Il6st (interleukin 6 cytokine family signal transducer) - Rat Genome Database

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Gene: Il6st (interleukin 6 cytokine family signal transducer) Ictidomys tridecemlineatus
Analyze
Symbol: Il6st
Name: interleukin 6 cytokine family signal transducer
RGD ID: 12602386
Description: ENCODES a protein that exhibits ciliary neurotrophic factor receptor activity (ortholog); ciliary neurotrophic factor receptor binding (ortholog); growth factor binding (ortholog); INVOLVED IN ciliary neurotrophic factor-mediated signaling pathway (ortholog); cytokine-mediated signaling pathway (ortholog); glycogen metabolic process (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; interleukin-6 signaling pathway; ASSOCIATED WITH allergic disease (ortholog); Alzheimer's disease (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell body (ortholog); ciliary neurotrophic factor receptor complex (ortholog); dendrite (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: interleukin 6 signal transducer; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin-6 receptor subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
SpeTri2.0NW_00493648011,867,573 - 11,913,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Il6st
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
SpeTri2.0NW_00493648011,867,573 - 11,913,563 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL6ST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl555,935,095 - 55,995,022 (-)EnsemblGRCh38hg38GRCh38
GRCh38555,935,095 - 55,994,963 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37555,230,923 - 55,290,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36555,272,451 - 55,326,520 (-)NCBINCBI36hg18NCBI36
Build 34555,272,451 - 55,326,520NCBI
Celera552,184,738 - 52,244,652 (-)NCBI
Cytogenetic Map5q11.2NCBI
HuRef552,204,630 - 52,264,547 (-)NCBIHuRef
CHM1_1555,234,877 - 55,294,748 (-)NCBICHM1_1
Il6st
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913112,600,604 - 112,643,394 (+)NCBIGRCm39mm39
GRCm39 Ensembl13112,600,604 - 112,646,620 (+)Ensembl
GRCm3813112,464,070 - 112,506,860 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13112,464,070 - 112,510,086 (+)EnsemblGRCm38mm10GRCm38
MGSCv3713113,254,278 - 113,297,068 (+)NCBIGRCm37mm9NCBIm37
MGSCv3613113,584,987 - 113,627,719 (+)NCBImm8
Celera13116,768,393 - 116,811,051 (+)NCBICelera
Cytogenetic Map13D2.2NCBI
cM Map1363.73NCBI
Il6st
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2244,065,979 - 44,106,255 (+)NCBI
Rnor_6.0 Ensembl244,289,393 - 44,314,944 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0244,279,199 - 44,319,427 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0263,320,957 - 63,361,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4243,806,301 - 43,842,365 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1243,736,911 - 43,762,480 (+)NCBI
Celera239,857,022 - 39,886,283 (+)NCBICelera
Cytogenetic Map2q14NCBI
Il6st
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544611,790,444 - 11,835,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544611,790,636 - 11,837,734 (+)NCBIChiLan1.0ChiLan1.0
IL6ST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1559,650,833 - 59,708,817 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl559,669,606 - 59,708,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0558,023,704 - 58,081,895 (+)NCBIMhudiblu_PPA_v0panPan3
IL6ST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1243,214,050 - 43,273,014 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl243,214,050 - 43,248,124 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha240,260,413 - 40,306,615 (-)NCBI
ROS_Cfam_1.0243,679,923 - 43,738,936 (-)NCBI
UMICH_Zoey_3.1240,758,131 - 40,804,315 (-)NCBI
UNSW_CanFamBas_1.0241,560,510 - 41,606,926 (-)NCBI
UU_Cfam_GSD_1.0242,380,727 - 42,426,940 (-)NCBI
IL6ST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1635,101,304 - 35,211,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11635,101,304 - 35,151,832 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21637,476,140 - 37,522,638 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL6ST
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1452,174,893 - 52,232,475 (-)NCBI
ChlSab1.1 Ensembl452,174,312 - 52,214,584 (-)Ensembl
Vero_WHO_p1.0NW_0236660491,050,897 - 1,108,503 (-)NCBI
Il6st
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247593,258,324 - 3,315,265 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005319617   ⟹   XP_005319674
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
SpeTri2.0NW_00493648011,867,573 - 11,909,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013356097   ⟹   XP_013211551
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
SpeTri2.0NW_00493648011,867,573 - 11,913,563 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013356098   ⟹   XP_013211552
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
SpeTri2.0NW_00493648011,867,573 - 11,909,635 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040271798   ⟹   XP_040127732
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024407213202,931,083 - 202,977,366 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005319674 (Get FASTA)   NCBI Sequence Viewer  
  XP_013211551 (Get FASTA)   NCBI Sequence Viewer  
  XP_013211552 (Get FASTA)   NCBI Sequence Viewer  
  XP_040127732 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013211551   ⟸   XM_013356097
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005319674   ⟸   XM_005319617
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013211552   ⟸   XM_013356098
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040127732   ⟸   XM_040271798
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005009 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000004501 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005019 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Hematopoietin_rcpt_Gp130_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  IgC2-like_lig-bd UniProtKB/TrEMBL
  TypeI_recpt_CBD UniProtKB/TrEMBL
NCBI Gene Il6st ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  IL6Ra-bind UniProtKB/TrEMBL
  Lep_receptor_Ig UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_L_F2 UniProtKB/TrEMBL
SMART FN3 UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/TrEMBL
UniProt I3M5B1_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-02-10 Il6st  interleukin 6 cytokine family signal transducer  Il6st  interleukin 6 signal transducer  Symbol and/or name change 5135510 APPROVED