Pla2g10 (phospholipase A2, group X) - Rat Genome Database

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Gene: Pla2g10 (phospholipase A2, group X) Rattus norvegicus
Analyze
Symbol: Pla2g10
Name: phospholipase A2, group X
RGD ID: 61935
Description: Exhibits phospholipase A2 activity. Predicted to be involved in several processes, including glycerophospholipid metabolic process; positive regulation of lipid localization; and regulation of gene expression. Predicted to localize to acrosomal vesicle and extracellular space. Orthologous to human PLA2G10 (phospholipase A2 group X); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH 17beta-estradiol; 3,7-dihydropurine-6-thione; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: group 10 secretory phospholipase A2; group X phospholipase A2; group X secretory phospholipase A2; GX sPLA2; phosphatidylcholine 2-acylhydrolase 10; phosphatidylcholine 2-acylhydrolase GX; phospholipase A2 group X; phospholipase A2, group 10; PLA2GX; sPLA2-X
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,597,761 - 1,610,822 (-)NCBI
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid secretion  (IEA)
axon guidance  (ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cholesterol homeostasis  (IEA,ISO)
defense response to virus  (IEA,ISO)
erythrocyte maturation  (IEA,ISO)
fertilization  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
intestinal stem cell homeostasis  (IEA,ISO)
low-density lipoprotein particle remodeling  (IEA,ISO)
lysophospholipid transport  (ISO)
macrophage activation  (IEA,ISO)
negative regulation of cholesterol efflux  (IEA,ISO)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (IBA,IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
phosphatidic acid metabolic process  (IEA,ISO,ISS)
phosphatidylcholine catabolic process  (IEA,ISO)
phosphatidylcholine metabolic process  (ISO,ISS)
phosphatidylethanolamine metabolic process  (IEA,ISO,ISS)
phosphatidylglycerol metabolic process  (IEA,ISO,ISS)
phosphatidylserine metabolic process  (IEA,ISO,ISS)
phospholipid metabolic process  (IBA,ISO)
platelet activating factor catabolic process  (IEA,ISO,ISS)
positive regulation of acrosome reaction  (IEA,ISO,ISS)
positive regulation of arachidonic acid secretion  (IEA,ISO)
positive regulation of cellular protein metabolic process  (IEA,ISO)
positive regulation of lipid storage  (IEA,ISO)
positive regulation of prostaglandin secretion  (IEA,ISO)
production of molecular mediator involved in inflammatory response  (IEA,ISO)
prostaglandin biosynthetic process  (IEA,ISO)
regulation of macrophage activation  (IEA,ISO)

Cellular Component

References

Additional References at PubMed
PMID:15927955   PMID:18511424   PMID:20439489   PMID:20844270   PMID:21805676  


Genomics

Comparative Map Data
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,597,761 - 1,610,822 (-)NCBI
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1614,672,545 - 14,694,669 (-)EnsemblGRCh38hg38GRCh38
GRCh381614,672,548 - 14,694,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,264 (-)NCBICHM1_1
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBImm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
PLA2G10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBI
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,311 - 7,641,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:48
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000004237
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7
Low 3 29 23 3
Below cutoff 6 26 12 16 12 5 6 16 4 11 8 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF166100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY651029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000004237   ⟹   ENSRNOP00000004237
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)Ensembl
RefSeq Acc Id: NM_017176   ⟹   NP_058872
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,000 (-)NCBI
Rnor_6.0101,509,732 - 1,520,970 (-)NCBI
Rnor_5.010406,661 - 417,899 (-)NCBI
RGSC_v3.41026,035 - 37,273 (-)RGD
Celera10658,651 - 669,889 (-)RGD
Sequence:
RefSeq Acc Id: XM_039085716   ⟹   XP_038941644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085717   ⟹   XP_038941645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,821 (-)NCBI
RefSeq Acc Id: XM_039085718   ⟹   XP_038941646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,245 (-)NCBI
RefSeq Acc Id: XM_039085719   ⟹   XP_038941647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085720   ⟹   XP_038941648
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085721   ⟹   XP_038941649
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085722   ⟹   XP_038941650
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085723   ⟹   XP_038941651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,821 (-)NCBI
RefSeq Acc Id: XM_039085724   ⟹   XP_038941652
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,032 (-)NCBI
RefSeq Acc Id: XM_039085726   ⟹   XP_038941654
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,040 (-)NCBI
RefSeq Acc Id: XM_039085727   ⟹   XP_038941655
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,821 (-)NCBI
RefSeq Acc Id: XM_039085728   ⟹   XP_038941656
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,529 (-)NCBI
RefSeq Acc Id: XM_039085729   ⟹   XP_038941657
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,821 (-)NCBI
RefSeq Acc Id: XM_039085730   ⟹   XP_038941658
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,821 (-)NCBI
RefSeq Acc Id: XM_039085731   ⟹   XP_038941659
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,609,021 (-)NCBI
RefSeq Acc Id: XM_039085732   ⟹   XP_038941660
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2101,597,761 - 1,610,822 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_058872   ⟸   NM_017176
- Peptide Label: precursor
- UniProtKB: Q9QZT3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004237   ⟸   ENSRNOT00000004237
RefSeq Acc Id: XP_038941660   ⟸   XM_039085732
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941651   ⟸   XM_039085723
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941657   ⟸   XM_039085729
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941658   ⟸   XM_039085730
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941655   ⟸   XM_039085727
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941645   ⟸   XM_039085717
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941647   ⟸   XM_039085719
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941656   ⟸   XM_039085728
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941649   ⟸   XM_039085721
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941650   ⟸   XM_039085722
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941648   ⟸   XM_039085720
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941644   ⟸   XM_039085716
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941646   ⟸   XM_039085718
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941654   ⟸   XM_039085726
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941652   ⟸   XM_039085724
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941659   ⟸   XM_039085731
- Peptide Label: isoform X1
Protein Domains
PA2c

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696926
Promoter ID:EPDNEW_R7451
Type:multiple initiation site
Name:Pla2g10_1
Description:phospholipase A2, group X
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0101,520,977 - 1,521,037EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61935 AgrOrtholog
Ensembl Genes ENSRNOG00000003164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004237 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004237 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29359 UniProtKB/Swiss-Prot
NCBI Gene 29359 ENTREZGENE
PANTHER PTHR11716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pla2g10 PhenoGen
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202847
UniProt G3V6E2_RAT UniProtKB/TrEMBL
  PA2GX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pla2g10  phospholipase A2, group X    phospholipase A2, group 10  Name updated 1299863 APPROVED
2002-06-10 Pla2g10  phospholipase A2, group 10      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference