Il6st (interleukin 6 signal transducer) - Rat Genome Database

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Gene: Il6st (interleukin 6 signal transducer) Mus musculus
Analyze
Symbol: Il6st
Name: interleukin 6 signal transducer
RGD ID: 731410
MGI Page MGI
Description: Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; hemolymphoid system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; hyperandrogenism; and primary immunodeficiency disease. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699; D13Ertd699e; gp13; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913112,600,604 - 112,643,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13112,600,604 - 112,646,620 (+)EnsemblGRCm39 Ensembl
GRCm3813112,464,070 - 112,506,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13112,464,070 - 112,510,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,254,278 - 113,297,068 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613113,584,987 - 113,627,719 (+)NCBIMGSCv36mm8
Celera13116,768,393 - 116,811,051 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-formyltetrahydrofolic acid  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aflatoxin M1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (EXP)
asperentin  (EXP)
auranofin  (ISO)
bazedoxifene  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
Brevianamide A  (EXP)
bromochloroacetic acid  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP,ISO)
CGP 52608  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (EXP)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
glucose  (EXP)
hexachlorobenzene  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
kojic acid  (ISO)
leflunomide  (ISO)
lenalidomide  (ISO)
lipopolysaccharide  (EXP,ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mycophenolic acid  (EXP)
mycotoxin  (EXP)
neoechinulin A  (EXP)
nickel atom  (ISO)
obeticholic acid  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
serpentine asbestos  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
Soman  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP)
succimer  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
TMC-120A  (EXP)
topotecan  (ISO)
torcetrapib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimethyltin  (EXP)
vancomycin  (EXP)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone marrow development  (IAGP)
abnormal bone structure  (IAGP)
abnormal channel response intensity  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal dendritic cell antigen presentation  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal digestive system physiology  (IAGP)
abnormal embryonic growth/weight/body size  (IAGP)
abnormal erythropoiesis  (IAGP)
abnormal femur morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal involution of the mammary gland  (IAGP)
abnormal joint morphology  (IAGP)
abnormal leukocyte cell number  (IAGP)
abnormal liver physiology  (IAGP)
abnormal liver regeneration  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal myelination  (IAGP)
abnormal myocardial fiber physiology  (IAGP)
abnormal negative T cell selection  (IAGP)
abnormal osteoblast physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal osteoclast morphology  (IAGP)
abnormal osteoclast physiology  (IAGP)
abnormal peritoneum morphology  (IAGP)
abnormal Schwann cell morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal spleen size  (IAGP)
abnormal stomach morphology  (IAGP)
abnormal stomach mucosa morphology  (IAGP)
abnormal synovial joint capsule morphology  (IAGP)
abnormal T cell activation  (IAGP)
abnormal T cell clonal deletion  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal thrombopoiesis  (IAGP)
abnormal thymocyte activation  (IAGP)
abnormal trabecular bone morphology  (IAGP)
anemia  (IAGP)
bowed femur  (IAGP)
bowed fibula  (IAGP)
bowed humerus  (IAGP)
bowed radius  (IAGP)
bowed tibia  (IAGP)
bowed ulna  (IAGP)
cecum inflammation  (IAGP)
conjunctivitis  (IAGP)
decreased B-1a cell number  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased common myeloid progenitor cell number  (IAGP)
decreased compact bone thickness  (IAGP)
decreased diameter of femur  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased embryo size  (IAGP)
decreased erythroid progenitor cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased IgG2b level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interferon-gamma secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased joint mobility  (IAGP)
decreased liver glycogen level  (IAGP)
decreased megakaryocyte cell number  (IAGP)
decreased osteoblast cell number  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased stomach tumor incidence  (IAGP)
decreased susceptibility to endotoxin shock  (IAGP)
decreased susceptibility to induced colitis  (IAGP)
decreased thymocyte number  (IAGP)
decreased trabecular bone thickness  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, incomplete penetrance  (IAGP)
enlarged axillary lymph nodes  (IAGP)
enlarged cervical lymph nodes  (IAGP)
enlarged inguinal lymph nodes  (IAGP)
enlarged mesenteric lymph nodes  (IAGP)
enlarged spleen  (IAGP)
enlarged stomach  (IAGP)
failure of embryo implantation  (IAGP)
female infertility  (IAGP)
gastric ulcer  (IAGP)
gastrointestinal hemorrhage  (IAGP)
gastrointestinal ulcer  (IAGP)
increased activated T cell number  (IAGP)
increased activity of parathyroid  (IAGP)
increased adenoma incidence  (IAGP)
increased anti-double stranded DNA antibody level  (IAGP)
increased anti-nuclear antigen antibody level  (IAGP)
increased anti-single stranded DNA antibody level  (IAGP)
increased autoantibody level  (IAGP)
increased B cell number  (IAGP)
increased bone mineral content  (IAGP)
increased bone mineral density  (IAGP)
increased bone mineralization  (IAGP)
increased bone ossification  (IAGP)
increased CD4-positive, alpha-beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased cell proliferation  (IAGP)
increased circulating bilirubin level  (IEA)
increased circulating interleukin-6 level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased double-negative T cell number  (IAGP)
increased IgA level  (IAGP)
increased IgE level  (IAGP)
increased IgG level  (IAGP)
increased IgG1 level  (IAGP)
increased IgG2a level  (IAGP)
increased IgG2b level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased interferon-gamma secretion  (IAGP)
increased interleukin-6 secretion  (IAGP)
increased leukocyte cell number  (IAGP)
increased mean corpuscular hemoglobin concentration  (IEA)
increased megakaryocyte cell number  (IAGP)
increased neutrophil cell number  (IAGP)
increased nucleated erythrocyte cell number  (IAGP)
increased osteoblast cell number  (IAGP)
increased osteoclast cell number  (IAGP)
increased physiological sensitivity to xenobiotic  (IAGP)
increased single-positive T cell number  (IAGP)
increased stomach mucosa thickness  (IAGP)
increased stomach pH  (IAGP)
increased stomach tumor incidence  (IAGP)
increased susceptibility to endotoxin shock  (IAGP)
increased susceptibility to induced arthritis  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced morbidity/mortality  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to xenobiotic induced morbidity/mortality  (IAGP)
increased trabecular bone thickness  (IAGP)
joint swelling  (IAGP)
lethality during fetal growth through weaning, complete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lymph node hyperplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IEA)
rectal prolapse  (IAGP)
rheumatoid arthritis  (IAGP)
short femur  (IAGP)
short limbs  (IAGP)
spleen hyperplasia  (IAGP)
stomach inflammation  (IAGP)
thin ventricular wall  (IAGP)
thrombocytopenia  (IAGP)
thymus hypoplasia  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential effects of locally and systemically administered soluble glycoprotein 130 on pain and inflammation in experimental arthritis. Boettger MK, etal., Arthritis Res Ther. 2010;12(4):R140. Epub 2010 Jul 13.
2. Upregulation of gp130 and differential activation of STAT and p42/44 MAPK in the rat hippocampus following kainic acid-induced seizures. Choi JS, etal., Brain Res Mol Brain Res. 2003 Nov 6;119(1):10-8.
3. Role of interleukin-6 in chronic muscle hyperalgesic priming. Dina OA, etal., Neuroscience. 2008 Mar 18;152(2):521-5. Epub 2008 Jan 12.
4. Association of polymorphisms in the interleukin 6 receptor complex with obesity and hyperandrogenism. Escobar-Morreale HF, etal., Obes Res. 2003 Aug;11(8):987-96.
5. Involvement of the gp130 cytokine transducer in MtT/S pituitary somatotroph tumour development in an autocrine-paracrine model. Graciarena M, etal., Eur J Endocrinol. 2004 Nov;151(5):595-604.
6. Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's disease. Hampel H, etal., Brain Res. 1999 Mar 27;823(1-2):104-12.
7. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Hirota H, etal., Cell 1999 Apr 16;97(2):189-98.
8. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Jones SA, etal., J Clin Invest. 2011 Sep 1;121(9):3375-83. doi: 10.1172/JCI57158. Epub 2011 Sep 1.
9. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
10. Ischemic preconditioning-induced expression of gp130 and STAT3 in astrocytes of the rat hippocampus. Kim SY, etal., Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):96-103.
11. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
12. [Determination of serum soluble interleukin-6 receptor and soluble gp130 levels in patient with pregnancy induced hypertension and its significance] Li Y, etal., Zhonghua Fu Chan Ke Za Zhi. 2001 Jan;36(1):18-9.
13. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. Luchtefeld M, etal., J Exp Med. 2007 Aug 6;204(8):1935-44. Epub 2007 Jul 30.
14. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
15. MGDs mouse GO annotations MGD data from the GO Consortium
16. MGD IEA MGD IEA
17. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Mihara M, etal., Clin Sci (Lond). 2012 Feb;122(4):143-59. doi: 10.1042/CS20110340.
18. Interleukin-6 inhibits cell proliferation in a rat model of hepatocellular carcinoma. Moran DM, etal., Liver Int. 2005 Apr;25(2):445-57.
19. LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats. Nonogaki K, etal., Am J Physiol. 1996 Sep;271(3 Pt 1):E521-8.
20. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Rosell DR, etal., Neuroscience. 2003;122(2):329-48.
26. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Tebbutt NC, etal., Nat Med 2002 Oct;8(10):1089-97.
27. Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors. Ueki Y, etal., Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21389-94. doi: 10.1073/pnas.0906156106. Epub 2009 Nov 30.
Additional References at PubMed
PMID:1542794   PMID:1602143   PMID:1915266   PMID:7621883   PMID:7957045   PMID:8552649   PMID:8607969   PMID:8666978   PMID:8843390   PMID:8889548   PMID:9122220   PMID:9324354  
PMID:9348227   PMID:9500603   PMID:9507023   PMID:9558387   PMID:9743535   PMID:9815272   PMID:9874564   PMID:9920829   PMID:9933112   PMID:9988212   PMID:10205167   PMID:10349636  
PMID:10486560   PMID:10564261   PMID:10661409   PMID:10922068   PMID:10989258   PMID:11042159   PMID:11076861   PMID:11160399   PMID:11262406   PMID:11275690   PMID:11457894   PMID:11493552  
PMID:11567054   PMID:11877449   PMID:12047380   PMID:12070777   PMID:12097503   PMID:12147685   PMID:12370259   PMID:12423677   PMID:12477932   PMID:12509437   PMID:12518458   PMID:12520002  
PMID:12629177   PMID:12691915   PMID:12754506   PMID:12830005   PMID:12891556   PMID:12900446   PMID:14600146   PMID:14610273   PMID:14617570   PMID:14699500   PMID:14749363   PMID:14755335  
PMID:14978019   PMID:14996842   PMID:15051883   PMID:15073037   PMID:15207851   PMID:15292206   PMID:15356132   PMID:15607729   PMID:15634701   PMID:15650055   PMID:15677447   PMID:15716858  
PMID:15761498   PMID:15852015   PMID:15976028   PMID:15996112   PMID:16014513   PMID:16041381   PMID:16118327   PMID:16141072   PMID:16141073   PMID:16143138   PMID:16250046   PMID:16286017  
PMID:16319110   PMID:16452715   PMID:16452727   PMID:16679075   PMID:16717113   PMID:16818888   PMID:16825607   PMID:16905102   PMID:16906166   PMID:17030178   PMID:17053039   PMID:17082315  
PMID:17101849   PMID:17105399   PMID:17114459   PMID:17179859   PMID:17182563   PMID:17241879   PMID:17249568   PMID:17256754   PMID:17299136   PMID:17493959   PMID:17567983   PMID:17603283  
PMID:17609432   PMID:17674319   PMID:17688421   PMID:17961593   PMID:18185532   PMID:18216023   PMID:18236210   PMID:18431520   PMID:18467707   PMID:18519587   PMID:18593565   PMID:18641358  
PMID:18684959   PMID:18714032   PMID:18805458   PMID:18848474   PMID:19015529   PMID:19050105   PMID:19097069   PMID:19109195   PMID:19121317   PMID:19136654   PMID:19185844   PMID:19213943  
PMID:19228423   PMID:19501045   PMID:19538749   PMID:19592611   PMID:19593768   PMID:19646521   PMID:19665497   PMID:19805641   PMID:19852956   PMID:19864560   PMID:19948109   PMID:20005819  
PMID:20016025   PMID:20042455   PMID:20051627   PMID:20062084   PMID:20091786   PMID:20100971   PMID:20144891   PMID:20200229   PMID:20238070   PMID:20348091   PMID:20353422   PMID:20382701  
PMID:20530204   PMID:20554759   PMID:20585009   PMID:20707873   PMID:21035185   PMID:21079661   PMID:21090245   PMID:21148800   PMID:21162133   PMID:21220456   PMID:21241805   PMID:21267068  
