Adora2b (adenosine A2B receptor) - Rat Genome Database

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Gene: Adora2b (adenosine A2B receptor) Rattus norvegicus
Analyze
Symbol: Adora2b
Name: adenosine A2B receptor
RGD ID: 2050
Description: Predicted to enable G protein-coupled receptor activity. Involved in several processes, including negative regulation of collagen biosynthetic process; positive regulation of cAMP-mediated signaling; and positive regulation of interleukin-6 production. Located in cell surface and plasma membrane. Orthologous to human ADORA2B (adenosine A2b receptor); PARTICIPATES IN adenosine signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (S)-AMPA; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: adenosine receptor A2b
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Adora2bem2Mcwi   Adora2bem1Mcwi  
Genetic Models: SS-Adora2bem1Mcwi SS-Adora2bem2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21046,940,394 - 46,956,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,644,175 - 51,660,562 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01051,134,721 - 51,151,112 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01046,638,130 - 46,654,520 (+)NCBIRnor_WKY
Rnor_6.01048,569,563 - 48,586,366 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01048,358,068 - 48,374,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,421,592 - 48,437,967 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11048,435,217 - 48,451,589 (+)NCBI
Celera1046,186,295 - 46,202,681 (+)NCBICelera
Cytogenetic Map10q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-AMPA  (EXP)
(S)-amphetamine  (ISO)
1,7-dimethylxanthine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-butylphenol  (ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
adenosine  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alloxazine  (EXP)
ammonium chloride  (EXP)
BAY 60-6583  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
DPCPX  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
indometacin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
methotrexate  (ISO)
modafinil  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-5'-carboxamidoadenosine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nitrogen dioxide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium dichromate  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IBA,IEA,ISO)
cellular response to extracellular stimulus  (IEA,ISO)
cGMP-mediated signaling  (IEA,ISO)
G protein-coupled adenosine receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway  (IBA)
mast cell degranulation  (IEA,ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of collagen biosynthetic process  (IMP)
positive regulation of cAMP-mediated signaling  (IMP)
positive regulation of catecholamine secretion  (IMP)
positive regulation of cell population proliferation  (IMP)
positive regulation of cGMP-mediated signaling  (IEA,ISO)
positive regulation of chemokine production  (IEA,ISO)
positive regulation of chronic inflammatory response to non-antigenic stimulus  (IEA,ISO)
positive regulation of endothelial cell migration  (IMP)
positive regulation of endothelial cell proliferation  (IMP)
positive regulation of guanylate cyclase activity  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,IMP,ISO)
positive regulation of mast cell degranulation  (IEA,ISO)
positive regulation of norepinephrine secretion  (IMP)
positive regulation of steroid biosynthetic process  (IMP)
positive regulation of vascular endothelial growth factor production  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
regulation of glucose metabolic process  (IMP)
regulation of synaptic vesicle exocytosis  (ISO)
relaxation of vascular associated smooth muscle  (IEA,ISO)
response to angiotensin  (IMP)
vasodilation  (IBA,IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adenosine-stimulated adrenal steroidogenesis involves the adenosine A2A and A2B receptors and the Janus kinase 2-mitogen-activated protein kinase kinase-extracellular signal-regulated kinase signaling pathway. Chen YC, etal., Int J Biochem Cell Biol. 2008;40(12):2815-25. Epub 2008 Jun 5.
2. An antagonistic interaction between A2B adenosine and D2 dopamine receptors modulates the function of rat carotid body chemoreceptor cells. Conde SV, etal., J Neurochem. 2008 Dec;107(5):1369-81. Epub 2008 Sep 24.
3. A(2B) adenosine receptors stimulate growth of porcine and rat arterial endothelial cells. Dubey RK, etal., Hypertension 2002 Feb;39(2 Pt 2):530-5.
4. Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors. Dubey RK, etal., Hypertension. 1998 Apr;31(4):943-8.
5. A(2b) receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts. Dubey RK, etal., Hypertension. 2001 Feb;37(2 Part 2):716-21.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. Hayallah AM, etal., J Med Chem 2002 Mar 28;45(7):1500-10.
9. Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice. Latasa MU, etal., PLoS One. 2010 Dec 29;5(12):e15690. doi: 10.1371/journal.pone.0015690.
10. Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells. Lynge J, etal., Biochem Biophys Res Commun. 2003 Jul 18;307(1):180-7.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension. Nayak S, etal., Purinergic Signal. 2015 Dec;11(4):519-31. doi: 10.1007/s11302-015-9470-7. Epub 2015 Sep 18.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Adenosine A2B-receptor-mediated cyclic AMP accumulation in primary rat astrocytes. Peakman MC and Hill SJ, Br J Pharmacol. 1994 Jan;111(1):191-8.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. Coupling to protein kinases A and C of adenosine A2B receptors involved in the facilitation of noradrenaline release in the prostatic portion of rat vas deferens. Queiroz G, etal., Neuropharmacology. 2004 Aug;47(2):216-24.
18. Adenosine-regulated cell proliferation in pituitary folliculostellate and endocrine cells: differential roles for the A(1) and A(2B) adenosine receptors. Rees DA, etal., Endocrinology 2002 Jun;143(6):2427-36.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Shin HK, etal., Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44.
22. Molecular cloning and expression of the cDNA for a novel A2-adenosine receptor subtype. Stehle JH, etal., Mol Endocrinol 1992 Mar;6(3):384-93.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Role of renal medullary adenosine in the control of blood flow and sodium excretion. Zou AP, etal., Am J Physiol 1999 Mar;276(3 Pt 2):R790-8.
Additional References at PubMed
PMID:1333049   PMID:8157966   PMID:11454903   PMID:12477932   PMID:12807441   PMID:12817016   PMID:15284071   PMID:16040158   PMID:16103269   PMID:16601261   PMID:16841096   PMID:16980350  
PMID:17363336   PMID:17391106   PMID:17519974   PMID:17920149   PMID:17979185   PMID:17995930   PMID:18060864   PMID:18340377   PMID:18559975   PMID:19536477   PMID:19695259   PMID:20462966  
PMID:20797398   PMID:20805305   PMID:21246204   PMID:21622827   PMID:23069939   PMID:23315335   PMID:23396225   PMID:23584760   PMID:23638125   PMID:23885058   PMID:24327108   PMID:25704806  
PMID:25728851   PMID:27466291   PMID:27757725   PMID:28266889   PMID:29587249   PMID:29626279   PMID:31206753   PMID:32251679   PMID:33771554   PMID:34288817   PMID:35653908   PMID:36330948  


Genomics

Comparative Map Data
Adora2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21046,940,394 - 46,956,772 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1051,644,175 - 51,660,562 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01051,134,721 - 51,151,112 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01046,638,130 - 46,654,520 (+)NCBIRnor_WKY
Rnor_6.01048,569,563 - 48,586,366 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01048,358,068 - 48,374,871 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41048,421,592 - 48,437,967 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11048,435,217 - 48,451,589 (+)NCBI
Celera1046,186,295 - 46,202,681 (+)NCBICelera
Cytogenetic Map10q23NCBI
ADORA2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381715,850,362 - 15,975,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1715,945,130 - 15,975,746 (+)EnsemblGRCh38hg38GRCh38
GRCh371715,848,444 - 15,879,060 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361715,788,956 - 15,819,935 (+)NCBINCBI36Build 36hg18NCBI36
Build 341715,788,955 - 15,819,935NCBI
Celera1715,751,524 - 15,782,216 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1715,715,812 - 15,746,515 (+)NCBIHuRef
CHM1_11715,856,999 - 15,887,687 (+)NCBICHM1_1
T2T-CHM13v2.01715,847,309 - 15,877,924 (+)NCBIT2T-CHM13v2.0
Adora2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391162,139,810 - 62,157,278 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1162,139,810 - 62,157,279 (+)EnsemblGRCm39 Ensembl
GRCm381162,248,984 - 62,266,452 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1162,248,984 - 62,266,453 (+)EnsemblGRCm38mm10GRCm38
MGSCv371162,062,486 - 62,079,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361162,065,179 - 62,082,647 (+)NCBIMGSCv36mm8
Celera1168,108,085 - 68,109,506 (+)NCBICelera
Cytogenetic Map11B2NCBI
Adora2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554671,342,271 - 1,363,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554671,342,271 - 1,363,149 (+)NCBIChiLan1.0ChiLan1.0
ADORA2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01734,849,466 - 34,880,088 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADORA2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1539,884,375 - 39,908,214 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha540,030,728 - 40,054,092 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0539,987,745 - 40,018,058 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl539,948,932 - 40,018,382 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1539,966,436 - 39,990,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0539,911,700 - 39,935,489 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0540,102,972 - 40,126,790 (-)NCBIUU_Cfam_GSD_1.0
Adora2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560259,204,009 - 59,233,091 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936821580,675 - 608,245 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936821583,463 - 608,189 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADORA2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1259,431,513 - 59,449,672 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11259,431,834 - 59,449,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ADORA2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11615,682,669 - 15,712,079 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1615,683,077 - 15,711,858 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660595,247,130 - 5,277,974 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adora2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248774,422,022 - 4,447,460 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248774,421,307 - 4,447,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adora2b
70 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:74
Count of miRNA genes:59
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000003966
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat

Markers in Region
RH138913  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,952,750 - 46,952,896 (+)MAPPERmRatBN7.2
Rnor_6.01048,582,345 - 48,582,490NCBIRnor6.0
Rnor_5.01048,370,850 - 48,370,995UniSTSRnor5.0
RGSC_v3.41048,433,946 - 48,434,091UniSTSRGSC3.4
Celera1046,198,660 - 46,198,805UniSTS
RH 3.4 Map10545.9UniSTS
Cytogenetic Map10q23UniSTS
RH131534  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21046,956,150 - 46,956,331 (+)MAPPERmRatBN7.2
Rnor_6.01048,585,745 - 48,585,925NCBIRnor6.0
Rnor_5.01048,374,250 - 48,374,430UniSTSRnor5.0
RGSC_v3.41048,437,346 - 48,437,526UniSTSRGSC3.4
Celera1046,202,060 - 46,202,240UniSTS
RH 3.4 Map10545.9UniSTS
Cytogenetic Map10q23UniSTS


Genetic Models
This gene Adora2b is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 3 1
Low 1 41 42 26 19 26 8 9 74 35 37 10 8
Below cutoff 2 15 15 15 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003966   ⟹   ENSRNOP00000003966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1046,940,384 - 46,956,772 (+)Ensembl
Rnor_6.0 Ensembl1048,569,555 - 48,586,365 (+)Ensembl
RefSeq Acc Id: NM_017161   ⟹   NP_058857
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21046,940,394 - 46,956,772 (+)NCBI
Rnor_6.01048,569,563 - 48,586,366 (+)NCBI
Rnor_5.01048,358,068 - 48,374,871 (+)NCBI
RGSC_v3.41048,421,592 - 48,437,967 (+)RGD
Celera1046,186,295 - 46,202,681 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058857 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA20981 (Get FASTA)   NCBI Sequence Viewer  
  AAC33130 (Get FASTA)   NCBI Sequence Viewer  
  AAI61854 (Get FASTA)   NCBI Sequence Viewer  
  EDM04698 (Get FASTA)   NCBI Sequence Viewer  
  P29276 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058857   ⟸   NM_017161
- UniProtKB: B1WBR3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003966   ⟸   ENSRNOT00000003966
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29276-F1-model_v2 AlphaFold P29276 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697269
Promoter ID:EPDNEW_R7794
Type:initiation region
Name:Adora2b_1
Description:adenosine A2B receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01048,569,552 - 48,569,612EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2050 AgrOrtholog
BioCyc Gene G2FUF-24779 BioCyc
Ensembl Genes ENSRNOG00000002922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003966 ENTREZGENE
  ENSRNOP00000003966.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003966 ENTREZGENE
  ENSRNOT00000003966.4 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9024632 IMAGE-MGC_LOAD
InterPro Adeno_A2B_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenosn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29316 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187380 IMAGE-MGC_LOAD
NCBI Gene 29316 ENTREZGENE
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ADORA2B RGD
PhenoGen Adora2b PhenoGen
PRINTS ADENOSINA2BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADENOSINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC233101
UniProt AA2BR_RAT UniProtKB/Swiss-Prot
  B1WBR3 ENTREZGENE, UniProtKB/TrEMBL
  P29276 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Adora2b  adenosine A2B receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_drugs inhibited by 1,8-disubstituted xanthine derivatives 631809
gene_expression expressed in pituitary 631808
gene_expression 3,7-dimethyl-1-prparglylxanthine (DMPX) decreases outer and inner medullary blood flows, urine flow and sodium excretion 628573
gene_function mediates adenosine induced endothelial cell growth 631750
gene_function diuretic and natriuretic adenosine receptor 628573
gene_process may regulate angiogenesis and blood vessel remodeling after injury 631750
gene_process may promote adenosine mediated dilation of medullary vessesl and increase in medullary blood flow 628573
gene_process upon activation dilates pre- and postglomerular vessels and inhibits reabsorption of tubular sodium 628573
gene_product member of the G-protein coupled receptor family 631750