Tmpo (thymopoietin) - Rat Genome Database

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Gene: Tmpo (thymopoietin) Rattus norvegicus
Analyze
Symbol: Tmpo
Name: thymopoietin
RGD ID: 3875
Description: Predicted to enable identical protein binding activity. Predicted to act upstream of or within regulation of DNA-templated transcription. Located in nuclear inner membrane. Orthologous to human TMPO (thymopoietin); INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lamina-associated polypeptide 2; lamina-associated polypeptide 2, isoform beta; LAP2; Thymopoietin (lamina associated polypeptide 2); thymopoietin isoform beta; TP beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,529,977 - 27,554,980 (-)NCBIGRCr8
mRatBN7.2725,642,752 - 25,667,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx727,637,188 - 27,662,145 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,799,573 - 29,824,530 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,576,981 - 29,601,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,847,412 - 31,872,416 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0731,934,412 - 31,959,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4728,086,576 - 28,111,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1728,106,846 - 28,132,071 (-)NCBI
Celera722,769,113 - 22,794,062 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
5-azacytidine  (ISO)
7,12-dimethyltetraphene  (EXP)
aconitine  (EXP)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
hydrogen peroxide  (ISO)
isoflavones  (EXP)
ivermectin  (ISO)
ketamine  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
menadione  (ISO)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nitroglycerin  (EXP)
oxaliplatin  (EXP)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulindac sulfide  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tremolite asbestos  (ISO)
triadimefon  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly. Dechat T, etal., J Cell Sci. 2004 Dec 1;117(Pt 25):6117-28. Epub 2004 Nov 16.
2. Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope. Furukawa K, etal., EMBO J 1995 Apr 18;14(8):1626-36.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
11. Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. Yang L, etal., J Cell Biol. 1997 Jun 16;137(6):1199-210.
Additional References at PubMed
PMID:9305626   PMID:11591818   PMID:16760672   PMID:17284516   PMID:17562312   PMID:18809722   PMID:19946888   PMID:25468996   PMID:35352799  


Genomics

Comparative Map Data
Tmpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8727,529,977 - 27,554,980 (-)NCBIGRCr8
mRatBN7.2725,642,752 - 25,667,756 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx727,637,188 - 27,662,145 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0729,799,573 - 29,824,530 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0729,576,981 - 29,601,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0731,847,412 - 31,872,416 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0731,934,412 - 31,959,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4728,086,576 - 28,111,800 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1728,106,846 - 28,132,071 (-)NCBI
Celera722,769,113 - 22,794,062 (-)NCBICelera
Cytogenetic Map7q13NCBI
TMPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,515,573 - 98,550,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1298,515,579 - 98,550,351 (+)EnsemblGRCh38hg38GRCh38
GRCh371298,909,351 - 98,944,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,433,540 - 97,466,866 (+)NCBINCBI36Build 36hg18NCBI36
Build 341297,411,909 - 97,430,789NCBI
Celera1298,573,064 - 98,608,807 (+)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1295,970,915 - 96,005,626 (+)NCBIHuRef
CHM1_11298,874,305 - 98,909,119 (+)NCBICHM1_1
T2T-CHM13v2.01298,488,849 - 98,523,648 (+)NCBIT2T-CHM13v2.0
Tmpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391090,983,433 - 91,017,614 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1090,983,433 - 91,017,177 (-)EnsemblGRCm39 Ensembl
GRCm381091,147,571 - 91,181,752 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1091,147,571 - 91,181,315 (-)EnsemblGRCm38mm10GRCm38
MGSCv371090,610,316 - 90,634,327 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361090,591,557 - 90,601,334 (-)NCBIMGSCv36mm8
Celera1093,141,641 - 93,165,652 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1045.66NCBI
Tmpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540534,535,306 - 34,554,835 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540534,526,420 - 34,556,740 (+)NCBIChiLan1.0ChiLan1.0
TMPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210106,581,193 - 106,618,955 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112106,577,581 - 106,615,344 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01296,100,509 - 96,135,364 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11299,513,335 - 99,547,506 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1299,514,803 - 99,546,535 (+)Ensemblpanpan1.1panPan2
TMPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11537,923,392 - 37,959,979 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1537,932,891 - 37,959,246 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1538,305,113 - 38,342,820 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01538,586,847 - 38,624,544 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1538,596,088 - 38,624,544 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11537,858,711 - 37,896,405 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01537,951,431 - 37,989,091 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01538,224,990 - 38,260,912 (+)NCBIUU_Cfam_GSD_1.0
Tmpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494521,961,559 - 21,989,703 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649214,971,968 - 15,000,060 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649214,972,391 - 15,000,115 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl585,315,290 - 85,346,538 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1585,317,648 - 85,346,528 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2589,640,642 - 89,669,567 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11193,815,870 - 93,852,577 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1193,817,820 - 93,853,703 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037151,219,876 - 151,256,234 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247509,009,085 - 9,036,747 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247509,009,085 - 9,036,713 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmpo
89 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:111
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000012715
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat

Markers in Region
AW214352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,642,903 - 25,643,036 (+)MAPPERmRatBN7.2
Rnor_6.0731,847,564 - 31,847,696NCBIRnor6.0
Rnor_5.0731,934,563 - 31,934,695UniSTSRnor5.0
RGSC_v3.4728,086,727 - 28,086,859UniSTSRGSC3.4
Celera722,769,264 - 22,769,396UniSTS
Cytogenetic Map7q13UniSTS
RH128337  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,655,577 - 25,655,774 (+)MAPPERmRatBN7.2
Rnor_6.0731,860,238 - 31,860,434NCBIRnor6.0
Rnor_5.0731,947,234 - 31,947,430UniSTSRnor5.0
RGSC_v3.4728,099,401 - 28,099,597UniSTSRGSC3.4
Celera722,781,922 - 22,782,118UniSTS
Cytogenetic Map7q13UniSTS
AI008347  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,651,255 - 25,651,892 (+)MAPPERmRatBN7.2
mRatBN7.2725,651,704 - 25,651,892 (+)MAPPERmRatBN7.2
Rnor_6.0731,856,365 - 31,856,552NCBIRnor6.0
Rnor_6.0731,855,916 - 31,856,552NCBIRnor6.0
Rnor_5.0731,943,361 - 31,943,548UniSTSRnor5.0
Rnor_5.0731,942,912 - 31,943,548UniSTSRnor5.0
RGSC_v3.4728,095,079 - 28,095,715UniSTSRGSC3.4
RGSC_v3.4728,095,528 - 28,095,715UniSTSRGSC3.4
Celera722,778,049 - 22,778,236UniSTS
Celera722,777,600 - 22,778,236UniSTS
RH 3.4 Map7154.3UniSTS
Cytogenetic Map7q13UniSTS
Tmpo  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2725,657,134 - 25,658,124 (+)MAPPERmRatBN7.2
Rnor_6.0731,861,795 - 31,862,784NCBIRnor6.0
Rnor_5.0731,948,791 - 31,949,780UniSTSRnor5.0
RGSC_v3.4728,100,958 - 28,101,947UniSTSRGSC3.4
Celera722,783,479 - 22,784,468UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 10 74 35 41 11 8
Low 2 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000011494   ⟹   ENSRNOP00000011494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,586,725 - 25,619,394 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000012715   ⟹   ENSRNOP00000012715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
Rnor_6.0 Ensembl731,847,410 - 31,872,423 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080824   ⟹   ENSRNOP00000070805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,611,938 - 25,619,401 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095834   ⟹   ENSRNOP00000092044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,655,558 - 25,667,702 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097150   ⟹   ENSRNOP00000084254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111659   ⟹   ENSRNOP00000090294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112365   ⟹   ENSRNOP00000078350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,642,752 - 25,667,727 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113184   ⟹   ENSRNOP00000091703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,611,937 - 25,619,383 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113551   ⟹   ENSRNOP00000087575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl725,586,725 - 25,667,727 (-)Ensembl
RefSeq Acc Id: NM_001395714   ⟹   NP_001382643
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,542,777 - 27,554,935 (-)NCBI
mRatBN7.2725,655,553 - 25,667,711 (-)NCBI
RefSeq Acc Id: NM_001395715   ⟹   NP_001382644
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,978 - 27,554,935 (-)NCBI
mRatBN7.2725,642,753 - 25,667,711 (-)NCBI
RefSeq Acc Id: NM_012887   ⟹   NP_037019
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,978 - 27,554,935 (-)NCBI
mRatBN7.2725,642,753 - 25,667,711 (-)NCBI
Rnor_6.0731,847,413 - 31,872,371 (-)NCBI
Rnor_5.0731,934,412 - 31,959,343 (-)NCBI
RGSC_v3.4728,086,576 - 28,111,800 (-)RGD
Celera722,769,113 - 22,794,062 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765219   ⟹   XP_008763441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,977 - 27,554,980 (-)NCBI
mRatBN7.2725,642,752 - 25,667,756 (-)NCBI
Rnor_6.0731,847,412 - 31,872,416 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078463   ⟹   XP_038934391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8727,529,977 - 27,554,980 (-)NCBI
mRatBN7.2725,642,752 - 25,667,756 (-)NCBI
RefSeq Acc Id: NP_037019   ⟸   NM_012887
- Peptide Label: isoform 2
- UniProtKB: Q62733 (UniProtKB/Swiss-Prot),   A6IFV8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763441   ⟸   XM_008765219
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZ38 (UniProtKB/TrEMBL),   A6IFV7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012715   ⟸   ENSRNOT00000012715
RefSeq Acc Id: XP_038934391   ⟸   XM_039078463
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000090294   ⟸   ENSRNOT00000111659
RefSeq Acc Id: ENSRNOP00000070805   ⟸   ENSRNOT00000080824
RefSeq Acc Id: ENSRNOP00000084254   ⟸   ENSRNOT00000097150
RefSeq Acc Id: ENSRNOP00000011494   ⟸   ENSRNOT00000011494
RefSeq Acc Id: ENSRNOP00000078350   ⟸   ENSRNOT00000112365
RefSeq Acc Id: ENSRNOP00000087575   ⟸   ENSRNOT00000113551
RefSeq Acc Id: ENSRNOP00000091703   ⟸   ENSRNOT00000113184
RefSeq Acc Id: ENSRNOP00000092044   ⟸   ENSRNOT00000095834
RefSeq Acc Id: NP_001382644   ⟸   NM_001395715
- Peptide Label: isoform 3
- UniProtKB: A0A8I6G2M4 (UniProtKB/TrEMBL),   A6IFV6 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382643   ⟸   NM_001395714
- Peptide Label: isoform 1
- UniProtKB: A0A8I6AFR4 (UniProtKB/TrEMBL),   A6IFV9 (UniProtKB/TrEMBL)
Protein Domains
LEM   LEM-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62733-F1-model_v2 AlphaFold Q62733 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695142
Promoter ID:EPDNEW_R5667
Type:initiation region
Name:Tmpo_1
Description:thymopoietin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0731,872,353 - 31,872,413EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3875 AgrOrtholog
BioCyc Gene G2FUF-34462 BioCyc
Ensembl Genes ENSRNOG00000008797 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022267 UniProtKB/Swiss-Prot
  ENSRNOG00060029835 UniProtKB/Swiss-Prot
  ENSRNOG00065025951 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012715 ENTREZGENE
  ENSRNOT00000012715.5 UniProtKB/Swiss-Prot
  ENSRNOT00000095834 ENTREZGENE
  ENSRNOT00000095834.1 UniProtKB/TrEMBL
  ENSRNOT00000097150 ENTREZGENE
  ENSRNOT00000097150.1 UniProtKB/TrEMBL
  ENSRNOT00000111659 ENTREZGENE
  ENSRNOT00000111659.1 UniProtKB/TrEMBL
  ENSRNOT00000112365 ENTREZGENE
  ENSRNOT00000112365.1 UniProtKB/TrEMBL
  ENSRNOT00000113551.1 UniProtKB/TrEMBL
  ENSRNOT00055038320 UniProtKB/Swiss-Prot
  ENSRNOT00060051929 UniProtKB/Swiss-Prot
  ENSRNOT00065044774 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.3160 UniProtKB/TrEMBL
  1.10.720.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.50.40.10 UniProtKB/TrEMBL
InterPro LAP2alpha_C UniProtKB/TrEMBL
  LEM-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEM/LEM-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom_sf UniProtKB/TrEMBL
KEGG Report rno:25359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25359 ENTREZGENE
PANTHER LAMINA-ASSOCIATED POLYPEPTIDE 2, ISOFORM ALPHA UniProtKB/TrEMBL
  LAMINA-ASSOCIATED POLYPEPTIDE 2, ISOFORM BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LAMINA-ASSOCIATED POLYPEPTIDE THYMOPOIETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LAP2alpha UniProtKB/TrEMBL
  LEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mito_carr UniProtKB/TrEMBL
  Thymopoietin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmpo PhenoGen
PROSITE LEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEM_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008797 RatGTEx
  ENSRNOG00055022267 RatGTEx
  ENSRNOG00060029835 RatGTEx
  ENSRNOG00065025951 RatGTEx
SMART LEM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thymopoietin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103506 UniProtKB/TrEMBL
  SSF63451 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204234
UniProt A0A8I5ZZ38 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AFR4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G2M4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GF99_RAT UniProtKB/TrEMBL
  A6IFV6 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV7 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV8 ENTREZGENE, UniProtKB/TrEMBL
  A6IFV9 ENTREZGENE, UniProtKB/TrEMBL
  LAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Tmpo  thymopoietin    Thymopoietin (lamina associated polypeptide 2)  Name updated 629478 APPROVED
2002-06-10 Tmpo  Thymopoietin (lamina associated polypeptide 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the inner nuclear membrane 634476
gene_domains contains a large hydrophilic domain with several potential cdc2 kinase phosphorylation sites and a single putative membrane-spanning sequence 634476