1-benzothiophenes - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	1-benzothiophenes	go back to main search page
Accession:	CHEBI:38836	browse the term

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Genes (1000)

LY 117018

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

LY 117018 results in decreased phosphorylation of AKT1 protein

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

estrogen receptor 1

affects binding

LY 117018 binds to ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

LY 117018 results in increased phosphorylation of MAPK1 protein
U 0126 inhibits the reaction [LY 117018 results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

LY 117018 results in increased phosphorylation of MAPK3 protein
U 0126 inhibits the reaction [LY 117018 results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

protein tyrosine phosphatase, non-receptor type 13

increases expression

LY 117018 results in increased expression of PTPN13 mRNA

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

RNA binding motif protein 17

multiple interactions

LY 117018 inhibits the reaction [RBM17 protein results in decreased susceptibility to Mitoxantrone]

NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014

raloxifene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis-associated tyrosine kinase

increases expression

Raloxifene Hydrochloride results in increased expression of AATK mRNA

NCBI chr10:105,290,752...105,327,219
Ensembl chr10:105,291,585...105,327,112

G

ATP binding cassette subfamily B member 1A

decreases expression
affects activity
multiple interactions

Raloxifene Hydrochloride results in decreased expression of ABCB1 mRNA; Raloxifene Hydrochloride results in decreased expression of ABCB1 protein
ABCB1 protein affects the activity of Raloxifene Hydrochloride
[Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 mRNA; [Cyclosporine co-treated with Raloxifene Hydrochloride] results in decreased expression of ABCB1 protein

PMID:16959878 PMID:17096884

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 9

affects expression

Raloxifene Hydrochloride affects the expression of ABCB9 mRNA

NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931

G

ATP binding cassette subfamily C member 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily G member 1

affects expression

Raloxifene Hydrochloride affects the expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

abhydrolase domain containing 2, acylglycerol lipase

decreases expression

Raloxifene Hydrochloride results in decreased expression of ABHD2 mRNA

NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061

G

abhydrolase domain containing 5, lysophosphatidic acid acyltransferase

affects expression

Raloxifene Hydrochloride affects the expression of ABHD5 mRNA

NCBI chr 8:122,000,241...122,026,447
Ensembl chr 8:122,000,389...122,026,447

G

abhydrolase domain containing 8

affects response to substance

ABHD8 affects the susceptibility to Raloxifene Hydrochloride

NCBI chr16:18,144,464...18,151,201
Ensembl chr16:18,144,464...18,157,667

G

actin binding LIM protein family, member 3

affects expression

Raloxifene Hydrochloride affects the expression of ABLIM3 mRNA

NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380

G

aggrecan

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in decreased expression of ACAN mRNA]

NCBI chr 1:132,981,582...133,044,416
Ensembl chr 1:132,981,582...133,043,627

G

angiotensin I converting enzyme

decreases expression

Raloxifene Hydrochloride results in decreased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

decreases activity

Raloxifene Hydrochloride results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

atypical chemokine receptor 3

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of ACKR3 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

acyl-CoA synthetase long-chain family member 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

actin alpha 2, smooth muscle

multiple interactions

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

activin A receptor like type 1

increases expression

Raloxifene Hydrochloride results in increased expression of ACVRL1 mRNA; Raloxifene Hydrochloride results in increased expression of ACVRL1 protein

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

ADAM metallopeptidase domain 19

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 22

decreases expression

Raloxifene Hydrochloride results in decreased expression of ADAM22 mRNA

NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962

G

ADAMTS-like 3

affects expression

Raloxifene Hydrochloride affects the expression of ADAMTSL3 mRNA

NCBI chr 1:136,288,793...136,596,986
Ensembl chr 1:136,288,793...136,596,986

G

adenylate cyclase 2

affects expression

Raloxifene Hydrochloride affects the expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase activating polypeptide 1

affects expression

Raloxifene Hydrochloride affects the expression of ADCYAP1 mRNA

NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773

G

adhesion G protein-coupled receptor A3

increases expression

Raloxifene Hydrochloride results in increased expression of ADGRA3 mRNA

NCBI chr14:60,874,719...60,976,341
Ensembl chr14:60,874,715...60,976,332

G

adhesion G protein-coupled receptor B2

affects expression

Raloxifene Hydrochloride affects the expression of ADGRB2 mRNA

NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540

G

adhesion G protein-coupled receptor G1

affects expression

Raloxifene Hydrochloride affects the expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

alcohol dehydrogenase 1C (class I), gamma polypeptide

increases expression

Raloxifene Hydrochloride results in increased expression of ADH1 mRNA

NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892

G

adiponectin, C1Q and collagen domain containing

increases expression

Raloxifene Hydrochloride results in increased expression of ADIPOQ mRNA

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

adenosine A2a receptor

increases expression

Raloxifene Hydrochloride results in increased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adenosine A2B receptor

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA

NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772

G

adrenoceptor alpha 1A

decreases expression

Raloxifene Hydrochloride results in decreased expression of ADRA1A mRNA

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

AE binding protein 1

increases expression

Raloxifene Hydrochloride results in increased expression of AEBP1 mRNA

NCBI chr14:80,738,800...80,748,878
Ensembl chr14:80,738,892...80,748,877

G

argonaute RISC catalytic component 2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of AGO2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974

G

angiotensinogen

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

adenosylhomocysteinase-like 1

affects expression

Raloxifene Hydrochloride affects the expression of AHCYL1 mRNA

NCBI chr 2:195,294,149...195,328,586
Ensembl chr 2:195,294,153...195,345,815

G

AHNAK nucleoprotein

decreases expression

Raloxifene Hydrochloride results in decreased expression of AHNAK mRNA

NCBI chr 1:205,882,225...205,970,934
Ensembl chr 1:205,882,273...205,970,926

G

aryl hydrocarbon receptor

multiple interactions
affects binding
affects localization

[Raloxifene Hydrochloride results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA
Raloxifene Hydrochloride binds to AHR protein
Raloxifene Hydrochloride inhibits the reaction [Methylcholanthrene binds to AHR protein]
Raloxifene Hydrochloride affects the localization of AHR protein

PMID:19901195 PMID:24481452

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

increases expression

Raloxifene Hydrochloride results in increased expression of AIMP1 mRNA

NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 3

affects expression

Raloxifene Hydrochloride affects the expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 1

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA
Raloxifene Hydrochloride affects the expression of AKAP1 mRNA

PMID:14699072 PMID:19059307

NCBI chr10:73,621,021...73,654,123
Ensembl chr10:73,621,883...73,653,896

G

aldo-keto reductase family 7, member A2

affects expression

Raloxifene Hydrochloride affects the expression of AKR7A2 mRNA

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions
increases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein
Raloxifene Hydrochloride inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]
Raloxifene Hydrochloride results in increased phosphorylation of AKT1 protein

PMID:15590986 PMID:15876410 PMID:16798746 PMID:25537862 PMID:35007301

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

increases expression

Raloxifene Hydrochloride results in increased expression of ALAD mRNA

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

5'-aminolevulinate synthase 2

affects expression

Raloxifene Hydrochloride affects the expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

activated leukocyte cell adhesion molecule

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ALCAM mRNA]

NCBI chr11:48,336,123...48,536,296
Ensembl chr11:48,336,169...48,537,954

G

arachidonate 5-lipoxygenase

multiple interactions

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

alkaline phosphatase, biomineralization associated

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of ALPL mRNA]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

adhesion molecule with Ig like domain 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

angiomotin like 2

affects expression

Raloxifene Hydrochloride affects the expression of AMOTL2 mRNA

NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910

G

angiogenin

increases expression

Raloxifene Hydrochloride results in increased expression of ANG mRNA

NCBI chr15:24,312,711...24,323,361

G

angiopoietin-like 2

affects expression

Raloxifene Hydrochloride affects the expression of ANGPTL2 mRNA

NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178

G

angiopoietin like 7

decreases expression

Raloxifene Hydrochloride results in decreased expression of ANGPTL7 mRNA

NCBI chr 5:158,932,096...158,937,281
Ensembl chr 5:158,932,794...158,937,324

G

ankyrin 3

affects expression

Raloxifene Hydrochloride affects the expression of ANK3 mRNA

NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300

G

ankyrin repeat domain 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

ankyrin repeat domain 28

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA

NCBI chr16:6,918,487...7,050,244
Ensembl chr16:6,914,336...7,050,249

G

aminopeptidase O

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of AOPEP mRNA

NCBI chr17:1,811,281...2,127,316
Ensembl chr17:1,811,980...2,127,331

G

aldehyde oxidase 1

multiple interactions
decreases activity

Raloxifene Hydrochloride inhibits the reaction [AOX1 protein results in increased metabolism of zoniporide]
Raloxifene Hydrochloride results in decreased activity of AOX1 protein

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

adaptor related protein complex 1 subunit gamma 1

affects expression

Raloxifene Hydrochloride affects the expression of AP1G1 mRNA

NCBI chr19:37,744,633...37,831,134
Ensembl chr19:37,744,633...37,829,167

G

APC regulator of WNT signaling pathway

multiple interactions
affects response to substance

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ALOX5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCL6 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCND1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CTNNB1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ESR2 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LAMB1 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PCNA protein; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGES mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 protein

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with Kainic Acid] results in increased expression of APEX1 mRNA
Raloxifene Hydrochloride results in increased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein D

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of APOD mRNA
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of APOD protein]

PMID:16514628 PMID:27163517

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

apolipoprotein E

multiple interactions

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ACTA2 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD68 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions
affects binding

Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]; Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TNF mRNA]
Raloxifene Hydrochloride binds to APP protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

androgen receptor

decreases expression
multiple interactions
affects expression

Raloxifene Hydrochloride results in decreased expression of AR mRNA; Raloxifene Hydrochloride results in decreased expression of AR protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of AR protein
Raloxifene Hydrochloride affects the expression of AR mRNA

PMID:11867264 PMID:15731164 PMID:16837883 PMID:27163517

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

amphiregulin

multiple interactions
increases expression
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA
Raloxifene Hydrochloride results in increased expression of AREG mRNA
Raloxifene Hydrochloride inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Raloxifene Hydrochloride results in decreased expression of AREG mRNA

PMID:16514628 PMID:19022889 PMID:19059307 PMID:26865669

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

arginase 2

increases expression

Raloxifene Hydrochloride results in increased expression of ARG2 mRNA

NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378

G

Rho GTPase activating protein 29

affects expression

Raloxifene Hydrochloride affects the expression of ARHGAP29 mRNA

NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028

G

AT-rich interaction domain 5A

multiple interactions

ARID5A protein inhibits the reaction [Raloxifene Hydrochloride results in increased activity of ESR1 protein]

NCBI chr 9:38,534,612...38,549,467
Ensembl chr 9:38,534,590...38,547,597

G

AT-rich interaction domain 5B

affects expression

Raloxifene Hydrochloride affects the expression of ARID5B mRNA

NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433

G

ARF like GTPase 1

affects expression

Raloxifene Hydrochloride affects the expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

ARF like GTPase 4C

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA
Raloxifene Hydrochloride affects the expression of ARL4C mRNA

PMID:14699072 PMID:19059307

NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of CYP1A1 protein]; ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of NQO1 protein]

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

Raloxifene Hydrochloride results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

ankyrin repeat and SOCS box-containing 13

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA

NCBI chr17:66,564,653...66,583,365
Ensembl chr17:66,562,434...66,583,337

G

asparagine synthetase (glutamine-hydrolyzing)

decreases expression

Raloxifene Hydrochloride results in decreased expression of ASNS mRNA

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

activating transcription factor 3

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ATF3 mRNA
Raloxifene Hydrochloride results in increased expression of ATF3 mRNA

PMID:16497877 PMID:19059307

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 7 interacting protein

increases expression

Raloxifene Hydrochloride results in increased expression of ATF7IP mRNA

NCBI chr 4:169,385,872...169,471,652
Ensembl chr 4:169,385,872...169,471,650

G

autophagy related 12

multiple interactions

Raloxifene Hydrochloride promotes the reaction [ATG12 protein binds to ATG5 protein]

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 5

multiple interactions

Raloxifene Hydrochloride promotes the reaction [ATG12 protein binds to ATG5 protein]

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

ATPase Na+/K+ transporting subunit alpha 1

affects expression

Raloxifene Hydrochloride affects the expression of ATP1A1 mRNA

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase phospholipid transporting 9A (putative)

affects expression

Raloxifene Hydrochloride affects the expression of ATP9A mRNA

NCBI chr 3:157,360,354...157,467,628
Ensembl chr 3:157,360,359...157,467,818

G

ataxin 3

increases expression

Raloxifene Hydrochloride results in increased expression of ATXN3 mRNA

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

aurora kinase A

decreases expression

Raloxifene Hydrochloride results in decreased expression of AURKA mRNA

NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390

G

arginine vasopressin

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of AVP mRNA
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]

NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425

G

axin 2

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of AXIN2 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA

NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231

G

BCL2-associated agonist of cell death

increases cleavage

Raloxifene Hydrochloride results in increased cleavage of BAD protein

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2-antagonist/killer 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BRCA1 associated deubiquitinase 1

multiple interactions

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of BAP1 mRNA

NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

Raloxifene Hydrochloride affects the expression of BAX protein
[Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of BAX mRNA
Raloxifene Hydrochloride results in increased expression of BAX mRNA

PMID:16009171 PMID:29705353

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

brain enriched myelin associated protein 1

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of BCAS1 mRNA

NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106

G

BCL2, apoptosis regulator

affects expression
multiple interactions
increases expression
decreases expression

Raloxifene Hydrochloride affects the expression of BCL2 protein
[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of BCL2 mRNA
Raloxifene Hydrochloride results in increased expression of BCL2 protein
Raloxifene Hydrochloride results in decreased expression of BCL2 mRNA; Raloxifene Hydrochloride results in decreased expression of BCL2 protein

PMID:16009171 PMID:16566921 PMID:16973256 PMID:17220163 PMID:20945400 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

Raloxifene Hydrochloride results in increased expression of BCL2L11 mRNA

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

BCL3, transcription coactivator

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]

NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607

G

BCL6, transcription repressor

increases expression

Raloxifene Hydrochloride results in increased expression of BCL6 mRNA

NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389

G

beclin 1

increases expression

Raloxifene Hydrochloride results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone gamma-carboxyglutamate protein

decreases expression

Raloxifene Hydrochloride results in decreased expression of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

biglycan

increases expression

Raloxifene Hydrochloride results in increased expression of BGN mRNA

PMID:15576828 PMID:19429434

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e40

multiple interactions

[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA

NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774

G

baculoviral IAP repeat-containing 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of BIRC5 protein

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

basic leucine zipper nuclear factor 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of BLZF1 mRNA

NCBI chr13:76,641,757...76,656,977
Ensembl chr13:76,641,515...76,656,999

G

bone morphogenetic protein 7

affects expression

Raloxifene Hydrochloride affects the expression of BMP7 mRNA

NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788

G

BMP/retinoic acid inducible neural specific 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of BRINP2 mRNA]

NCBI chr13:70,431,006...70,532,766
Ensembl chr13:70,431,010...70,531,810

G

BTG anti-proliferation factor 2

increases expression

Raloxifene Hydrochloride results in increased expression of BTG2 mRNA

NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628

G

complement C1q B chain

affects expression

Raloxifene Hydrochloride affects the expression of C1QB mRNA

NCBI chr 5:149,118,843...149,124,394
Ensembl chr 5:149,118,846...149,124,407

G

C2 calcium-dependent domain containing 2

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA
Raloxifene Hydrochloride affects the expression of C2CD2 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739

G

complement C3

increases expression

Raloxifene Hydrochloride results in increased expression of C3 mRNA

NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 14 open reading frame 132

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of C14ORF132 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA

PMID:14699072 PMID:19059307

NCBI chr 6:124,365,466...124,398,449

G

calcineurin binding protein 1

increases expression

Raloxifene Hydrochloride results in increased expression of CABIN1 mRNA

NCBI chr20:12,893,314...13,015,357
Ensembl chr20:12,893,358...13,015,357

G

calcium voltage-gated channel subunit alpha1 H

decreases expression

Raloxifene Hydrochloride results in decreased expression of CACNA1H mRNA

NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376

G

calcium voltage-gated channel subunit alpha1 I

decreases expression

Raloxifene Hydrochloride results in decreased expression of CACNA1I mRNA

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

calbindin 2

increases expression

Raloxifene Hydrochloride results in increased expression of CALB2 mRNA

NCBI chr19:38,114,435...38,141,438
Ensembl chr19:38,114,424...38,141,438

G

caldesmon 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of CALD1 mRNA

NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932

G

calmodulin 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

G

cyclase associated actin cytoskeleton regulatory protein 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of CAP2 mRNA

NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373

G

calpain 2

affects expression

Raloxifene Hydrochloride affects the expression of CAPN2 mRNA

NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969

G

carbonic anhydrase 12

affects expression
decreases expression
multiple interactions

Raloxifene Hydrochloride affects the expression of CA12 mRNA
Raloxifene Hydrochloride results in decreased expression of CA12 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440

G

carbonic anhydrase 4

affects expression

Raloxifene Hydrochloride affects the expression of CA4 mRNA

NCBI chr10:69,827,945...69,836,501
Ensembl chr10:69,827,945...69,836,501

G

caspase recruitment domain family, member 10

affects expression

Raloxifene Hydrochloride affects the expression of CARD10 mRNA

NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224

G

cask-interacting protein 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA

NCBI chr10:101,027,196...101,041,429
Ensembl chr10:101,027,260...101,041,414

G

caspase 3

increases expression
multiple interactions
increases cleavage
decreases expression

Raloxifene Hydrochloride results in increased expression of CASP3 mRNA; Raloxifene Hydrochloride results in increased expression of CASP3 protein modified form
[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP3 mRNA; STAT3 protein affects the reaction [Raloxifene Hydrochloride results in increased cleavage of CASP3 protein]
Raloxifene Hydrochloride results in decreased expression of CASP3 mRNA; Raloxifene Hydrochloride results in decreased expression of CASP3 protein
Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased activity of CASP3 protein]

PMID:20945400 PMID:22965848 PMID:23385821 PMID:27999800 PMID:28430601 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases expression

Raloxifene Hydrochloride results in increased expression of CASP4 mRNA

NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA
Raloxifene Hydrochloride affects the expression of CASP7 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases expression
decreases expression

[Resveratrol co-treated with Raloxifene Hydrochloride] results in decreased expression of CASP8 mRNA
Raloxifene Hydrochloride results in increased expression of CASP8 mRNA
Raloxifene Hydrochloride results in decreased expression of CASP8 mRNA; Raloxifene Hydrochloride results in decreased expression of CASP8 protein

PMID:27999800 PMID:29705353

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

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catalase

increases activity

Raloxifene Hydrochloride results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

affects expression
increases expression
multiple interactions

Raloxifene Hydrochloride affects the expression of CAV1 mRNA
Raloxifene Hydrochloride results in increased expression of CAV1 mRNA; Raloxifene Hydrochloride results in increased expression of CAV1 protein
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 mRNA]; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of CAV1 protein]

PMID:14699072 PMID:17091190

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

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chromobox 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of CBX1 mRNA

NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096

G

chromobox 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of CBX3 mRNA

NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283

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C-C motif chemokine ligand 2

multiple interactions
decreases activity
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL2 mRNA; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased activity of CCL2 protein]
Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
Raloxifene Hydrochloride affects the expression of CCL2 mRNA

PMID:14699072 PMID:17006379 PMID:19059307 PMID:25305410

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of CCL20 mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA

PMID:14699072 PMID:19059307 PMID:24722370

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to CCL3 promoter]; Raloxifene Hydrochloride inhibits the reaction [RELA protein binds to CCL3 promoter]
Raloxifene Hydrochloride results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

increases expression
decreases expression

Raloxifene Hydrochloride results in increased expression of CCL5 mRNA
Raloxifene Hydrochloride results in decreased expression of CCL5 protein

PMID:12154049 PMID:16842799

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

multiple interactions

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA

NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019

G

cyclin A2

increases expression

Raloxifene Hydrochloride results in increased expression of CCNA2 mRNA; Raloxifene Hydrochloride results in increased expression of CCNA2 protein

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression

Raloxifene Hydrochloride results in increased expression of CCNB1 mRNA; Raloxifene Hydrochloride results in increased expression of CCNB1 protein

PMID:12154049 PMID:17445807

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions
decreases expression
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CCND1 mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 protein]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of CCND1 protein]
Raloxifene Hydrochloride results in decreased expression of CCND1 mRNA
Raloxifene Hydrochloride affects the expression of CCND1 mRNA

PMID:14699072 PMID:19059307 PMID:22965848 PMID:24080207 PMID:24431404 More...

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

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cyclin E2

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA
Raloxifene Hydrochloride results in decreased expression of CCNE2 protein

NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632

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cyclin G2

increases expression

Raloxifene Hydrochloride results in increased expression of CCNG2 mRNA

PMID:16497877 PMID:26865669

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

Cd200 molecule

decreases expression

Raloxifene Hydrochloride results in decreased expression of CD200 mRNA

NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648

G

CD24 molecule

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of CD24 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD24 protein

PMID:16514628 PMID:24431404

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

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CD3 gamma subunit of T-cell receptor complex

affects expression

Raloxifene Hydrochloride affects the expression of CD3G mRNA

NCBI chr 8:45,280,797...45,287,271
Ensembl chr 8:45,281,204...45,287,147

G

CD40 molecule

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 protein]

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

CD44 molecule

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of CD44 mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CD44 protein

PMID:24431404 PMID:26865669

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD52 molecule

affects expression

Raloxifene Hydrochloride affects the expression of CD52 mRNA

NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348

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Cd68 molecule

multiple interactions

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of CD68 protein]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

CD74 molecule

affects expression

Raloxifene Hydrochloride affects the expression of CD74 mRNA

NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003

G

Cd80 molecule

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]

NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030

G

CD86 molecule

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein]

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

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CD8 subunit alpha

affects expression

Raloxifene Hydrochloride affects the expression of CD8A mRNA

NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040

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cell division cycle 6

multiple interactions

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cadherin 2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of CDH2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA

PMID:14699072 PMID:16079270 PMID:19059307

NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167

G

cadherin 6

affects expression

Raloxifene Hydrochloride affects the expression of CDH6 mRNA

NCBI chr 2:62,079,139...62,225,298
Ensembl chr 2:62,079,137...62,225,228

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cyclin-dependent kinase 1

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]; trichostatin A inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

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cyclin dependent kinase 2

multiple interactions

[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

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cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

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CDK5 regulatory subunit associated protein 3

affects expression

Raloxifene Hydrochloride affects the expression of CDK5RAP3 mRNA

NCBI chr10:81,894,393...81,903,581
Ensembl chr10:81,894,393...81,903,590

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cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of CDKN1A mRNA; Raloxifene Hydrochloride results in increased expression of CDKN1A protein
[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CDKN1A protein]

PMID:12154049 PMID:16497877 PMID:24080207 PMID:27017931

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression

Raloxifene Hydrochloride results in increased expression of CDKN1B protein

PMID:16536755 PMID:22965848

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

cysteine dioxygenase type 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

cell adhesion associated, oncogene regulated

affects expression

Raloxifene Hydrochloride affects the expression of CDON mRNA

NCBI chr 8:33,775,123...33,861,635
Ensembl chr 8:33,806,183...33,859,033

G

CCAAT/enhancer binding protein alpha

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of CEBPA mRNA
IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]

PMID:15849065 PMID:31470850

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

CCAAT/enhancer binding protein beta

affects expression
increases expression
multiple interactions

Raloxifene Hydrochloride affects the expression of CEBPB mRNA
Raloxifene Hydrochloride results in increased expression of CEBPB mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA

PMID:14699072 PMID:16497877 PMID:19059307

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

centromere protein A

decreases expression

Raloxifene Hydrochloride results in decreased expression of CENPA mRNA

NCBI chr 6:25,700,142...25,711,767
Ensembl chr 6:25,700,142...25,711,675

G

ceramide synthase 6

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA

NCBI chr 3:53,630,637...53,879,692
Ensembl chr 3:53,630,959...53,876,848

G

complement factor D

increases expression

Raloxifene Hydrochloride results in increased expression of CFD mRNA

NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053

G

chordin

affects expression

Raloxifene Hydrochloride affects the expression of CHRD mRNA

NCBI chr11:80,171,994...80,181,166
Ensembl chr11:80,171,994...80,180,673

G

cytokine inducible SH2-containing protein

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

creatine kinase B

increases activity
multiple interactions

Raloxifene Hydrochloride results in increased activity of CKB protein
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased activity of CKB protein]

PMID:16621514 PMID:17029789

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

chloride voltage-gated channel 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA

NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238

G

chloride voltage-gated channel 6

increases expression

Raloxifene Hydrochloride results in increased expression of CLCN6 mRNA

NCBI chr 5:158,434,299...158,465,174
Ensembl chr 5:158,434,299...158,465,059

G

chloride intracellular channel 4

increases expression

Raloxifene Hydrochloride results in increased expression of CLIC4 mRNA

NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452

G

CDC-like kinase 1

increases expression

Raloxifene Hydrochloride results in increased expression of CLK1 mRNA

NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000

G

calmin

increases expression

Raloxifene Hydrochloride results in increased expression of CLMN mRNA

NCBI chr 6:123,707,710...123,807,283
Ensembl chr 6:123,713,507...123,807,272

G

calsyntenin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of CLSTN1 mRNA

NCBI chr 5:160,031,235...160,094,585
Ensembl chr 5:160,031,308...160,094,583

G

clathrin, light chain B

affects expression

Raloxifene Hydrochloride affects the expression of CLTB mRNA

NCBI chr17:10,001,512...10,019,201
Ensembl chr17:10,001,513...10,019,169

G

clusterin

increases expression

Raloxifene Hydrochloride results in increased expression of CLU mRNA

PMID:12370124 PMID:16202921

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

CCHC-type zinc finger, nucleic acid binding protein

increases expression

Raloxifene Hydrochloride results in increased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

collagen type X alpha 1 chain

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of COL10A1 mRNA]

NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494

G

collagen type XI alpha 1 chain

affects expression

Raloxifene Hydrochloride affects the expression of COL11A1 mRNA

NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853

G

collagen type I alpha 2 chain

decreases expression

Raloxifene Hydrochloride results in decreased expression of COL1A2 mRNA

NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867

G

collagen type XXVI alpha 1 chain

increases expression

Raloxifene Hydrochloride results in increased expression of COL26A1 mRNA

NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556

G

collagen type II alpha 1 chain

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Decitabine results in decreased expression of COL2A1 mRNA]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

collagen type V alpha 1 chain

affects expression

Raloxifene Hydrochloride affects the expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type V alpha 2 chain

affects expression

Raloxifene Hydrochloride affects the expression of COL5A2 mRNA

NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154

G

COPI coat complex subunit beta 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of COPB2 mRNA

NCBI chr 8:99,161,324...99,183,452
Ensembl chr 8:99,161,350...99,185,197

G

carboxypeptidase B2

decreases expression

Raloxifene Hydrochloride results in decreased expression of CPB2 protein

NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556

G

carboxypeptidase E

affects expression

Raloxifene Hydrochloride affects the expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

carboxypeptidase M

increases expression

Raloxifene Hydrochloride results in increased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

G

cAMP responsive element binding protein 1

increases phosphorylation

Raloxifene Hydrochloride results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

CREB binding protein

multiple interactions

Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to PTGS2 promoter]

NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888

G

cysteine-rich secretory protein LCCL domain containing 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA

NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465

G

crystallin, beta B2

affects expression

Raloxifene Hydrochloride affects the expression of CRYBB2 mRNA

NCBI chr12:43,569,747...43,579,671
Ensembl chr12:43,569,747...43,579,671

G

cold shock domain containing C2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA

NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463

G

colony stimulating factor 1

increases expression

Raloxifene Hydrochloride results in increased expression of CSF1 mRNA

NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704

G

colony stimulating factor 1 receptor

multiple interactions

[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of CSF1R protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of CSF1R protein

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of CSF3 mRNA

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

catenin beta 1

multiple interactions
increases expression

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of CTNNB1 mRNA; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CTNNB1 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CTNNB1 protein]
Raloxifene Hydrochloride results in increased expression of CTNNB1 protein

PMID:24080207 PMID:24431404 PMID:25571714 PMID:31470850

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

affects expression

Raloxifene Hydrochloride affects the expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin H

increases expression

Raloxifene Hydrochloride results in increased expression of CTSH mRNA

NCBI chr 8:90,608,941...90,627,824
Ensembl chr 8:90,608,941...90,627,824

G

cathepsin K

affects expression

Raloxifene Hydrochloride affects the expression of CTSK mRNA

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

CUE domain containing 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA

NCBI chr10:72,892,637...72,986,546
Ensembl chr10:72,892,637...72,986,542

G

CXADR, Ig-like cell adhesion molecule

affects expression

Raloxifene Hydrochloride affects the expression of CXADR mRNA

NCBI chr11:16,982,864...17,030,078
Ensembl chr11:16,982,860...17,030,046

G

C-X-C motif chemokine ligand 10

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL10 protein]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCL12 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased secretion of CXCL12 protein]
Raloxifene Hydrochloride results in decreased expression of CXCL12 mRNA

PMID:19059307 PMID:20549624 PMID:21185374 PMID:26865669

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CXCL2 mRNA]

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

cylicin 2

increases expression

Raloxifene Hydrochloride results in increased expression of CYLC2 mRNA

NCBI chr 5:65,554,320...65,576,251
Ensembl chr 5:65,554,309...65,589,282

G

CYLD lysine 63 deubiquitinase

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of CYLD mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of CYLD mRNA

NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA
Raloxifene Hydrochloride results in decreased expression of CYP19A1 mRNA

PMID:10704911 PMID:19059307

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression

[Raloxifene Hydrochloride results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; Raloxifene Hydrochloride inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of CYP1A1 protein]
Raloxifene Hydrochloride results in increased expression of CYP1A1 mRNA; Raloxifene Hydrochloride results in increased expression of CYP1A1 protein

PMID:18493746 PMID:19901195 PMID:24481452

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 26, subfamily a, polypeptide 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 26, subfamily b, polypeptide 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

G

cytochrome P450, family 27, subfamily a, polypeptide 1

affects expression

Raloxifene Hydrochloride affects the expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

Raloxifene Hydrochloride results in increased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 1

affects expression

Raloxifene Hydrochloride affects the expression of CYP2A1 mRNA

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily c, polypeptide 79

decreases activity

Raloxifene Hydrochloride results in decreased activity of CYP2C8 protein

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

Raloxifene Hydrochloride results in decreased activity of CYP3A4 protein
Raloxifene Hydrochloride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]

PMID:15860655 PMID:19299527 PMID:23721565

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dishevelled-binding antagonist of beta-catenin 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DACT1 mRNA

NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906

G

dystroglycan 1

increases expression

Raloxifene Hydrochloride results in increased expression of DAG1 mRNA

NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325

G

death-domain associated protein

affects expression

Raloxifene Hydrochloride affects the expression of DAXX mRNA

NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843

G

D-box binding PAR bZIP transcription factor

increases expression

Raloxifene Hydrochloride results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

discoidin, CUB and LCCL domain containing 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA

NCBI chr11:42,125,525...42,179,927
Ensembl chr11:42,125,787...42,179,697

G

DNA-damage-inducible transcript 4

affects expression

Raloxifene Hydrochloride affects the expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

DExD-box helicase 21

decreases expression

Raloxifene Hydrochloride results in decreased expression of DDX21 mRNA

NCBI chr20:30,534,319...30,554,513
Ensembl chr20:30,534,319...30,554,543

G

DEAD box helicase 3, Y-linked

decreases expression

Raloxifene Hydrochloride results in decreased expression of DDX3Y mRNA

NCBI chr Y:1,115,095...1,135,754
Ensembl chr Y:1,116,309...1,135,706

G

DExD-box helicase 50

affects expression

Raloxifene Hydrochloride affects the expression of DDX50 mRNA

NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152

G

defensin beta 1

multiple interactions

[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

DEPP autophagy regulator 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

desumoylating isopeptidase 2

increases expression

Raloxifene Hydrochloride results in increased expression of DESI2 mRNA

NCBI chr13:89,961,767...90,011,255
Ensembl chr13:89,961,934...90,016,416

G

24-dehydrocholesterol reductase

decreases expression

Raloxifene Hydrochloride results in decreased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dehydrogenase/reductase 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of DHRS2 mRNA]

NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644

G

DExH-box helicase 9

decreases expression

Raloxifene Hydrochloride results in decreased expression of DHX9 mRNA

NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069

G

dicer 1 ribonuclease III

decreases expression

Raloxifene Hydrochloride results in decreased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of DKK1 protein

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

dickkopf WNT signaling pathway inhibitor 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of DKK2 mRNA

NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225

G

deleted in malignant brain tumors 1

increases expression

Raloxifene Hydrochloride results in increased expression of DMBT1 mRNA; Raloxifene Hydrochloride results in increased expression of DMBT1 protein

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

DnaJ heat shock protein family (Hsp40) member A1

decreases expression

Raloxifene Hydrochloride results in decreased expression of DNAJA1 mRNA

NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967

G

DnaJ heat shock protein family (Hsp40) member B1

increases expression

Raloxifene Hydrochloride results in increased expression of DNAJB1 mRNA

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

Raloxifene Hydrochloride results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Raloxifene Hydrochloride results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

dynamin binding protein

affects expression

Raloxifene Hydrochloride affects the expression of DNMBP mRNA

NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604

G

dedicator of cytokinesis 9

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA

NCBI chr15:98,611,518...98,883,306
Ensembl chr15:98,618,084...98,883,153

G

DNA-damage regulated autophagy modulator 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of DRAM1 mRNA]

NCBI chr 7:22,742,794...22,776,888
Ensembl chr 7:22,742,849...22,776,765

G

dopamine receptor D5

increases expression

Raloxifene Hydrochloride results in increased expression of DRD5 mRNA

NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774

G

dual specificity phosphatase 2

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of DUSP2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA

PMID:16497877 PMID:19059307

NCBI chr 3:114,556,325...114,558,510
Ensembl chr 3:114,556,325...114,558,499

G

dual specificity phosphatase 4

decreases expression

Raloxifene Hydrochloride results in decreased expression of DUSP4 mRNA

NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138

G

dual specificity phosphatase 5

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

dual specificity phosphatase 6

affects expression

Raloxifene Hydrochloride affects the expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dynein, cytoplasmic 1 light intermediate chain 2

affects expression

Raloxifene Hydrochloride affects the expression of DYNC1LI2 mRNA

NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670

G

dynein light chain LC8-type 1

increases expression

Raloxifene Hydrochloride results in increased expression of DYNLL1 mRNA

NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741

G

dual specificity tyrosine phosphorylation regulated kinase 2

increases expression

Raloxifene Hydrochloride results in increased expression of DYRK2 mRNA

NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106

G

E2F transcription factor 1

multiple interactions

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 2

increases expression

Raloxifene Hydrochloride results in increased expression of E2F2 mRNA

NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217

G

enoyl-CoA delta isomerase 1

affects expression

Raloxifene Hydrochloride affects the expression of ECI1 mRNA

NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061

G

endothelin 3

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of EDN3 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EDN3 mRNA]

NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093

G

endothelin receptor type A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA

NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049

G

EGF containing fibulin extracellular matrix protein 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of EFEMP1 mRNA
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of EFEMP1 mRNA]

PMID:14699072 PMID:21185374

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

ephrin A1

increases expression

Raloxifene Hydrochloride results in increased expression of EFNA1 mRNA

NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866

G

epidermal growth factor receptor

multiple interactions
decreases phosphorylation
increases phosphorylation

[Raloxifene Hydrochloride co-treated with epigallocatechin gallate] results in decreased phosphorylation of EGFR protein; Raloxifene Hydrochloride results in decreased expression of and affects the localization of EGFR protein
Raloxifene Hydrochloride results in decreased phosphorylation of EGFR protein
Raloxifene Hydrochloride results in increased phosphorylation of EGFR protein

PMID:18371987 PMID:23842642 PMID:24782323

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 3

affects expression

Raloxifene Hydrochloride affects the expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 3

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of EGR3 mRNA]
Raloxifene Hydrochloride results in decreased expression of EGR3 mRNA

PMID:21185374 PMID:26865669

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

eukaryotic translation initiation factor 1

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EIF1 mRNA
Raloxifene Hydrochloride results in increased expression of EIF1 mRNA

PMID:16497877 PMID:19059307

NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327

G

eukaryotic translation initiation factor 2 subunit alpha

decreases expression

Raloxifene Hydrochloride results in decreased expression of EIF2S1 mRNA

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

eukaryotic translation initiation factor 5A

decreases expression

Raloxifene Hydrochloride results in decreased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

E74 like ETS transcription factor 3

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA
Raloxifene Hydrochloride results in increased expression of ELF3 mRNA

PMID:16202921 PMID:19059307

NCBI chr13:46,690,460...46,695,394
Ensembl chr13:46,690,466...46,695,481

G

elongation factor for RNA polymerase II

increases expression

Raloxifene Hydrochloride results in increased expression of ELL mRNA

NCBI chr16:18,843,775...18,891,484
Ensembl chr16:18,843,780...18,891,118

G

elongin B

decreases expression

Raloxifene Hydrochloride results in decreased expression of ELOB mRNA

NCBI chr10:12,848,830...12,853,897
Ensembl chr10:12,848,827...12,853,635

G

ELOVL fatty acid elongase 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of ELOVL5 mRNA

NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284

G

epithelial membrane protein 1

multiple interactions

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EMP1 mRNA]

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

ectodermal-neural cortex 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of ENC1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ENC1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

endonuclease domain containing 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA

NCBI chr 8:11,209,113...11,238,507
Ensembl chr 8:11,211,110...11,238,892

G

endoglin

increases expression

Raloxifene Hydrochloride results in increased expression of ENG mRNA; Raloxifene Hydrochloride results in increased expression of ENG protein

PMID:20135064 PMID:32947957

NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230

G

enolase 2

affects expression

Raloxifene Hydrochloride affects the expression of ENO2 mRNA

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA
Raloxifene Hydrochloride affects the expression of ENPP2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 2

increases expression

Raloxifene Hydrochloride results in increased expression of ENTPD2 mRNA

NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866

G

epithelial cell adhesion molecule

multiple interactions

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of EPCAM protein

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

Eph receptor A1

increases expression

Raloxifene Hydrochloride results in increased expression of EPHA1 mRNA

NCBI chr 4:71,246,409...71,260,920
Ensembl chr 4:71,246,409...71,260,846

G

Eph receptor A4

increases expression

Raloxifene Hydrochloride results in increased expression of EPHA4 mRNA

NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139

G

erythropoietin receptor

affects expression

Raloxifene Hydrochloride affects the expression of EPOR mRNA

NCBI chr 8:20,489,678...20,494,257
Ensembl chr 8:20,489,678...20,494,257

G

erb-b2 receptor tyrosine kinase 2

decreases response to substance

ERBB2 protein results in decreased susceptibility to Raloxifene Hydrochloride

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

erb-b2 receptor tyrosine kinase 3

affects expression

Raloxifene Hydrochloride affects the expression of ERBB3 mRNA

NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525

G

erb-b2 receptor tyrosine kinase 4

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of ERBB4 mRNA]

NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595

G

estrogen receptor 1

affects response to substance
decreases expression
increases expression
multiple interactions
affects expression
affects binding
decreases activity
affects folding
increases response to substance

ESR1 gene polymorphism affects the susceptibility to Raloxifene Hydrochloride
Raloxifene Hydrochloride results in decreased expression of ESR1 protein
Raloxifene Hydrochloride results in increased expression of ESR1 mRNA; Raloxifene Hydrochloride results in increased expression of ESR1 protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of ESR1 protein; [Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased expression of ESR1 protein; Raloxifene Hydrochloride affects the reaction [Oxygen deficiency affects the expression of ESR1 protein alternative form]; Raloxifene Hydrochloride binds to and affects the folding of ESR1 protein mutant form; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in decreased expression of ESR1 mRNA]
Raloxifene Hydrochloride affects the expression of ESR1 mRNA
Raloxifene Hydrochloride metabolite binds to ESR1 protein
ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]
Raloxifene Hydrochloride results in decreased expression of ESR1 mRNA; Raloxifene Hydrochloride results in decreased expression of ESR1 protein
Raloxifene Hydrochloride results in decreased activity of ESR1 protein
Raloxifene Hydrochloride binds to ESR1 protein
[Raloxifene Hydrochloride binds to ESR1 protein] which binds to SERPINB9 protein; [Raloxifene Hydrochloride binds to ESR1 protein] which binds to TFF1 protein; Raloxifene Hydrochloride binds to ESR1 protein
Raloxifene Hydrochloride affects the folding of ESR1 protein
[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ANKRD28 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CCN3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of CSF2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LINC00312 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of PLAU mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of SLN mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EIF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of G0S2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of GRK5 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ISG20 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of LPL mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of MSMB mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PTPRE mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SGK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TIPARP mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA; [Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; ARID5A protein inhibits the reaction [Raloxifene Hydrochloride results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EMP1 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of HSPA1B mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MFAP5 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased secretion of IL6 protein]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC2 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of PLPP3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TGFB3 mRNA]; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of ZFP36 mRNA]; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride affects the folding of and affects the activity of ESR1 protein; Raloxifene Hydrochloride binds to and affects the activity of ESR1 protein; Raloxifene Hydrochloride binds to and results in decreased activity of ESR1 protein; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to CCL3 promoter]; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to RELA protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol binds to ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein]; Raloxifene Hydrochloride inhibits the reaction [trichostatin A results in decreased expression of ESR1 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride results in increased activity of and affects the localization of ESR1 protein
ESR1 exon polymorphism results in increased susceptibility to Raloxifene Hydrochloride

PMID:9751507 PMID:11535548 PMID:11867264 PMID:14617632 PMID:14699072 More...

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases expression
affects expression
increases activity
decreases activity
increases response to substance

[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ABCC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACKR3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ACSL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AGO2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of AKAP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ARL4C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ASB13 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C14ORF132 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of C2CD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CA12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CALM1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASKIN2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CASP7 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CCND1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CDK5R1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CEBPB mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CERS6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CLCN4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CRISPLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CSDC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CUEDC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP24A1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of CYP26B1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of DOCK9 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ELF3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ENDOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FLNB mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LBH mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAFF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAGEA8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PCTP mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RHOF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of STK24 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADAM19 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ADORA2B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AMIGO2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ANKRD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of AREG mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ATF3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of BIRC3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CCL20 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDH2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CDO1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of CXCL8 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DACT1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DCBLD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of DUSP5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of EGR1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ENC1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GYG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of INHBA mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT17 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT34 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NAB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of OCLN mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PDP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SOD2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TCIM mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA; [trichostatin A co-treated with Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 protein; [trichostatin A co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 mRNA; [trichostatin A co-treated with Raloxifene Hydrochloride] results in increased expression of ESR2 protein; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of EDN3 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of FLNB mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of IER3 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of KLRC2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MSMB mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TMT1A mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride binds to and results in increased activity of ESR2 protein; Raloxifene Hydrochloride inhibits the reaction [3,3'-diindolylmethane results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride promotes the reaction [[trichostatin A co-treated with Estradiol] results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to ESR2 protein]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in increased expression of ESR2 protein
Raloxifene Hydrochloride affects the expression of ESR2 mRNA
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 protein]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; Raloxifene Hydrochloride affects the reaction [Azoxymethane affects the expression of ESR2 protein]
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of ESR2 protein; ESR2 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; Raloxifene Hydrochloride binds to and affects the activity of ESR2 protein alternative form; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of ESR2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of ESR2 protein]
Raloxifene Hydrochloride results in increased activity of ESR2 protein
Raloxifene Hydrochloride results in decreased activity of ESR2 protein
ESR2 protein results in increased susceptibility to Raloxifene Hydrochloride

PMID:14699072 PMID:15924412 PMID:16798746 PMID:17638070 PMID:17654759 More...

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

ecotropic viral integration site 2A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EVI2A mRNA

NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843

G

coagulation factor XI

increases activity

Raloxifene Hydrochloride results in increased activity of F11 protein

NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437

G

coagulation factor XII

increases activity

Raloxifene Hydrochloride results in increased activity of F12 protein

NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530

G

coagulation factor XIII A1 chain

affects expression

Raloxifene Hydrochloride affects the expression of F13A1 mRNA

NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700

G

coagulation factor II (thrombin) receptor

increases expression

Raloxifene Hydrochloride results in increased expression of F2R mRNA

NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870

G

coagulation factor VIII

increases activity
increases expression

Raloxifene Hydrochloride results in increased activity of F8 protein
Raloxifene Hydrochloride results in increased expression of F8 protein

PMID:15850603 PMID:16359964

NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857

G

fatty acid binding protein 4

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of FABP4 mRNA
Raloxifene Hydrochloride affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]

PMID:16643890 PMID:31470850

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas associated via death domain

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

family with sequence similarity 171, member B

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of FAM171B mRNA

NCBI chr 3:68,930,755...68,986,113
Ensembl chr 3:68,930,822...68,986,127

G

fibroblast activation protein, alpha

affects expression

Raloxifene Hydrochloride affects the expression of FAP mRNA

NCBI chr 3:47,138,823...47,207,671
Ensembl chr 3:47,138,813...47,225,545

G

FYVE, RhoGEF and PH domain containing 6

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGD6 mRNA

NCBI chr 7:28,597,609...28,712,908
Ensembl chr 7:28,597,609...28,712,456

G

fibroblast growth factor 8

increases expression

Raloxifene Hydrochloride results in increased expression of FGF8 mRNA

NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359

G

fibroblast growth factor 9

affects expression

Raloxifene Hydrochloride affects the expression of FGF9 mRNA

NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309

G

fibroblast growth factor receptor 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FGFR2 mRNA

NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626

G

four and a half LIM domains 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of FHL1 mRNA]

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

four and a half LIM domains 2

multiple interactions
decreases expression
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of FHL2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FHL2 mRNA
Raloxifene Hydrochloride results in decreased expression of FHL2 mRNA
Raloxifene Hydrochloride affects the expression of FHL2 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

fission, mitochondrial 1

affects expression
increases expression

Raloxifene Hydrochloride affects the expression of FIS1 mRNA
Raloxifene Hydrochloride results in increased expression of FIS1 mRNA

PMID:15576828 PMID:16079270

NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377

G

FKBP prolyl isomerase 3

affects expression

Raloxifene Hydrochloride affects the expression of FKBP3 mRNA

NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011

G

FKBP prolyl isomerase 5

increases expression

Raloxifene Hydrochloride results in increased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

filamin B

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of FLNB mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FLNB mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of FLNB mRNA]

PMID:14699072 PMID:19059307

NCBI chr15:16,961,999...17,095,059
Ensembl chr15:16,962,003...17,095,006

G

filamin C

decreases expression

Raloxifene Hydrochloride results in decreased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

fibronectin leucine rich transmembrane protein 1

affects expression

Raloxifene Hydrochloride affects the expression of FLRT1 mRNA

NCBI chr 1:204,275,785...204,292,844
Ensembl chr 1:204,275,367...204,353,750

G

formin-like 1

affects expression

Raloxifene Hydrochloride affects the expression of FMNL1 mRNA

NCBI chr10:88,115,876...88,143,342
Ensembl chr10:88,116,009...88,143,357

G

fibronectin 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

FOS like 2, AP-1 transcription factor subunit

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOSL2 mRNA

NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034

G

forkhead box A2

increases expression

Raloxifene Hydrochloride results in increased expression of FOXA2 mRNA

NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326

G

forkhead box C1

decreases expression

Raloxifene Hydrochloride results in decreased expression of FOXC1 mRNA

NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803

G

forkhead box E1

affects expression

Raloxifene Hydrochloride affects the expression of FOXE1 mRNA

NCBI chr 5:60,630,027...60,632,835
Ensembl chr 5:60,630,027...60,632,835

G

forkhead box O1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of FOXO1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FOXO1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

forkhead box O3

affects localization
multiple interactions

Raloxifene Hydrochloride affects the localization of FOXO3 protein
ESR1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follistatin

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of FST mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of FST mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571

G

fucosyltransferase 9

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of FUT9 mRNA

NCBI chr 5:39,351,815...39,565,256
Ensembl chr 5:39,351,819...39,565,130

G

forty-two-three domain containing 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of FYTTD1 mRNA

NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511

G

frizzled class receptor 6

affects expression

Raloxifene Hydrochloride affects the expression of FZD6 mRNA

NCBI chr 7:70,055,012...70,086,781
Ensembl chr 7:70,055,068...70,086,776

G

G0/G1switch 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

GABA type A receptor-associated protein

affects expression

Raloxifene Hydrochloride affects the expression of GABARAP mRNA

NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765

G

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of GABBR2 mRNA]

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

G

GA binding protein transcription factor subunit alpha

increases expression

Raloxifene Hydrochloride results in increased expression of GABPA mRNA

NCBI chr11:23,888,586...23,917,612
Ensembl chr11:23,888,815...23,917,605

G

gamma-aminobutyric acid type A receptor subunit gamma 1

affects expression

Raloxifene Hydrochloride affects the expression of GABRG1 mRNA

NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956

G

gamma-aminobutyric acid type A receptor subunit rho 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of GABRR1 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of GABRR1 mRNA]

NCBI chr 5:47,524,151...47,561,228
Ensembl chr 5:47,524,151...47,561,228

G

glutamate decarboxylase 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GAD1 mRNA

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

galanin and GMAP prepropeptide

decreases expression

Raloxifene Hydrochloride results in decreased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

growth arrest specific 6

increases expression
affects expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of GAS6 mRNA
Raloxifene Hydrochloride affects the expression of GAS6 mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of GAS6 mRNA]

PMID:16079270 PMID:19429434

NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904

G

GATA binding protein 2

increases expression

Raloxifene Hydrochloride results in increased expression of GATA2 mRNA

NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761

G

glucosaminyl (N-acetyl) transferase 1

affects expression

Raloxifene Hydrochloride affects the expression of GCNT1 mRNA

NCBI chr 1:214,718,344...214,755,735
Ensembl chr 1:214,718,293...214,758,776

G

growth differentiation factor 9

increases expression

Raloxifene Hydrochloride results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

GDNF family receptor alpha 2

increases expression

Raloxifene Hydrochloride results in increased expression of GFRA2 mRNA

NCBI chr15:45,941,841...46,033,715
Ensembl chr15:45,941,828...46,033,714

G

growth hormone 1

multiple interactions

Raloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

growth hormone receptor

decreases expression

Raloxifene Hydrochloride results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

growth hormone releasing hormone

affects expression

Raloxifene Hydrochloride affects the expression of GHRH mRNA

NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889

G

growth hormone releasing hormone receptor

affects expression
affects response to substance

Raloxifene Hydrochloride affects the expression of GHRHR mRNA
GHRHR affects the susceptibility to Raloxifene Hydrochloride

PMID:16079270 PMID:32934756

NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776

G

gap junction protein, beta 2

increases expression

Raloxifene Hydrochloride results in increased expression of GJB2 mRNA

NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177

G

glycine receptor, beta

affects expression

Raloxifene Hydrochloride affects the expression of GLRB mRNA

NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489

G

glutaredoxin

affects expression

Raloxifene Hydrochloride affects the expression of GLRX mRNA

NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680

G

glutamate-ammonia ligase

affects expression

Raloxifene Hydrochloride affects the expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

glycine-N-acyltransferase

affects expression

Raloxifene Hydrochloride affects the expression of GLYAT mRNA

NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942

G

G protein subunit beta 1

affects expression

Raloxifene Hydrochloride affects the expression of GNB1 mRNA

NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124

G

G protein subunit beta 4

increases expression

Raloxifene Hydrochloride results in increased expression of GNB4 mRNA

NCBI chr 2:115,360,746...115,400,680
Ensembl chr 2:115,364,918...115,400,579

G

gonadotropin releasing hormone 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

G

golgin A5

decreases expression

Raloxifene Hydrochloride results in decreased expression of GOLGA5 mRNA

NCBI chr 6:121,612,389...121,640,552
Ensembl chr 6:121,612,529...121,640,413

G

glypican 1

affects expression

Raloxifene Hydrochloride affects the expression of GPC1 mRNA

NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047

G

glypican 3

increases expression

Raloxifene Hydrochloride results in increased expression of GPC3 mRNA

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

G protein-coupled estrogen receptor 1

multiple interactions
increases activity

[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein
Raloxifene Hydrochloride inhibits the reaction [Oxygen deficiency results in increased expression of GPER1 mRNA]
GPER1 protein affects the reaction [Raloxifene Hydrochloride affects the localization of FOXO3 protein]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of AVP mRNA]; GPER1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of MYC mRNA]

PMID:22453024 PMID:24782323 PMID:24846829 PMID:26200092 PMID:26470790

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

G

glycoprotein nmb

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of GPNMB mRNA]

NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367

G

G protein-coupled receptor, class C, group 5, member C

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of GPRC5C mRNA

NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926

G

growth factor receptor bound protein 10

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of GRB10 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GRB10 mRNA

PMID:14699072 PMID:19059307

NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806

G

growth regulating estrogen receptor binding 1

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]
Raloxifene Hydrochloride results in decreased expression of GREB1 mRNA

PMID:21185374 PMID:26879975

NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633

G

grainyhead-like transcription factor 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of GRHL1 mRNA

NCBI chr 6:41,207,325...41,257,516
Ensembl chr 6:41,207,348...41,254,301

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

affects expression

Raloxifene Hydrochloride affects the expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

G protein-coupled receptor kinase 5

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of GRK5 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of GRK5 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701

G

glycogenin 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of GYG1 mRNA

NCBI chr 2:102,611,888...102,653,916
Ensembl chr 2:102,598,496...102,653,797

G

H19 imprinted maternally expressed transcript

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of H19 mRNA]

NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134

G

histidine ammonia lyase

affects expression

Raloxifene Hydrochloride affects the expression of HAL mRNA

NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701

G

hyaluronan and proteoglycan link protein 1

affects expression

Raloxifene Hydrochloride affects the expression of HAPLN1 mRNA

NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777

G

hyaluronan synthase 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA

NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933

G

hemoglobin alpha, adult chain 1

affects expression

Raloxifene Hydrochloride affects the expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

G

heparin-binding EGF-like growth factor

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of HBEGF mRNA; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA
Raloxifene Hydrochloride results in decreased expression of HBEGF mRNA

PMID:19059307 PMID:27017931

NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441

G

hemoglobin subunit gamma 1

affects expression

Raloxifene Hydrochloride affects the expression of HBG1 mRNA

NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425

G

HMG-box transcription factor 1

increases expression

Raloxifene Hydrochloride results in increased expression of HBP1 mRNA

NCBI chr 6:48,529,633...48,555,775
Ensembl chr 6:48,529,372...48,555,787

G

heart development protein with EGF-like domains 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of HEG1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HEG1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HEG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr11:67,006,954...67,095,020
Ensembl chr11:66,957,190...67,095,051

G

homocysteine inducible ER protein with ubiquitin like domain 1

increases expression

Raloxifene Hydrochloride results in increased expression of HERPUD1 mRNA

NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424

G

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HEY2 mRNA]

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

G

hepatocyte growth factor

decreases expression

Raloxifene Hydrochloride results in decreased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

hexokinase 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of HK1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

hemicentin 1

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of HMCN1 mRNA

NCBI chr13:62,615,461...63,084,524
Ensembl chr13:62,615,461...63,084,524

G

high mobility group AT-hook 2

affects expression

Raloxifene Hydrochloride affects the expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

G

high mobility group box 1

decreases expression
affects expression

Raloxifene Hydrochloride results in decreased expression of HMGB1 mRNA
Raloxifene Hydrochloride affects the expression of HMGB1 mRNA

PMID:16079270 PMID:16514628

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

heme oxygenase 1

multiple interactions
affects expression
decreases expression
increases expression

1,10-phenanthroline inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HMOX1 mRNA; Allopurinol inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Copper promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; dimethyl sulfate inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; Iron promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; MAP2K6 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 protein]; TEMPO inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]
Raloxifene Hydrochloride affects the expression of HMOX1 mRNA
Raloxifene Hydrochloride results in decreased expression of HMOX1 mRNA
Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA; Raloxifene Hydrochloride results in increased expression of HMOX1 protein

PMID:16079270 PMID:16298037 PMID:19059307 PMID:20888885

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hepatocyte nuclear factor 4, alpha

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of HNF4A mRNA]

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

heterogeneous nuclear ribonucleoprotein A2/B1

decreases expression

Raloxifene Hydrochloride results in decreased expression of HNRNPA2B1 mRNA

NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249

G

heterogeneous nuclear ribonucleoprotein H1

decreases expression

Raloxifene Hydrochloride results in decreased expression of HNRNPH1 mRNA

NCBI chr10:34,692,868...34,702,849
Ensembl chr10:34,693,555...34,702,846

G

heterogeneous nuclear ribonucleoprotein U

decreases expression

Raloxifene Hydrochloride results in decreased expression of HNRNPU mRNA

NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588

G

homer scaffold protein 2

affects expression

Raloxifene Hydrochloride affects the expression of HOMER2 mRNA

NCBI chr 1:135,558,977...135,659,780
Ensembl chr 1:135,567,414...135,659,772

G

homeobox A1

affects expression

Raloxifene Hydrochloride affects the expression of HOXA1 mRNA

NCBI chr 4:81,255,814...81,258,587
Ensembl chr 4:81,255,883...81,258,504

G

hippocalcin-like 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HPCAL1 mRNA

NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687

G

15-hydroxyprostaglandin dehydrogenase

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HPGD mRNA]

NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228

G

hydroxysteroid (17-beta) dehydrogenase 11

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of HSD17B11 mRNA

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

hydroxysteroid (17-beta) dehydrogenase 4

affects expression

Raloxifene Hydrochloride affects the expression of HSD17B4 mRNA

NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952

G

heat shock protein 90 alpha family class B member 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

affects expression
increases expression

Raloxifene Hydrochloride affects the expression of HSPA1A mRNA
Raloxifene Hydrochloride results in increased expression of HSPA1A protein

PMID:14699072 PMID:15860553

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
affects expression

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of HSPA1B mRNA]
Raloxifene Hydrochloride affects the expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

decreases expression

Raloxifene Hydrochloride results in decreased expression of HSPA4 mRNA

NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

decreases expression

Raloxifene Hydrochloride results in decreased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 8

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HSPB8 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of HSPB8 mRNA]

PMID:19059307 PMID:21185374

NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185

G

heat shock protein family D (Hsp60) member 1

decreases expression
affects expression

Raloxifene Hydrochloride results in decreased expression of HSPD1 mRNA
Raloxifene Hydrochloride affects the expression of HSPD1 mRNA

PMID:16079270 PMID:16514628

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

5-hydroxytryptamine receptor 2A

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of HTR2A mRNA
Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A mRNA]; Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of HTR2A protein]

PMID:14699072 PMID:17398000

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

5-hydroxytryptamine receptor 3A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of HTR3A mRNA

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

5-hydroxytryptamine receptor 5A

affects expression

Raloxifene Hydrochloride affects the expression of HTR5A mRNA

NCBI chr 4:7,444,968...7,454,651
Ensembl chr 4:7,444,968...7,454,651

G

intercellular adhesion molecule 1

multiple interactions

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

inhibitor of DNA binding 1

affects expression

Raloxifene Hydrochloride affects the expression of ID1 mRNA

NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419

G

inhibitor of DNA binding 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of ID4 mRNA

NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of IDH2 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of IDH2 mRNA]
Raloxifene Hydrochloride affects the expression of IDH2 mRNA

PMID:14699072 PMID:16079270 PMID:19059307

NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025

G

indoleamine 2,3-dioxygenase 1

multiple interactions
increases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
Raloxifene Hydrochloride results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

immediate early response 3

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of IER3 mRNA
ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of IER3 mRNA]

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

interferon-induced protein with tetratricopeptide repeats 2

affects expression

Raloxifene Hydrochloride affects the expression of IFIT2 mRNA

NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635

G

interferon gamma receptor 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of IFNGR2 mRNA

NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005

G

interferon-related developmental regulator 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of IFRD1 mRNA

NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990

G

insulin-like growth factor 1

multiple interactions
affects expression
increases expression
decreases expression

Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]
Raloxifene Hydrochloride affects the expression of IGF1 mRNA
Raloxifene Hydrochloride results in increased expression of IGF1 mRNA
Raloxifene Hydrochloride results in decreased expression of IGF1 mRNA; Raloxifene Hydrochloride results in decreased expression of IGF1 protein

PMID:15762036 PMID:15978972 PMID:16912660 PMID:17645796 PMID:17872375 More...

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 2

increases expression

Raloxifene Hydrochloride results in increased expression of IGF2 mRNA

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 3

increases expression

Raloxifene Hydrochloride results in increased expression of IGFBP3 protein

PMID:15855258 PMID:16912660

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

insulin-like growth factor binding protein 4

affects expression

Raloxifene Hydrochloride affects the expression of IGFBP4 mRNA

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

insulin-like growth factor binding protein 6

increases expression

Raloxifene Hydrochloride results in increased expression of IGFBP6 mRNA

NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966

G

interleukin 10 receptor subunit alpha

increases expression

Raloxifene Hydrochloride results in increased expression of IL10RA mRNA

NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061

G

interleukin 11

multiple interactions

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA

NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129

G

interleukin 12A

decreases expression

Raloxifene Hydrochloride results in decreased expression of IL12A mRNA

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 13 receptor subunit alpha 1

increases expression

Raloxifene Hydrochloride results in increased expression of IL13RA1 mRNA

NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681

G

interleukin 1 beta

multiple interactions

[Raloxifene Hydrochloride co-treated with IL1B protein] results in increased expression of PTGDS mRNA; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]]; Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of BCL3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CCL20 protein]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CISH mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of CXCL5 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of IL1B protein]

PMID:12072388 PMID:24722370 PMID:25305410

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

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interleukin 1 receptor type 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of IL1R1 mRNA]

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

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interleukin 1 receptor accessory protein

affects expression

Raloxifene Hydrochloride affects the expression of IL1RAP mRNA

NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530

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interleukin 4

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [IL4 protein results in increased phosphorylation of STAT3 protein]
[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of IL4 mRNA]

PMID:24080207 PMID:24456369

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

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interleukin 4 receptor

affects expression

Raloxifene Hydrochloride affects the expression of IL4R mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

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interleukin 6

decreases expression
decreases secretion
multiple interactions

Raloxifene Hydrochloride results in decreased expression of IL6 mRNA; Raloxifene Hydrochloride results in decreased expression of IL6 protein
Raloxifene Hydrochloride results in decreased secretion of IL6 protein
ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased secretion of IL6 protein]; Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of IL6 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:15579764 PMID:15762036 PMID:15953991 PMID:16298037 PMID:19533603 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

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interleukin 6 receptor

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]

NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536

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interleukin 6 cytokine family signal transducer

affects binding

Raloxifene Hydrochloride binds to IL6ST protein

PMID:24456369 PMID:32940862

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

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interleukin 7 receptor

affects expression

Raloxifene Hydrochloride affects the expression of IL7R mRNA

NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757

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inflammation and lipid regulator with UBA-like and NBR1-like domains

decreases expression

Raloxifene Hydrochloride results in decreased expression of ILRUN mRNA

NCBI chr20:5,809,931...5,876,197
Ensembl chr20:5,809,936...5,876,012

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inhibin subunit beta A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

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inositol polyphosphate-4-phosphatase type II B

affects expression

Raloxifene Hydrochloride affects the expression of INPP4B mRNA

NCBI chr19:25,920,189...26,670,085
Ensembl chr19:25,925,358...26,280,634

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inositol polyphosphate-5-phosphatase A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of INPP5A mRNA

NCBI chr 1:194,190,086...194,380,429
Ensembl chr 1:194,190,393...194,380,428

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insulin 1

multiple interactions

IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]]; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]]; IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]]; Raloxifene Hydrochloride affects the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of FABP4 protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CTNNB1 protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of CEBPA protein]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

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insulin induced gene 1

increases expression

Raloxifene Hydrochloride results in increased expression of INSIG1 mRNA

NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952

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IQ motif containing GTPase activating protein 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of IQGAP1 mRNA

NCBI chr 1:134,679,581...134,769,776
Ensembl chr 1:134,679,586...134,769,755

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interferon regulatory factor 7

affects expression

Raloxifene Hydrochloride affects the expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

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interferon stimulated exonuclease gene 20

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ISG20 mRNA
Raloxifene Hydrochloride affects the expression of ISG20 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

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integrin subunit beta 1

increases expression

Raloxifene Hydrochloride results in increased expression of ITGB1 mRNA

PMID:12154049 PMID:19429434

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

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integrin subunit beta 3

increases expression

Raloxifene Hydrochloride results in increased expression of ITGB3 mRNA

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

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inositol 1,4,5-trisphosphate receptor, type 3

affects expression

Raloxifene Hydrochloride affects the expression of ITPR3 mRNA

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

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involucrin

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of IVL mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of IVL mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100

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jagged canonical Notch ligand 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of JAG1 mRNA

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

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Janus kinase 2

multiple interactions
decreases expression

Raloxifene Hydrochloride promotes the reaction [GH1 protein results in increased phosphorylation of JAK2 protein]
Raloxifene Hydrochloride results in decreased expression of JAK2 mRNA

PMID:17272397 PMID:26865669

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

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Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Raloxifene Hydrochloride results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

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kazrin, periplakin interacting protein

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KAZN mRNA

NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074

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potassium voltage-gated channel subfamily D member 3

multiple interactions
decreases expression
decreases activity

Raloxifene Hydrochloride promotes the reaction [Fulvestrant results in decreased activity of KCND3 protein]
Raloxifene Hydrochloride results in decreased expression of KCND3 mRNA
[KCNIP2 protein co-treated with Raloxifene Hydrochloride] results in decreased activity of KCND3 protein
Raloxifene Hydrochloride results in decreased activity of KCND3 protein

NCBI chr 2:192,937,950...193,155,345
Ensembl chr 2:192,937,950...193,155,345

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potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

Raloxifene Hydrochloride results in increased expression of KCNE1 mRNA

NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901

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potassium voltage-gated channel subfamily H member 5

affects expression

Raloxifene Hydrochloride affects the expression of KCNH5 mRNA

NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:93,624,529...93,908,107

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potassium voltage-gated channel interacting protein 2

multiple interactions

[KCNIP2 protein co-treated with Raloxifene Hydrochloride] results in decreased activity of KCND3 protein

NCBI chr 1:244,641,147...244,664,939
Ensembl chr 1:244,641,150...244,664,874

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potassium calcium-activated channel subfamily N member 4

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of KCNN4 mRNA
Raloxifene Hydrochloride affects the expression of KCNN4 mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340

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potassium channel tetramerization domain containing 12

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KCTD12 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KCTD12 mRNA
Raloxifene Hydrochloride affects the expression of KCTD12 mRNA

PMID:14699072 PMID:19059307

NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282

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kinesin family member 20A

decreases expression

Raloxifene Hydrochloride results in decreased expression of KIF20A mRNA

NCBI chr18:26,230,294...26,238,780
Ensembl chr18:26,230,230...26,238,780

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kinesin family member 3C

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KIF3C mRNA

NCBI chr 6:26,367,092...26,406,033
Ensembl chr 6:26,366,531...26,406,130

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KiSS-1 metastasis-suppressor

decreases expression

Raloxifene Hydrochloride results in decreased expression of KISS1 mRNA

NCBI chr13:44,775,106...44,780,707
Ensembl chr13:44,774,823...44,780,612

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KLF transcription factor 10

affects expression

Raloxifene Hydrochloride affects the expression of KLF10 mRNA

NCBI chr 7:69,467,658...69,473,726
Ensembl chr 7:69,465,619...69,473,994

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KLF transcription factor 6

decreases expression

Raloxifene Hydrochloride results in decreased expression of KLF6 mRNA

NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570

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kelch-like family member 24

increases expression

Raloxifene Hydrochloride results in increased expression of KLHL24 mRNA

NCBI chr11:80,843,621...80,877,649
Ensembl chr11:80,846,755...80,877,636

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killer cell lectin like receptor C1

increases expression

Raloxifene Hydrochloride results in increased expression of KLRC1 mRNA

NCBI chr 4:163,142,142...163,152,425
Ensembl chr 4:163,147,189...163,152,425

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killer cell lectin like receptor C2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of KLRC2 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of KLRC2 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC2 mRNA]; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of KLRC2 mRNA]

PMID:14699072 PMID:19059307

NCBI chr 4:163,122,700...163,133,843
Ensembl chr 4:163,122,704...163,133,843

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killer cell lectin like receptor C3

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRC3 mRNA; ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of KLRC3 mRNA]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]

PMID:17395694 PMID:19059307

NCBI chr 4:163,105,081...163,112,737
Ensembl chr 4:163,106,024...163,112,336

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killer cell lectin like receptor K1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of KLRK1 mRNA

NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459

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karyopherin subunit alpha 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of KPNA2 mRNA

NCBI chr10:91,933,951...91,946,115
Ensembl chr10:91,933,951...91,946,150

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karyopherin subunit beta 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of KPNB1 mRNA

NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605

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keratin 17

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT17 mRNA

NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392

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keratin 34

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of KRT34 mRNA

NCBI chr10:84,969,988...84,974,098
Ensembl chr10:84,970,017...84,974,040

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L3MBTL histone methyl-lysine binding protein 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of L3MBTL1 mRNA

NCBI chr 3:151,597,903...151,633,657
Ensembl chr 3:151,602,980...151,631,233

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laminin subunit beta 1

multiple interactions

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LAMB1 mRNA

NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585

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laminin subunit gamma 1

affects expression

Raloxifene Hydrochloride affects the expression of LAMC1 mRNA

NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492

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LBH regulator of WNT signaling pathway

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LBH mRNA

NCBI chr 6:22,569,238...22,593,056
Ensembl chr 6:22,568,834...22,593,079

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lipocalin 2

affects expression

Raloxifene Hydrochloride affects the expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

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low density lipoprotein receptor

increases expression

Raloxifene Hydrochloride results in increased expression of LDLR mRNA

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

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low density lipoprotein receptor class A domain containing 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LDLRAD4 mRNA

NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238

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leptin receptor

affects expression

Raloxifene decreases Lepr protein expression in adipose tissue at 7 weeks and increases it at 22 weeks

RGD

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

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leucine rich repeat containing G protein coupled receptor 5

multiple interactions

[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of LGR5 protein

NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446

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luteinizing hormone subunit beta

multiple interactions
decreases secretion

Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased secretion of LHB protein]
Raloxifene Hydrochloride results in decreased secretion of LHB protein

PMID:17398000 PMID:27395752

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

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LIF, interleukin 6 family cytokine

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA
Raloxifene Hydrochloride results in decreased expression of LIF mRNA

PMID:26603317 PMID:27017931

NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482

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LIM and calponin homology domains 1

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of LIMCH1 mRNA]

NCBI chr14:41,112,579...41,425,001
Ensembl chr14:41,114,803...41,425,191

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lipase H

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LIPH mRNA

NCBI chr11:79,032,229...79,081,625
Ensembl chr11:79,033,312...79,081,625

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LIM and cysteine-rich domains 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of LMCD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of LMCD1 mRNA

NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046

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lamin B2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of LMNB2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LMNB2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:8,792,628...8,808,665
Ensembl chr 7:8,789,314...8,808,665

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lysyl oxidase

affects expression

Raloxifene Hydrochloride affects the expression of LOX mRNA

NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477

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lipoprotein lipase

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of LPL mRNA
Raloxifene Hydrochloride results in increased expression of LPL mRNA

PMID:16643890 PMID:19059307

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine-rich repeats and immunoglobulin-like domains 1

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRIG1 mRNA
Raloxifene Hydrochloride affects the expression of LRIG1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 4:127,130,899...127,230,956
Ensembl chr 4:127,130,898...127,231,513

G

leucine rich repeat containing 20

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LRRC20 mRNA

NCBI chr20:29,422,858...29,528,372
Ensembl chr20:29,422,925...29,528,369

G

lymphotoxin beta

decreases expression

Raloxifene Hydrochloride results in decreased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

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latent transforming growth factor beta binding protein 1

affects expression

Raloxifene Hydrochloride affects the expression of LTBP1 mRNA

NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349

G

lumican

affects expression

Raloxifene Hydrochloride affects the expression of LUM mRNA

NCBI chr 7:32,358,990...32,365,794
Ensembl chr 7:32,358,614...32,365,793

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lymphocyte antigen 6 complex, locus I

affects expression

Raloxifene Hydrochloride affects the expression of LY6B mRNA

NCBI chr 7:107,062,320...107,067,743
Ensembl chr 7:107,062,325...107,067,310

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of LYN mRNA

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

LysM domain containing 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of LYSMD4 mRNA

NCBI chr 1:120,839,180...120,845,148
Ensembl chr 1:120,839,282...120,845,135

G

macroH2A.1 histone

affects expression

Raloxifene Hydrochloride affects the expression of MACROH2A1 mRNA

NCBI chr17:8,479,331...8,542,071
Ensembl chr17:8,479,372...8,542,072

G

MAF bZIP transcription factor

increases expression

Raloxifene Hydrochloride results in increased expression of MAF mRNA

NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365

G

MAF bZIP transcription factor F

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAFF mRNA

NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851

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mannosidase, alpha, class 2A, member 2

affects expression

Raloxifene Hydrochloride affects the expression of MAN2A2 mRNA

NCBI chr 1:134,304,714...134,327,611
Ensembl chr 1:134,306,236...134,327,315

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases lipidation

[Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased lipidation of MAP1LC3B protein
Raloxifene Hydrochloride results in increased lipidation of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

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mitogen activated protein kinase kinase 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of MAP2K3 mRNA

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

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mitogen-activated protein kinase kinase 6

multiple interactions

MAP2K6 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 protein]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

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mitogen-activated protein kinase kinase kinase 11

increases expression

Raloxifene Hydrochloride results in increased expression of MAP3K11 mRNA

NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652

G

mitogen-activated protein kinase kinase kinase 20

decreases expression

Raloxifene Hydrochloride results in decreased expression of MAP3K20 mRNA

NCBI chr 3:57,130,539...57,289,943
Ensembl chr 3:57,130,551...57,289,626

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K5 mRNA

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen-activated protein kinase kinase kinase 8

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAP3K8 mRNA

NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; Raloxifene Hydrochloride inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK1 protein]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK1 protein]

PMID:15712295 PMID:16798746 PMID:17174166 PMID:20945400 PMID:24782323 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

affects expression

Raloxifene Hydrochloride affects the expression of MAPK14 mRNA

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; Raloxifene Hydrochloride inhibits the reaction [Methylmercury Compounds results in increased activity of MAPK3 protein]; sotrastaurin inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of MAPK3 protein]

PMID:15712295 PMID:16798746 PMID:17174166 PMID:20945400 PMID:24782323 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MAPK activated protein kinase 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MAPKAPK2 mRNA

NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457

G

MARCKS-like 1

affects expression

Raloxifene Hydrochloride affects the expression of MARCKSL1 mRNA

NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817

G

matrin 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of MATR3 mRNA

NCBI chr18:27,154,098...27,193,212
Ensembl chr18:27,163,714...27,193,166

G

muscleblind-like splicing regulator 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

multiple C2 and transmembrane domain containing 1

increases expression

Raloxifene Hydrochloride results in increased expression of MCTP1 mRNA

NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833

G

MyoD family inhibitor domain containing

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of MDFIC mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MDFIC mRNA

PMID:14699072 PMID:19059307

NCBI chr 4:43,972,310...44,052,162
Ensembl chr 4:43,972,507...44,052,161

G

MDM2 proto-oncogene

multiple interactions

[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

myocyte enhancer factor 2a

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA

NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948

G

microfibril associated protein 5

multiple interactions
affects expression

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MFAP5 mRNA]
Raloxifene Hydrochloride affects the expression of MFAP5 mRNA

NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458

G

matrix Gla protein

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MGP mRNA]
Raloxifene Hydrochloride results in decreased expression of MGP mRNA

PMID:16514628 PMID:21185374

NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667

G

microtubule associated monooxygenase, calponin and LIM domain containing 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of MICAL2 mRNA

NCBI chr 1:166,345,853...166,530,575
Ensembl chr 1:166,345,859...166,471,719
Ensembl chr 1:166,345,859...166,471,719

G

midline 1

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of MID1 mRNA]

NCBI chr X:24,116,674...24,491,205
Ensembl chr X:24,120,293...24,248,353

G

marker of proliferation Ki-67

decreases expression

Raloxifene Hydrochloride results in decreased expression of MKI67 protein

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

monocyte to macrophage differentiation-associated 2

increases expression

Raloxifene Hydrochloride results in increased expression of MMD2 mRNA

NCBI chr12:11,962,733...12,009,776
Ensembl chr12:11,962,757...12,009,773

G

matrix metallopeptidase 12

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of MMP12 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MMP12 mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 13

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of MMP2 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; ESR2 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased expression of MMP2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in decreased secretion of MMP2 protein]

PMID:16079270 PMID:23471663

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Decitabine results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

decreases activity
multiple interactions
increases expression
decreases expression

Raloxifene Hydrochloride results in decreased activity of MMP9 protein
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 protein; [9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride] affects the expression of MMP9 protein
Raloxifene Hydrochloride results in increased expression of MMP9 mRNA
Raloxifene Hydrochloride results in decreased expression of MMP9 mRNA

PMID:17582780 PMID:22841776 PMID:31332895

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

MN1 proto-oncogene, transcriptional regulator

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MN1 mRNA

NCBI chr12:45,181,794...45,220,959
Ensembl chr12:45,183,085...45,221,651

G

myeloperoxidase

multiple interactions

Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallophosphoesterase domain containing 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MPPED2 mRNA

NCBI chr 3:93,180,895...93,355,605
Ensembl chr 3:93,181,167...93,355,618

G

major histocompatibility complex, class I-related

increases expression

Raloxifene Hydrochloride results in increased expression of MR1 mRNA

NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970

G

mitochondrial ribosomal protein L33

affects expression

Raloxifene Hydrochloride affects the expression of MRPL33 mRNA

NCBI chr 6:24,825,800...24,833,994
Ensembl chr 6:24,825,827...24,833,834

G

microseminoprotein, beta

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of MSMB mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of MSMB mRNA]
Raloxifene Hydrochloride affects the expression of MSMB mRNA

PMID:14699072 PMID:19059307

NCBI chr16:7,366,536...7,387,124
Ensembl chr16:7,366,536...7,387,123

G

macrophage stimulating 1

increases expression

Raloxifene Hydrochloride results in increased expression of MST1 mRNA

NCBI chr 8:108,767,886...108,773,425
Ensembl chr 8:108,768,839...108,773,416

G

metallothionein 2A

increases expression

Raloxifene Hydrochloride results in increased expression of MT2A mRNA

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate reductase

decreases expression

Raloxifene Hydrochloride results in decreased expression of MTHFR mRNA

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

G

mechanistic target of rapamycin kinase

increases phosphorylation

Raloxifene Hydrochloride results in increased phosphorylation of MTOR protein

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 1, cell surface associated

increases expression
affects expression

Raloxifene Hydrochloride results in increased expression of MUC1 protein
Raloxifene Hydrochloride affects the expression of MUC1 mRNA

PMID:16012748 PMID:16079270

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

MYB proto-oncogene, transcription factor

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of MYB mRNA]
Raloxifene Hydrochloride results in decreased expression of MYB mRNA

PMID:21185374 PMID:26865669

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

MYB proto-oncogene like 1

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of MYBL1 mRNA
Raloxifene Hydrochloride results in decreased expression of MYBL1 mRNA

PMID:21185374 PMID:26865669

NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

GPER1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of MYC mRNA]; Raloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]
Raloxifene Hydrochloride results in decreased expression of MYC mRNA; Raloxifene Hydrochloride results in decreased expression of MYC protein

PMID:16497877 PMID:20945400 PMID:22453024 PMID:26502914

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myosin light chain 9

affects expression

Raloxifene Hydrochloride affects the expression of MYL9 mRNA

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin X

affects expression

Raloxifene Hydrochloride affects the expression of MYO10 mRNA

NCBI chr 2:76,100,989...76,305,619
Ensembl chr 2:76,100,987...76,303,030

G

myogenic differentiation 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of MYOD1 mRNA

NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554

G

myelin transcription factor 1-like

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MYT1L mRNA

NCBI chr 6:46,164,742...46,564,234
Ensembl chr 6:46,428,150...46,561,671

G

Ngfi-A binding protein 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NAB1 mRNA

NCBI chr 9:49,053,579...49,093,078
Ensembl chr 9:49,053,758...49,092,098

G

asparaginyl-tRNA synthetase 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of NARS1 mRNA

NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622

G

neuron navigator 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NAV2 mRNA

NCBI chr 1:98,957,629...99,322,339
Ensembl chr 1:98,663,759...99,322,337

G

NBL1, DAN family BMP antagonist

increases expression

Raloxifene Hydrochloride results in increased expression of NBL1 mRNA

NCBI chr 5:151,318,752...151,329,948
Ensembl chr 5:151,318,754...151,338,719

G

non-SMC condensin I complex, subunit H

decreases expression

Raloxifene Hydrochloride results in decreased expression of NCAPH mRNA

NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180

G

neutrophil cytosolic factor 2

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCF2 mRNA; ESR2 protein affects the reaction [Raloxifene Hydrochloride results in decreased expression of NCF2 mRNA]
Raloxifene Hydrochloride affects the expression of NCF2 mRNA

PMID:14699072 PMID:19059307

NCBI chr13:64,955,622...64,986,144
Ensembl chr13:64,955,503...64,986,277

G

nucleolin

decreases expression

Raloxifene Hydrochloride results in decreased expression of NCL mRNA

NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136

G

nuclear receptor coactivator 1

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA1 mRNA; Raloxifene Hydrochloride promotes the reaction [NCOA1 protein binds to IGF1 promoter]
Raloxifene Hydrochloride results in increased expression of NCOA1 mRNA

PMID:17872375 PMID:19059307 PMID:19432593

NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664

G

nuclear receptor coactivator 2

multiple interactions
increases expression

Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in increased expression of NCOA2 protein

PMID:16739346 PMID:17872375

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor coactivator 3

multiple interactions

Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to IGF1 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to KLRC3 gene]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to PTGS2 promoter]

PMID:17395694 PMID:17872375

NCBI chr 3:154,738,566...154,821,395
Ensembl chr 3:154,738,581...154,818,594

G

nuclear receptor coactivator 4

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of NCOA4 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NCOA4 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641

G

nuclear receptor co-repressor 2

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to IGF1 promoter]; Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]
Raloxifene Hydrochloride results in decreased expression of NCOR2 mRNA

PMID:17872375 PMID:19432593

NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319

G

NDRG family member 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NDRG4 mRNA

NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914

G

NADH:ubiquinone oxidoreductase subunit A2

affects expression

Raloxifene Hydrochloride affects the expression of NDUFA2 mRNA

NCBI chr18:28,355,774...28,357,863
Ensembl chr18:28,355,774...28,358,076

G

nectin cell adhesion molecule 1

affects expression

Raloxifene Hydrochloride affects the expression of NECTIN1 mRNA

NCBI chr 8:44,101,776...44,164,863
Ensembl chr 8:44,101,776...44,189,787

G

neurofilament light chain

affects expression

Raloxifene Hydrochloride affects the expression of NEFL mRNA

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

NIMA-related kinase 7

affects expression

Raloxifene Hydrochloride affects the expression of NEK7 mRNA

NCBI chr13:50,022,212...50,149,374
Ensembl chr13:50,022,218...50,149,296

G

neurofibromin 1

increases expression

Raloxifene Hydrochloride results in increased expression of NF1 mRNA

NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658

G

nuclear factor of activated T-cells 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFATC1 mRNA

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

NFE2 like bZIP transcription factor 1

increases expression

Raloxifene Hydrochloride results in increased expression of NFE2L1 mRNA

NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318

G

nuclear factor, interleukin 3 regulated

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of NFIL3 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFIL3 mRNA

PMID:14699072 PMID:19059307

NCBI chr17:12,280,499...12,295,728
Ensembl chr17:12,280,484...12,295,858

G

nuclear factor kappa B subunit 1

multiple interactions

Raloxifene Hydrochloride promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
affects expression
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NFKBIA mRNA
Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Raloxifene Hydrochloride affects the expression of NFKBIA mRNA
Raloxifene Hydrochloride results in decreased expression of NFKBIA mRNA

PMID:14699072 PMID:16298037 PMID:19059307 PMID:31470850

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

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NFKB inhibitor epsilon

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NFKBIE mRNA

NCBI chr 9:15,443,600...15,450,437
Ensembl chr 9:15,436,941...15,450,437

G

NHERF family PDZ scaffold protein 1

affects expression

Raloxifene Hydrochloride affects the expression of NHERF1 mRNA

NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598

G

ninjurin 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

NLR family, pyrin domain containing 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NLRP3 mRNA

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

NME/NM23 nucleoside diphosphate kinase 6

affects expression

Raloxifene Hydrochloride affects the expression of NME6 mRNA

NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301

G

nicotinamide riboside kinase 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of NMRK1 mRNA

