Otud7b (OTU deubiquitinase 7B) - Rat Genome Database

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Gene: Otud7b (OTU deubiquitinase 7B) Rattus norvegicus
Analyze
Symbol: Otud7b
Name: OTU deubiquitinase 7B
RGD ID: 1308111
Description: Predicted to enable K48-linked deubiquitinase activity; K63-linked polyubiquitin modification-dependent protein binding activity; and cysteine-type deubiquitinase activity. Predicted to be involved in several processes, including negative regulation of canonical NF-kappaB signal transduction; negative regulation of macromolecule biosynthetic process; and negative regulation of protein localization to nucleus. Predicted to act upstream of or within in utero embryonic development. Predicted to be active in cytoplasm and nucleus. Orthologous to human OTUD7B (OTU deubiquitinase 7B); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,2',5,5'-tetrachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cellular zinc finger anti-NF-kappaB Cezanne; LOC310677; OTU domain containing 7B; OTU domain-containing protein 7B; RGD1308111; similar to zinc finger protein Cezanne
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,350,811 - 186,411,461 (+)NCBIGRCr8
mRatBN7.22183,661,955 - 183,722,584 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,325,797 - 191,384,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,130,056 - 189,188,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,958,342 - 184,016,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,231,353 - 198,302,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,231,291 - 198,300,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,720,895 - 217,789,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,905,522 - 190,964,454 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,868,275 - 190,938,314 (+)NCBI
Celera2176,190,012 - 176,247,856 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11463333   PMID:12682062   PMID:16778019   PMID:18281465   PMID:20622874   PMID:21097510   PMID:23334419   PMID:23564640   PMID:23827681   PMID:27996060   PMID:34324860   PMID:35523269  
PMID:38084712  


Genomics

Comparative Map Data
Otud7b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82186,350,811 - 186,411,461 (+)NCBIGRCr8
mRatBN7.22183,661,955 - 183,722,584 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2191,325,797 - 191,384,171 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02189,130,056 - 189,188,470 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02183,958,342 - 184,016,709 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02198,231,353 - 198,302,220 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2198,231,291 - 198,300,201 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02217,720,895 - 217,789,205 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,905,522 - 190,964,454 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12190,868,275 - 190,938,314 (+)NCBI
Celera2176,190,012 - 176,247,856 (+)NCBICelera
Cytogenetic Map2q34NCBI
OTUD7B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381149,937,812 - 150,067,653 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1149,937,812 - 150,010,726 (-)EnsemblGRCh38hg38GRCh38
GRCh371149,909,705 - 149,982,675 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361148,178,855 - 148,249,310 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,728,409 - 146,795,602NCBI
Celera1123,028,202 - 123,098,656 (-)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1121,292,712 - 121,362,691 (-)NCBIHuRef
CHM1_11151,308,456 - 151,378,863 (-)NCBICHM1_1
T2T-CHM13v2.01149,062,296 - 149,192,273 (-)NCBIT2T-CHM13v2.0
Otud7b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,011,759 - 96,068,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,011,839 - 96,068,446 (+)EnsemblGRCm39 Ensembl
GRCm38396,104,504 - 96,161,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,104,527 - 96,161,129 (+)EnsemblGRCm38mm10GRCm38
MGSCv37395,908,450 - 95,965,052 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36396,189,932 - 96,246,534 (+)NCBIMGSCv36mm8
Celera397,540,463 - 97,597,279 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map341.65NCBI
Otud7b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955413751,546 - 812,605 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955413758,098 - 812,605 (+)NCBIChiLan1.0ChiLan1.0
OTUD7B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,828,379 - 99,901,338 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,583,331 - 99,653,002 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01125,282,599 - 125,355,441 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11128,941,260 - 129,005,678 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1128,944,782 - 128,976,474 (-)Ensemblpanpan1.1panPan2
OTUD7B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11759,225,640 - 59,280,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1759,229,362 - 59,280,934 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1758,672,817 - 58,728,223 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01760,221,922 - 60,277,210 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1760,221,941 - 60,276,960 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11759,071,375 - 59,126,610 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01759,155,099 - 59,210,354 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01759,882,202 - 59,937,666 (-)NCBIUU_Cfam_GSD_1.0
Otud7b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505821,248,716 - 21,350,025 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936580278,257 - 338,526 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936580278,263 - 300,278 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD7B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,054,426 - 99,114,162 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,054,426 - 99,111,649 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24108,609,708 - 108,632,906 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD7B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603813,235,718 - 13,366,144 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otud7b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477217,721,218 - 17,787,299 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477217,717,178 - 17,776,940 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Otud7b
267 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:396
Count of miRNA genes:205
Interacting mature miRNAs:276
Transcripts:ENSRNOT00000046739
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat

Markers in Region
D2Rat134  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,719,124 - 183,719,262 (+)MAPPERmRatBN7.2
Rnor_6.02198,298,764 - 198,298,901NCBIRnor6.0
Rnor_5.02217,785,747 - 217,785,884UniSTSRnor5.0
RGSC_v3.42190,963,017 - 190,963,154UniSTSRGSC3.4
Celera2176,246,419 - 176,246,556UniSTS
RH 3.4 Map21223.0UniSTS
RH 3.4 Map21223.0RGD
RH 2.0 Map2898.3RGD
FHH x ACI Map278.8099RGD
Cytogenetic Map2q34UniSTS
AI462125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,718,362 - 183,718,466 (+)MAPPERmRatBN7.2
Rnor_6.02198,298,002 - 198,298,105NCBIRnor6.0
Rnor_5.02217,784,985 - 217,785,088UniSTSRnor5.0
RGSC_v3.42190,962,255 - 190,962,358UniSTSRGSC3.4
Celera2176,245,657 - 176,245,760UniSTS
Cytogenetic Map2q34UniSTS
RH142787  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,718,278 - 183,718,415 (+)MAPPERmRatBN7.2
Rnor_6.02198,297,918 - 198,298,054NCBIRnor6.0
Rnor_5.02217,784,901 - 217,785,037UniSTSRnor5.0
RGSC_v3.42190,962,171 - 190,962,307UniSTSRGSC3.4
Celera2176,245,573 - 176,245,709UniSTS
RH 3.4 Map21222.7UniSTS
Cytogenetic Map2q34UniSTS
RH141601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,720,158 - 183,720,375 (+)MAPPERmRatBN7.2
Rnor_6.02198,299,797 - 198,300,013NCBIRnor6.0
Rnor_5.02217,786,780 - 217,786,996UniSTSRnor5.0
RGSC_v3.42190,964,050 - 190,964,266UniSTSRGSC3.4
Celera2176,247,452 - 176,247,668UniSTS
RH 3.4 Map21221.5UniSTS
Cytogenetic Map2q34UniSTS
BE117295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22183,687,097 - 183,687,296 (+)MAPPERmRatBN7.2
Rnor_6.02198,267,069 - 198,267,267NCBIRnor6.0
Rnor_5.02217,754,356 - 217,754,554UniSTSRnor5.0
RGSC_v3.42190,930,693 - 190,930,891UniSTSRGSC3.4
Celera2176,214,936 - 176,215,134UniSTS
RH 3.4 Map21222.7UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 19 6 16 6 8 11 58 30 41 11 8
Low 5 38 35 3 35 16 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000046739   ⟹   ENSRNOP00000039488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2198,231,353 - 198,300,201 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078288   ⟹   ENSRNOP00000073488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2183,662,163 - 183,718,674 (+)Ensembl
Rnor_6.0 Ensembl2198,231,291 - 198,297,323 (+)Ensembl
RefSeq Acc Id: NM_001107697   ⟹   NP_001101167
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,844 - 186,409,440 (+)NCBI
mRatBN7.22183,661,955 - 183,720,563 (+)NCBI
Rnor_6.02198,231,353 - 198,300,201 (+)NCBI
Rnor_5.02217,720,895 - 217,789,205 (+)NCBI
RGSC_v3.42190,905,522 - 190,964,454 (+)RGD
Celera2176,190,012 - 176,247,856 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232957   ⟹   XP_006233019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,963 - 186,411,461 (+)NCBI
mRatBN7.22183,662,106 - 183,722,584 (+)NCBI
Rnor_6.02198,231,552 - 198,302,220 (+)NCBI
Rnor_5.02217,720,895 - 217,789,205 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063281880   ⟹   XP_063137950
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,963 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281881   ⟹   XP_063137951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,376,453 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281882   ⟹   XP_063137952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,354,942 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281883   ⟹   XP_063137953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,811 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281884   ⟹   XP_063137954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,389,133 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281885   ⟹   XP_063137955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,350,816 - 186,411,461 (+)NCBI
RefSeq Acc Id: XM_063281886   ⟹   XP_063137956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82186,389,127 - 186,411,461 (+)NCBI
RefSeq Acc Id: NP_001101167   ⟸   NM_001107697
- UniProtKB: A6K349 (UniProtKB/TrEMBL),   A0A0G2K5N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233019   ⟸   XM_006232957
- Peptide Label: isoform X1
- UniProtKB: A6K349 (UniProtKB/TrEMBL),   A0A0G2K5N0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073488   ⟸   ENSRNOT00000078288
RefSeq Acc Id: ENSRNOP00000039488   ⟸   ENSRNOT00000046739
RefSeq Acc Id: XP_063137953   ⟸   XM_063281883
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL),   A6K349 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137955   ⟸   XM_063281885
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL),   A6K349 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137950   ⟸   XM_063281880
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL),   A6K349 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137952   ⟸   XM_063281882
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL),   A6K349 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137951   ⟸   XM_063281881
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL),   A6K349 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137956   ⟸   XM_063281886
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137954   ⟸   XM_063281884
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5N0 (UniProtKB/TrEMBL)
Protein Domains
A20-type   OTU

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZH40-F1-model_v2 AlphaFold D3ZH40 1-841 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691565
Promoter ID:EPDNEW_R2089
Type:initiation region
Name:Otud7b_1
Description:OTU deubiquitinase 7B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02198,231,372 - 198,231,432EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308111 AgrOrtholog
BioCyc Gene G2FUF-52054 BioCyc
Ensembl Genes ENSRNOG00000042068 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078288 ENTREZGENE
  ENSRNOT00000078288.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4770 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro OTU UniProtKB/TrEMBL
  Znf_A20 UniProtKB/TrEMBL
KEGG Report rno:310677 UniProtKB/TrEMBL
NCBI Gene 310677 ENTREZGENE
PANTHER OTU DOMAIN-CONTAINING PROTEIN 7B UniProtKB/TrEMBL
  UBIQUITIN THIOESTERASE UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
  zf-A20 UniProtKB/TrEMBL
PhenoGen Otud7b PhenoGen
PROSITE OTU UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
  ZF_A20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042068 RatGTEx
SMART ZnF_A20 UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
UniProt A0A0G2K5N0 ENTREZGENE, UniProtKB/TrEMBL
  A6K349 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Otud7b  OTU deubiquitinase 7B  Otud7b  OTU domain containing 7B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Otud7b  OTU domain containing 7B  RGD1308111_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308111_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)  LOC310677_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310677_predicted  similar to zinc finger protein Cezanne; cellular zinc finger anti-NF-kappaB Cezanne (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL