Wnt11 (Wnt family member 11) - Rat Genome Database

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Gene: Wnt11 (Wnt family member 11) Rattus norvegicus
Analyze
Symbol: Wnt11
Name: Wnt family member 11
RGD ID: 621463
Description: Predicted to enable enzyme activator activity and signaling receptor binding activity. Involved in cell differentiation and response to nutrient levels. Predicted to be located in cytoplasm; extracellular matrix; and extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; INTERACTS WITH 6-propyl-2-thiouracil; alpha-Zearalanol; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: wingless-related MMTV integration site 11; wingless-type MMTV integration site family, member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,545,660 - 162,565,456 (+)NCBIGRCr8
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,133,836 - 161,149,936 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,314,007 - 168,330,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,187,522 - 161,203,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Celera1151,224,671 - 151,240,729 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
cannabidiol  (EXP)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
fenfluramine  (ISO)
fluvastatin  (ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycerol 2-phosphate  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
nickel atom  (EXP)
nitrofen  (EXP)
paracetamol  (EXP,ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
retinyl acetate  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal gland development  (ISO)
apoptotic process  (ISO)
artery morphogenesis  (ISO)
atrial septum development  (ISO)
bicellular tight junction assembly  (ISO)
bone mineralization  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (IEP)
cell fate commitment  (IBA)
cellular response to mechanical stimulus  (ISO)
cloacal septation  (ISO)
convergent extension involved in axis elongation  (ISO)
embryonic skeletal system development  (ISO)
epithelial cell apoptotic process  (ISO)
epithelial to mesenchymal transition  (ISO)
kidney development  (ISO)
lung-associated mesenchyme development  (ISO)
maintenance of epithelial cell apical/basal polarity  (ISO)
mesenchymal cell proliferation  (ISO)
mesonephric duct development  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of mesenchymal cell proliferation  (ISO)
negative regulation of stem cell proliferation  (ISO)
neuroendocrine cell differentiation  (ISO)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (ISO)
notochord morphogenesis  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
paraxial mesoderm formation  (ISO)
planar cell polarity pathway involved in axis elongation  (ISO)
planar cell polarity pathway involved in gastrula mediolateral intercalation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of protein kinase C signaling  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of transforming growth factor beta2 production  (ISO)
primary heart field specification  (ISO)
protein localization to cell surface  (ISO)
response to nutrient levels  (IEP)
roof of mouth development  (ISO)
secondary heart field specification  (ISO)
secondary palate development  (ISO)
signal transduction  (ISO)
somite development  (ISO)
stem cell proliferation  (ISO)
ureteric bud morphogenesis  (ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms of impaired nephrogenesis with fetal growth restriction: altered renal transcription and growth factor expression. Abdel-Hakeem AK, etal., Am J Obstet Gynecol. 2008 Sep;199(3):252.e1-7. Epub 2008 Jul 17.
2. Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer. Andrade Filho PA, etal., J Dent Res. 2011 Jun;90(6):740-6. doi: 10.1177/0022034511401622. Epub 2011 Mar 10.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Molecular cloning and characterization of human WNT11. Kirikoshi H, etal., Int J Mol Med. 2001 Dec;8(6):651-6.
6. Wnt signal pathways and neural stem cell differentiation. Lange C, etal., Neurodegener Dis. 2006;3(1-2):76-86.
7. Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Majumdar A, etal., Development 2003 Jul;130(14):3175-85.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Wnt11 signaling promotes proliferation, transformation, and migration of IEC6 intestinal epithelial cells. Ouko L, etal., J Biol Chem 2004 Jun 18;279(25):26707-15. Epub 2004 Apr 14.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Ricken A, etal., Endocrinology 2002 Jul;143(7):2741-9.
17. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
18. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
19. Analysis of Wnt gene expression in prostate cancer: mutual inhibition by WNT11 and the androgen receptor. Zhu H, etal., Cancer Res. 2004 Nov 1;64(21):7918-26.
Additional References at PubMed
PMID:8700530   PMID:9757009   PMID:17767158   PMID:18155657   PMID:18191119   PMID:18413325   PMID:19213727   PMID:19847889   PMID:20103596   PMID:20219091   PMID:21281623   PMID:22569553  
PMID:22829700   PMID:22985995   PMID:23998262   PMID:24474615   PMID:25813538   PMID:25959411   PMID:26193266   PMID:33137935  