NCBI chr 1:216,049,350...216,076,792
Ensembl chr 1:216,049,437...216,076,791

G

nitric oxide synthase 2

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein; [Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide; Cycloheximide inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; Dactinomycin inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; Fulvestrant inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; HMOX1 protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]; pyrrolidine dithiocarbamic acid inhibits the reaction [[Raloxifene Hydrochloride co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in increased expression of NOS2 protein]; XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]
Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NOS2 protein]

PMID:15860553 PMID:20888885 PMID:28138957

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

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nitric oxide synthase 3

increases expression

Raloxifene Hydrochloride results in increased expression of NOS3 mRNA

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

notch receptor 3

affects expression

Raloxifene Hydrochloride affects the expression of NOTCH3 mRNA

NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025

G

nucleophosmin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of NPM1 mRNA

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645

G

natriuretic peptide receptor 2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of NPR2 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of NPR2 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NPR2 mRNA

PMID:14699072 PMID:19059307

NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580

G

neuropeptide Y receptor Y1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of NPY1R mRNA]

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of NQO1 protein
ARNT protein affects the reaction [Raloxifene Hydrochloride results in increased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group D, member 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR1D1 mRNA

NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705

G

nuclear receptor subfamily 2, group F, member 6

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of NR2F6 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NR2F6 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR3C1 mRNA

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Raloxifene Hydrochloride results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuronal regeneration related protein

affects expression

Raloxifene Hydrochloride affects the expression of NREP mRNA

NCBI chr18:25,017,069...25,046,593
Ensembl chr18:25,017,083...25,046,591

G

nuclear respiratory factor 1

multiple interactions
increases expression

fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NRF1 mRNA]; Vehicle Emissions inhibits the reaction [Raloxifene Hydrochloride results in increased expression of NRF1 mRNA]

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

neuregulin 1

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [[NRG1 protein co-treated with Estradiol] results in increased expression of MYC protein]

NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884

G

neuregulin 2

increases expression

Raloxifene Hydrochloride results in increased expression of NRG2 mRNA

NCBI chr18:27,616,542...27,798,505
Ensembl chr18:27,619,661...27,798,505

G

NUAK family kinase 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of NUAK1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of NUAK1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913

G

nucleoporin 160

increases expression

Raloxifene Hydrochloride results in increased expression of NUP160 mRNA

NCBI chr 3:76,665,786...76,729,296
Ensembl chr 3:76,665,786...76,724,565

G

NUS1 dehydrodolichyl diphosphate synthase subunit

decreases expression

Raloxifene Hydrochloride results in decreased expression of NUS1 mRNA

NCBI chr20:31,811,817...31,838,562
Ensembl chr20:31,811,817...31,838,561

G

nuclear RNA export factor 1

affects expression

Raloxifene Hydrochloride affects the expression of NXF1 mRNA

NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636

G

occludin

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of OCLN mRNA

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

olfactomedin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of OLFM1 mRNA

NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239

G

olfactomedin-like 2A

affects expression

Raloxifene Hydrochloride affects the expression of OLFML2A mRNA

NCBI chr 3:22,688,590...22,717,917
Ensembl chr 3:22,688,598...22,717,909

G

olfactory receptor family 10 subfamily AL member 6

affects expression

Raloxifene Hydrochloride affects the expression of OR10AL6 mRNA

NCBI chr20:738,257...739,607
Ensembl chr20:734,965...811,125

G

olfactory receptor family 1 subfamily F member 45

affects expression

Raloxifene Hydrochloride affects the expression of OR1F45 mRNA

NCBI chr10:11,992,870...11,993,811
Ensembl chr10:11,992,870...11,993,811

G

oxysterol binding protein-like 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of OSBPL3 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OSBPL3 mRNA

NCBI chr 4:79,346,583...79,523,523
Ensembl chr 4:79,350,349...79,523,393

G

oxysterol binding protein-like 7

increases expression

Raloxifene Hydrochloride results in increased expression of OSBPL7 mRNA

NCBI chr10:82,035,995...82,053,566
Ensembl chr10:82,036,042...82,053,557

G

OTU deubiquitinase, ubiquitin aldehyde binding 2

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of OTUB2 mRNA
Raloxifene Hydrochloride results in decreased expression of OTUB2 mRNA

PMID:19059307 PMID:33269387

NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644

G

OTU deubiquitinase 1

multiple interactions

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD1 mRNA

NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995

G

OTU deubiquitinase 3

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of OTUD3 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of OTUD3 mRNA

NCBI chr 5:151,135,826...151,162,207
Ensembl chr 5:151,140,059...151,163,560

G

OTU deubiquitinase 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of OTUD5 mRNA

NCBI chr X:14,626,173...14,659,331
Ensembl chr X:14,626,164...14,659,573

G

OTU deubiquitinase 7A

decreases expression

Raloxifene Hydrochloride results in decreased expression of OTUD7A mRNA

NCBI chr 1:117,064,428...117,388,217
Ensembl chr 1:117,064,496...117,386,480

G

OTU deubiquitinase 7B

multiple interactions
increases expression

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD7B mRNA
Raloxifene Hydrochloride results in increased expression of OTUD7B mRNA

NCBI chr 2:183,661,955...183,722,584
Ensembl chr 2:183,662,163...183,718,674

G

purinergic receptor P2Y14

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]

NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141

G

palladin, cytoskeletal associated protein

affects expression

Raloxifene Hydrochloride affects the expression of PALLD mRNA

NCBI chr16:28,228,006...28,621,349
Ensembl chr16:27,981,354...28,621,337

G

poly (A) polymerase alpha

affects expression

Raloxifene Hydrochloride affects the expression of PAPOLA mRNA

NCBI chr 6:124,682,015...124,734,706
Ensembl chr 6:124,682,105...124,734,468

G

pappalysin

increases expression

Raloxifene Hydrochloride results in increased expression of PAPPA mRNA

NCBI chr 5:78,497,660...78,735,873
Ensembl chr 5:78,498,300...78,730,666

G

Parkinsonism associated deglycase

increases expression

Raloxifene Hydrochloride results in increased expression of PARK7 mRNA

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

Raloxifene Hydrochloride results in increased cleavage of PARP1 protein
[ESR1 protein co-treated with ESR2 protein] affects the reaction [Raloxifene Hydrochloride results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

pro-apoptotic WT1 regulator

increases expression

Raloxifene Hydrochloride results in increased expression of PAWR mRNA; Raloxifene Hydrochloride results in increased expression of PAWR protein

NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028

G

paired box 5

increases expression

Raloxifene Hydrochloride results in increased expression of PAX5 mRNA

NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326

G

protocadherin 7

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PCDH7 mRNA

NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051

G

protocadherin gamma subfamily A, 3

increases expression

Raloxifene Hydrochloride results in increased expression of PCDHGA3 mRNA

NCBI chr18:29,499,148...29,667,865
Ensembl chr18:29,493,954...29,667,868

G

PCNA clamp associated factor

decreases expression

Raloxifene Hydrochloride results in decreased expression of PCLAF mRNA

NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994
Ensembl chr 8:66,420,587...66,432,994

G

proliferating cell nuclear antigen

increases expression
multiple interactions
affects expression
decreases expression

Raloxifene Hydrochloride results in increased expression of PCNA protein
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PCNA protein
Raloxifene Hydrochloride affects the expression of PCNA protein
Raloxifene Hydrochloride results in decreased expression of PCNA protein

PMID:15731164 PMID:16009171 PMID:17220163 PMID:24431404

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

procollagen C-endopeptidase enhancer

affects expression
increases expression

Raloxifene Hydrochloride affects the expression of PCOLCE mRNA
Raloxifene Hydrochloride results in increased expression of PCOLCE mRNA

PMID:15576828 PMID:16079270

NCBI chr12:19,084,191...19,090,508
Ensembl chr12:19,084,210...19,090,508

G

phosphatidylcholine transfer protein

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PCTP mRNA

NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867

G

programmed cell death 5

increases expression

Raloxifene Hydrochloride results in increased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

phosphodiesterase 3B

increases expression

Raloxifene Hydrochloride results in increased expression of PDE3B mRNA

NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334

G

phosphodiesterase 4D

increases expression

Raloxifene Hydrochloride results in increased expression of PDE4D mRNA

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

phosphodiesterase 5A

decreases expression

Raloxifene Hydrochloride results in decreased expression of PDE5A mRNA

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

platelet derived growth factor receptor alpha

affects expression

Raloxifene Hydrochloride affects the expression of PDGFRA mRNA

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

G

platelet derived growth factor receptor beta

affects expression

Raloxifene Hydrochloride affects the expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

PDZ and LIM domain 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PDLIM3 mRNA

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

pyruvate dehydrogenase phosphatase catalytic subunit 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PDP1 mRNA

NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217

G

prodynorphin

affects expression

Raloxifene Hydrochloride affects the expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

PDZ domain containing 1

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PDZK1 mRNA]
Raloxifene Hydrochloride results in decreased expression of PDZK1 mRNA

PMID:21185374 PMID:26865669

NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514

G

period circadian regulator 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PER2 mRNA]

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

peroxisomal biogenesis factor 5

affects expression

Raloxifene Hydrochloride affects the expression of PEX5 mRNA

NCBI chr 4:157,270,671...157,296,432
Ensembl chr 4:157,270,672...157,296,431

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

progesterone receptor

multiple interactions
decreases expression
increases expression

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA; [trichostatin A co-treated with Raloxifene Hydrochloride] results in decreased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]; trichostatin A inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA]
[Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of PGR mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]
Raloxifene Hydrochloride results in decreased expression of PGR mRNA; Raloxifene Hydrochloride results in decreased expression of PGR protein
Raloxifene Hydrochloride results in increased expression of PGR protein

PMID:11867264 PMID:16837883 PMID:16973256 PMID:21185374 PMID:22476901 More...

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

polyhomeotic homolog 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHC2 mRNA

NCBI chr 5:141,000,604...141,099,268
Ensembl chr 5:141,050,842...141,099,268

G

PHD finger protein 11

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PHF11 mRNA

NCBI chr15:33,390,290...33,414,647
Ensembl chr15:33,390,292...33,413,009

G

PH domain and leucine rich repeat protein phosphatase 1

affects expression

Raloxifene Hydrochloride affects the expression of PHLPP mRNA

NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977

G

protein inhibitor of activated STAT, 3

affects expression

Raloxifene Hydrochloride affects the expression of PIAS3 mRNA

NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:184,232,571...184,241,480

G

phosphatidylinositol glycan anchor biosynthesis, class N

increases expression

Raloxifene Hydrochloride results in increased expression of PIGN mRNA

NCBI chr13:21,659,092...21,812,932
Ensembl chr13:21,662,455...21,806,790

G

polymeric immunoglobulin receptor

affects expression

Raloxifene Hydrochloride affects the expression of PIGR mRNA

NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875

G

phosphoinositide-3-kinase regulatory subunit 3

increases expression

Raloxifene Hydrochloride results in increased expression of PIK3R3 mRNA

NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583

G

Pim-1 proto-oncogene, serine/threonine kinase

affects expression

Raloxifene Hydrochloride affects the expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

phosphatidylinositol transfer protein, cytoplasmic 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PITPNC1 mRNA

NCBI chr10:92,163,558...92,428,971
Ensembl chr10:92,167,196...92,429,297

G

phospholipase A2, group X

multiple interactions

Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of PLA2G10 mRNA]

NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000

G

phospholipase A2 group VII

decreases expression

Raloxifene Hydrochloride results in decreased expression of PLA2G7 mRNA

NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476

G

plasminogen activator, tissue type

increases expression

Raloxifene Hydrochloride results in increased expression of PLAT protein

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of PLAU mRNA
Raloxifene Hydrochloride results in decreased expression of PLAU protein

PMID:16277677 PMID:19059307

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

plasminogen activator, urokinase receptor

decreases expression

Raloxifene Hydrochloride results in decreased expression of PLAUR mRNA; Raloxifene Hydrochloride results in decreased expression of PLAUR protein

PMID:16277677 PMID:26865669

NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595

G

pleckstrin homology and FYVE domain containing 2

increases expression

Raloxifene Hydrochloride results in increased expression of PLEKHF2 mRNA

NCBI chr 5:24,091,077...24,106,758
Ensembl chr 5:24,090,688...24,106,601

G

pleckstrin homology domain containing S1

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PLEKHS1 mRNA

NCBI chr 1:255,495,634...255,525,353
Ensembl chr 1:255,495,634...255,525,353

G

polo-like kinase 3

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased expression of PLK3 mRNA]

NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317

G

phospholipid phosphatase 1

affects expression

Raloxifene Hydrochloride affects the expression of PLPP1 mRNA

NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268

G

phospholipid phosphatase 3

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of PLPP3 mRNA
ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of PLPP3 mRNA]

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

plexin D1

increases expression

Raloxifene Hydrochloride results in increased expression of PLXND1 mRNA

NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244

G

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Raloxifene Hydrochloride results in increased expression of PMAIP1 mRNA

NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429

G

peripheral myelin protein 22

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in decreased expression of PMP22 mRNA]

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

PMS1 homolog 2, mismatch repair system component

increases expression

Raloxifene Hydrochloride results in increased expression of PMS2 mRNA

NCBI chr12:10,676,818...10,701,161
Ensembl chr12:10,676,764...10,701,066

G

podocalyxin-like

affects expression

Raloxifene Hydrochloride affects the expression of PODXL mRNA

NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899

G

DNA polymerase mu

increases expression

Raloxifene Hydrochloride results in increased expression of POLM mRNA

NCBI chr14:80,707,075...80,716,677
Ensembl chr14:80,706,345...80,717,086

G

RNA polymerase II subunit B

decreases expression

Raloxifene Hydrochloride results in decreased expression of POLR2B mRNA

NCBI chr14:30,797,228...30,834,916
Ensembl chr14:30,797,228...30,834,916

G

periostin

decreases expression

Raloxifene Hydrochloride results in decreased expression of POSTN mRNA; Raloxifene Hydrochloride results in decreased expression of POSTN protein

NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099

G

peroxisome proliferator-activated receptor gamma

multiple interactions

IWR-1 compound inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]]; Raloxifene Hydrochloride inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PPARG protein]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

decreases expression

Raloxifene Hydrochloride results in decreased expression of PPM1D mRNA

NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607

G

protein phosphatase 1, regulatory subunit 10

increases expression

Raloxifene Hydrochloride results in increased expression of PPP1R10 mRNA

NCBI chr20:2,822,995...2,838,125
Ensembl chr20:2,822,995...2,837,611

G

protein phosphatase 1, regulatory subunit 13B

decreases expression

Raloxifene Hydrochloride results in decreased expression of PPP1R13B mRNA

NCBI chr 6:130,890,682...130,963,845
Ensembl chr 6:130,890,679...130,963,330

G

protein phosphatase 1, regulatory subunit 15A

increases expression
affects expression

Raloxifene Hydrochloride results in increased expression of PPP1R15A mRNA
Raloxifene Hydrochloride affects the expression of PPP1R15A mRNA

PMID:16079270 PMID:16497877

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

peroxiredoxin 2

affects expression

Raloxifene Hydrochloride affects the expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein kinase C, zeta

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

G

protein kinase, DNA-activated, catalytic subunit

decreases expression

Raloxifene Hydrochloride results in decreased expression of PRKDC mRNA

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

prolactin

multiple interactions
decreases secretion

[Raloxifene Hydrochloride co-treated with Dopamine] results in decreased expression of PRL protein; Raloxifene Hydrochloride inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased secretion of PRL protein]
Raloxifene Hydrochloride results in decreased secretion of PRL protein

PMID:15950373 PMID:17054466 PMID:30865525

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

protein C, inactivator of coagulation factors Va and VIIIa

decreases activity

Raloxifene Hydrochloride results in decreased activity of PROC protein

NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133

G

protein S

affects expression
decreases expression

Raloxifene Hydrochloride affects the expression of PROS1 protein
Raloxifene Hydrochloride results in decreased expression of PROS1 protein

PMID:15850603 PMID:16202731

NCBI chr11:230,597...311,288
Ensembl chr11:230,696...311,286

G

pre-mRNA processing factor 4B

decreases expression

Raloxifene Hydrochloride results in decreased expression of PRP4K mRNA

NCBI chr17:29,985,343...30,020,285
Ensembl chr17:29,985,343...30,019,625

G

serine protease 23

decreases expression

Raloxifene Hydrochloride results in decreased expression of PRSS23 mRNA

NCBI chr 1:143,402,725...143,422,182
Ensembl chr 1:143,401,396...143,422,091

G

prosaposin

affects expression

Raloxifene Hydrochloride affects the expression of PSAP mRNA

NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498

G

proteasome 26S subunit, non-ATPase 14

decreases expression

Raloxifene Hydrochloride results in decreased expression of PSMD14 mRNA

NCBI chr 3:46,254,338...46,347,076
Ensembl chr 3:46,254,330...46,347,076

G

proteasome 26S subunit, non-ATPase 6

decreases expression

Raloxifene Hydrochloride results in decreased expression of PSMD6 mRNA

NCBI chr15:11,102,174...11,112,180
Ensembl chr15:11,102,180...11,205,620

G

proteasome activator subunit 1

affects expression

Raloxifene Hydrochloride affects the expression of PSME1 mRNA

NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890

G

proteasome activator subunit 4

decreases expression

Raloxifene Hydrochloride results in decreased expression of PSME4 mRNA

NCBI chr14:104,505,716...104,609,410
Ensembl chr14:104,505,716...104,609,408

G

prostaglandin D2 synthase

multiple interactions

[Raloxifene Hydrochloride co-treated with IL1B protein] results in increased expression of PTGDS mRNA

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

prostaglandin E receptor 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGER3 mRNA

NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434

G

prostaglandin E synthase

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of PTGES mRNA
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGES mRNA
Raloxifene Hydrochloride results in decreased expression of PTGES mRNA

PMID:19059307 PMID:24431404 PMID:26865669

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin F2 receptor inhibitor

affects expression

Raloxifene Hydrochloride affects the expression of PTGFRN mRNA

NCBI chr 2:188,469,521...188,544,795
Ensembl chr 2:188,469,521...188,544,795

G

prostaglandin I2 synthase

affects expression

Raloxifene Hydrochloride affects the expression of PTGIS mRNA

NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression
decreases expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTGS2 mRNA; Raloxifene Hydrochloride inhibits the reaction [NCOR2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [CREBBP protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR1 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [ESR2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA2 protein binds to PTGS2 promoter]; Raloxifene Hydrochloride promotes the reaction [NCOA3 protein binds to PTGS2 promoter]
[APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 mRNA; [APC protein affects the susceptibility to Raloxifene Hydrochloride] which affects the expression of PTGS2 protein
Carrageenan inhibits the reaction [Raloxifene Hydrochloride results in increased expression of PTGS2 protein]
Raloxifene Hydrochloride results in decreased expression of PTGS2 mRNA
Raloxifene Hydrochloride results in increased expression of PTGS2 mRNA

PMID:15860553 PMID:17549036 PMID:17872375 PMID:19059307 PMID:24431404

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

parathyroid hormone

decreases expression

Raloxifene Hydrochloride results in decreased expression of PTH protein

NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530

G

protein tyrosine phosphatase 4A3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTP4A3 mRNA

NCBI chr 7:105,650,640...105,660,921
Ensembl chr 7:105,628,029...105,660,919

G

protein tyrosine phosphatase, non-receptor type 13

increases expression

Raloxifene Hydrochloride results in increased expression of PTPN13 mRNA

NCBI chr14:6,108,202...6,282,619
Ensembl chr14:6,108,211...6,282,563

G

protein tyrosine phosphatase, non-receptor type 4

affects expression

Raloxifene Hydrochloride affects the expression of PTPN4 mRNA

NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170

G

protein tyrosine phosphatase, non-receptor type 6

decreases activity

Raloxifene Hydrochloride results in decreased activity of PTPN6 protein

NCBI chr 4:157,526,034...157,550,783
Ensembl chr 4:157,526,035...157,550,984

G

protein tyrosine phosphatase, receptor type, E

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of PTPRE mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of PTPRE mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534

G

protein tyrosine phosphatase, receptor type, H

affects expression

Raloxifene Hydrochloride affects the expression of PTPRH mRNA

NCBI chr 1:69,243,704...69,276,294
Ensembl chr 1:69,242,321...69,285,077

G

protein tyrosine phosphatase, receptor type, R

affects expression

Raloxifene Hydrochloride affects the expression of PTPRR mRNA

NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603

G

pentraxin 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of PTX3 mRNA

NCBI chr 2:150,487,513...150,493,323
Ensembl chr 2:150,487,513...150,493,323

G

peptide YY

increases expression

Raloxifene Hydrochloride results in increased expression of PYY mRNA

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

QKI, KH domain containing RNA binding

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of QKI mRNA

NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831

G

RAB11B, member RAS oncogene family

increases expression

Raloxifene Hydrochloride results in increased expression of RAB11B mRNA

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

RAB2A, member RAS oncogene family

increases expression

Raloxifene Hydrochloride results in increased expression of RAB2A mRNA

NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899

G

RAB31, member RAS oncogene family

affects expression

Raloxifene Hydrochloride affects the expression of RAB31 mRNA

NCBI chr 9:105,246,712...105,382,973
Ensembl chr 9:105,246,709...105,381,253

G

Rab40c, member RAS oncogene family

increases expression

Raloxifene Hydrochloride results in increased expression of RAB40C mRNA

NCBI chr10:14,900,926...14,936,153
Ensembl chr10:14,900,929...14,936,557

G

Rac GTPase-activating protein 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of RACGAP1 mRNA

NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831

G

ral guanine nucleotide dissociation stimulator like 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RGL1 mRNA

NCBI chr13:64,634,489...64,904,170
Ensembl chr13:64,635,246...64,904,191

G

RAP1A, member of RAS oncogene family

decreases expression

Raloxifene Hydrochloride results in decreased expression of RAP1A mRNA

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

Rap guanine nucleotide exchange factor like 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of RAPGEFL1 mRNA

NCBI chr10:83,793,711...83,810,373
Ensembl chr10:83,793,694...83,810,371

G

retinoic acid receptor, alpha

affects expression

Raloxifene Hydrochloride affects the expression of RARA mRNA

NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142

G

RAS p21 protein activator 1

increases expression

Raloxifene Hydrochloride results in increased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

RAS and EF hand domain containing

decreases expression

Raloxifene Hydrochloride results in decreased expression of RASEF mRNA

NCBI chr 5:87,548,908...87,619,286
Ensembl chr 5:87,548,908...87,619,031

G

RAS protein-specific guanine nucleotide-releasing factor 1

affects expression

Raloxifene Hydrochloride affects the expression of RASGRF1 mRNA

NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269

G

RAS guanyl releasing protein 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RASGRP1 mRNA

NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056

G

RB transcriptional corepressor 1

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of RB1 mRNA
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein

PMID:19429434 PMID:26660119

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RB binding protein 7, chromatin remodeling factor

decreases expression

Raloxifene Hydrochloride results in decreased expression of RBBP7 mRNA

NCBI chr X:31,913,080...31,931,245
Ensembl chr X:31,913,081...31,931,226

G

RB binding protein 8, endonuclease

decreases expression

Raloxifene Hydrochloride results in decreased expression of RBBP8 mRNA

NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846

G

RB transcriptional corepressor like 1

decreases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of RBL1 protein

NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330

G

RNA binding motif protein 10

increases expression

Raloxifene Hydrochloride results in increased expression of RBM10 mRNA

NCBI chr X:1,540,399...1,572,571
Ensembl chr X:1,540,398...1,572,575

G

regulator of calcineurin 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RCAN2 mRNA

NCBI chr 9:16,959,478...17,174,823
Ensembl chr 9:16,959,480...17,174,856

G

RNA terminal phosphate cyclase-like 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of RCL1 mRNA

NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315

G

REST corepressor 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RCOR3 mRNA

NCBI chr13:103,624,966...103,665,565
Ensembl chr13:103,624,971...103,665,565

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases activity

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]; Raloxifene Hydrochloride affects the localization of and results in decreased activity of RELA protein; Raloxifene Hydrochloride inhibits the reaction [ESR1 protein binds to RELA protein]; Raloxifene Hydrochloride inhibits the reaction [RELA protein binds to CCL3 promoter]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]]; Raloxifene Hydrochloride inhibits the reaction [IL1B protein results in increased phosphorylation of and affects the localization of RELA protein]; Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]
Raloxifene Hydrochloride results in decreased activity of RELA protein
Raloxifene Hydrochloride promotes the reaction [RELA protein binds to SLC1A2 promoter]; Raloxifene Hydrochloride promotes the reaction [TERT protein binds to RELA protein]

PMID:15590986 PMID:16497877 PMID:16798746 PMID:24722370 PMID:24782323 More...

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RAS-like, estrogen-regulated, growth-inhibitor

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of RERG mRNA]

NCBI chr 4:169,981,634...170,089,777
Ensembl chr 4:169,982,279...170,089,715

G

ret proto-oncogene

multiple interactions
decreases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RET mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RET mRNA
Raloxifene Hydrochloride results in decreased expression of RET mRNA

PMID:19059307 PMID:26865669

NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176

G

reticulophagy regulator 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RETREG1 mRNA

NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898

G

riboflavin kinase

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of RFK mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RFK mRNA

PMID:14699072 PMID:19059307

NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

raftlin lipid raft linker 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RFTN1 mRNA

NCBI chr 9:10,804,611...11,002,084
Ensembl chr 9:10,804,611...11,002,084

G

regulator of G-protein signaling 10

affects expression

Raloxifene Hydrochloride affects the expression of RGS10 mRNA

NCBI chr 1:182,946,334...182,987,729
Ensembl chr 1:182,946,336...182,987,697

G

regulator of G-protein signaling 13

affects expression

Raloxifene Hydrochloride affects the expression of RGS13 mRNA

NCBI chr13:55,922,290...55,955,753
Ensembl chr13:55,922,395...55,955,648

G

regulator of G-protein signaling 16

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of RGS16 mRNA

NCBI chr13:65,887,668...65,892,862
Ensembl chr13:65,887,530...65,892,857

G

regulator of G-protein signaling 4

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RGS4 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

rhomboid 5 homolog 1

increases expression

Raloxifene Hydrochloride results in increased expression of RHBDF1 mRNA

NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763

G

ras homolog family member A

decreases expression

Raloxifene Hydrochloride results in decreased expression of RHOA mRNA

NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746

G

Rho-related BTB domain containing 3

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RHOBTB3 mRNA
Raloxifene Hydrochloride affects the expression of RHOBTB3 mRNA

PMID:14699072 PMID:19059307

NCBI chr 2:5,363,388...5,419,164
Ensembl chr 2:5,363,388...5,419,041

G

ras homolog family member F, filopodia associated

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RHOF mRNA

NCBI chr12:33,422,375...33,446,689
Ensembl chr12:33,431,280...33,446,703

G

RHO family interacting cell polarization regulator 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of RIPOR2 mRNA

NCBI chr17:40,323,748...40,547,482
Ensembl chr17:40,323,867...40,548,092

G

Rho family GTPase 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of RND3 mRNA

NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327

G

ring finger protein 130

decreases expression

Raloxifene Hydrochloride results in decreased expression of RNF130 mRNA

NCBI chr10:34,342,835...34,456,048
Ensembl chr10:34,342,830...34,456,062

G

ring finger protein 144B

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of RNF144B mRNA

NCBI chr17:17,431,271...17,580,687
Ensembl chr17:17,432,786...17,562,760

G

Rho-associated coiled-coil containing protein kinase 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

Rho-associated coiled-coil containing protein kinase 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of ROCK2 mRNA

NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031

G

retinal outer segment membrane protein 1

increases expression

Raloxifene Hydrochloride results in increased expression of ROM1 mRNA

NCBI chr 1:205,824,050...205,826,058
Ensembl chr 1:205,824,052...205,826,175

G

ribosomal protein L6

decreases expression

Raloxifene Hydrochloride results in decreased expression of RPL6 mRNA

NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921

G

regulation of nuclear pre-mRNA domain containing 1B

affects response to substance

RPRD1B protein affects the susceptibility to Raloxifene Hydrochloride

NCBI chr 3:146,682,975...146,729,251
Ensembl chr 3:146,682,922...146,786,452

G

ribosomal protein S6 kinase A2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

G

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of RRAD mRNA

NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417

G

RAS related

affects expression

Raloxifene Hydrochloride affects the expression of RRAS mRNA

NCBI chr 1:95,500,582...95,504,362
Ensembl chr 1:95,500,566...95,504,357

G

ribonucleotide reductase catalytic subunit M1

decreases expression

Raloxifene Hydrochloride results in decreased expression of RRM1 mRNA

NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261

G

RT1 class II, locus Bb

affects expression

Raloxifene Hydrochloride affects the expression of RT1-BB mRNA

NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597

G

RUNX family transcription factor 2

affects expression

Raloxifene Hydrochloride affects the expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

retinoid X receptor beta

increases expression

Raloxifene Hydrochloride results in increased expression of RXRB mRNA

NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773

G

ryanodine receptor 1

affects expression

Raloxifene Hydrochloride affects the expression of RYR1 mRNA

NCBI chr 1:84,292,578...84,423,824
Ensembl chr 1:84,292,578...84,423,812

G

S100 calcium binding protein A6

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of S100A6 protein]

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

scaffold attachment factor B

increases expression

Raloxifene Hydrochloride results in increased expression of SAFB mRNA

NCBI chr 9:1,417,449...1,438,408
Ensembl chr 9:1,417,525...1,438,644

G

spalt-like transcription factor 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SALL1 mRNA

NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705

G

stearoyl-Coenzyme A desaturase 2

affects expression

Raloxifene Hydrochloride affects the expression of SCD2 mRNA

NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232

G

sodium voltage-gated channel alpha subunit 4

affects expression

Raloxifene Hydrochloride affects the expression of SCN4A mRNA

NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545

G

sodium channel epithelial 1 subunit alpha

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SCNN1A mRNA

NCBI chr 4:158,122,962...158,146,184
Ensembl chr 4:158,122,962...158,146,181

G

syndecan 1

affects expression

Raloxifene Hydrochloride affects the expression of SDC1 mRNA

NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264

G

semaphorin 3A

decreases expression

Raloxifene Hydrochloride results in decreased expression of SEMA3A mRNA

NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432

G

semaphorin 3B

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SEMA3B mRNA
Raloxifene Hydrochloride results in increased expression of SEMA3B mRNA

PMID:16202921 PMID:19059307

NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919

G

semaphorin 3F

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SEMA3F mRNA

NCBI chr 8:108,357,629...108,386,569
Ensembl chr 8:108,357,629...108,387,083

G

semaphorin 4B

decreases expression

Raloxifene Hydrochloride results in decreased expression of SEMA4B mRNA

NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775

G

serpin family A member 3N

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINA3 mRNA]

NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433

G

serpin family B member 2

increases expression
decreases expression

Raloxifene Hydrochloride results in increased expression of SERPINB2 mRNA
Raloxifene Hydrochloride results in decreased expression of SERPINB2 mRNA

PMID:16202921 PMID:16298037

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family B member 6A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SERPINB6 mRNA

NCBI chr17:30,871,468...30,989,703
Ensembl chr17:30,871,468...31,014,427

G

serpin family B member 9

affects binding
multiple interactions

[Raloxifene Hydrochloride binds to ESR1 protein] which binds to SERPINB9 protein
Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of SERPINB9 mRNA]

PMID:14617632 PMID:17237823

NCBI chr17:31,420,118...31,443,237
Ensembl chr17:31,420,125...31,443,230

G

serpin family E member 1

increases expression
multiple interactions
decreases expression

Raloxifene Hydrochloride results in increased expression of SERPINE1 protein
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SERPINE1 mRNA
Raloxifene Hydrochloride results in decreased expression of SERPINE1 protein

PMID:15850603 PMID:16277677 PMID:19059307

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

serpin family E member 2

affects expression

Raloxifene Hydrochloride affects the expression of SERPINE2 mRNA

PMID:14699072 PMID:16079270

NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826

G

serpin family H member 1

affects expression

Raloxifene Hydrochloride affects the expression of SERPINH1 mRNA

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

splicing factor proline and glutamine rich

decreases expression

Raloxifene Hydrochloride results in decreased expression of SFPQ mRNA

NCBI chr 5:139,338,034...139,353,476
Ensembl chr 5:139,338,075...139,353,472

G

secreted frizzled-related protein 5

multiple interactions

SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]

NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224

G

serum/glucocorticoid regulated kinase 1

multiple interactions
decreases expression
affects expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SGK1 mRNA
Raloxifene Hydrochloride results in decreased expression of SGK1 mRNA
Raloxifene Hydrochloride affects the expression of SGK1 mRNA

PMID:14699072 PMID:19059307 PMID:26865669

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

serum/glucocorticoid regulated kinase family, member 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of SGK3 mRNA

NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476

G

SH2 domain containing adaptor protein B

affects expression

Raloxifene Hydrochloride affects the expression of SHB mRNA

NCBI chr 5:59,678,066...59,785,443
Ensembl chr 5:59,678,216...59,785,538

G

sex hormone binding globulin

increases expression

Raloxifene Hydrochloride results in increased expression of SHBG protein

PMID:16775175 PMID:16912660

NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057

G

shisa family member 2

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of SHISA2 mRNA

NCBI chr15:33,806,715...33,811,013
Ensembl chr15:33,805,958...33,811,013

G

siah E3 ubiquitin protein ligase 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of SIAH2 mRNA

NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950

G

S-phase kinase associated protein 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of SKP2 mRNA

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

solute carrier family 17 member 7

decreases expression

Raloxifene Hydrochloride results in decreased expression of SLC17A7 mRNA

NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588

G

solute carrier family 18 member A2

affects expression

Raloxifene Hydrochloride affects the expression of SLC18A2 mRNA

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

G

solute carrier family 18 member A3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SLC18A3 mRNA

NCBI chr16:7,713,630...7,716,491

G

solute carrier family 19 member 1

affects expression

Raloxifene Hydrochloride affects the expression of SLC19A1 mRNA

NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972

G

solute carrier family 1 member 2

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline binds to and results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Raloxifene Hydrochloride promotes the reaction [NFKB1 protein binds to SLC1A2 promoter]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to SLC1A2 promoter]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; RTKI cpd inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein]
Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA; Raloxifene Hydrochloride results in increased expression of SLC1A2 protein

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 3

multiple interactions
increases expression

[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline results in decreased activity of GPER1 protein] inhibits the reaction [[Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein]; [Raloxifene Hydrochloride results in increased activity of GPER1 protein] which results in increased expression of SLC1A3 protein; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A3 protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in decreased expression of SLC1A3 protein]
Raloxifene Hydrochloride results in increased expression of SLC1A3 mRNA; Raloxifene Hydrochloride results in increased expression of SLC1A3 protein

NCBI chr 2:57,755,495...57,830,605
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 22 member 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 5

affects expression

Raloxifene Hydrochloride affects the expression of SLC22A5 mRNA

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 10

increases expression

Raloxifene Hydrochloride results in increased expression of SLC25A10 mRNA

NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556

G

solute carrier family 26 member 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of SLC26A2 mRNA

NCBI chr18:54,648,276...54,666,627
Ensembl chr18:54,652,951...54,666,626

G

solute carrier family 2 member 3

affects expression

Raloxifene Hydrochloride affects the expression of SLC2A3 mRNA

NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472

G

solute carrier family 2 member 4

increases expression

Raloxifene Hydrochloride results in increased expression of SLC2A4 mRNA

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 38, member 2

increases expression

Raloxifene Hydrochloride results in increased expression of SLC38A2 mRNA

NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 39 member 6

decreases expression

Raloxifene Hydrochloride results in decreased expression of SLC39A6 mRNA

NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417

G

solute carrier family 3 member 2

increases expression

Raloxifene Hydrochloride results in increased expression of SLC3A2 mRNA

NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 6 member 3

increases expression

Raloxifene Hydrochloride results in increased expression of SLC6A3 protein

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

G

solute carrier family 6 member 4

multiple interactions
affects expression

Raloxifene Hydrochloride inhibits the reaction [estradiol 3-benzoate results in increased expression of SLC6A4 protein]
Raloxifene Hydrochloride affects the expression of SLC6A4 mRNA

PMID:16079270 PMID:17398000

NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384

G

solute carrier family 7 member 11

increases expression

Raloxifene Hydrochloride results in increased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

solute carrier family 7, member 4

affects expression

Raloxifene Hydrochloride affects the expression of SLC7A4 mRNA

NCBI chr11:83,435,093...83,439,078
Ensembl chr11:83,435,211...83,438,881

G

solute carrier family 7 member 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of SLC7A5 mRNA

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 4C1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SLCO4C1 mRNA

NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715

G

slit guidance ligand 1

affects expression

Raloxifene Hydrochloride affects the expression of SLIT1 mRNA

NCBI chr 1:240,409,559...240,558,127
Ensembl chr 1:240,409,561...240,558,127

G

sarcolipin

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of SLN mRNA

NCBI chr 8:54,221,389...54,248,110
Ensembl chr 8:54,243,542...54,247,791

G

SMAD family member 1

decreases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of SMAD1 protein

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

SMAD family member 2

decreases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 7

affects expression

Raloxifene Hydrochloride affects the expression of SMAD7 mRNA

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

SMAD specific E3 ubiquitin protein ligase 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of SMURF2 mRNA

NCBI chr10:91,761,798...91,862,485
Ensembl chr10:91,761,807...91,862,488

G

synuclein alpha

affects expression

Raloxifene Hydrochloride affects the expression of SNCA mRNA

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

stannin

affects expression

Raloxifene Hydrochloride affects the expression of SNN mRNA

NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021

G

superoxide dismutase 1

increases expression
affects response to substance
multiple interactions

Raloxifene Hydrochloride results in increased expression of SOD1 mRNA
SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of BAP1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of CYLD mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of OTUD3 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP33 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP50 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of VCPIP1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of OTUD7B mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of UBXN1 mRNA; [SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of YOD1 mRNA

PMID:12154049 PMID:33269387

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

superoxide dismutase 3

increases expression

Raloxifene Hydrochloride results in increased expression of SOD3 mRNA

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

SON DNA and RNA binding protein

decreases expression

Raloxifene Hydrochloride results in decreased expression of SON mRNA

NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167

G

Sp4 transcription factor

decreases expression

Raloxifene Hydrochloride results in decreased expression of SP4 protein

NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126

G

secreted protein acidic and cysteine rich

affects expression

Raloxifene Hydrochloride affects the expression of SPARC mRNA

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

spermatogenesis associated 13

increases expression

Raloxifene Hydrochloride results in increased expression of SPATA13 mRNA

NCBI chr15:34,778,479...34,907,645
Ensembl chr15:34,778,473...34,905,114

G

serine peptidase inhibitor, Kazal type 1

multiple interactions

[Progesterone co-treated with Raloxifene Hydrochloride] results in increased expression of SPINK1 mRNA

NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642

G

sialophorin

affects expression

Raloxifene Hydrochloride affects the expression of SPN mRNA

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3

increases expression

Raloxifene Hydrochloride results in increased expression of SPOCK3 mRNA

NCBI chr16:26,382,895...26,815,943
Ensembl chr16:26,383,383...26,815,205

G

secreted phosphoprotein 1

affects expression

Raloxifene Hydrochloride affects the expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of SQSTM1 mRNA
Raloxifene Hydrochloride results in increased expression of SQSTM1 protein
[Raloxifene Hydrochloride co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein

PMID:15576828 PMID:33203845

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

SRSF protein kinase 2

affects expression

Raloxifene Hydrochloride affects the expression of SRPK2 mRNA

NCBI chr 4:11,464,684...11,655,993
Ensembl chr 4:11,464,674...11,655,990

G

serine and arginine rich splicing factor 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of SRSF1 mRNA

NCBI chr10:72,838,926...72,859,066
Ensembl chr10:72,839,274...72,845,336

G

serine and arginine rich splicing factor 3

affects expression

Raloxifene Hydrochloride affects the expression of SRSF3 mRNA

NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078

G

serine and arginine rich splicing factor 7

decreases expression

Raloxifene Hydrochloride results in decreased expression of SRSF7 mRNA

NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965

G

single-stranded DNA binding protein 2

increases expression

Raloxifene Hydrochloride results in increased expression of SSBP2 mRNA

NCBI chr 2:22,650,488...22,938,669
Ensembl chr 2:22,651,258...22,933,696

G

slingshot protein phosphatase 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SSH1 mRNA

NCBI chr12:42,621,127...42,683,262
Ensembl chr12:42,621,135...42,683,274

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ST3GAL1 mRNA

NCBI chr 7:98,845,270...98,913,409
Ensembl chr 7:98,845,270...98,913,236

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 2

increases expression

Raloxifene Hydrochloride results in increased expression of ST3GAL2 mRNA

NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869

G

signal transducer and activator of transcription 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased phosphorylation of STAT3 protein]]; Raloxifene Hydrochloride inhibits the reaction [[IL6R protein co-treated with IL6 protein] results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL4 protein results in increased phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [Raloxifene Hydrochloride results in increased cleavage of CASP3 protein]
Raloxifene Hydrochloride results in decreased phosphorylation of STAT3 protein
Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to IL6 protein] which affects the phosphorylation of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of and affects the localization of STAT3 protein]; Raloxifene Hydrochloride inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]

PMID:17336289 PMID:24456369 PMID:28430601 PMID:28711499 PMID:32828944 More...

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

starch binding domain 1

affects expression

Raloxifene Hydrochloride affects the expression of STBD1 mRNA

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

stanniocalcin 2

increases expression

Raloxifene Hydrochloride results in increased expression of STC2 mRNA

NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973

G

serine/threonine kinase 24

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of STK24 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of STK24 mRNA

PMID:14699072 PMID:19059307

NCBI chr15:98,363,707...98,458,940
Ensembl chr15:98,365,791...98,460,553

G

serine/threonine kinase 26

decreases expression

Raloxifene Hydrochloride results in decreased expression of STK26 mRNA

NCBI chr X:130,325,064...130,375,674
Ensembl chr X:130,310,885...130,374,291

G

stathmin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

syntaxin 16

increases expression

Raloxifene Hydrochloride results in increased expression of STX16 mRNA

NCBI chr 3:162,853,764...162,882,489
Ensembl chr 3:162,853,782...162,882,489

G

syntaxin 1A

increases expression

Raloxifene Hydrochloride results in increased expression of STX1A mRNA

NCBI chr12:21,641,971...21,670,022
Ensembl chr12:21,641,969...21,669,930

G

syntabulin

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of SYBU mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYBU mRNA

NCBI chr 7:75,847,000...75,948,919
Ensembl chr 7:75,847,003...75,948,828

G

synaptojanin 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNJ2 mRNA

NCBI chr 1:46,518,594...46,621,919
Ensembl chr 1:46,518,709...46,633,687

G

synaptopodin

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of SYNPO mRNA

NCBI chr18:54,048,299...54,106,388
Ensembl chr18:54,026,152...54,102,126

G

transforming, acidic coiled-coil containing protein 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of TACC1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733

G

transforming, acidic coiled-coil containing protein 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TACC2 mRNA

NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881

G

TATA-box binding protein associated factor 9

increases expression
decreases expression

Raloxifene Hydrochloride results in increased expression of TAF9 mRNA
Raloxifene Hydrochloride results in decreased expression of TAF9 mRNA

PMID:12154049 PMID:16514628

NCBI chr 2:31,794,316...31,798,324
Ensembl chr 2:31,794,142...31,798,769

G

TAO kinase 3

increases expression

Raloxifene Hydrochloride results in increased expression of TAOK3 mRNA

NCBI chr12:39,312,354...39,473,656
Ensembl chr12:39,314,027...39,461,244

G

threonyl-tRNA synthetase 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of TARS1 mRNA

NCBI chr 2:60,368,893...60,387,715
Ensembl chr 2:60,367,796...60,387,717

G

T-box transcription factor 2

increases expression

Raloxifene Hydrochloride results in increased expression of TBX2 mRNA

NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529

G

thromboxane A2 receptor

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TBXA2R mRNA

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

T-box transcription factor T

increases expression

Raloxifene Hydrochloride results in increased expression of TBXT mRNA

NCBI chr 1:52,298,104...52,309,813
Ensembl chr 1:52,298,099...52,305,864

G

transcriptional and immune response regulator

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TCIM mRNA

NCBI chr16:67,595,762...67,597,055
Ensembl chr16:67,593,410...67,597,581

G

t-complex 1

affects expression

Raloxifene Hydrochloride affects the expression of TCP1 mRNA

NCBI chr 1:47,829,061...47,836,809
Ensembl chr 1:47,828,652...47,836,839

G

telomerase reverse transcriptase

multiple interactions
increases expression
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA; ESR1 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; ESR2 protein promotes the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride promotes the reaction [RELA protein binds to TERT protein]; Raloxifene Hydrochloride results in increased expression of and results in increased activity of TERT protein; SN50 peptide inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]; Raloxifene Hydrochloride promotes the reaction [TERT protein binds to RELA protein]; Raloxifene Hydrochloride results in increased phosphorylation of and results in increased activity of TERT protein
Raloxifene Hydrochloride results in increased expression of TERT mRNA
Raloxifene Hydrochloride results in increased phosphorylation of TERT protein

PMID:15590986 PMID:16798746 PMID:27017931

NCBI chr 1:29,637,213...29,659,561
Ensembl chr 1:29,637,506...29,659,561

G

transcription factor A, mitochondrial

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of TFAM mRNA
fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased expression of TFAM mRNA]

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

transcription factor AP-2 alpha

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of TFAP2A mRNA
[Streptozocin co-treated with Raloxifene Hydrochloride] results in increased expression of TFAP2A protein

PMID:23471663 PMID:26865669

NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507

G

transcription factor AP-2 gamma

decreases expression

Raloxifene Hydrochloride results in decreased expression of TFAP2C mRNA

NCBI chr 3:161,315,114...161,322,998
Ensembl chr 3:161,315,031...161,322,995

G

trefoil factor 1

affects binding
multiple interactions
decreases expression

[Raloxifene Hydrochloride binds to ESR1 protein] which binds to TFF1 protein
[Raloxifene Hydrochloride co-treated with Estradiol] results in decreased expression of TFF1 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TFF1 mRNA; [Raloxifene Hydrochloride co-treated with trichostatin A] results in decreased expression of TFF1 mRNA; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TFF1 protein]; trichostatin A inhibits the reaction [[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TFF1 mRNA]
Raloxifene Hydrochloride results in decreased expression of TFF1 mRNA; Raloxifene Hydrochloride results in decreased expression of TFF1 protein

PMID:14617632 PMID:16202921 PMID:16514628 PMID:21185374 PMID:22476901 More...

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

trefoil factor 3

affects expression
decreases expression

Raloxifene Hydrochloride affects the expression of TFF3 mRNA
Raloxifene Hydrochloride results in decreased expression of TFF3 mRNA

NCBI chr20:9,193,259...9,197,969
Ensembl chr20:9,193,262...9,198,054

G

tissue factor pathway inhibitor

multiple interactions
increases expression

[fulvestrant co-treated with Raloxifene Hydrochloride] results in increased secretion of TFPI protein; fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein]; Raloxifene Hydrochloride results in decreased expression of and results in decreased secretion of TFPI protein
Raloxifene Hydrochloride results in increased expression of TFPI mRNA

PMID:17029634 PMID:26865669

NCBI chr 3:69,533,156...69,582,547
Ensembl chr 3:69,533,156...69,576,880

G

transferrin receptor

increases expression

Raloxifene Hydrochloride results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor alpha

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TGFA mRNA; Raloxifene Hydrochloride inhibits the reaction [TGFA protein results in increased phosphorylation of AKT1 protein]

PMID:19059307 PMID:35007301

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions
decreases expression

Raloxifene Hydrochloride inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
Raloxifene Hydrochloride results in decreased expression of TGFB1 mRNA; Raloxifene Hydrochloride results in decreased expression of TGFB1 protein modified form
Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TGFB1 mRNA]

PMID:15920148 PMID:31583774 PMID:32947957

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta 2

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of TGFB2 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFB2 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TGFB2 mRNA

PMID:14699072 PMID:19059307 PMID:21185374

NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405

G

transforming growth factor, beta 3

multiple interactions
affects expression

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TGFB3 mRNA]
Raloxifene Hydrochloride affects the expression of TGFB3 mRNA

NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564

G

transforming growth factor, beta induced

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of TGFBI mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TGFBI mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TGFBI mRNA

PMID:14699072 PMID:19059307

NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240

G

transforming growth factor, beta receptor 2

affects expression

Raloxifene Hydrochloride affects the expression of TGFBR2 mRNA

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

transglutaminase 2

affects expression

Raloxifene Hydrochloride affects the expression of TGM2 mRNA

NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981

G

thrombospondin 1

increases expression

Raloxifene Hydrochloride results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

Thy-1 cell surface antigen

affects expression
increases expression

Raloxifene Hydrochloride affects the expression of THY1 mRNA
Raloxifene Hydrochloride results in increased expression of THY1 mRNA

PMID:14699072 PMID:15576828

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions
affects expression

Raloxifene Hydrochloride results in increased expression of TIMP1 mRNA; Raloxifene Hydrochloride results in increased expression of TIMP1 protein
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of TIMP1 protein
Raloxifene Hydrochloride affects the expression of TIMP1 mRNA

PMID:16079270 PMID:16202921 PMID:21935668 PMID:31332895

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

TIMP metallopeptidase inhibitor 2

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in increased expression of TIMP2 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Streptozocin results in increased secretion of TIMP2 protein]

NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611

G

TIMP metallopeptidase inhibitor 3

increases expression

Raloxifene Hydrochloride results in increased expression of TIMP3 mRNA; Raloxifene Hydrochloride results in increased expression of TIMP3 protein

NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839

G

TCDD-inducible poly(ADP-ribose) polymerase

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TIPARP mRNA

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

TLE family member 1, transcriptional corepressor

affects expression

Raloxifene Hydrochloride affects the expression of TLE1 mRNA

NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774

G

toll-like receptor 2

increases expression

Raloxifene Hydrochloride results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

transmembrane protein 158

multiple interactions
affects expression

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TMEM158 mRNA
Raloxifene Hydrochloride affects the expression of TMEM158 mRNA

PMID:14699072 PMID:19059307

NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673

G

tropomodulin 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of TMOD1 mRNA
[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMOD1 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TMOD1 mRNA

PMID:14699072 PMID:19059307

NCBI chr 5:60,316,445...60,393,957
Ensembl chr 5:60,338,512...60,393,956

G

thymopoietin

decreases expression

Raloxifene Hydrochloride results in decreased expression of TMPO mRNA

NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727

G

transmembrane serine protease 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA

NCBI chr20:9,254,102...9,273,808
Ensembl chr20:9,254,109...9,274,363

G

transmembrane serine protease 6

affects response to substance

TMPRSS6 affects the susceptibility to Raloxifene Hydrochloride

NCBI chr 7:109,991,008...110,021,626
Ensembl chr 7:109,985,931...110,021,624

G

thiol methyltransferase 1A

multiple interactions
affects expression

ESR2 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of TMT1A mRNA]
Raloxifene Hydrochloride affects the expression of TMT1A mRNA

NCBI chr 7:131,452,099...131,460,154
Ensembl chr 7:131,451,641...131,460,154

G

tenascin C

affects expression
decreases expression
multiple interactions

Raloxifene Hydrochloride affects the expression of TNC mRNA
Raloxifene Hydrochloride results in decreased expression of TNC mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNC mRNA

PMID:14699072 PMID:19059307 PMID:32947957

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of TNF protein
Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SFRP5 protein affects the reaction [Raloxifene Hydrochloride inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
Raloxifene Hydrochloride inhibits the reaction [APP protein results in increased expression of TNF mRNA]
Raloxifene Hydrochloride results in decreased expression of TNF mRNA
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]; Raloxifene Hydrochloride inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased secretion of TNF protein]; Raloxifene Hydrochloride inhibits the reaction [manganese chloride results in increased secretion of TNF protein]

PMID:15579764 PMID:24782323 PMID:25305410 PMID:31470850 PMID:31583774

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

decreases expression

Raloxifene Hydrochloride results in decreased expression of TNFAIP3 mRNA

PMID:19429434 PMID:33269387

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

G

TNF receptor superfamily member 11A

decreases expression

Raloxifene Hydrochloride results in decreased expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 11B

multiple interactions
increases expression
decreases expression

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TNFRSF11B mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF11B mRNA; Raloxifene Hydrochloride results in increased expression of and results in increased secretion of TNFRSF11B protein
Raloxifene Hydrochloride results in increased expression of TNFRSF11B mRNA; Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein
Raloxifene Hydrochloride results in decreased expression of TNFRSF11B mRNA

PMID:16005483 PMID:16787719 PMID:17420779 PMID:19059307 PMID:19429434 More...

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 21

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNFRSF21 mRNA

NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085

G

TNF receptor superfamily member 25

decreases expression

Raloxifene Hydrochloride results in decreased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

TNF superfamily member 11

decreases expression

Raloxifene Hydrochloride results in decreased expression of TNFSF11 mRNA; Raloxifene Hydrochloride results in decreased expression of TNFSF11 protein

PMID:16005483 PMID:19401787 PMID:27576059

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

TNF superfamily member 15

increases expression

Raloxifene Hydrochloride results in increased expression of TNFSF15 mRNA

NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228

G

TRAF2 and NCK interacting kinase

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TNIK mRNA

NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750

G

troponin I3, cardiac type

affects expression

Raloxifene Hydrochloride affects the expression of TNNI3 mRNA

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

transportin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of TNPO1 mRNA

NCBI chr 2:30,207,529...30,300,162
Ensembl chr 2:30,211,510...30,300,375

G

tensin 3

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TNS3 mRNA; [Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TNS3 mRNA

PMID:19059307 PMID:21185374

NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998

G

transducer of ErbB-2.1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TOB1 mRNA

NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215

G

target of myb1 membrane trafficking protein

affects expression

Raloxifene Hydrochloride affects the expression of TOM1 mRNA

NCBI chr19:13,405,482...13,440,384
Ensembl chr19:13,405,501...13,440,384

G

DNA topoisomerase I

decreases expression

Raloxifene Hydrochloride results in decreased expression of TOP1 mRNA

NCBI chr 3:149,293,469...149,376,618
Ensembl chr 3:149,293,403...149,376,623

G

DNA topoisomerase II alpha

increases expression

Raloxifene Hydrochloride results in increased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

DNA topoisomerase II beta

decreases expression

Raloxifene Hydrochloride results in decreased expression of TOP2B mRNA

NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085

G

tumor protein p53

multiple interactions
increases expression

[Raloxifene Hydrochloride co-treated with Resveratrol] results in increased expression of TP53 mRNA
Raloxifene Hydrochloride results in increased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tumor protein p53 inducible protein 11

affects expression

Raloxifene Hydrochloride affects the expression of TP53I11 mRNA

NCBI chr 3:79,144,824...79,160,056
Ensembl chr 3:79,144,895...79,160,050

G

tumor protein p53 inducible nuclear protein 1

multiple interactions

[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of TP53INP1 mRNA

NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968

G

tumor protein p73

decreases expression

Raloxifene Hydrochloride results in decreased expression of TP73 mRNA

NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128

G

tropomyosin 1

affects expression

Raloxifene Hydrochloride affects the expression of TPM1 mRNA

PMID:14699072 PMID:16079270

NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802

G

tyrosylprotein sulfotransferase 1

increases expression

Raloxifene Hydrochloride results in increased expression of TPST1 mRNA

NCBI chr12:26,544,536...26,605,706
Ensembl chr12:26,544,536...26,605,704

G

Traf3 interacting protein 2

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of TRAF3IP2 mRNA

NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667

G

TNF receptor-associated factor 5

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRAF5 mRNA

NCBI chr13:103,569,944...103,618,747
Ensembl chr13:103,572,314...103,618,709

G

trafficking kinesin protein 2

decreases expression

Raloxifene Hydrochloride results in decreased expression of TRAK2 mRNA

NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996

G

tribbles pseudokinase 1

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIB1 mRNA

NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731

G

tribbles pseudokinase 2

affects expression

Raloxifene Hydrochloride affects the expression of TRIB2 mRNA

NCBI chr 6:38,545,971...38,570,349
Ensembl chr 6:38,545,975...38,569,370

G

tripartite motif-containing 25

multiple interactions

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of TRIM25 protein]

NCBI chr10:73,812,818...73,831,271
Ensembl chr10:73,812,818...73,831,257

G

tripartite motif-containing 36

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in increased expression of TRIM36 mRNA

NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859

G

tubulin, alpha 1B

increases expression

Raloxifene Hydrochloride results in increased expression of TUBA1B mRNA

NCBI chr 7:130,090,663...130,093,644
Ensembl chr 7:130,081,032...130,196,186

G

twinfilin actin-binding protein 2

affects expression

Raloxifene Hydrochloride affects the expression of TWF2 mRNA

NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298

G

thioredoxin interacting protein

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin B

affects expression

Raloxifene Hydrochloride affects the expression of UBB mRNA

NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333

G

ubiquitin protein ligase E3C

decreases expression

Raloxifene Hydrochloride results in decreased expression of UBE3C mRNA

NCBI chr 4:5,648,932...5,749,922
Ensembl chr 4:5,648,690...5,750,011

G

UBX domain protein 1

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of UBXN1 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of UBXN1 mRNA

NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520

G

UDP glucuronosyltransferase family 1 member A1

affects glucuronidation
multiple interactions
increases glucuronidation

UGT1A1 mRNA alternative form affects the glucuronidation of Raloxifene Hydrochloride
[[MIR491 results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Raloxifene Hydrochloride] which results in decreased abundance of Raloxifene Hydrochloride metabolite; [MIR491 results in decreased activity of UGT1A1 protein] which results in decreased abundance of Raloxifene Hydrochloride metabolite; [MIR491 results in decreased activity of UGT1A1 protein] which results in decreased metabolism of Raloxifene Hydrochloride
UGT1A1 protein results in increased glucuronidation of Raloxifene Hydrochloride

PMID:22661630 PMID:23682072 PMID:24399855

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase 1 family, polypeptide A2

increases glucuronidation

UGT1A3 protein results in increased glucuronidation of Raloxifene Hydrochloride

NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

UGT1A9 protein results in increased glucuronidation of Raloxifene Hydrochloride

NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

uracil-DNA glycosylase

decreases expression

Raloxifene Hydrochloride results in decreased expression of UNG mRNA

NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206

G

UPF1, RNA helicase and ATPase

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of UPF1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of UPF1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568

G

ubiquitin specific peptidase 13

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP13 mRNA

NCBI chr 2:115,576,912...115,689,153
Ensembl chr 2:115,577,091...115,686,222

G

ubiquitin specific peptidase 19

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP19 mRNA

NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741

G

ubiquitin specific peptidase 20

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP20 mRNA

NCBI chr 3:14,272,737...14,306,409
Ensembl chr 3:14,272,908...14,306,409

G

ubiquitin specific peptidase 25

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP25 mRNA

NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348

G

ubiquitin specific peptidase 32

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP32 mRNA

NCBI chr10:69,855,895...70,029,075
Ensembl chr10:69,855,885...70,029,137

G

ubiquitin specific peptidase 33

decreases expression
multiple interactions

Raloxifene Hydrochloride results in decreased expression of USP33 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP33 mRNA

NCBI chr 2:241,283,209...241,328,479
Ensembl chr 2:241,292,985...241,328,479

G

ubiquitin specific peptidase 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP5 mRNA

NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711

G

ubiquitin specific peptidase 50

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of USP50 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of USP50 mRNA

NCBI chr 3:114,012,104...114,035,468
Ensembl chr 3:114,011,702...114,035,476

G

ubiquitin specific peptidase 7

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP7 mRNA

NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355

G

ubiquitin specific peptidase 8

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP8 mRNA

NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666

G

ubiquitin specific peptidase 9, X-linked

decreases expression

Raloxifene Hydrochloride results in decreased expression of USP9X mRNA

NCBI chr X:9,588,825...9,726,993
Ensembl chr X:9,588,825...9,696,711

G

vascular cell adhesion molecule 1

multiple interactions

Raloxifene Hydrochloride affects the reaction [[APOE protein affects the susceptibility to Dietary Fats] which affects the expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

valosin containing protein interacting protein 1

multiple interactions
decreases expression

[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in decreased expression of VCPIP1 mRNA
Raloxifene Hydrochloride results in decreased expression of VCPIP1 mRNA

NCBI chr 5:9,534,247...9,560,889
Ensembl chr 5:9,534,129...9,562,040

G

vitamin D receptor

affects response to substance
multiple interactions

VDR gene polymorphism affects the susceptibility to Raloxifene Hydrochloride
VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Raloxifene Hydrochloride]

PMID:15739035 PMID:16604479

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

multiple interactions
increases expression

Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA protein]
[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of VEGFA protein
Raloxifene Hydrochloride results in increased expression of VEGFA mRNA

PMID:16497877 PMID:19148513 PMID:31332895

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

von Willebrand factor

increases expression

Raloxifene Hydrochloride results in increased expression of VWF protein

NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539

G

WASP actin nucleation promoting factor

decreases expression

Raloxifene Hydrochloride results in decreased expression of WAS mRNA

NCBI chr X:14,405,105...14,413,850
Ensembl chr X:14,405,124...14,413,849

G

WD repeat domain 1

affects expression

Raloxifene Hydrochloride affects the expression of WDR1 mRNA

NCBI chr14:72,258,032...72,291,768
Ensembl chr14:72,257,956...72,291,766

G

WAP four-disulfide core domain 1

increases expression

Raloxifene Hydrochloride results in increased expression of WFDC1 mRNA

NCBI chr19:47,720,191...47,739,121
Ensembl chr19:47,720,423...47,739,108

G

Wnt family member 11

decreases expression

Raloxifene Hydrochloride results in decreased expression of WNT11 mRNA

NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294

G

Wnt family member 5A

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of WNT5A mRNA

NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234

G

WW and C2 domain containing 1

affects expression
decreases expression

Raloxifene Hydrochloride affects the expression of WWC1 mRNA
Raloxifene Hydrochloride results in decreased expression of WWC1 mRNA

PMID:14699072 PMID:26865669

NCBI chr10:20,300,735...20,454,393
Ensembl chr10:20,300,833...20,454,497

G

xanthine dehydrogenase

increases activity
multiple interactions

Raloxifene Hydrochloride results in increased activity of XDH protein
XDH protein promotes the reaction [[Raloxifene Hydrochloride results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

G

exportin 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of XPO1 mRNA

NCBI chr14:97,233,282...97,275,536
Ensembl chr14:97,233,270...97,275,498

G

X-ray repair cross complementing 5

decreases expression

Raloxifene Hydrochloride results in decreased expression of XRCC5 mRNA

NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018

G

Y box binding protein 3

affects expression

Raloxifene Hydrochloride affects the expression of YBX3 mRNA

NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161

G

YOD1 deubiquitinase

increases expression
multiple interactions

Raloxifene Hydrochloride results in increased expression of YOD1 mRNA
[SOD1 protein mutant form affects the susceptibility to Raloxifene Hydrochloride] which results in increased expression of YOD1 mRNA

NCBI chr13:42,175,047...42,181,661
Ensembl chr13:42,174,820...42,177,205

G

zinc finger CCHC-type containing 24

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of ZCCHC24 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZCCHC24 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:1,274,544...1,326,664
Ensembl chr16:1,274,548...1,326,696

G

zinc finger E-box binding homeobox 1

decreases expression

Raloxifene Hydrochloride results in decreased expression of ZEB1 mRNA

NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214

G

zinc finger protein 36

multiple interactions
affects expression

ESR1 protein affects the reaction [Raloxifene Hydrochloride results in increased expression of ZFP36 mRNA]
Raloxifene Hydrochloride affects the expression of ZFP36 mRNA

NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564

G

zinc finger protein 395

multiple interactions

[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ZNF395 mRNA; [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZNF395 mRNA

