WNT11 (Wnt family member 11) - Rat Genome Database

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Gene: WNT11 (Wnt family member 11) Homo sapiens
Analyze
Symbol: WNT11
Name: Wnt family member 11
RGD ID: 1344477
HGNC Page HGNC
Description: Enables GTPase activator activity and protein kinase activator activity. Involved in several processes, including regulation of cell migration; regulation of gene expression; and urogenital system development. Located in cytoplasm. Biomarker of renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HWNT11; MGC141946; MGC141948; protein Wnt-11; wingless-type MMTV integration site family member 11; wingless-type MMTV integration site family, member 11
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1176,186,325 - 76,210,736 (-)EnsemblGRCh38hg38GRCh38
GRCh381176,186,325 - 76,210,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371175,897,369 - 75,917,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,575,018 - 75,595,222 (-)NCBINCBI36hg18NCBI36
Build 341175,575,017 - 75,595,222NCBI
Celera1173,205,187 - 73,225,391 (-)NCBI
Cytogenetic Map11q13.5NCBI
HuRef1172,194,546 - 72,214,753 (-)NCBIHuRef
CHM1_11175,780,888 - 75,801,091 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
adrenal gland development  (IEP)
artery morphogenesis  (IEA,ISO)
atrial septum development  (IEA)
bicellular tight junction assembly  (IEA,ISO)
bone mineralization  (IEA,ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell differentiation  (ISO)
cell fate commitment  (IBA)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to retinoic acid  (ISS)
cloacal septation  (IEP)
convergent extension involved in axis elongation  (IEA,ISO)
embryonic skeletal system development  (IEP)
epithelial to mesenchymal transition  (IEA,ISO)
kidney development  (ISO)
lung-associated mesenchyme development  (IEP)
maintenance of epithelial cell apical/basal polarity  (IEA,ISO)
mesonephric duct development  (IEP)
negative regulation of apoptotic process  (IMP)
negative regulation of canonical Wnt signaling pathway  (IMP,ISO)
negative regulation of cartilage development  (NAS)
negative regulation of cell death  (IMP)
negative regulation of cell growth  (IMP)
negative regulation of cell migration  (IMP)
negative regulation of fibroblast growth factor production  (IEA,ISO)
negative regulation of mesenchymal cell proliferation  (IEA,ISO)
negative regulation of transcription, DNA-templated  (IMP)
neuroendocrine cell differentiation  (IMP)
neuron differentiation  (IBA,ISS)
non-canonical Wnt signaling pathway  (ISO)
notochord morphogenesis  (IEA,ISO)
osteoblast differentiation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
paraxial mesoderm formation  (IEA,ISO)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in gastrula mediolateral intercalation  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of cell migration  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of GTPase activity  (IMP)
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of protein kinase C signaling  (IMP)
positive regulation of stress fiber assembly  (IMP)
positive regulation of transcription, DNA-templated  (IMP)
positive regulation of transforming growth factor beta2 production  (IEA,ISO)
primary heart field specification  (IEA)
protein localization to cell surface  (IMP)
protein phosphorylation  (IMP)
response to nutrient levels  (IEA,ISO)
roof of mouth development  (ISO)
secondary heart field specification  (IEA)
secondary palate development  (IMP)
somite development  (IEA,ISO)
ureteric bud morphogenesis  (IEP)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (IEA,ISO)
Wnt signaling pathway  (IEA)
Wnt signaling pathway, calcium modulating pathway  (NAS)
Wnt signaling pathway, planar cell polarity pathway  (NAS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

Additional References at PubMed
PMID:8167409   PMID:9757009   PMID:12477932   PMID:15489334   PMID:15543138   PMID:15701629   PMID:15708567   PMID:16303743   PMID:17967789   PMID:18413325   PMID:18572162   PMID:19265664  
PMID:19453261   PMID:19847889   PMID:20062060   PMID:20103596   PMID:20219091   PMID:20379614   PMID:20819778   PMID:20870744   PMID:20890934   PMID:21242973   PMID:21280163   PMID:21873635  
PMID:21903761   PMID:22161723   PMID:22715413   PMID:23549873   PMID:24082114   PMID:24431302   PMID:24606488   PMID:24737009   PMID:25416956   PMID:26261605   PMID:26818191   PMID:27034261  
PMID:27386628   PMID:27422998   PMID:27628667   PMID:27932350   PMID:28514442   PMID:28515276   PMID:29244788   PMID:29427622   PMID:29717114   PMID:29753625   PMID:29872092   PMID:29955137  
PMID:30537177   PMID:30886144   PMID:31231131   PMID:31718047   PMID:31756673   PMID:32147424   PMID:32296183   PMID:32460013   PMID:32513696   PMID:32635983   PMID:33137935  


Genomics

Comparative Map Data
WNT11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1176,186,325 - 76,210,736 (-)EnsemblGRCh38hg38GRCh38
GRCh381176,186,325 - 76,210,842 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371175,897,369 - 75,917,546 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,575,018 - 75,595,222 (-)NCBINCBI36hg18NCBI36
Build 341175,575,017 - 75,595,222NCBI
Celera1173,205,187 - 73,225,391 (-)NCBI
Cytogenetic Map11q13.5NCBI
HuRef1172,194,546 - 72,214,753 (-)NCBIHuRef
CHM1_11175,780,888 - 75,801,091 (-)NCBICHM1_1
Wnt11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,484,293 - 98,503,954 (+)NCBIGRCm39mm39
GRCm39 Ensembl798,484,319 - 98,504,402 (+)Ensembl
GRCm38798,835,084 - 98,854,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,835,112 - 98,855,195 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,987,355 - 106,003,257 (+)NCBIGRCm37mm9NCBIm37
MGSCv36798,714,037 - 98,728,940 (+)NCBImm8
Celera799,160,445 - 99,176,286 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.9NCBI
Wnt11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21153,134,503 - 153,154,294 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1153,138,197 - 153,154,294 (+)Ensembl
Rnor_6.01163,794,136 - 163,813,756 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,797,660 - 163,813,756 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,997,286 - 170,016,829 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41156,125,969 - 156,142,065 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11156,213,816 - 156,216,652 (+)NCBI
Celera1151,224,671 - 151,240,729 (+)NCBICelera
Cytogenetic Map1q32NCBI
Wnt11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,674,940 - 15,694,883 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,674,478 - 15,694,758 (+)NCBIChiLan1.0ChiLan1.0
WNT11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11174,540,025 - 74,560,024 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1174,540,169 - 74,560,024 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01171,239,781 - 71,263,915 (-)NCBIMhudiblu_PPA_v0panPan3
WNT11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,442,496 - 22,463,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,446,051 - 22,463,173 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2122,210,200 - 22,227,251 (+)NCBI
ROS_Cfam_1.02122,648,822 - 22,665,821 (+)NCBI
UMICH_Zoey_3.12122,423,226 - 22,440,217 (+)NCBI
UNSW_CanFamBas_1.02122,642,741 - 22,659,738 (+)NCBI
UU_Cfam_GSD_1.02122,561,731 - 22,578,745 (+)NCBI
Wnt11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,309,313 - 63,329,371 (-)NCBI
SpeTri2.0NW_0049364984,909,041 - 4,927,482 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,413,187 - 10,435,100 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,413,182 - 10,435,158 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,487,189 - 11,509,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,393,975 - 67,427,247 (-)NCBI
ChlSab1.1167,393,975 - 67,427,247 (-)NCBI
ChlSab1.1 Ensembl167,399,074 - 67,418,509 (-)Ensembl
Vero_WHO_p1.0NW_02366604358,377,747 - 58,402,147 (+)NCBI
Wnt11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624817931,686 - 952,474 (+)NCBI

Position Markers
D11S2457  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,903,011 - 75,903,175UniSTSGRCh37
Build 361175,580,659 - 75,580,823RGDNCBI36
Celera1173,210,828 - 73,210,992RGD
Cytogenetic Map11q13.5UniSTS
HuRef1172,200,188 - 72,200,352UniSTS
SHGC-36303  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,897,406 - 75,897,506UniSTSGRCh37
Build 361175,575,054 - 75,575,154RGDNCBI36
Celera1173,205,223 - 73,205,323RGD
Cytogenetic Map11q13.5UniSTS
HuRef1172,194,582 - 72,194,682UniSTS
Stanford-G3 RH Map113343.0UniSTS
NCBI RH Map11632.6UniSTS
GeneMap99-G3 RH Map113343.0UniSTS
STS-W81325  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,897,728 - 75,897,855UniSTSGRCh37
Build 361175,575,376 - 75,575,503RGDNCBI36
Celera1173,205,545 - 73,205,672RGD
Cytogenetic Map11q13.5UniSTS
HuRef1172,194,904 - 72,195,031UniSTS
GeneMap99-GB4 RH Map11274.08UniSTS
NCBI RH Map11631.8UniSTS
WNT11_3888  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371175,897,288 - 75,897,814UniSTSGRCh37
Build 361175,574,936 - 75,575,462RGDNCBI36
Celera1173,205,105 - 73,205,631RGD
HuRef1172,194,464 - 72,194,990UniSTS
SGC44542  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11q13.5UniSTS
GeneMap99-GB4 RH Map11271.36UniSTS
Whitehead-RH Map11370.7UniSTS
NCBI RH Map11626.7UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1104
Count of miRNA genes:614
Interacting mature miRNAs:696
Transcripts:ENST00000322563, ENST00000529461, ENST00000532150
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 1
Medium 245 521 874 57 80 47 1684 201 216 42 252 847 12 1183 849 3
Low 2004 2074 777 510 1204 363 2495 1957 2545 188 1142 644 153 21 1939 1
Below cutoff 175 382 63 52 543 51 153 30 935 166 46 95 7 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_046931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011545240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024448678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002957190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB070218 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC113388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ970138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF800675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ715612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ715613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y13847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000322563   ⟹   ENSP00000325526
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1176,186,325 - 76,206,502 (-)Ensembl
RefSeq Acc Id: ENST00000529461   ⟹   ENSP00000436140
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1176,206,392 - 76,210,736 (-)Ensembl
RefSeq Acc Id: ENST00000532150
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1176,206,422 - 76,210,730 (-)Ensembl
RefSeq Acc Id: ENST00000621122   ⟹   ENSP00000483229
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1176,187,065 - 76,206,407 (-)Ensembl
RefSeq Acc Id: NM_004626   ⟹   NP_004617
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,325 - 76,206,502 (-)NCBI
GRCh371175,897,370 - 75,921,803 (-)NCBI
Build 361175,575,018 - 75,595,222 (-)NCBI Archive
HuRef1172,194,546 - 72,214,753 (-)ENTREZGENE
CHM1_11175,780,888 - 75,801,091 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005274231   ⟹   XP_005274288
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,210,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011545238   ⟹   XP_011543540
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,210,759 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011545239   ⟹   XP_011543541
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,210,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011545240   ⟹   XP_011543542
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,210,842 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024448678   ⟹   XP_024304446
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,206,498 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002957190
RefSeq Status:
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,186,396 - 76,208,733 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_004617   ⟸   NM_004626
- Peptide Label: precursor
- UniProtKB: O96014 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005274288   ⟸   XM_005274231
- Peptide Label: isoform X2
- UniProtKB: O96014 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011543542   ⟸   XM_011545240
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011543541   ⟸   XM_011545239
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011543540   ⟸   XM_011545238
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024304446   ⟸   XM_024448678
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000483229   ⟸   ENST00000621122
RefSeq Acc Id: ENSP00000325526   ⟸   ENST00000322563
RefSeq Acc Id: ENSP00000436140   ⟸   ENST00000529461