Genomics

Comparative Map Data
Wnt11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,545,660 - 162,565,456 (+)NCBIGRCr8
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1161,133,836 - 161,149,936 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,314,007 - 168,330,107 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,187,522 - 161,203,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Celera1151,224,671 - 151,240,729 (+)NCBICelera
Cytogenetic Map1q32NCBI
WNT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381176,186,325 - 76,210,761 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1176,186,325 - 76,210,736 (-)EnsemblGRCh38hg38GRCh38
GRCh371175,897,369 - 75,917,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,575,018 - 75,595,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 341175,575,017 - 75,595,222NCBI
Celera1173,205,187 - 73,225,391 (-)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1172,194,546 - 72,214,753 (-)NCBIHuRef
CHM1_11175,780,888 - 75,801,091 (-)NCBICHM1_1
T2T-CHM13v2.01176,116,041 - 76,140,519 (-)NCBIT2T-CHM13v2.0
Wnt11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,484,293 - 98,503,954 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,484,319 - 98,504,402 (+)EnsemblGRCm39 Ensembl
GRCm38798,835,084 - 98,854,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,835,112 - 98,855,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,987,355 - 106,003,257 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36798,714,037 - 98,728,940 (+)NCBIMGSCv36mm8
Celera799,160,445 - 99,176,286 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.9NCBI
Wnt11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,674,940 - 15,694,883 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,674,478 - 15,694,758 (+)NCBIChiLan1.0ChiLan1.0
WNT11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,110,987 - 77,161,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,156,064 - 78,180,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01171,239,781 - 71,263,915 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11174,540,025 - 74,560,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,540,169 - 74,560,024 (-)Ensemblpanpan1.1panPan2
WNT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,442,496 - 22,463,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2122,648,814 - 22,665,904 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBIUU_Cfam_GSD_1.0
Wnt11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,309,313 - 63,329,371 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,908,978 - 4,927,165 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,909,041 - 4,927,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,413,263 - 10,435,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,413,182 - 10,435,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,487,189 - 11,509,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,393,975 - 67,427,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,399,074 - 67,418,509 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604358,377,747 - 58,402,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624817932,970 - 952,326 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624817931,686 - 952,474 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wnt11
72 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:355
Count of miRNA genes:194
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000021674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat

Markers in Region
D1Mgh8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,136,852 - 153,136,969 (+)MAPPERmRatBN7.2
Rnor_6.01163,796,316 - 163,796,432NCBIRnor6.0
Rnor_5.01169,999,389 - 169,999,505UniSTSRnor5.0
RGSC_v3.41156,124,624 - 156,124,741RGDRGSC3.4
RGSC_v3.41156,124,625 - 156,124,741UniSTSRGSC3.4
RGSC_v3.11156,203,030 - 156,203,147RGD
Celera1151,223,327 - 151,223,443UniSTS
RH 3.4 Map11215.0UniSTS
RH 3.4 Map11215.0RGD
RH 2.0 Map1788.6RGD
Cytogenetic Map1q32UniSTS
RP_L27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,154,521 - 153,154,640 (+)MAPPERmRatBN7.2
Rnor_6.01163,813,984 - 163,814,102NCBIRnor6.0
Rnor_5.01170,017,057 - 170,017,175UniSTSRnor5.0
RGSC_v3.41156,142,293 - 156,142,411UniSTSRGSC3.4
Celera1151,240,957 - 151,241,075UniSTS
Cytogenetic Map1q32UniSTS
UniSTS:471854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,145,737 - 153,145,942 (+)MAPPERmRatBN7.2
Rnor_6.01163,805,200 - 163,805,404NCBIRnor6.0
Rnor_5.01170,008,273 - 170,008,477UniSTSRnor5.0
RGSC_v3.41156,133,509 - 156,133,713UniSTSRGSC3.4
Celera1151,232,211 - 151,232,415UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 18 11 2
Low 3 39 18 6 8 6 8 11 50 6 25 9 8
Below cutoff 25 21 11 21 24 11 5

Sequence


Ensembl Acc Id: ENSRNOT00000021674   ⟹   ENSRNOP00000021674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)Ensembl
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)Ensembl
RefSeq Acc Id: NM_080401   ⟹   NP_536326
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,549,360 - 162,565,456 (+)NCBI
mRatBN7.21153,138,197 - 153,154,294 (+)NCBI
Rnor_6.01163,797,660 - 163,813,756 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
RGSC_v3.41156,125,969 - 156,142,065 (+)RGD
Celera1151,224,671 - 151,240,729 (+)RGD
Sequence:
RefSeq Acc Id: XM_006229718   ⟹   XP_006229780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,545,660 - 162,564,758 (+)NCBI
mRatBN7.21153,134,503 - 153,153,554 (+)NCBI
Rnor_6.01163,794,136 - 163,813,751 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006229720   ⟹   XP_006229782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,547,414 - 162,564,758 (+)NCBI
mRatBN7.21153,136,144 - 153,153,554 (+)NCBI
Rnor_6.01163,794,543 - 163,813,751 (+)NCBI
Rnor_5.01169,997,286 - 170,016,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008759667   ⟹   XP_008757889
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,556,967 - 162,564,758 (+)NCBI
mRatBN7.21153,138,460 - 153,153,554 (+)NCBI
Rnor_6.01163,797,923 - 163,813,561 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270171   ⟹   XP_063126241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81162,546,552 - 162,564,758 (+)NCBI
RefSeq Acc Id: NP_536326   ⟸   NM_080401
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229780   ⟸   XM_006229718
- Peptide Label: isoform X1
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229782   ⟸   XM_006229720
- Peptide Label: isoform X1
- UniProtKB: G3V819 (UniProtKB/TrEMBL),   A6I6F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757889   ⟸   XM_008759667
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000021674   ⟸   ENSRNOT00000021674
RefSeq Acc Id: XP_063126241   ⟸   XM_063270171
- Peptide Label: isoform X1
- UniProtKB: A6I6F2 (UniProtKB/TrEMBL),   G3V819 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V819-F1-model_v2 AlphaFold G3V819 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621463 AgrOrtholog
BioCyc Gene G2FUF-58414 BioCyc
Ensembl Genes ENSRNOG00000015982 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021674.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/TrEMBL
InterPro Wnt UniProtKB/TrEMBL
  Wnt_C UniProtKB/TrEMBL
  Wnt_grthfactor_CS UniProtKB/TrEMBL
KEGG Report rno:140584 UniProtKB/TrEMBL
NCBI Gene 140584 ENTREZGENE
PANTHER PTHR12027:SF7 UniProtKB/TrEMBL
  Wnt UniProtKB/TrEMBL
Pfam wnt UniProtKB/TrEMBL
PhenoGen Wnt11 PhenoGen
PRINTS WNTPROTEIN UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015982 RatGTEx
SMART WNT1 UniProtKB/TrEMBL
UniProt A6I6F2 ENTREZGENE, UniProtKB/TrEMBL
  G3V819 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-29 Wnt11  Wnt family member 11  Wnt11  wingless-type MMTV integration site family, member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-14 Wnt11  wingless-type MMTV integration site family, member 11  Wnt11  wingless-related MMTV integration site 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Wnt11  wingless-related MMTV integration site 11  Wnt11  wingless-type MMTV integration site family, member 11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-08-07 Wnt11  wingless-type MMTV integration site family, member 11      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the Wnt family of secreted glycoproteins 727217