Gene: Il6st (interleukin 6 signal transducer) Rattus norvegicus
Analyze
Symbol:
Il6st
Name:
interleukin 6 signal transducer
Description:
Predicted to contribute to cytokine receptor activity; growth factor binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including interleukin-6-mediated signaling pathway; negative regulation of cytosolic calcium ion concentration; and triglyceride mobilization. Localizes to neuronal cell body membrane. Biomarker of brain ischemia; hepatocellular carcinoma; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 signal transducer); PARTICIPATES IN interleukin-6 signaling pathway; interleukin-27 signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Ac1055; Gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
IL6ST (interleukin 6 signal transducer) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):
Il6st (interleukin 6 signal transducer) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Il6st (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
IL6ST (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
IL6ST (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Il6st (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
IL6ST (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
IL6ST (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Il6st (interleukin 6 signal transducer) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
IL6ST (interleukin 6 signal transducer)
Alliance
DIOPT (InParanoid|HGNC|PANTHER|OrthoInspector|OrthoFinder|Hieranoid)
Mus musculus (house mouse):
Il6st (interleukin 6 signal transducer)
Alliance
DIOPT (InParanoid|PANTHER|OrthoInspector|OrthoFinder|Hieranoid)
Danio rerio (zebrafish):
il6st (interleukin 6 signal transducer)
Alliance
DIOPT (Hieranoid|OrthoInspector|InParanoid|OrthoFinder)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 44,279,199 - 44,319,427 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 44,289,393 - 44,314,944 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 63,320,957 - 63,361,404 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 43,806,301 - 43,842,365 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 43,736,911 - 43,762,480 (+) NCBI Celera 2 39,857,022 - 39,886,283 (+) NCBI Celera Cytogenetic Map 2 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
hyper IgE recurrent infection syndrome 4 ISO RGD:731409 8554872 ClinVar Annotator: match by term: HYPER-IgE RECURRENT INFECTION SYNDROME 4, AUTOSOMAL RECESSIVE ClinVar PMID:28747427 hyper IgE recurrent infection syndrome 4 ISO RGD:731409 8554872 ClinVar Annotator: match by term: HYPER-IgE RECURRENT INFECTION SYNDROME 4, AUTOSOMAL RECESSIVE ClinVar PMID:30309848 Neurodevelopmental Disorders ISO RGD:731409 8554872 ClinVar Annotator: match by term: Neurodevelopmental disorder ClinVar PMID:25741868 Stuve-Wiedemann Syndrome ISO RGD:731409 8554872 ClinVar Annotator: match by term: Stuve-Wiedemann syndrome ClinVar
Imported Annotations - CTD
allergic hypersensitivity disease ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21625544 Animal Mammary Neoplasms ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12606953 carcinoma ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12606953 Colorectal Neoplasms ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:19223499 Mammary Neoplasms, Experimental ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12606953 middle cerebral artery infarction ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21940958 Myocardial Ischemia ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16214533 Ovarian Neoplasms ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:11161848 pneumonia ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21625544 Prostatic Neoplasms ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:29610475 , PMID:29662167 Reperfusion Injury ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21940958 rheumatoid arthritis ISO RGD:731409 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:20453842 Imported Annotations - MGI
stomach cancer ISS RGD:731410 13592920 OMIM:137215 , OMIM:613659MouseDO Imported Annotations - OMIM
hyper IgE recurrent infection syndrome 4 ISO RGD:731409 7240710 OMIM
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine decreases expression EXP 6480464 chlorcyclizine results in decreased expression of IL6ST mRNA CTD PMID:21058326 1-octadec-9-enoylglycero-3-phosphate multiple interactions ISO RGD:731410 6480464 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of IL6ST protein] CTD PMID:25822713 1-octadec-9-enoylglycero-3-phosphate increases expression ISO RGD:731410 6480464 lysophosphatidic acid results in increased expression of IL6ST protein CTD PMID:25822713 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of IL6ST mRNA CTD PMID:29097150 17beta-estradiol affects expression ISO RGD:731409 6480464 Estradiol affects the expression of IL6ST mRNA, Estradiol affects the expression of IL6ST protein CTD PMID:19401270 17beta-estradiol increases expression ISO RGD:731409 6480464 Estradiol results in increased expression of IL6ST mRNA CTD PMID:21185374 17beta-estradiol multiple interactions ISO RGD:731409 6480464 [Progesterone co-treated with Estradiol] results in increased expression of IL6ST mRNA CTD PMID:17404688 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:731409 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNA] CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:731410 6480464 Tetrachlorodibenzodioxin affects the expression of IL6ST mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:731409 6480464 Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNA CTD PMID:11007951 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of IL6ST mRNA CTD PMID:16960034 3,5-diethoxycarbonyl-1,4-dihydrocollidine multiple interactions ISO RGD:731410 6480464 SULT2B1 protein promotes the reaction [3 more ... CTD PMID:27052460 3,5-diethoxycarbonyl-1,4-dihydrocollidine increases expression ISO RGD:731410 6480464 3 more ... CTD PMID:27052460 3-methylcholanthrene multiple interactions ISO RGD:731410 6480464 [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL6ST mRNA CTD PMID:25926378 4,4'-sulfonyldiphenol increases expression ISO RGD:731410 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of IL6ST mRNA CTD PMID:30951980 4-hydroxynon-2-enal decreases expression ISO RGD:731410 6480464 4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA CTD PMID:19191707 4-hydroxynon-2-enal decreases expression ISO RGD:731409 6480464 4-hydroxy-2-nonenal results in decreased expression of IL6ST mRNA CTD PMID:12419474 5-aza-2'-deoxycytidine increases expression ISO RGD:731409 6480464 Decitabine results in increased expression of IL6ST mRNA CTD PMID:19223499 acetic acid increases expression ISO RGD:731410 6480464 Acetic Acid results in increased expression of IL6ST protein CTD PMID:21296659 acetylsalicylic acid decreases expression ISO RGD:731409 6480464 Aspirin results in decreased expression of IL6ST mRNA CTD PMID:19595669 aflatoxin B1 affects expression ISO RGD:731409 6480464 Aflatoxin B1 affects the expression of IL6ST protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:731409 6480464 Aflatoxin B1 results in decreased methylation of IL6ST gene, Aflatoxin B1 results in decreased methylation of IL6ST intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 decreases methylation ISO RGD:731409 6480464 aflatoxin B2 results in decreased methylation of IL6ST intron CTD PMID:30157460 aflatoxin M1 decreases expression ISO RGD:731409 6480464 Aflatoxin M1 results in decreased expression of IL6ST mRNA CTD PMID:30928695 aldehydo-D-glucose multiple interactions ISO RGD:731410 6480464 [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein] more ... CTD PMID:21940958 all-trans-retinoic acid increases expression ISO RGD:731409 6480464 Tretinoin results in increased expression of IL6ST mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of IL6ST mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:731409 6480464 Antirheumatic Agents results in increased expression of IL6ST mRNA CTD PMID:24449571 arsenous acid increases expression ISO RGD:731410 6480464 Arsenic Trioxide results in increased expression of IL6ST mRNA CTD PMID:15073043 asperentin decreases expression ISO