Promoters
RGD ID:6789581
Promoter ID:HG_KWN:13760
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:NM_004626
Position:
Human AssemblyChrPosition (strand)Source
Build 361175,594,961 - 75,595,461 (-)MPROMDB
RGD ID:6814508
Promoter ID:HG_XEF:1535
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3
Transcripts:NM_001082456
Position:
Human AssemblyChrPosition (strand)Source
Build 361175,597,606 - 75,598,127 (-)MPROMDB
RGD ID:6789583
Promoter ID:HG_KWN:13761
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   CD4+TCell_2Hour
Transcripts:UC001OXF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361175,599,114 - 75,599,614 (-)MPROMDB
RGD ID:7221595
Promoter ID:EPDNEW_H16543
Type:initiation region
Name:WNT11_1
Description:Wnt family member 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381176,206,502 - 76,206,562EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.4-14.1(chr11:71923251-79662025)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052684]|See cases [RCV000052684] Chr11:71923251..79662025 [GRCh38]
Chr11:71634297..79373069 [GRCh37]
Chr11:71311945..79050717 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
GRCh38/hg38 11q13.4-13.5(chr11:71928796-77064521)x1 copy number loss See cases [RCV000052708] Chr11:71928796..77064521 [GRCh38]
Chr11:71639842..76751808 [GRCh37]
Chr11:71317490..76453216 [NCBI36]
Chr11:11q13.4-13.5
pathogenic
GRCh38/hg38 11q13.4-14.1(chr11:71969881-78232895)x1 copy number loss See cases [RCV000052709] Chr11:71969881..78232895 [GRCh38]
Chr11:71680927..77943941 [GRCh37]
Chr11:71358575..77621589 [NCBI36]
Chr11:11q13.4-14.1
pathogenic
NM_004626.2(WNT11):c.278C>T (p.Ser93Phe) single nucleotide variant Malignant melanoma [RCV000069695] Chr11:76196524 [GRCh38]
Chr11:75907568 [GRCh37]
Chr11:75585216 [NCBI36]
Chr11:11q13.5
not provided
NM_004626.2(WNT11):c.246G>A (p.Arg82=) single nucleotide variant Malignant melanoma [RCV000069696] Chr11:76196556 [GRCh38]
Chr11:75907600 [GRCh37]
Chr11:75585248 [NCBI36]
Chr11:11q13.5
not provided
NM_004626.2(WNT11):c.83+2925G>T single nucleotide variant Lung cancer [RCV000110264] Chr11:76203400 [GRCh38]
Chr11:75914444 [GRCh37]
Chr11:11q13.5
uncertain significance
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3
pathogenic
GRCh38/hg38 11q13.5-22.1(chr11:75941754-98357960)x1 copy number loss See cases [RCV000133838] Chr11:75941754..98357960 [GRCh38]
Chr11:75652798..98228688 [GRCh37]
Chr11:75330446..97733898 [NCBI36]
Chr11:11q13.5-22.1
pathogenic
NM_004626.3(WNT11):c.947G>A (p.Arg316His) single nucleotide variant Exstrophy-epispadias complex [RCV000172903] Chr11:76187183 [GRCh38]
Chr11:75898227 [GRCh37]
Chr11:11q13.5
uncertain significance
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25
pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25
pathogenic
NM_004626.3(WNT11):c.813G>A (p.Ser271=) single nucleotide variant not provided [RCV000965209] Chr11:76191641 [GRCh38]
Chr11:75902685 [GRCh37]
Chr11:11q13.5
benign
NM_004626.3(WNT11):c.361G>A (p.Ala121Thr) single nucleotide variant not provided [RCV000965210] Chr11:76194803 [GRCh38]
Chr11:75905847 [GRCh37]
Chr11:11q13.5
benign
NM_004626.3(WNT11):c.813G>T (p.Ser271=) single nucleotide variant not provided [RCV000974102] Chr11:76191641 [GRCh38]
Chr11:75902685 [GRCh37]
Chr11:11q13.5
benign
NM_004626.3(WNT11):c.216C>T (p.Ala72=) single nucleotide variant not provided [RCV000907287] Chr11:76196586 [GRCh38]
Chr11:75907630 [GRCh37]
Chr11:11q13.5
benign
NM_004626.3(WNT11):c.633C>T (p.Cys211=) single nucleotide variant not provided [RCV000909277] Chr11:76191821 [GRCh38]
Chr11:75902865 [GRCh37]
Chr11:11q13.5
benign

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12776 AgrOrtholog
COSMIC WNT11 COSMIC
Ensembl Genes ENSG00000085741 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000325526 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000483229 UniProtKB/TrEMBL
Ensembl Transcript ENST00000322563 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000621122 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000085741 GTEx
HGNC ID HGNC:12776 ENTREZGENE
Human Proteome Map WNT11 Human Proteome Map
InterPro Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt-11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot
KEGG Report hsa:7481 UniProtKB/Swiss-Prot
NCBI Gene 7481 ENTREZGENE
OMIM 603699 OMIM
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12027:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37378 PharmGKB
PRINTS WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H8YS97_HUMAN UniProtKB/TrEMBL
  O96014 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2R8Z6 UniProtKB/Swiss-Prot
  Q14DE8 UniProtKB/Swiss-Prot
  Q8WZ98 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 WNT11  Wnt family member 11  WNT11  wingless-type MMTV integration site family member 11  Symbol and/or name change 5135510 APPROVED
2015-11-24 WNT11  wingless-type MMTV integration site family member 11  WNT11  wingless-type MMTV integration site family, member 11  Symbol and/or name change 5135510 APPROVED