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Gene: IL6ST (interleukin 6 signal transducer) Homo sapiens
Symbol: IL6ST
Name: interleukin 6 signal transducer
Description: Exhibits several functions, including ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding activity; and identical protein binding activity. Contributes to cytokine receptor activity; interleukin-6 binding activity; and interleukin-6 receptor binding activity. Involved in several processes, including cytokine-mediated signaling pathway; positive regulation of osteoblast differentiation; and regulation of signal transduction. Localizes to the extracellular space and integral component of plasma membrane. Implicated in arteriosclerosis and hyperandrogenism. Biomarker of Alzheimer's disease; hypertension; status epilepticus; and visual epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD130; CD130 antigen; CDw130; DKFZp564F053; GP130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130 transducer chain; gp130, oncostatin M receptor; GP130-RAPS; HIES4; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6R-beta; IL6ST nirs variant 3; interleukin receptor beta chain; interleukin-6 receptor subunit beta; interleukin-6 signal transducer; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin M receptor; oncostatin-M receptor subunit alpha; sGP130
Mus musculus (house mouse) : Il6st (interleukin 6 signal transducer)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il6st (interleukin 6 signal transducer)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il6st (interleukin 6 signal transducer)
Pan paniscus (bonobo/pygmy chimpanzee) : IL6ST (interleukin 6 signal transducer)
Canis lupus familiaris (dog) : IL6ST (interleukin 6 signal transducer)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il6st (interleukin 6 signal transducer)
Sus scrofa (pig) : IL6ST (interleukin 6 signal transducer)
Chlorocebus sabaeus (green monkey) : IL6ST (interleukin 6 signal transducer)
Heterocephalus glaber (naked mole-rat) : Il6st (interleukin 6 signal transducer)
more info ...
Related Pseudogenes: IL6STP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl555,935,095 - 55,995,022 (-)Ensembl
GRCh38555,935,095 - 55,994,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37555,230,923 - 55,290,821 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36555,272,451 - 55,326,520 (-)NCBINCBI36hg18NCBI36
Build 34555,272,451 - 55,326,520NCBI
Celera552,184,738 - 52,244,652 (-)NCBI
Cytogenetic Map5q11.2NCBI
HuRef552,204,630 - 52,264,547 (-)NCBIHuRef
CHM1_1555,234,877 - 55,294,748 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL6ST
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731409
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.