RGD:731410 6480464 cladosporin results in decreased expression of IL6ST mRNA CTD PMID:19818335 auranofin multiple interactions ISO RGD:731409 6480464 [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein CTD PMID:20542334 benzo[a]pyrene decreases expression ISO RGD:731410 6480464 Benzo(a)pyrene results in decreased expression of IL6ST mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:731409 6480464 Benzo(a)pyrene affects the methylation of IL6ST intron CTD PMID:30157460 benzo[a]pyrene increases expression ISO RGD:731410 6480464 Benzo(a)pyrene results in increased expression of IL6ST mRNA CTD PMID:22228805 bisphenol A increases expression ISO RGD:731410 6480464 bisphenol A results in increased expression of IL6ST mRNA CTD PMID:26063408 , PMID:30951980 bisphenol A increases expression ISO RGD:731409 6480464 bisphenol A results in increased expression of IL6ST mRNA CTD PMID:29275510 bisphenol A decreases expression ISO RGD:731409 6480464 bisphenol A results in decreased expression of IL6ST protein CTD PMID:31339859 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of IL6ST mRNA CTD PMID:30816183 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of IL6ST gene CTD PMID:28505145 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of IL6ST mRNA CTD PMID:25181051 bisphenol F increases expression ISO RGD:731410 6480464 bisphenol F results in increased expression of IL6ST mRNA CTD PMID:30951980 bromochloroacetic acid increases expression ISO RGD:731410 6480464 bromochloroacetic acid results in increased expression of IL6ST protein CTD PMID:21296659 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of IL6ST mRNA CTD PMID:25993096 calcitriol multiple interactions ISO RGD:731409 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of IL6ST mRNA CTD PMID:21592394 calcitriol increases expression ISO RGD:731409 6480464 Calcitriol results in increased expression of IL6ST mRNA CTD PMID:21592394 calcium atom multiple interactions ISO RGD:731410 6480464 IL6ST protein promotes the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 calcium(0) multiple interactions ISO RGD:731410 6480464 IL6ST protein promotes the reaction [IL11 protein results in increased abundance of Calcium] CTD PMID:12110441 capsaicin decreases expression EXP 6480464 Capsaicin results in decreased expression of IL6ST protein CTD PMID:19285962 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon results in decreased expression of IL6ST protein CTD PMID:26589480 carbon nanotube multiple interactions ISO RGD:731410 6480464 [Methylcholanthrene co-treated with Nanotubes, Carbon] results in decreased expression of IL6ST mRNA CTD PMID:25926378 carbon nanotube increases expression ISO RGD:731410 6480464 Nanotubes, Carbon results in increased expression of IL6ST mRNA CTD PMID:25554681 , PMID:25620056 carbon nanotube affects expression EXP 6480464 Nanotubes, Carbon affects the expression of IL6ST mRNA CTD PMID:26589480 ciglitazone multiple interactions ISO RGD:731409 6480464 [ciglitazone binds to PPARG protein] which results in increased expression of IL6ST mRNA CTD PMID:16197558 ciguatoxin CTX1B affects expression ISO RGD:731410 6480464 Ciguatoxins affects the expression of IL6ST mRNA CTD PMID:18353800 cisplatin decreases expression ISO RGD:731409 6480464 Cisplatin results in decreased expression of IL6ST mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:731409 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of IL6ST mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO RGD:731409 6480464 cobaltous chloride results in decreased expression of IL6ST mRNA CTD PMID:19320972 copper atom multiple interactions ISO RGD:731409 6480464 [NSC 689534 binds to Copper] which results in increased expression of IL6ST mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:731409 6480464 [NSC 689534 binds to Copper] which results in increased expression of IL6ST mRNA CTD PMID:20971185 copper(II) sulfate increases expression ISO RGD:731409 6480464 Copper Sulfate results in increased expression of IL6ST mRNA CTD PMID:19549813 coumestrol multiple interactions ISO RGD:731409 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of IL6ST mRNA CTD PMID:19167446 cycloheximide multiple interactions ISO RGD:731409 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL6ST mRNA] CTD PMID:11007951 cyclosporin A decreases expression ISO RGD:731409 6480464 Cyclosporine results in decreased expression of IL6ST mRNA CTD PMID:25562108 D-glucose multiple interactions ISO RGD:731410 6480464 [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein] more ... CTD PMID:21940958 dexamethasone increases expression ISO RGD:731410 6480464 Dexamethasone results in increased expression of IL6ST mRNA CTD PMID:21041162 dextran sulfate multiple interactions ISO RGD:731410 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IL6ST mRNA CTD PMID:29950665 diarsenic trioxide increases expression ISO RGD:731410 6480464 Arsenic Trioxide results in increased expression of IL6ST mRNA CTD PMID:15073043 dicrotophos decreases expression ISO RGD:731409 6480464 dicrotophos results in decreased expression of IL6ST mRNA CTD PMID:28302478 dioxygen multiple interactions ISO RGD:731410 6480464 [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein] more ... CTD PMID:21940958 diuron increases expression EXP 6480464 Diuron results in increased expression of IL6ST mRNA CTD PMID:21551480 dorsomorphin multiple interactions ISO RGD:731409 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6ST mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:731409 6480464 Doxorubicin results in decreased expression of IL6ST mRNA CTD PMID:29803840 elemental selenium decreases expression ISO RGD:731409 6480464 Selenium results in decreased expression of IL6ST mRNA CTD PMID:19244175 ethanol increases expression ISO RGD:731410 6480464 Ethanol results in increased expression of IL6ST mRNA CTD PMID:30319688 ethanol affects splicing ISO RGD:731410 6480464 Ethanol affects the splicing of IL6ST mRNA CTD PMID:30319688 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of IL6ST mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of IL6ST mRNA CTD PMID:20566332 formaldehyde increases expression ISO RGD:731409 6480464 Formaldehyde results in increased expression of IL6ST mRNA CTD PMID:23649840 geldanamycin increases expression ISO RGD:731409 6480464 geldanamycin results in increased expression of IL6ST mRNA CTD PMID:26705709 glucose multiple interactions ISO RGD:731410 6480464 [[[Oxygen deficiency co-treated with Glucose deficiency] co-treated with Oxygen] inhibits the reaction [IL6RA protein binds to IL6ST protein]] promotes the reaction [IL6ST protein binds to and results in increased phosphorylation of STAT3 protein] more ... CTD PMID:21940958 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of IL6ST mRNA CTD PMID:15159207 hydroquinone O-beta-D-glucopyranoside decreases expression ISO RGD:731409 6480464 Arbutin results in decreased expression of IL6ST mRNA CTD PMID:17103032 indometacin decreases expression ISO RGD:731409 6480464 Indomethacin results in decreased expression of IL6ST mRNA CTD PMID:16984733 kojic acid decreases expression ISO RGD:731409 6480464 kojic acid results in decreased expression of IL6ST mRNA CTD PMID:16595896 leflunomide increases expression ISO RGD:731409 6480464 leflunomide results in increased expression of IL6ST mRNA CTD PMID:28988120 lenalidomide decreases expression ISO RGD:731409 6480464 lenalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 lipopolysaccharide increases expression ISO RGD:731410 6480464 Lipopolysaccharides results in increased expression of IL6ST mRNA CTD PMID:15919760 lipopolysaccharide multiple interactions ISO RGD:731409 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of IL6ST mRNA CTD PMID:31059760 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of IL6ST mRNA CTD PMID:30467583 methyl methanesulfonate increases expression ISO RGD:731409 6480464 Methyl Methanesulfonate results in increased expression of IL6ST mRNA CTD PMID:23649840 methylmercury chloride decreases expression ISO RGD:731409 6480464 methylmercuric chloride results in decreased expression of IL6ST mRNA CTD PMID:28001369 mycophenolic acid increases expression ISO RGD:731410 6480464 Mycophenolic Acid results in increased expression of IL6ST mRNA CTD PMID:19818335 mycotoxin decreases expression ISO RGD:731410 6480464 Mycotoxins results in decreased expression of IL6ST mRNA CTD PMID:19818335 neoechinulin A increases expression ISO RGD:731410 6480464 neoechinulin A results in increased expression of IL6ST mRNA CTD PMID:19818335 nickel atom decreases expression ISO RGD:731409 6480464 Nickel results in decreased expression of IL6ST mRNA CTD PMID:25583101 obeticholic acid decreases expression ISO RGD:731409 6480464 obeticholic acid results in decreased expression of IL6ST mRNA CTD PMID:27939613 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL6ST mRNA CTD PMID:25729387 oxaliplatin increases expression EXP 6480464 oxaliplatin results in increased expression of IL6ST mRNA CTD PMID:25729387 ozone decreases expression ISO RGD:731410 6480464 Ozone results in decreased expression of IL6ST mRNA CTD PMID:17460151 paracetamol affects expression ISO RGD:731410 6480464 Acetaminophen affects the expression of IL6ST mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:731409 6480464 [Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of IL6ST mRNA CTD PMID:31059760 paracetamol increases expression ISO RGD:731409 6480464 Acetaminophen results in increased expression of IL6ST mRNA CTD PMID:27761495 , PMID:31059760 paracetamol decreases expression ISO RGD:731409 6480464 Acetaminophen results in decreased expression of IL6ST mRNA CTD PMID:22230336 , PMID:27761495 paracetamol increases expression ISO RGD:731410 6480464 Acetaminophen results in increased expression of IL6ST mRNA CTD PMID:19420014 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:731409 6480464 perfluorooctane sulfonic acid results in decreased expression of IL6ST mRNA CTD PMID:27153767 phenobarbital affects expression ISO RGD:731410 6480464 Phenobarbital affects the expression of IL6ST mRNA CTD PMID:23091169 phenylmercury acetate increases expression ISO RGD:731409 6480464 Phenylmercuric Acetate results in increased expression of IL6ST mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:731409 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6ST mRNA CTD PMID:27188386 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 more ... CTD PMID:12606953 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of IL6ST mRNA CTD PMID:19162173 progesterone multiple interactions ISO RGD:731409 6480464 [Progesterone co-treated with Estradiol] results in increased expression of IL6ST mRNA CTD PMID:17404688 quercetin multiple interactions ISO RGD:731409 6480464 Quercetin inhibits the reaction [IL6 protein results in increased phosphorylation of IL6ST protein] CTD PMID:22394507 quercetin decreases expression ISO RGD:731409 6480464 Quercetin results in decreased expression of IL6ST mRNA CTD PMID:21632981 quinolin-8-ol decreases expression ISO RGD:731409 6480464 Oxyquinoline results in decreased expression of IL6ST mRNA CTD PMID:21632981 resveratrol multiple interactions ISO RGD:731409 6480464 [Coumestrol co-treated with resveratrol] results in increased expression of IL6ST mRNA CTD PMID:19167446 SB 431542 multiple interactions ISO RGD:731409 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of IL6ST mRNA CTD PMID:27188386 selenium atom decreases expression ISO RGD:731409 6480464 Selenium results in decreased expression of IL6ST mRNA CTD PMID:19244175 serpentine asbestos increases expression ISO RGD:731410 6480464 Asbestos, Serpentine results in increased expression of IL6ST mRNA CTD PMID:16251409 sodium arsenate decreases expression ISO RGD:731410 6480464 sodium arsenate results in decreased expression of IL6ST mRNA CTD PMID:21795629 sodium arsenate increases expression ISO RGD:731410 6480464 sodium arsenate results in increased expression of IL6ST mRNA CTD PMID:21795629 sodium arsenite multiple interactions ISO RGD:731409 6480464 sodium arsenite inhibits the reaction [IL6 protein results in increased phosphorylation of IL6ST protein] CTD PMID:15116095 sodium arsenite decreases expression ISO RGD:731410 6480464 sodium arsenite results in decreased expression of IL6ST mRNA CTD PMID:28370166 sodium