PMID:21297079   PMID:21515788   PMID:21565387   PMID:21606248   PMID:21677750   PMID:21710691   PMID:21873635   PMID:21990364   PMID:21995459   PMID:22007720   PMID:22082679   PMID:22100262  
PMID:22140267   PMID:22196363   PMID:22268122   PMID:22304915   PMID:22306691   PMID:22323722   PMID:22523320   PMID:22567975   PMID:22640806   PMID:22645143   PMID:22715999   PMID:22745821  
PMID:22798669   PMID:22911828   PMID:22986785   PMID:22999927   PMID:23077604   PMID:23079657   PMID:23091017   PMID:23192694   PMID:23209286   PMID:23306157   PMID:23321674   PMID:23335749  
PMID:23454976   PMID:23728346   PMID:23809164   PMID:23831387   PMID:23853585   PMID:23885093   PMID:23888778   PMID:23948300   PMID:23993651   PMID:24069548   PMID:24081661   PMID:24145720  
PMID:24191003   PMID:24194600   PMID:24339143   PMID:24398427   PMID:24463703   PMID:24519625   PMID:24727895   PMID:24802098   PMID:24804649   PMID:24812426   PMID:24859004   PMID:24899055  
PMID:24944284   PMID:24952961   PMID:25057188   PMID:25088199   PMID:25103368   PMID:25127137   PMID:25228504   PMID:25253866   PMID:25268586   PMID:25270258   PMID:25384216   PMID:25528766  
PMID:25545330   PMID:25722214   PMID:25731159   PMID:26255596   PMID:26384383   PMID:26758839   PMID:26837764   PMID:26848037   PMID:26974160   PMID:27053713   PMID:27086282   PMID:27226573  
PMID:27373892   PMID:27503072   PMID:27626380   PMID:27893707   PMID:28170160   PMID:28280243   PMID:28402851   PMID:28481875   PMID:28700664   PMID:29282220   PMID:29309623   PMID:29379870  
PMID:29417587   PMID:29562203   PMID:29629897   PMID:29641213   PMID:29668931   PMID:29770132   PMID:29789201   PMID:30201812   PMID:30374128   PMID:30622113   PMID:30726111   PMID:30887098  
PMID:30918582   PMID:30936494   PMID:31079916   PMID:31481496   PMID:32164044   PMID:32242005   PMID:32325033   PMID:32458800   PMID:32554809   PMID:32600062   PMID:32987028   PMID:33181031  
PMID:34034544   PMID:34252913   PMID:34402137   PMID:34547509   PMID:34999736   PMID:35020406   PMID:35039652   PMID:35579694   PMID:35588797   PMID:35594067   PMID:35677533   PMID:36552868  
PMID:36617342   PMID:36646738   PMID:36787740   PMID:37022703   PMID:37058108   PMID:37058116   PMID:37100060   PMID:37272871   PMID:37528140   PMID:37957015   PMID:38165930  


Genomics

Comparative Map Data
Il6st
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913112,600,604 - 112,643,394 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13112,600,604 - 112,646,620 (+)EnsemblGRCm39 Ensembl
GRCm3813112,464,070 - 112,506,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13112,464,070 - 112,510,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,254,278 - 113,297,068 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613113,584,987 - 113,627,719 (+)NCBIMGSCv36mm8
Celera13116,768,393 - 116,811,051 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.73NCBI
IL6ST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38555,935,095 - 55,994,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl555,935,095 - 55,995,022 (-)EnsemblGRCh38hg38GRCh38
GRCh37555,230,923 - 55,290,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36555,272,451 - 55,326,520 (-)NCBINCBI36Build 36hg18NCBI36
Build 34555,272,451 - 55,326,520NCBI
Celera552,184,738 - 52,244,652 (-)NCBICelera
Cytogenetic Map5q11.2NCBI
HuRef552,204,630 - 52,264,547 (-)NCBIHuRef
CHM1_1555,234,877 - 55,294,748 (-)NCBICHM1_1
T2T-CHM13v2.0556,763,505 - 56,823,387 (-)NCBIT2T-CHM13v2.0
Il6st
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8245,798,872 - 45,839,501 (+)NCBIGRCr8
mRatBN7.2244,065,979 - 44,106,255 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl244,066,130 - 44,109,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx251,196,571 - 51,225,818 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0249,255,007 - 49,284,254 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0244,122,946 - 44,152,152 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0244,279,199 - 44,319,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0263,320,957 - 63,361,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,806,301 - 43,842,365 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1243,736,911 - 43,762,480 (+)NCBI
Celera239,857,022 - 39,886,283 (+)NCBICelera
Cytogenetic Map2q14NCBI
Il6st
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,790,444 - 11,835,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,790,636 - 11,837,734 (+)NCBIChiLan1.0ChiLan1.0
IL6ST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2457,932,421 - 57,993,400 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1556,088,793 - 56,147,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0558,023,704 - 58,081,895 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1559,650,833 - 59,708,817 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl559,669,606 - 59,708,817 (+)Ensemblpanpan1.1panPan2
IL6ST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,214,050 - 43,273,014 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,214,050 - 43,248,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,260,413 - 40,306,615 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0243,679,923 - 43,738,936 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl243,679,928 - 43,738,942 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1240,758,131 - 40,804,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0241,560,510 - 41,606,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0242,380,727 - 42,426,940 (-)NCBIUU_Cfam_GSD_1.0
Il6st
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648011,884,582 - 11,909,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648011,867,573 - 11,913,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6ST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,101,306 - 35,192,220 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,101,304 - 35,151,832 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21637,476,140 - 37,522,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL6ST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1452,174,893 - 52,232,475 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl452,174,312 - 52,214,584 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660491,050,897 - 1,108,503 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il6st
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247593,276,741 - 3,312,601 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247593,258,324 - 3,315,265 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il6st
1205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4168
Count of miRNA genes:919
Interacting mature miRNAs:1301
Transcripts:ENSMUST00000070731, ENSMUST00000183513, ENSMUST00000183663, ENSMUST00000183829, ENSMUST00000183868, ENSMUST00000183886, ENSMUST00000184276, ENSMUST00000184311, ENSMUST00000184445, ENSMUST00000184949
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142147Mvwf4_mmodifier of von Willebrand factor 4 (mouse)Not determined20477612112898424Mouse
10043997Bw40_mbody weight QTL 40 (mouse)Not determined1479239045113239162Mouse
10045623Heal18_mwound healing regeneration 18 (mouse)Not determined1379239045113239162Mouse
1558741Ses10_msalmonella enteritidis susceptibility 10 (mouse)Not determined1382739968116740106Mouse
4142465Pbwg17_mpostnatal body weight growth 17 (mouse)Not determined1383876060117876256Mouse
14700691Cisaq1_mcoxsackieviral infection serum ALT QTL 1 (mouse)1386148119120461536Mouse
4140995Fbtq6_mfemoral bone trait QTL 6 (mouse)Not determined1386341617120341758Mouse
1300939Hrtfm6_mheart failure modifier 6 (mouse)Not determined1391383692120883175Mouse
1300876Tanidd2_mtally ho associated non-insulin dependednt diabetes mellitus 2 (mouse)Not determined1391965303120883175Mouse
1301142Heal2_mwound healing/regeneration 2 (mouse)Not determined1393875267120883175Mouse
4142338Skmw18_mskeletal muscle weight 18 (mouse)Not determined1394528399120883175Mouse
1558763Gct9_mgranulosa cell tumorigenesis 9 (mouse)Not determined1395036824120883175Mouse
1357468Rplag_mreduced platelet aggregation (mouse)Not determined1395502130120883175Mouse
