Tmpo (thymopoietin) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tmpo (thymopoietin) Rattus norvegicus
Analyze
Symbol: Tmpo (Ensembl: Slc25a3)
Name: thymopoietin (Ensembl:solute carrier family 25 member 3)
RGD ID: 3875
Description: Predicted to enable identical protein binding activity. Predicted to be involved in nuclear membrane reassembly. Predicted to act upstream of or within regulation of DNA-templated transcription. Located in nuclear inner membrane. Orthologous to human TMPO (thymopoietin); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamina-associated polypeptide 2; lamina-associated polypeptide 2, isoform beta; LAP2; Thymopoietin (lamina associated polypeptide 2); thymopoietin isoform beta; TP beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,529,977 - 27,554,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl727,529,978 - 27,554,937 (-)EnsemblGRCr8
mRatBN7.2725,642,752 - 25,667,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx727,637,188 - 27,662,145 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,799,573 - 29,824,530 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,576,981 - 29,601,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,847,412 - 31,872,416 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)Ensemblrn6Rnor6.0
Rnor_5.0731,934,412 - 31,959,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4728,086,576 - 28,111,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera722,769,113 - 22,794,062 (-)NCBICelera
RGSC_v3.1728,106,846 - 28,132,071 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
aconitine  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitroglycerin  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. Dechat T, etal., J Cell Sci. 2004 Dec 1;117(Pt 25):6117-28. Epub 2004 Nov 16.
2. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. Furukawa K, etal., EMBO J 1995 Apr 18;14(8):1626-36.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, etal., J Cell Biol. 1997 Jun 16;137(6):1199-210.
Additional References at PubMed
PMID:9305626   PMID:11591818   PMID:16760672   PMID:17284516   PMID:17562312   PMID:18809722   PMID:19946888   PMID:25468996   PMID:35352799  


Genomics

Comparative Map Data
Tmpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,529,977 - 27,554,980 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl727,529,978 - 27,554,937 (-)EnsemblGRCr8
mRatBN7.2725,642,752 - 25,667,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx727,637,188 - 27,662,145 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,799,573 - 29,824,530 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,576,981 - 29,601,936 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,847,412 - 31,872,416 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)Ensemblrn6Rnor6.0
Rnor_5.0731,934,412 - 31,959,343 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4728,086,576 - 28,111,800 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera722,769,113 - 22,794,062 (-)NCBICelera
RGSC_v3.1728,106,846 - 28,132,071 (-)NCBI
Cytogenetic Map7q13NCBI
TMPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,515,573 - 98,550,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,515,561 - 98,550,351 (+)Ensemblhg38GRCh38
GRCh371298,909,351 - 98,944,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,433,540 - 97,466,866 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341297,411,909 - 97,430,789NCBI
Celera1298,573,064 - 98,608,807 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1295,970,915 - 96,005,626 (+)NCBIHuRef
CHM1_11298,874,305 - 98,909,119 (+)NCBICHM1_1
T2T-CHM13v2.01298,488,849 - 98,523,648 (+)NCBIT2T-CHM13v2.0
Tmpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,983,433 - 91,017,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,983,433 - 91,017,177 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381091,147,571 - 91,181,752 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1091,147,571 - 91,181,315 (-)Ensemblmm10GRCm38
MGSCv371090,610,316 - 90,634,327 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361090,591,557 - 90,601,334 (-)NCBIMGSCv36mm8
Celera1093,141,641 - 93,165,652 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.66NCBI
Tmpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,535,306 - 34,554,835 (+)Ensembl
ChiLan1.0NW_00495540534,526,420 - 34,556,740 (+)NCBIChiLan1.0ChiLan1.0
TMPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,581,193 - 106,618,955 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,577,581 - 106,615,344 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,100,509 - 96,135,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,513,335 - 99,547,506 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,514,803 - 99,546,535 (+)EnsemblpanPan2panpan1.1
TMPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11537,923,392 - 37,959,979 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1537,932,891 - 37,959,246 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1538,305,113 - 38,342,820 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01538,586,847 - 38,624,544 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,596,088 - 38,624,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,858,711 - 37,896,405 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01537,951,431 - 37,989,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,224,990 - 38,260,912 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,961,559 - 21,989,703 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,971,968 - 15,000,060 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,972,391 - 15,000,115 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,315,290 - 85,346,538 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1585,317,648 - 85,346,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,640,642 - 89,669,567 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,815,870 - 93,852,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,817,820 - 93,853,703 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037151,219,876 - 151,256,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247509,009,085 - 9,036,747 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247509,009,085 - 9,036,713 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmpo
146 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:111
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000012715
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
AW214352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,642,903 - 25,643,036 (+)MAPPERmRatBN7.2
Rnor_6.0731,847,564 - 31,847,696NCBIRnor6.0
Rnor_5.0731,934,563 - 31,934,695UniSTSRnor5.0
RGSC_v3.4728,086,727 - 28,086,859UniSTSRGSC3.4
Celera722,769,264 - 22,769,396UniSTS
Cytogenetic Map7q13UniSTS
RH128337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,655,577 - 25,655,774 (+)MAPPERmRatBN7.2
Rnor_6.0731,860,238 - 31,860,434NCBIRnor6.0
Rnor_5.0731,947,234 - 31,947,430UniSTSRnor5.0
RGSC_v3.4728,099,401 - 28,099,597UniSTSRGSC3.4
Celera722,781,922 - 22,782,118UniSTS
Cytogenetic Map7q13UniSTS
AI008347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,651,255 - 25,651,892 (+)MAPPERmRatBN7.2
mRatBN7.2725,651,704 - 25,651,892 (+)MAPPERmRatBN7.2
Rnor_6.0731,856,365 - 31,856,552NCBIRnor6.0
Rnor_6.0731,855,916 - 31,856,552NCBIRnor6.0
Rnor_5.0731,943,361 - 31,943,548UniSTSRnor5.0
Rnor_5.0731,942,912 - 31,943,548UniSTSRnor5.0
RGSC_v3.4728,095,079 - 28,095,715UniSTSRGSC3.4
RGSC_v3.4728,095,528 - 28,095,715UniSTSRGSC3.4
Celera722,778,049 - 22,778,236UniSTS
Celera722,777,600 - 22,778,236UniSTS
RH 3.4 Map7154.3UniSTS
Cytogenetic Map7q13UniSTS
Tmpo  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,657,134 - 25,658,124 (+)MAPPERmRatBN7.2
Rnor_6.0731,861,795 - 31,862,784NCBIRnor6.0
Rnor_5.0731,948,791 - 31,949,780UniSTSRnor5.0
RGSC_v3.4728,100,958 - 28,101,947UniSTSRGSC3.4
Celera722,783,479 - 22,784,468UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 83 215 91 90 59 155 59 6 476 280 20 194 106 124 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000011494   ⟹   ENSRNOP00000011494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,586,725 - 25,619,394 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000012715   ⟹   ENSRNOP00000012715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,529,978 - 27,554,937 (-)Ensembl
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080824   ⟹   ENSRNOP00000070805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,611,938 - 25,619,401 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095834   ⟹   ENSRNOP00000092044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,542,777 - 27,554,935 (-)Ensembl
mRatBN7.2 Ensembl725,655,558 - 25,667,702 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097150   ⟹   ENSRNOP00000084254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111659   ⟹   ENSRNOP00000090294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl727,529,978 - 27,554,937 (-)Ensembl
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112365   ⟹   ENSRNOP00000078350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113184   ⟹   ENSRNOP00000091703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,611,937 - 25,619,383 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113551   ⟹   ENSRNOP00000087575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)Ensembl