arsenite decreases expression ISO RGD:731409 6480464 sodium arsenite results in decreased expression of IL6ST mRNA CTD PMID:22714537 , PMID:28595984 Soman increases expression EXP 6480464 Soman results in increased expression of IL6ST mRNA CTD PMID:19281266 sterigmatocystin decreases expression ISO RGD:731410 6480464 Sterigmatocystin results in decreased expression of IL6ST mRNA CTD PMID:19818335 streptozocin affects expression ISO RGD:731410 6480464 Streptozocin affects the expression of IL6ST mRNA CTD PMID:26073000 succimer multiple interactions ISO RGD:731410 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of IL6ST mRNA CTD PMID:21641980 sunitinib decreases expression ISO RGD:731409 6480464 Sunitinib results in decreased expression of IL6ST mRNA CTD PMID:31533062 tert-butyl hydroperoxide decreases expression ISO RGD:731409 6480464 tert-Butylhydroperoxide results in decreased expression of IL6ST mRNA CTD PMID:12419474 testosterone multiple interactions ISO RGD:731409 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of IL6ST mRNA CTD PMID:21592394 testosterone increases expression ISO RGD:731409 6480464 Testosterone results in increased expression of IL6ST mRNA CTD PMID:21592394 testosterone enanthate affects expression ISO RGD:731409 6480464 testosterone enanthate affects the expression of IL6ST mRNA CTD PMID:17440010 tetrachloromethane multiple interactions ISO RGD:731410 6480464 IL6ST protein affects the reaction [Carbon Tetrachloride results in increased activity of STAT3 protein] CTD PMID:12830005 thalidomide decreases expression ISO RGD:731409 6480464 Thalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 thapsigargin decreases expression EXP 6480464 Thapsigargin results in decreased expression of IL6ST protein CTD PMID:19285962 theophylline increases expression ISO RGD:731409 6480464 Theophylline results in increased expression of IL6ST mRNA CTD PMID:16083514 titanium dioxide multiple interactions ISO RGD:731410 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of IL6ST mRNA CTD PMID:29950665 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of IL6ST mRNA CTD PMID:25729387 topotecan increases expression EXP 6480464 Topotecan results in increased expression of IL6ST mRNA CTD PMID:25729387 torcetrapib increases expression ISO RGD:731409 6480464 torcetrapib results in increased expression of IL6ST mRNA CTD PMID:23228038 trichloroethene affects expression ISO RGD:731410 6480464 Trichloroethylene affects the expression of IL6ST mRNA CTD PMID:25026505 trichloroethene increases expression ISO RGD:731410 6480464 Trichloroethylene results in increased expression of IL6ST mRNA CTD PMID:29669109 trichloroethene multiple interactions ISO RGD:731410 6480464 Trichloroethylene promotes the reaction [Dietary Fats results in increased expression of IL6ST mRNA] CTD PMID:29669109 trichostatin A increases expression ISO RGD:731409 6480464 trichostatin A results in increased expression of IL6ST mRNA CTD PMID:19223499 trimethyltin increases expression ISO RGD:731410 6480464 trimethyltin results in increased expression of IL6ST mRNA CTD PMID:20833246 vancomycin decreases expression ISO RGD:731410 6480464 Vancomycin results in decreased expression of IL6ST mRNA CTD PMID:18930951 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of IL6ST mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of IL6ST mRNA CTD PMID:18629315 zinc atom multiple interactions ISO RGD:731409 6480464 Zinc inhibits the reaction [TNF protein results in increased secretion of IL6ST protein] CTD PMID:16606632 zinc sulfate multiple interactions ISO RGD:731409 6480464 Zinc Sulfate inhibits the reaction [TNF protein results in increased secretion of IL6ST protein] CTD PMID:16606632 zinc sulfate decreases expression ISO RGD:731409 6480464 Zinc Sulfate results in decreased expression of IL6ST mRNA CTD PMID:16330358 zinc(0) multiple interactions ISO RGD:731409 6480464 Zinc inhibits the reaction [TNF protein results in increased secretion of IL6ST protein] CTD PMID:16606632
Biological Process ciliary neurotrophic factor-mediated signaling pathway ISO RGD:731409 1624291 (PMID:12643274) RGD PMID:12643274 ciliary neurotrophic factor-mediated signaling pathway IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytokine-mediated signaling pathway ISO RGD:731409 1624291 (PMID:2261637) RGD PMID:2261637 cytokine-mediated signaling pathway IBA MGI:MGI:104993 more ... 13792537 PMID:21873635 GO_Central cytokine-mediated signaling pathway ISO RGD:731410 1624291 (MGI:MGI:69257, PMID:7957045) RGD MGI:MGI:69257 , PMID:7957045 glycogen metabolic process ISO RGD:731410 1624291 MGI:MGI:2176787 (MGI:MGI:1335676 , PMID:10205167) RGD MGI:MGI:1335676 , PMID:10205167 glycogen metabolic process IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-11-mediated signaling pathway IEA GO:0004921 1600115 GO_REF:0000108 GOC GO_REF:0000108 interleukin-27-mediated signaling pathway ISO RGD:731409 1624291 (PMID:14764690) RGD PMID:14764690 interleukin-27-mediated signaling pathway IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-6-mediated signaling pathway IMP 5686900 RGD interleukin-6-mediated signaling pathway IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-6-mediated signaling pathway ISO RGD:731409 1624291 (PMID:12643274), (PMID:2261637) RGD PMID:12643274 , PMID:2261637 leukemia inhibitory factor signaling pathway ISO RGD:731409 1624291 (PMID:12643274), (PMID:8999038) RGD PMID:12643274 , PMID:8999038 leukemia inhibitory factor signaling pathway IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of cytosolic calcium ion concentration IMP 1626700 RGD negative regulation of interleukin-6-mediated signaling pathway ISO RGD:731409 1624291 (PMID:8353278) RGD PMID:8353278 oncostatin-M-mediated signaling pathway ISO RGD:731409 1624291 (PMID:8999038) RGD PMID:8999038 oncostatin-M-mediated signaling pathway IBA MGI:MGI:1330819 more ... 13792537 PMID:21873635 GO_Central oncostatin-M-mediated signaling pathway IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of astrocyte differentiation ISO RGD:731410 1624291 (MGI:MGI:1343608, PMID:10486560) RGD MGI:MGI:1343608 , PMID:10486560 positive regulation of astrocyte differentiation IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell population proliferation ISO RGD:731410 1624291 MGI:MGI:2684607 (MGI:MGI:3039221 , PMID:15051883) RGD MGI:MGI:3039221 , PMID:15051883 positive regulation of cell population proliferation IBA MGI:MGI:96560 more ... 13792537 PMID:21873635 GO_Central positive regulation of cell population proliferation ISO RGD:731409 1624291 (PMID:2261637), (PMID:8999038) RGD PMID:2261637 , PMID:8999038 positive regulation of osteoblast differentiation ISO RGD:731409 1624291 (PMID:12372336) RGD PMID:12372336 positive regulation of osteoblast differentiation IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of smooth muscle cell migration IMP 1626703 RGD positive regulation of T cell proliferation ISO RGD:731409 1624291 (PMID:14764690) RGD PMID:14764690 positive regulation of T cell proliferation IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of tyrosine phosphorylation of STAT protein ISO RGD:731409 1624291 (PMID:14764690) RGD PMID:14764690 positive regulation of tyrosine phosphorylation of STAT protein IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of hormone secretion TAS 629528 RGD regulation of Notch signaling pathway ISO RGD:731410 1624291 (MGI:MGI:2651972, PMID:12629177) RGD MGI:MGI:2651972 , PMID:12629177 regulation of Notch signaling pathway IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to cytokine ISO RGD:731409 1624291 (PMID:2261637), (PMID:8999038) RGD PMID:2261637 , PMID:8999038 response to nutrient IEP 1627569 RGD signal transduction ISO RGD:731410 1624291 (MGI:MGI:2387739, PMID:12147685) RGD MGI:MGI:2387739 , PMID:12147685 triglyceride mobilization IMP 1626687 RGD Cellular Component cell body ISO RGD:731410 1624291 (MGI:MGI:2157598, PMID:10989258) RGD MGI:MGI:2157598 , PMID:10989258 ciliary neurotrophic factor receptor complex ISO RGD:731409 1624291 (PMID:12707266) RGD PMID:12707266 ciliary neurotrophic factor receptor complex IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 dendrite ISO RGD:731410 1624291 (MGI:MGI:2157598, PMID:10989258) RGD MGI:MGI:2157598 , PMID:10989258 dendrite IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 external side of plasma membrane ISO RGD:731410 1624291 (MGI:MGI:1932624, PMID:11275690) RGD MGI:MGI:1932624 , PMID:11275690 external side of plasma membrane IBA MGI:MGI:104579 more ... 