WNT11 (Wnt family member 11) - Rat Genome Database

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Gene: WNT11 (Wnt family member 11) Canis lupus familiaris
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Symbol: WNT11
Name: Wnt family member 11
RGD ID: 12104415
Description: ENCODES a protein that exhibits GTPase activator activity (inferred); protein kinase activator activity (inferred); INVOLVED IN artery morphogenesis (ortholog); bicellular tight junction assembly (ortholog); bone mineralization (ortholog); PARTICIPATES IN the Wnt/calcium signaling pathway; Wnt signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); Animal Disease Models (ortholog); bladder exstrophy-epispadias-cloacal exstrophy complex (ortholog); FOUND IN extracellular region (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: protein Wnt-11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,442,496 - 22,463,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBI
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBI
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBI
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBI
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
adrenal gland development  (IEA)
artery morphogenesis  (IEA,ISO)
atrial septum development  (IEA)
bicellular tight junction assembly  (IEA,ISO)
bone mineralization  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (ISO)
cell fate commitment  (IBA)
cellular response to mechanical stimulus  (IEA,ISO)
cloacal septation  (IEA)
convergent extension involved in axis elongation  (IEA,ISO)
embryonic skeletal system development  (IEA)
epithelial to mesenchymal transition  (IEA,ISO)
kidney development  (ISO)
lung-associated mesenchyme development  (IEA)
maintenance of epithelial cell apical/basal polarity  (IEA,ISO)
mesonephric duct development  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of fibroblast growth factor production  (IEA,ISO)
negative regulation of mesenchymal cell proliferation  (IEA,ISO)
negative regulation of transcription, DNA-templated  (IEA)
neuroendocrine cell differentiation  (IEA)
neuron differentiation  (IBA)
non-canonical Wnt signaling pathway  (ISO)
notochord morphogenesis  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
paraxial mesoderm formation  (IEA,ISO)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in gastrula mediolateral intercalation  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell migration  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of GTPase activity  (IEA)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of protein kinase C signaling  (IEA)
positive regulation of stress fiber assembly  (IEA)
positive regulation of transcription, DNA-templated  (IEA)
positive regulation of transforming growth factor beta2 production  (IEA,ISO)
primary heart field specification  (IEA)
protein localization to cell surface  (IEA)
protein phosphorylation  (IEA)
response to nutrient levels  (ISO)
roof of mouth development  (ISO)
secondary heart field specification  (IEA)
secondary palate development  (IEA)
somite development  (IEA,ISO)
ureteric bud morphogenesis  (IEA)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
WNT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,442,496 - 22,463,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBI
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBI
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBI
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBI
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBI
WNT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1176,186,325 - 76,210,736 (-)EnsemblGRCh38hg38GRCh38
GRCh381176,186,325 - 76,210,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371175,897,369 - 75,917,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,575,018 - 75,595,222 (-)NCBINCBI36hg18NCBI36
Build 341175,575,017 - 75,595,222NCBI
Celera1173,205,187 - 73,225,391 (-)NCBI
Cytogenetic Map11q13.5NCBI
HuRef1172,194,546 - 72,214,753 (-)NCBIHuRef
CHM1_11175,780,888 - 75,801,091 (-)NCBICHM1_1
Wnt11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,484,293 - 98,503,954 (+)NCBIGRCm39mm39
GRCm39 Ensembl798,484,319 - 98,504,402 (+)Ensembl
GRCm38798,835,084 - 98,854,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,835,112 - 98,855,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,987,355 - 106,003,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv36798,714,037 - 98,728,940 (+)NCBImm8
Celera799,160,445 - 99,176,286 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.9NCBI
Wnt11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Celera1151,224,671 - 151,240,729 (+)NCBICelera
Cytogenetic Map1q32NCBI
Wnt11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,674,940 - 15,694,883 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,674,478 - 15,694,758 (+)NCBIChiLan1.0ChiLan1.0
WNT11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11174,540,025 - 74,560,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,540,169 - 74,560,024 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01171,239,781 - 71,263,915 (-)NCBIMhudiblu_PPA_v0panPan3
Wnt11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,309,313 - 63,329,371 (-)NCBI
SpeTri2.0NW_0049364984,909,041 - 4,927,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,413,187 - 10,435,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,413,182 - 10,435,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,487,189 - 11,509,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,393,975 - 67,427,247 (-)NCBI
ChlSab1.1167,393,975 - 67,427,247 (-)NCBI
ChlSab1.1 Ensembl167,399,074 - 67,418,509 (-)Ensembl
Vero_WHO_p1.0NW_02366604358,377,747 - 58,402,147 (+)NCBI
Wnt11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624817931,686 - 952,474 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 6 1 4
Low 4 5 7 6 5 8 9 2
Below cutoff 1 11 5 6 5 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000008531   ⟹   ENSCAFP00000007907
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)Ensembl
RefSeq Acc Id: XM_038430036   ⟹   XP_038285964
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBI
RefSeq Acc Id: XM_038505428   ⟹   XP_038361356
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBI
RefSeq Acc Id: XM_038568579   ⟹   XP_038424507
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBI
RefSeq Acc Id: XM_038632738   ⟹   XP_038488666
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBI
RefSeq Acc Id: XM_542301   ⟹   XP_542301
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12122,442,496 - 22,463,040 (+)NCBI
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038285964 (Get FASTA)   NCBI Sequence Viewer  
  XP_038361356 (Get FASTA)   NCBI Sequence Viewer  
  XP_038424507 (Get FASTA)   NCBI Sequence Viewer  
  XP_038488666 (Get FASTA)   NCBI Sequence Viewer  
  XP_542301 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_542301   ⟸   XM_542301
- UniProtKB: E2QXQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000007907   ⟸   ENSCAFT00000008531
RefSeq Acc Id: XP_038361356   ⟸   XM_038505428
RefSeq Acc Id: XP_038488666   ⟸   XM_038632738
RefSeq Acc Id: XP_038285964   ⟸   XM_038430036
RefSeq Acc Id: XP_038424507   ⟸   XM_038568579


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005291 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000007907 ENTREZGENE
NCBI Gene WNT11 ENTREZGENE
UniProt E2QXQ3 ENTREZGENE
VGNC ID VGNC:48421 ENTREZGENE