RefSeq Acc Id: NM_001395714   ⟹   NP_001382643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,542,777 - 27,554,935 (-)NCBI
mRatBN7.2725,655,553 - 25,667,711 (-)NCBI
RefSeq Acc Id: NM_001395715   ⟹   NP_001382644
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,978 - 27,554,935 (-)NCBI
mRatBN7.2725,642,753 - 25,667,711 (-)NCBI
RefSeq Acc Id: NM_012887   ⟹   NP_037019
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,978 - 27,554,935 (-)NCBI
mRatBN7.2725,642,753 - 25,667,711 (-)NCBI
Rnor_6.0731,847,413 - 31,872,371 (-)NCBI
Rnor_5.0731,934,412 - 31,959,343 (-)NCBI
RGSC_v3.4728,086,576 - 28,111,800 (-)RGD
Celera722,769,113 - 22,794,062 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765219   ⟹   XP_008763441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,977 - 27,554,980 (-)NCBI
mRatBN7.2725,642,752 - 25,667,756 (-)NCBI
Rnor_6.0731,847,412 - 31,872,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078463   ⟹   XP_038934391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,977 - 27,554,980 (-)NCBI
mRatBN7.2725,642,752 - 25,667,756 (-)NCBI
RefSeq Acc Id: NP_037019   ⟸   NM_012887
- Peptide Label: isoform 2
- UniProtKB: Q62733 (UniProtKB/Swiss-Prot),   A6IFV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763441   ⟸   XM_008765219
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZ38 (UniProtKB/TrEMBL),   A6IFV7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012715   ⟸   ENSRNOT00000012715
RefSeq Acc Id: XP_038934391   ⟸   XM_039078463
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADD0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090294   ⟸   ENSRNOT00000111659
Ensembl Acc Id: ENSRNOP00000070805   ⟸   ENSRNOT00000080824
Ensembl Acc Id: ENSRNOP00000084254   ⟸   ENSRNOT00000097150
Ensembl Acc Id: ENSRNOP00000011494   ⟸   ENSRNOT00000011494
Ensembl Acc Id: ENSRNOP00000078350   ⟸   ENSRNOT00000112365
Ensembl Acc Id: ENSRNOP00000087575   ⟸   ENSRNOT00000113551
Ensembl Acc Id: ENSRNOP00000091703   ⟸   ENSRNOT00000113184
Ensembl Acc Id: ENSRNOP00000092044   ⟸   ENSRNOT00000095834
RefSeq Acc Id: NP_001382644   ⟸   NM_001395715
- Peptide Label: isoform 3
- UniProtKB: A0A8I6G2M4 (UniProtKB/TrEMBL),   A6IFV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382643   ⟸   NM_001395714
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AFR4 (UniProtKB/TrEMBL),   A6IFV9 (UniProtKB/TrEMBL)
Protein Domains
LEM   LEM-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62733-F1-model_v2 AlphaFold Q62733 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695142
Promoter ID:EPDNEW_R5667
Type:initiation region
Name:Tmpo_1
Description:thymopoietin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0731,872,353 - 31,872,413EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3875 AgrOrtholog
BioCyc Gene G2FUF-34462 BioCyc
Ensembl Genes ENSRNOG00000008797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012715 ENTREZGENE
  ENSRNOT00000012715.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095834 ENTREZGENE
  ENSRNOT00000111659 ENTREZGENE
Gene3D-CATH 1.10.720.40 UniProtKB/Swiss-Prot
InterPro LEM-like_dom UniProtKB/Swiss-Prot
  LEM/LEM-like_dom_sf UniProtKB/Swiss-Prot
  LEM_dom UniProtKB/Swiss-Prot
  LEM_domain UniProtKB/Swiss-Prot
NCBI Gene 25359 ENTREZGENE
PANTHER LAMINA-ASSOCIATED POLYPEPTIDE 2, ISOFORM BETA UniProtKB/Swiss-Prot
  LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN UniProtKB/Swiss-Prot
Pfam LEM UniProtKB/Swiss-Prot
  Thymopoietin UniProtKB/Swiss-Prot
PhenoGen Tmpo PhenoGen
PROSITE LEM UniProtKB/Swiss-Prot
  LEM_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008797 RatGTEx
SMART LEM UniProtKB/Swiss-Prot
  Thymopoietin UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63451 UniProtKB/Swiss-Prot
TIGR TC204234
UniProt A0A8I5ZZ38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GF99_RAT UniProtKB/TrEMBL
  A6IFV6 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV7 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV8 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV9 ENTREZGENE, UniProtKB/TrEMBL
  LAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tmpo  thymopoietin    Thymopoietin (lamina associated polypeptide 2)  Name updated 629478 APPROVED
2002-06-10 Tmpo  Thymopoietin (lamina associated polypeptide 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the inner nuclear membrane 634476
gene_domains contains a large hydrophilic domain with several potential cdc2 kinase phosphorylation sites and a single putative membrane-spanning sequence 634476