NCBI chr15:39,581,603...39,621,911
Ensembl chr15:39,608,080...39,619,950

G

zinc finger protein X-linked

increases expression

Raloxifene Hydrochloride results in increased expression of ZFX mRNA

NCBI chr X:58,804,690...58,853,155
Ensembl chr X:58,804,691...58,853,265

G

zinc finger, MIZ-type containing 1

affects expression
multiple interactions

Raloxifene Hydrochloride affects the expression of ZMIZ1 mRNA
[Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of ZMIZ1 mRNA

PMID:14699072 PMID:19059307

NCBI chr16:1,027,083...1,232,616
Ensembl chr16:1,027,325...1,232,597

G

zinc finger MYM-type containing 2

increases expression

Raloxifene Hydrochloride results in increased expression of ZMYM2 mRNA

NCBI chr15:31,035,835...31,108,945
Ensembl chr15:31,035,838...31,109,357

sertaconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

potassium voltage-gated channel subfamily H member 2

decreases activity

sertaconazole results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

stattic

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

BCL2, apoptosis regulator

decreases expression

stattic results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

baculoviral IAP repeat-containing 5

multiple interactions

stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA]

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

cellular communication network factor 2

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]
stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of CCND1 protein]

PMID:30670587 PMID:33396024

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD44 molecule

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cadherin 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cytokine inducible SH2-containing protein

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

collagen type I alpha 1 chain

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA]

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

cathepsin C

multiple interactions

stattic inhibits the reaction [[IL6 protein results in increased phosphorylation of STAT3 protein] promotes the reaction [toosendanin results in decreased expression of CTSC protein]]

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

endothelin 1

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]

NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885

G

epidermal growth factor

multiple interactions

stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein]

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

glutamic--pyruvic transaminase

multiple interactions

stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

intercellular adhesion molecule 1

multiple interactions

stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 12A

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 1 beta

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [[IL6 protein results in increased phosphorylation of STAT3 protein] promotes the reaction [toosendanin results in decreased expression of CTSC protein]]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]

PMID:22454431 PMID:25740948 PMID:26297436 PMID:28739487 PMID:29341321 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Janus kinase 2

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

keratin 1

multiple interactions

stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased expression of KRT1 protein]]

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

keratin 10

multiple interactions

stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased expression of KRT10 protein]]

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

stattic results in increased lipidation of and results in increased localization of MAP1LC3B protein

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen-activated protein kinase 9

multiple interactions

stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

multiple interactions

stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased expression of KRT1 protein]]; stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased expression of KRT10 protein]]; stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]]

NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041

G

microRNA 21

affects expression
multiple interactions

stattic affects the expression of MIR21 mRNA
stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

matrix metallopeptidase 10

decreases expression

stattic results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

myeloperoxidase

multiple interactions

stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

proliferating cell nuclear antigen

multiple interactions

stattic affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; stattic affects the reaction [CXCL8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proteasome 20S subunit beta 1

decreases expression

stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

G

proteasome 20S subunit beta 2

decreases expression

stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

G

proteasome 20S subunit beta 3

decreases expression

stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 20S subunit beta 4

decreases expression

stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 5

decreases expression
multiple interactions

stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]

NCBI chr15:28,072,772...28,077,367
Ensembl chr15:28,072,781...28,077,440

G

proteasome 20S subunit beta 6

decreases expression

stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 7

decreases expression

stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein

NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937

G

ribosomal oxygenase 2

multiple interactions

stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein]

NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574

G

S-phase kinase associated protein 2

multiple interactions

stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein]

NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338

G

snail family transcriptional repressor 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 mRNA]]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 mRNA]]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

suppressor of cytokine signaling 3

multiple interactions

[stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

sequestosome 1

increases expression

stattic results in increased expression of SQSTM1 protein

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

signal transducer and activator of transcription 1

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein]

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [[IL6 protein results in increased phosphorylation of STAT3 protein] promotes the reaction [toosendanin results in decreased expression of CTSC protein]]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [METTL3 protein promotes the reaction [sodium arsenite results in increased phosphorylation of STAT3 protein]]
Stattic inhibits the reaction [Il-6 increases phosphorylation of STAT3 protein in the stomach)
stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
stattic results in decreased phosphorylation of STAT3 protein

CTD
RGD

PMID:20942815 PMID:22454431 PMID:23255093 PMID:24627483 PMID:25740948 More...

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

twist family bHLH transcription factor 1

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 mRNA]]

NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653

G

vimentin

multiple interactions

stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]; stattic inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; stattic inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM mRNA]]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

zileuton

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

affects response to substance

ABCC1 gene SNP affects the susceptibility to zileuton

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

actin alpha 2, smooth muscle

multiple interactions

zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

albumin

multiple interactions

zileuton metabolite binds to and results in increased alkylation of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 5-lipoxygenase

affects response to substance
decreases expression
multiple interactions
decreases activity

ALOX5 gene SNP affects the susceptibility to zileuton
zileuton results in decreased expression of ALOX5 mRNA
[[zileuton co-treated with Calcimycin] results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Indomethacin results in increased abundance of Leukotriene B4]; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; zileuton binds to and results in decreased activity of ALOX5 protein; zileuton inhibits the reaction [ALOX5 protein affects the abundance of lipoxin A4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of ALOX5 protein]; zileuton inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of ALOX5 protein]; zileuton inhibits the reaction [Peroxynitrous Acid results in increased nitrosation of ALOX5 protein]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene C4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene D4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]; zileuton inhibits the reaction [Ovalbumin results in increased expression of ALOX5 mRNA]
[zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; [zileuton results in decreased activity of ALOX5 protein] which affects the abundance of Arachidonic Acid; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene B4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene C4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene D4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4; [zileuton results in decreased activity of ALOX5 protein] which results in decreased susceptibility to Arachidonic Acid; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; zileuton inhibits the reaction [ALOX5 protein results in increased metabolism of Arachidonic Acid]; zileuton inhibits the reaction [ALOX5 protein results in increased susceptibility to [Histamine results in increased abundance of Leukotriene B4]]; zileuton inhibits the reaction [L 708714 binds to ALOX5 protein]

PMID:1781415 PMID:7577949 PMID:7592874 PMID:7665580 PMID:7812673 More...

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

caspase 3

multiple interactions
increases activity

Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions
increases activity

Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

C-C motif chemokine ligand 11

multiple interactions

zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL11 mRNA]

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

multiple interactions

zileuton inhibits the reaction [CCL12 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL12 mRNA]

PMID:12388339 PMID:12794006

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 2

multiple interactions

zileuton inhibits the reaction [CCL2 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [Ovalbumin results in increased expression of CCL2 mRNA]

PMID:12388339 PMID:12794006

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

collagen type X alpha 1 chain

increases expression

zileuton results in increased expression of COL10A1 mRNA

NCBI chr20:38,183,103...38,189,488
Ensembl chr20:38,182,494...38,189,494

G

collagen type II alpha 1 chain

increases expression

zileuton results in increased expression of COL2A1 mRNA

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

C-X-C motif chemokine ligand 3

multiple interactions

zileuton inhibits the reaction [CXCL1 protein results in increased abundance of Leukotriene B4]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity

zileuton results in increased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
decreases activity

zileuton inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
zileuton results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 2

increases expression

zileuton results in increased expression of CYP2B2 mRNA

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

zileuton results in decreased activity of CYP3A4 protein

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

DNA-damage inducible transcript 3

decreases expression

zileuton results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

eosinophil peroxidase

multiple interactions

zileuton inhibits the reaction [Ovalbumin results in increased expression of EPX protein]

NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952

G

ferritin heavy chain 1

decreases expression

zileuton results in decreased expression of FTH1 mRNA

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

G

histone deacetylase 1

decreases expression

zileuton results in decreased expression of HDAC1 mRNA

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

zileuton results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

hydroxysteroid 11-beta dehydrogenase 2

increases activity

zileuton results in increased activity of HSD11B2 protein

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

intercellular adhesion molecule 1

affects expression
multiple interactions

zileuton affects the expression of ICAM1 protein
zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of ICAM1 protein]

PMID:15266012 PMID:15821759

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 12A

multiple interactions

zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions

zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of [IL12A protein binds to IL12B protein]]

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

affects expression
multiple interactions

zileuton affects the expression of IL13 protein
zileuton inhibits the reaction [Ovalbumin results in increased expression of IL13 mRNA]
zileuton inhibits the reaction [IL13 protein results in increased abundance of Leukotriene B4]; zileuton inhibits the reaction [IL13 protein results in increased expression of ALOX5 mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]

PMID:12654629 PMID:12794006 PMID:15927844

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 beta

multiple interactions

zileuton inhibits the reaction [Bleomycin results in increased expression of IL1B protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

zileuton inhibits the reaction [Ovalbumin results in increased expression of IL4 mRNA]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
decreases secretion

zileuton inhibits the reaction [Endotoxins results in increased expression of IL6 protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of IL6 protein]
zileuton results in decreased secretion of IL6 protein

PMID:7496871 PMID:19118273 PMID:20436887

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit alpha M

multiple interactions

zileuton inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

mitogen activated protein kinase 1

affects expression

zileuton affects the expression of MAPK1 protein modified form

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

affects expression
decreases expression

zileuton affects the expression of MAPK3 protein modified form
zileuton results in decreased expression of MAPK3 mRNA

PMID:12883083 PMID:18059327

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microsomal glutathione S-transferase 1

decreases activity

zileuton results in decreased activity of MGST1 protein

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

matrix metallopeptidase 9

decreases activity
decreases expression

zileuton results in decreased activity of MMP9 protein
zileuton results in decreased expression of MMP9 mRNA

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions
decreases activity

zileuton inhibits the reaction [Bleomycin results in increased activity of MPO protein]; zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased activity of MPO protein]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MPO protein]; zileuton inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MPO protein]
zileuton results in decreased activity of MPO protein
zileuton inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; zileuton inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:7812673 PMID:11698051 PMID:12794006 PMID:15339030 PMID:15821759 More...

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [Ovalbumin results in increased expression of MUC5AC protein]
zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; zileuton inhibits the reaction [IL13 protein results in increased expression of MUC5AC protein]

PMID:12654629 PMID:12794006

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

nitric oxide synthase 1

multiple interactions

[zileuton results in decreased activity of ALOX5 protein] which results in decreased expression of NOS1

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

occludin

multiple interactions

zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

platelet-activating factor receptor

multiple interactions

zileuton binds to and results in decreased activity of PTAFR protein; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

zileuton affects the expression of PTGS2 protein
zileuton inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]

PMID:18059327 PMID:28487374

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

ribosomal protein lateral stalk subunit P0

decreases expression

zileuton results in decreased expression of RPLP0 mRNA

NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632

G

selectin E

multiple interactions

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

selectin P

multiple interactions

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of SELP protein]
zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]

PMID:11116075 PMID:15821759

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

SRY-box transcription factor 9

increases expression

zileuton results in increased expression of SOX9 mRNA

NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994

G

tight junction protein 1

multiple interactions

zileuton inhibits the reaction [dinitrobenzenesulfonic acid affects the localization of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

tumor necrosis factor

affects expression
multiple interactions

zileuton affects the expression of TNF protein
zileuton inhibits the reaction [Bleomycin results in increased expression of TNF protein]
zileuton inhibits the reaction [Endotoxins results in increased expression of TNF protein]; zileuton inhibits the reaction [Leukotriene D4 results in increased secretion of TNF protein]

PMID:7496871 PMID:17118201 PMID:18059327 PMID:19118273

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

multiple interactions

zileuton inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19898
chemical entity	19896
atom	19896
nonmetal atom	19818
sulfur atom	17772
sulfur molecular entity	17772
organosulfur compound	17470
organosulfur heterocyclic compound	10039
benzothiophenes	1000
1-benzothiophenes	1000
(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl ester	0
(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-N-(phenylmethyl)-3,4-dihydro-2H-pyran-6-carboxamide	0
(4-methyl-1-piperazinyl)-(2-thieno[3,2-b][1]benzothiolyl)methanone	0
1,2-Dihydrodibenzothiophene-1alpha,2alpha-diol	0
1-Benzothiophen-3-ylmethanol	0
1-Benzothiophen-5-amine	0
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine	0
1-[1-(1-benzothiophen-2-yl)cyclohexyl]pyrrolidine	0
1-[2-(4-\{3-[4-(2-pyrrolidin-1-ylethoxy)benzyl]-1-benzothiophen-2-yl\}phenoxy)ethyl]pyrrolidine	0
1-\{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl\}imidazole +	1
1-benzothiophene +	47
2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid	0
2-(tert-butylsulfonyl)-3-(3-methylbenzo[b]thiophen-2-yl)acrylonitrile	0
2-Benzo[b]thiophen-3-ylacetic acid	0
2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenol	0
2-\{1-[2-(1-benzothiophen-5-ylamino)-2-oxoethyl]cyclohexyl\}acetic acid	0
3,4-dichloro-N-[(1-methyl-4-pyrazolyl)methyl]-1-benzothiophene-2-carboxamide	0
3,6-dichloro-N-(3-pyridinylmethyl)-1-benzothiophene-2-carboxamide	0
3,6-dichloro-N-(4-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide	0
3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamide	0
3-(2-aminoethyl)-1-benzothiophen-5-ol	0
3-[3-bromo-4-(pyrrolidin-1-ylmethyl)benzyl]-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-benzothiophen-6-ol	0
3-[4-(2-pyrrolidin-1-ylethoxy)benzyl]-2-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1-benzothiophen-6-ol	0
3-chloro-4-fluoro-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-6-methyl-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-6-methyl-N-[3-(4-morpholinyl)propyl]-1-benzothiophene-2-carboxamide	0
3-chloro-N-(3-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-N-[(1-methyl-2-pyrrolyl)methylideneamino]-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-(4-morpholinyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-[(2-furanylmethylamino)-oxomethyl]-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-1-benzothiophene-2-carboxamide	0
3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide	0
3-hydroxy-2-formyl-1-benzothiophene	0
3-methyl-1-benzothiophene-2-carbaldehyde oxime	0
4-(3-hydroxy-1-benzothiophen-2-yl)-2-oxobut-3-enoate +	0
4-(3-hydroxy-1-benzothiophen-2-yl)-2-oxobut-3-enoic acid +	0
5-Chloropyridin-3-yl benzo[b]thiophene-2-carboxylate	0
5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide	0
6-chloro-1-(2-\{[(5-chloro-1-benzothiophen-3-yl)methyl]amino\}ethyl)-3-[(2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol	0
6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide	0
ANA-12	0
Benzo[b]thien-7-ylmethanol	0
Dehydroxyzyleuton	0
GSK1016790A	0
IKK16	0
LY 117018	6
Methyl 5-amino-1-benzothiophene-2-carboxylate	0
N,N-bis(2-methoxyethyl)-2-thieno[3,2-b][1]benzothiolecarboxamide	0
N-(1-benzothien-2-ylmethyl)-N-methylamine hydrochloride	0
N-(1-benzothiophen-7-ylmethyl)-2-thiophenecarboxamide	0
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide	0
N-[(5-chloro-1-benzothiophen-3-yl)methyl]-2-[(2R,6S)-2-chloro-6-hydroxy-5-[(2-pyridin-2-ylethyl)amino]-3,6-dihydropyrazin-1(2H)-yl]acetamide	0
N-phenyl-2-benzo[g][1]benzothiolecarboxamide	0
N2-phenyl-3-methylbenzo[b]thiophene-2-carbothioamide	0
Zileuton sulfoxide	0
[(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone	0
[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone	0
\{2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-benzothiophen-3-yl\}[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]methanone	0
\{[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl\}acetic acid	0
caldariellaquinol	0
caldariellaquinone	0
hydroxyzileuton	0
metizoline	0
raloxifene	946
stattic	49
zileuton	47
Path 2
Term	Annotations
CHEBI ontology	19898
subatomic particle	19896
composite particle	19896
hadron	19896
baryon	19896
nucleon	19896
atomic nucleus	19896
atom	19896
main group element atom	19835
p-block element atom	19835
carbon group element atom	19774
carbon atom	19771
organic molecular entity	19771
organic molecule	19724
organic cyclic compound	19515
organic heterocyclic compound	18890
organic heteropolycyclic compound	18310
organic heterobicyclic compound	17252
benzothiophenes	1000
1-benzothiophenes	1000
(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid prop-2-enyl ester	0
(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-N-(phenylmethyl)-3,4-dihydro-2H-pyran-6-carboxamide	0
(4-methyl-1-piperazinyl)-(2-thieno[3,2-b][1]benzothiolyl)methanone	0
1,2-Dihydrodibenzothiophene-1alpha,2alpha-diol	0
1-Benzothiophen-3-ylmethanol	0
1-Benzothiophen-5-amine	0
1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine	0
1-[1-(1-benzothiophen-2-yl)cyclohexyl]pyrrolidine	0
1-[2-(4-\{3-[4-(2-pyrrolidin-1-ylethoxy)benzyl]-1-benzothiophen-2-yl\}phenoxy)ethyl]pyrrolidine	0
1-\{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl\}imidazole +	1
1-benzothiophene +	47
2-(5-Chlorobenzo[b]thiophen-3-yl)acetic acid	0
2-(tert-butylsulfonyl)-3-(3-methylbenzo[b]thiophen-2-yl)acrylonitrile	0
2-Benzo[b]thiophen-3-ylacetic acid	0
2-[(3-chloro-1-benzothiophen-2-yl)methylideneamino]phenol	0
2-\{1-[2-(1-benzothiophen-5-ylamino)-2-oxoethyl]cyclohexyl\}acetic acid	0
3,4-dichloro-N-[(1-methyl-4-pyrazolyl)methyl]-1-benzothiophene-2-carboxamide	0
3,6-dichloro-N-(3-pyridinylmethyl)-1-benzothiophene-2-carboxamide	0
3,6-dichloro-N-(4-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide	0
3,7-dichloro-N-[3-(1-imidazolyl)propyl]-6-methoxy-1-benzothiophene-2-carboxamide	0
3-(2-aminoethyl)-1-benzothiophen-5-ol	0
3-[3-bromo-4-(pyrrolidin-1-ylmethyl)benzyl]-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-benzothiophen-6-ol	0
3-[4-(2-pyrrolidin-1-ylethoxy)benzyl]-2-[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]-1-benzothiophen-6-ol	0
3-chloro-4-fluoro-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-6-methyl-N-(3-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-6-methyl-N-[3-(4-morpholinyl)propyl]-1-benzothiophene-2-carboxamide	0
3-chloro-N-(3-methyl-2-pyridinyl)-1-benzothiophene-2-carboxamide	0
3-chloro-N-[(1-methyl-2-pyrrolyl)methylideneamino]-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-(1-imidazolyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-(4-morpholinyl)propyl]-6-nitro-1-benzothiophene-2-carboxamide	0
3-chloro-N-[3-[(2-furanylmethylamino)-oxomethyl]-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl]-1-benzothiophene-2-carboxamide	0
3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[3-(pyridin-4-yl)benzyl]-1-benzothiophene-2-carboxamide	0
3-hydroxy-2-formyl-1-benzothiophene	0
3-methyl-1-benzothiophene-2-carbaldehyde oxime	0
4-(3-hydroxy-1-benzothiophen-2-yl)-2-oxobut-3-enoate +	0
4-(3-hydroxy-1-benzothiophen-2-yl)-2-oxobut-3-enoic acid +	0
5-Chloropyridin-3-yl benzo[b]thiophene-2-carboxylate	0
5-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide	0
6-chloro-1-(2-\{[(5-chloro-1-benzothiophen-3-yl)methyl]amino\}ethyl)-3-[(2-pyridin-2-ylethyl)amino]-1,4-dihydropyrazin-2-ol	0
6-chloro-N-\{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl\}-1-benzothiophene-2-sulfonamide	0
ANA-12	0
Benzo[b]thien-7-ylmethanol	0
Dehydroxyzyleuton	0
GSK1016790A	0
IKK16	0
LY 117018	6
Methyl 5-amino-1-benzothiophene-2-carboxylate	0
N,N-bis(2-methoxyethyl)-2-thieno[3,2-b][1]benzothiolecarboxamide	0
N-(1-benzothien-2-ylmethyl)-N-methylamine hydrochloride	0
N-(1-benzothiophen-7-ylmethyl)-2-thiophenecarboxamide	0
N-(3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)-2-fluorobenzamide	0
N-[(5-chloro-1-benzothiophen-3-yl)methyl]-2-[(2R,6S)-2-chloro-6-hydroxy-5-[(2-pyridin-2-ylethyl)amino]-3,6-dihydropyrazin-1(2H)-yl]acetamide	0
N-phenyl-2-benzo[g][1]benzothiolecarboxamide	0
N2-phenyl-3-methylbenzo[b]thiophene-2-carbothioamide	0
Zileuton sulfoxide	0
[(2R,3R,4S)-4-(1-benzothiophen-3-yl)-2-ethoxy-3-(3-hydroxypropyl)-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone	0
[(2S,4S)-4-(1-benzothiophen-3-yl)-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-yl]-[4-(phenylmethyl)-1-piperazinyl]methanone	0
\{2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-benzothiophen-3-yl\}[6-(2-pyrrolidin-1-ylethoxy)pyridin-3-yl]methanone	0
\{[6-(1-benzothiophen-2-yl)thieno[3,2-d]pyrimidin-4-yl]sulfanyl\}acetic acid	0
caldariellaquinol	0
caldariellaquinone	0
hydroxyzileuton	0
metizoline	0
raloxifene	946
stattic	49
zileuton	47

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