14746974Manh75_mmandible shape 75 (mouse)1399386647120883175Mouse
12879496Fexq2_mfear expression QTL 2 (mouse)13100741519120883175Mouse
4142400Tgq24_mtriglyceride QTL 24 (mouse)Not determined102602630120883175Mouse
4141826Tbqt5_mtibia bone quality traits 5 (mouse)Not determined13103341617117043216Mouse
4142334Svtms_msurvival time modifier of Sod2 (mouse)Not determined13107613580119476372Mouse
4141704Hipq1_mhyperinsulin production QTL 1 (mouse)Not determined110409487119476372Mouse

Markers in Region
X62646  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813112,504,460 - 112,504,540UniSTSGRCm38
MGSCv3713113,294,668 - 113,294,748UniSTSGRCm37
Celera13116,808,651 - 116,808,731UniSTS
Cytogenetic Map13D2.2UniSTS
Whitehead/MRC_RH13969.7UniSTS
M83336  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813112,504,493 - 112,504,595UniSTSGRCm38
MGSCv3713113,294,701 - 113,294,803UniSTSGRCm37
Celera13116,808,684 - 116,808,786UniSTS
Cytogenetic Map13D2.2UniSTS
Whitehead_YAC13 UniSTS
UniSTS:237111  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813112,508,156 - 112,508,401UniSTSGRCm38
MGSCv3713113,298,364 - 113,298,609UniSTSGRCm37
Celera13116,812,347 - 116,812,592UniSTS
Cytogenetic Map13D2.2UniSTS
UniSTS:237112  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3813112,505,571 - 112,505,972UniSTSGRCm38
MGSCv3713113,295,779 - 113,296,180UniSTSGRCm37
Celera13116,809,762 - 116,810,163UniSTS
Cytogenetic Map13D2.2UniSTS
AU015818  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map1367.0UniSTS
Whitehead/MRC_RH13969.7UniSTS
Il6st  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13D2.2UniSTS
cM Map13 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036157858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC159196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK017211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK142637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC049887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU709006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ177012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV556562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ085376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ085377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JQ085378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M83336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X62646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000070731   ⟹   ENSMUSP00000064205
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,611,542 - 112,643,394 (+)Ensembl
GRCm38.p6 Ensembl13112,475,008 - 112,506,860 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183513   ⟹   ENSMUSP00000139016
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,611,580 - 112,640,293 (+)Ensembl
GRCm38.p6 Ensembl13112,475,046 - 112,503,759 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183663   ⟹   ENSMUSP00000138836
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,600,604 - 112,646,620 (+)Ensembl
GRCm38.p6 Ensembl13112,464,070 - 112,510,086 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183829   ⟹   ENSMUSP00000138987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,611,580 - 112,640,293 (+)Ensembl
GRCm38.p6 Ensembl13112,475,046 - 112,503,759 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183868   ⟹   ENSMUSP00000139180
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,604,127 - 112,616,591 (+)Ensembl
GRCm38.p6 Ensembl13112,467,593 - 112,480,057 (+)Ensembl
RefSeq Acc Id: ENSMUST00000183886   ⟹   ENSMUSP00000138820
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,600,646 - 112,620,150 (+)Ensembl
GRCm38.p6 Ensembl13112,464,112 - 112,483,616 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184276   ⟹   ENSMUSP00000139060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,600,775 - 112,641,079 (+)Ensembl
GRCm38.p6 Ensembl13112,464,241 - 112,504,545 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184311   ⟹   ENSMUSP00000139227
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,600,615 - 112,641,025 (+)Ensembl
