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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308111
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Otud7b
Name: OTU deubiquitinase 7B
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Otud7bincreases expressionEXP 6480464CTDDoxorubicin results in increased expression of OTUD7B mRNA; Doxorubicin results in increased expression of OTUD7B proteinPMID:36639017
Otud7bmultiple interactionsEXP 6480464CTDOTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]PMID:36639017
Otud7bdecreases expressionISOOTUD7B (Homo sapiens)6480464CTDDoxorubicin results in decreased expression of OTUD7B mRNAPMID:29803840
Otud7bincreases expressionISOOtud7b (Mus musculus)6480464CTDDoxorubicin results in increased expression of OTUD7B mRNA; Doxorubicin results in increased expression of OTUD7B proteinPMID:36639017
Otud7bmultiple interactionsISOOtud7b (Mus musculus)6480464CTDOTUD7B protein affects the reaction [Doxorubicin results in increased expression of CASP3 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in decreased phosphorylation of MTOR protein]; OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in decreased expression of SQSTM1 protein]]; Sirolimus inhibits the reaction [OTUD7B protein inhibits the reaction [Doxorubicin results in increased expression of ATG5 protein]]PMID:36639017
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