAACCAGGGATCT
TTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCGGTCCTTCCGCTTGGAG
AGTTCTCGGAGCCGTTTGTACATTTCATCACTCAGTGCATGAGGAAGCAGCCCAAGGAAAGACC
AGCGCCCGAGGAGCTGATGGGTCACCCATTCATCGTGCAGTTCAATGACGGAAACGCCACTGTG
GTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGAGACGGAGCCAGCAGGGGCCCCCATGAGACC
TCAGCAGGACACTGACCACCCAGGACCAGGCATCAAGGTCACAACAAGCCGTGACCCCTCTGTC
TGCTGCCTGATTGGGAAGAGATGTACTGGGCACAGCCTCCTGCTTTCACCTTCTACCTTACCTG
GGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCCCTCACCACTGGTAGGGAGGAGGCACTGACA
ATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGATGAGGTTATGGAACCTCCTCTGGCCCCACCC
TCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTATCAGCAGCACTGATGGGAATAAAGTATTAC
TGCTTTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243229 ⟹ XP_006243291

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,852,084 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,656 (-)	NCBI
Rnor_5.0	8	67,784,868 - 68,010,809 (-)	NCBI

Sequence:

show sequence

CCATCGCGTTTTGGTTCCGGAGTAACAGCGGTCTAGCGGCCGCCTTCCTCCTCCTCCTCCTCCT
CTCGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTC
TCCGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGG
TGGAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCA
CGCTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAAC
CAGGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTT
TGTCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTC
CCCAGTATGCTTCTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCT
GCAAGCTCCCTCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCT
GTCTTCTGTCTATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTC
CTTGCCGCAGGATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTG
CCATGGAGAACCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGAC
CGTGCACTCCGGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCT
GAAGCAACGACGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTG
ACGAAGAGATGAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGG
CCAGCTAATAGAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATA
CATGGCCTGAAGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATT
CACTTCCAAGCAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCA
GATGAATGAACAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTAC
AAAGCATATCATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACAC
TGGAGCTTCAGAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATAT
CATAGGATTTTACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGAT
GGGGGGTCTTTGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAG
TTGTTAAAGGCCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAA
CATGCTTGTAAACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTG
AATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAG
AGCAGTATGGGATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGG
GAGGTTTCCATATCCTCAGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGATTCGCCGGTC
CTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTACATTTCATCACTCAGTGCATGAGGAAGCAGC
CCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGGTCACCCATTCATCGTGCAGTTCAATGACGG
AAACGCCACTGTGGTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGAGACGGAGCCAGCAGGGG
CCCCCATGAGACCTCAGCAGGACACTGACCACCCAGGACCAGGCATCAAGGTCACAACAAGCCG
TGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGATGTACTGGGCACAGCCTCCTGCTTTCACCT
TCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCCCTCACCACTGGTAGGGA
GGAGGCACTGACAATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGATGAGGTTATGGAACCTCC
TCTGGCCCCACCCTCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTATCAGCAGCACTGATGGG
AATAAAGTATTACTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_017595501 ⟹ XP_017450990

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,852,085 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,282,655 (-)	NCBI

Sequence:

show sequence

CATCGCGTTTTGGTTCCGGAGTAACAGCGGTCTAGCGGCCGCCTTCCTCCTCCTCCTCCTCCTC
TCGCCGCCACCTTCGCCGCCGGGACGAGGGCCTCAGTCGGCCGATCCCGCACGCGCCGCACTCT
CCGGTTCCGGCTGCGGCCTGGGACCCGCCCCCTGACCCCGCGGCCCTGAGCCCTCCTGCCTGGT
GGAGGGCTGGCGGCACCGGTGCACCTCCGAAACAGCCCCGACCCAGCCCGCGGCGCCGGGCCAC
GCTCCCCTTGCCCACCGAGCCGCTCAGGAAGGCAGGACCCTAGTCGCTGTATCTGCCTTAAACC
AGGCCGTTGCTCCGTTGTCTCCTCTTACTCACGAGGACTACAAAATACTTGTGGGTTCTGTTTT
GTCCACTTTTGTAACTCCAGGACCTTCCGCTCTCTGCTAATTCCTCTTGGCCCATACCCCTTCC
CCAGTATGCTTCTGCATCCTCCCCCAGAGACACTCCATACGACCTGGGCCTGGTTCAGGGCCTG
CAAGCTCCCTCCTGATCGCCCCTCTTCACTTCTCCCCACCTTCCTGCTCCCTATTTATCGCCTG
TCTTCTGTCTATCATTCCCCTTGTCACTTCTTGGGGCTCCTAAGTAGGGGCCAGTCGGTACTCC
TTGCCGCAGGATGTGAGACCCTTTAACCTGTAATGCTGTGGCTGGCCCTTGGCCCCTTTCGTGC
CATGGAGAACCAGGTGCTGGTGATTCGGATCAAGATTCCAAATAGTGGCGCGGTGGACTGGACC
GTGCACTCCGGGCCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTG
AAGCAACGACGACAGCCTTTGAATATGAAGATGAAGATGGTGATAGGATTACAGTAAGAAGTGA
CGAAGAGATGAAGGCAATGCTGTCCTACTATTATTCCACAGTAATGGAACAGCAAGTAAATGGC
CAGCTAATAGAGCCGCTGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATAC
ATGGCCTGAAGGTGAATACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTC
ACTTCCAAGCAATAGCTTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAG
ATGAATGAACAAGACATACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACA
AAGCATATCATGTCCCAAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACT
GGAGCTTCAGAAGCAGATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATC
ATAGGATTTTACGGGGCATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATG
GGGGGTCTTTGGATGTATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGT
TGTTAAAGGCCTTACCTATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAAC
ATGCTTGTAAACACAAGCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGA
ATTCTATAGCCAAGACGTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGA
GCAGTATGGGATCCATTCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGGG
AGGTTTCCATATCCTCAGGATTCGCCGGTCCTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTAC
ATTTCATCACTCAGTGCATGAGGAAGCAGCCCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGG
TCACCCATTCATCGTGCAGTTCAATGACGGAAACGCCACTGTGGTGTCCATGTGGGTTTGCCGA
GCTCTGGAGGAGAGACGGAGCCAGCAGGGGCCCCCATGAGACCTCAGCAGGACACTGACCACCC
AGGACCAGGCATCAAGGTCACAACAAGCCGTGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGA
TGTACTGGGCACAGCCTCCTGCTTTCACCTTCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGC
CTCTGCCGAACCCCTCACCACTGGTAGGGAGGAGGCACTGACAATGGCAGGTGGAGATGGTGCA
GGGTTGGGGTGATGAGGTTATGGAACCTCCTCTGGCCCCACCCTCATCTCTCCCTACTGTTGTA
AAGGGTCAGCCTATCAGCAGCACTGATGGGAATAAAGTATTACTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_017595502 ⟹ XP_017450991

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,851,329 (-)	NCBI
Rnor_6.0	8	68,055,976 - 68,281,875 (-)	NCBI

Sequence:

show sequence

CCGCAGTTACTCTTCAGGGACGTGCTGGATGTGATAGGCCAGGTTCTGCCTGAAGCAACGACGA
CAGCCTTTGAATTATTATTCCACAGTAATGGAACAGCAAGTAAATGGCCAGCTAATAGAGCCGC
TGCAGATCTTTCCAAGAGCCTGCAAGCCTCCTGGGGAACGGAACATACATGGCCTGAAGGTGAA
TACACGGGCTGGACCATCTCAGCACACCAGCCCTGTGGTCTCAGATTCACTTCCAAGCAATAGC
TTGAAGAAGTCCTCGGCTGAACTGAGAAAGATACTGGCCAACGGCCAGATGAATGAACAAGACA
TACGGTATCGAGACACCCTTGGTCATGGCAACGGAGGCACAGTCTACAAAGCATATCATGTCCC
AAGTGGGAAAATCTTAGCTGTAAAGGTTATTCTGTTAGACATCACACTGGAGCTTCAGAAGCAG
ATCATGTCTGAGTTGGAAATTCTTTATAAGTGTGACTCATCGTATATCATAGGATTTTACGGGG
CATTTTTTGTAGAAAACAGGATTTCGATTTGTACAGAATTCATGGATGGGGGGTCTTTGGATGT
ATATAGGAAAATTCCAGAGCACGTCCTCGGAAGAATTGCAGTAGCAGTTGTTAAAGGCCTTACC
TATCTGTGGAGTTTAAAGATTTTACACAGAGATGTGAAGCCTTCCAACATGCTTGTAAACACAA
GCGGACAGGTCAAGCTGTGTGACTTCGGCGTGAGCACCCAGCTGGTGAATTCTATAGCCAAGAC
GTATGTTGGAACAAATGCTTATATGGCACCCGAAAGGATTTCAGGAGAGCAGTATGGGATCCAT
TCCGACGTGTGGAGCTTAGGGATCTCTTTCATGGAGCTTGCTCTTGGGAGGTTTCCATATCCTC
AGATTCAGAAAAACCAGGGATCTTTAATGCCTCTCCAGCTTCTGCAGTGCATTGTTGATGAGGA
TTCGCCGGTCCTTCCGCTTGGAGAGTTCTCGGAGCCGTTTGTACATTTCATCACTCAGTGCATG
AGGAAGCAGCCCAAGGAAAGACCAGCGCCCGAGGAGCTGATGGGTCACCCATTCATCGTGCAGT
TCAATGACGGAAACGCCACTGTGGTGTCCATGTGGGTTTGCCGAGCTCTGGAGGAGAGACGGAG
CCAGCAGGGGCCCCCATGAGACCTCAGCAGGACACTGACCACCCAGGACCAGGCATCAAGGTCA
CAACAAGCCGTGACCCCTCTGTCTGCTGCCTGATTGGGAAGAGATGTACTGGGCACAGCCTCCT
GCTTTCACCTTCTACCTTACCTGGGAGTCTTCAAGAAGGCTGGCCTCTGCCGAACCCCTCACCA
CTGGTAGGGAGGAGGCACTGACAATGGCAGGTGGAGATGGTGCAGGGTTGGGGTGATGAGGTTA
TGGAACCTCCTCTGGCCCCACCCTCATCTCTCCCTACTGTTGTAAAGGGTCAGCCTATCAGCAG
CACTGATGGGAATAAAGTATTACTGCTTTGGA

hide sequence

RefSeq Acc Id:

XM_039080953 ⟹ XP_038936881

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,660,201 - 63,852,089 (-)	NCBI

RefSeq Acc Id:

XM_039080954 ⟹ XP_038936882

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080955 ⟹ XP_038936883

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080956 ⟹ XP_038936884

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,660,201 - 63,852,090 (-)	NCBI

RefSeq Acc Id:

XM_039080957 ⟹ XP_038936885

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,654,803 - 63,852,086 (-)	NCBI

RefSeq Acc Id:

XM_039080958 ⟹ XP_038936886

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,852,085 (-)	NCBI

RefSeq Acc Id:

XM_039080959 ⟹ XP_038936887

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,625,220 - 63,852,086 (-)	NCBI

RefSeq Acc Id:

XM_039080960 ⟹ XP_038936888

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,660,201 - 63,851,329 (-)	NCBI

RefSeq Acc Id:

XM_039080961 ⟹ XP_038936889

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,663,749 - 63,852,086 (-)	NCBI

RefSeq Acc Id:

XM_039080962 ⟹ XP_038936890

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	8	63,663,749 - 63,852,086 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001029159	(Get FASTA)	NCBI Sequence Viewer
	NP_058942	(Get FASTA)	NCBI Sequence Viewer
	XP_006243291	(Get FASTA)	NCBI Sequence Viewer
	XP_017450990	(Get FASTA)	NCBI Sequence Viewer
	XP_017450991	(Get FASTA)	NCBI Sequence Viewer
	XP_038936881	(Get FASTA)	NCBI Sequence Viewer
	XP_038936882	(Get FASTA)	NCBI Sequence Viewer
	XP_038936883	(Get FASTA)	NCBI Sequence Viewer
	XP_038936884	(Get FASTA)	NCBI Sequence Viewer
	XP_038936885	(Get FASTA)	NCBI Sequence Viewer
	XP_038936886	(Get FASTA)	NCBI Sequence Viewer
	XP_038936887	(Get FASTA)	NCBI Sequence Viewer
	XP_038936888	(Get FASTA)	NCBI Sequence Viewer
	XP_038936889	(Get FASTA)	NCBI Sequence Viewer
	XP_038936890	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC52320	(Get FASTA)	NCBI Sequence Viewer
	AAC52321	(Get FASTA)	NCBI Sequence Viewer
	AAC52322	(Get FASTA)	NCBI Sequence Viewer
	AAH78860	(Get FASTA)	NCBI Sequence Viewer
	EDL95767	(Get FASTA)	NCBI Sequence Viewer
	EDL95768	(Get FASTA)	NCBI Sequence Viewer
	EDL95769	(Get FASTA)	NCBI Sequence Viewer
	EDL95770	(Get FASTA)	NCBI Sequence Viewer
	EDL95771	(Get FASTA)	NCBI Sequence Viewer
	Q62862	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001029159 ⟸ NM_001033987
- Peptide Label:	isoform a
- UniProtKB:	Q62862 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLP LGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:	NP_058942 ⟸ NM_017246
- Peptide Label:	isoform b
- UniProtKB:	Q62862 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN AYMAPERISGEQYGIHSDVWSLGISFMEIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVH FITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:

XP_006243291 ⟸ XM_006243229

- Peptide Label:

isoform X5

- Sequence:

show sequence

MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED
EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP
SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL
AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP
EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN
AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQPLQLLQCIVDEDSPVLPLGEFSEPFV
HFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

hide sequence

RefSeq Acc Id:

XP_017450990 ⟸ XM_017595501

- Peptide Label:

isoform X6

- Sequence:

show sequence

MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYED
EDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGP
SQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKIL
AVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIP
EHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTN
AYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQDSPVLPLGEFSEPFVHFITQCMRKQP
KERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP

hide sequence

RefSeq Acc Id:	XP_017450991 ⟸ XM_017595502
- Peptide Label:	isoform X13
- UniProtKB:	Q62862 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELR KILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILY KCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILH RDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGIS FMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPA PEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP hide sequence

RefSeq Acc Id:

ENSRNOP00000070803 ⟸ ENSRNOT00000079122

RefSeq Acc Id:

ENSRNOP00000050528 ⟸ ENSRNOT00000051558

RefSeq Acc Id:

ENSRNOP00000010991 ⟸ ENSRNOT00000010991

RefSeq Acc Id:	XP_038936887 ⟸ XM_039080959
- Peptide Label:	isoform X9

RefSeq Acc Id:	XP_038936886 ⟸ XM_039080958
- Peptide Label:	isoform X8

RefSeq Acc Id:	XP_038936885 ⟸ XM_039080957
- Peptide Label:	isoform X7

RefSeq Acc Id:	XP_038936883 ⟸ XM_039080955
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038936884 ⟸ XM_039080956
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038936882 ⟸ XM_039080954
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038936881 ⟸ XM_039080953
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038936888 ⟸ XM_039080960
- Peptide Label:	isoform X10

RefSeq Acc Id:	XP_038936890 ⟸ XM_039080962
- Peptide Label:	isoform X12

RefSeq Acc Id:	XP_038936889 ⟸ XM_039080961
- Peptide Label:	isoform X11

Protein Domains

PB1 Protein kinase

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696058

Promoter ID:

EPDNEW_R6583

Type:

initiation region

Name:

Map2k5_1

Description:

mitogen activated protein kinase kinase 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	68,282,594 - 68,282,654	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61890	AgrOrtholog
Ensembl Genes	ENSRNOG00000007926	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000010991	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000050528	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000070803	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000010991	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000051558	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000079122	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7122708	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot
	PB1_dom	UniProtKB/Swiss-Prot
	PB1_MAP2K5	UniProtKB/Swiss-Prot
	Prot_kinase_dom	UniProtKB/Swiss-Prot
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot
KEGG Report	rno:29568	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93521	IMAGE-MGC_LOAD
NCBI Gene	29568	ENTREZGENE
Pfam	PB1	UniProtKB/Swiss-Prot
	Pkinase	UniProtKB/Swiss-Prot
PhenoGen	Map2k5	PhenoGen
PROSITE	PB1	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot
SMART	PB1	UniProtKB/Swiss-Prot
	S_TKc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF56112	UniProtKB/Swiss-Prot
TIGR	TC216643
UniProt	MP2K5_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q62863	UniProtKB/Swiss-Prot
	Q62864	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Map2k5	mitogen activated protein kinase kinase 5			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	does not phosphorylate ERK1, ERK2, ERK3, JNK/SAPK, or p38/HOG1	61658

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - KEGG (archival)