13792537 PMID:21873635 GO_Central external side of plasma membrane IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 extracellular space ISO RGD:731409 1624291 (PMID:8353278) RGD PMID:8353278 interleukin-6 receptor complex ISO RGD:731409 1624291 (PMID:12643274), (PMID:12829785), (PMID:2261637) RGD PMID:12643274 more ... interleukin-6 receptor complex IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuronal cell body ISO RGD:731410 1624291 (MGI:MGI:2157598, PMID:10989258) RGD MGI:MGI:2157598 , PMID:10989258 neuronal cell body IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 neuronal cell body membrane IDA 5686896 RGD oncostatin-M receptor complex ISO RGD:731409 1624291 (PMID:8999038) RGD PMID:8999038 oncostatin-M receptor complex IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 receptor complex IBA PANTHER:PTN002745476 more ... 13792537 PMID:21873635 GO_Central Molecular Function ciliary neurotrophic factor receptor activity ISO RGD:731409 1624291 (PMID:12643274) RGD PMID:12643274 ciliary neurotrophic factor receptor binding ISO RGD:731409 1624291 UniProtKB:P26992 (PMID:12707266) RGD PMID:12707266 ciliary neurotrophic factor receptor binding IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytokine binding IBA MGI:MGI:105304 more ... 13792537 PMID:21873635 GO_Central cytokine receptor activity IBA MGI:MGI:104993 more ... 13792537 PMID:21873635 GO_Central growth factor binding contributes_to ISO RGD:731409 1624291 UniProtKB:P15018 (PMID:8999038) RGD PMID:8999038 growth factor binding ISO RGD:731409 1624291 UniProtKB:P13725 (PMID:8999038) RGD PMID:8999038 identical protein binding ISO RGD:731409 1624291 UniProtKB:P40189 (PMID:24501689) RGD PMID:24501689 identical protein binding IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-11 binding contributes_to ISO RGD:731410 1624291 (MGI:MGI:69257, PMID:7957045) RGD MGI:MGI:69257 , PMID:7957045 interleukin-11 binding IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-11 receptor activity contributes_to ISO RGD:731410 1624291 (MGI:MGI:69257, PMID:7957045) RGD MGI:MGI:69257 , PMID:7957045 interleukin-11 receptor activity IEA UniProtKB:Q00560 , ensembl:ENSMUSP000001388361600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-6 binding contributes_to ISO RGD:731409 1624291 UniProtKB:P05231 (PMID:12829785) RGD PMID:12829785 interleukin-6 binding contributes_to IBA PANTHER:PTN000547687 , UniProtKB:P40189 13792537 PMID:21873635 GO_Central interleukin-6 binding IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-6 receptor activity contributes_to ISO RGD:731409 1624291 (PMID:12643274), (PMID:2261637) RGD PMID:12643274 , PMID:2261637 interleukin-6 receptor activity contributes_to IBA PANTHER:PTN000547687 , UniProtKB:P40189 13792537 PMID:21873635 GO_Central interleukin-6 receptor activity IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 interleukin-6 receptor binding contributes_to ISO RGD:731409 1624291 UniProtKB:P08887 (PMID:12829785) RGD PMID:12829785 interleukin-6 receptor binding IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 leukemia inhibitory factor receptor activity contributes_to ISO RGD:731409 1624291 (PMID:12643274), (PMID:8999038) RGD PMID:12643274 , PMID:8999038 leukemia inhibitory factor receptor activity IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 oncostatin-M receptor activity contributes_to ISO RGD:731409 1624291 (PMID:8999038) RGD PMID:8999038 oncostatin-M receptor activity contributes_to IBA MGI:MGI:1330819 more ... 13792537 PMID:21873635 GO_Central oncostatin-M receptor activity IEA UniProtKB:P40189 , ensembl:ENSP000003706981600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding ISO RGD:731410 1624291 PR:P42703 more ... RGD MGI:MGI:3614252 more ... protein binding ISO RGD:731409 1624291 UniProtKB:P13725 more ... RGD PMID:10982829 more ...
Gene-Chemical Interaction Annotations