GRCm38.p6 Ensembl13112,464,081 - 112,504,491 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184445   ⟹   ENSMUSP00000139311
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,609,133 - 112,637,675 (+)Ensembl
GRCm38.p6 Ensembl13112,472,599 - 112,501,141 (+)Ensembl
RefSeq Acc Id: ENSMUST00000184949   ⟹   ENSMUSP00000138915
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl13112,611,580 - 112,640,979 (+)Ensembl
GRCm38.p6 Ensembl13112,475,046 - 112,504,445 (+)Ensembl
RefSeq Acc Id: NM_010560   ⟹   NP_034690
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913112,600,604 - 112,643,394 (+)NCBI
GRCm3813112,464,070 - 112,506,860 (+)ENTREZGENE
MGSCv3713113,254,278 - 113,297,068 (+)RGD
Celera13116,768,393 - 116,811,051 (+)RGD
cM Map13 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157858   ⟹   XP_036013751
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3913112,602,194 - 112,643,383 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034690   ⟸   NM_010560
- Peptide Label: precursor
- UniProtKB: G5E8D2 (UniProtKB/Swiss-Prot),   Q00560 (UniProtKB/Swiss-Prot),   Q6PDI9 (UniProtKB/TrEMBL),   H6WCS3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000139060   ⟸   ENSMUST00000184276
RefSeq Acc Id: ENSMUSP00000138915   ⟸   ENSMUST00000184949
RefSeq Acc Id: ENSMUSP00000139227   ⟸   ENSMUST00000184311
RefSeq Acc Id: ENSMUSP00000139311   ⟸   ENSMUST00000184445
RefSeq Acc Id: ENSMUSP00000139016   ⟸   ENSMUST00000183513
RefSeq Acc Id: ENSMUSP00000138836   ⟸   ENSMUST00000183663
RefSeq Acc Id: ENSMUSP00000138820   ⟸   ENSMUST00000183886
RefSeq Acc Id: ENSMUSP00000139180   ⟸   ENSMUST00000183868
RefSeq Acc Id: ENSMUSP00000138987   ⟸   ENSMUST00000183829
RefSeq Acc Id: ENSMUSP00000064205   ⟸   ENSMUST00000070731
RefSeq Acc Id: XP_036013751   ⟸   XM_036157858
- Peptide Label: isoform X1
- UniProtKB: Q00560 (UniProtKB/Swiss-Prot),   G5E8D2 (UniProtKB/Swiss-Prot),   H6WCS3 (UniProtKB/TrEMBL),   Q6PDI9 (UniProtKB/TrEMBL)
Protein Domains
Fibronectin type-III   Ig-like C2-type   Immunoglobulin C2-set-like ligand-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00560-F1-model_v2 AlphaFold Q00560 1-917 view protein structure

Promoters
RGD ID:8681308
Promoter ID:EPDNEW_M18684
Type:initiation region
Name:Il6st_1
Description:Mus musculus interleukin 6 signal transducer , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3813112,464,130 - 112,464,190EPDNEW
RGD ID:6824082
Promoter ID:MM_KWN:15275
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK020154_6720470G18RIK,   NM_010560,   UC007RWF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3613113,253,676 - 113,254,867 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96560 AgrOrtholog
Ensembl Genes ENSMUSG00000021756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000070731.11 UniProtKB/Swiss-Prot
  ENSMUST00000183513.8 UniProtKB/TrEMBL
  ENSMUST00000183663 ENTREZGENE
  ENSMUST00000183663.8 UniProtKB/Swiss-Prot
  ENSMUST00000183829.8 UniProtKB/TrEMBL
  ENSMUST00000183868.8 UniProtKB/TrEMBL
  ENSMUST00000183886.8 UniProtKB/TrEMBL
  ENSMUST00000184276.8 UniProtKB/TrEMBL
  ENSMUST00000184311.8 UniProtKB/Swiss-Prot
  ENSMUST00000184445.8 UniProtKB/TrEMBL
  ENSMUST00000184949.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16195 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96560 ENTREZGENE
NCBI Gene 16195 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-6 RECEPTOR SUBUNIT BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL6Ra-bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il6st PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G5E8D2 ENTREZGENE
  H6WCS3 ENTREZGENE, UniProtKB/TrEMBL
  IL6RB_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TDT5_MOUSE UniProtKB/TrEMBL
  Q3UQA0_MOUSE UniProtKB/TrEMBL
  Q6PDI9 ENTREZGENE, UniProtKB/TrEMBL
  V9GX00_MOUSE UniProtKB/TrEMBL
  V9GX52_MOUSE UniProtKB/TrEMBL
  V9GX73_MOUSE UniProtKB/TrEMBL
  V9GXA2_MOUSE UniProtKB/TrEMBL
  V9GXJ5_MOUSE UniProtKB/TrEMBL
  V9GXT4_MOUSE UniProtKB/TrEMBL
UniProt Secondary G5E8D2 UniProtKB/Swiss-Prot