Pla2g10 (phospholipase A2, group X)

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Gene: Pla2g10 (phospholipase A2, group X) Rattus norvegicus

Analyze

Symbol:

Pla2g10

Name:

phospholipase A2, group X

RGD ID:

61935

Description:

Enables phospholipase A2 activity. Predicted to be involved in several processes, including cholesterol homeostasis; glycerophospholipid metabolic process; and positive regulation of lipid localization. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; lysophospholipid transport; and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in acrosomal vesicle and extracellular space. Orthologous to human PLA2G10 (phospholipase A2 group X); PARTICIPATES IN alpha-linolenic acid metabolic pathway; arachidonic acid metabolic pathway; ether lipid metabolic pathway; INTERACTS WITH 17beta-estradiol; 3,7-dihydropurine-6-thione; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

group 10 secretory phospholipase A2; group X phospholipase A2; group X secretory phospholipase A2; GX sPLA2; phosphatidylcholine 2-acylhydrolase 10; phosphatidylcholine 2-acylhydrolase GX; phospholipase A2 group X; phospholipase A2, group 10; PLA2GX; sPLA2-X

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLA2G10 (phospholipase A2 group X)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pla2g10 (phospholipase A2, group X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pla2g10 (phospholipase A2 group X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLA2G10 (phospholipase A2 group X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLA2G10 (phospholipase A2 group X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101960864 (group 10 secretory phospholipase A2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LOC110259864 (group 10 secretory phospholipase A2-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pla2g10 (phospholipase A2 group X)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Pla2g10 (phospholipase A2, group X)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PLA2G10 (phospholipase A2 group X)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	zgc:92162	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG14507	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C03H5.4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	1,597,761 - 1,610,822 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	1,597,761 - 1,609,000 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	6,294,586 - 6,305,824 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	34,260,010 - 34,271,250 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	1,612,004 - 1,623,245 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	1,509,732 - 1,520,970 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	1,509,732 - 1,520,970 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	406,661 - 417,899 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	26,035 - 37,273 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	26,034 - 37,266 (-)	NCBI
Celera	10	658,651 - 669,889 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,7-dihydropurine-6-thione (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

graphite (EXP)

mercaptopurine (EXP)

methylisothiazolinone (ISO)

progesterone (ISO)

propanal (ISO)

purine-6-thiol (EXP)

raloxifene (ISO)

silicon dioxide (ISO)

tamoxifen (ISO)

titanium dioxide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonic acid secretion (IEA)

axon guidance (ISO)

cellular response to leukemia inhibitory factor (IEA,ISO)

cholesterol homeostasis (IEA,ISO)

defense response to virus (ISO)

erythrocyte maturation (IEA,ISO)

fertilization (IEA,ISO)

hair follicle morphogenesis (IEA,ISO)

intestinal stem cell homeostasis (IEA,ISO)

lipid catabolic process (IEA)

low-density lipoprotein particle remodeling (ISO)

lysophospholipid transport (ISO)

macrophage activation (IEA,ISO)

negative regulation of cholesterol efflux (IEA,ISO)

negative regulation of cytokine production involved in inflammatory response (IEA,ISO)

negative regulation of DNA-binding transcription factor activity (IBA,IEA,ISO)

negative regulation of inflammatory response (IEA,ISO)

phosphatidic acid metabolic process (IEA,ISO,ISS)

phosphatidylcholine catabolic process (ISO)

phosphatidylcholine metabolic process (IEA,ISO,ISS)

phosphatidylethanolamine metabolic process (IEA,ISO,ISS)

phosphatidylglycerol metabolic process (IEA,ISO,ISS)

phosphatidylserine metabolic process (IEA,ISO,ISS)

phospholipid metabolic process (IBA,IEA,ISO)

platelet activating factor catabolic process (ISO,ISS)

positive regulation of acrosome reaction (IEA,ISO,ISS)

positive regulation of arachidonic acid secretion (IEA,ISO)

positive regulation of lipid storage (ISO)

positive regulation of prostaglandin secretion (ISO)

positive regulation of protein metabolic process (ISO)

production of molecular mediator involved in inflammatory response (IEA,ISO)

prostaglandin biosynthetic process (IEA,ISO)

regulation of macrophage activation (ISO)

Cellular Component

acrosomal vesicle (IEA,ISO,ISS)

extracellular region (IEA,TAS)

extracellular space (ISO)

lysosome (IEA)

Molecular Function

1-alkyl-2-acetylglycerophosphocholine esterase activity (ISO,ISS)

calcium ion binding (IBA,IEA)

calcium-dependent phospholipase A2 activity (IBA,IEA,ISO,ISS)

phospholipase A2 activity (IDA,IEA)

phospholipase activity (ISO)

phospholipid binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

alpha-linolenic acid metabolic pathway (IEA)

arachidonic acid metabolic pathway (IEA)

ether lipid metabolic pathway (IEA)

Fc epsilon receptor mediated signaling pathway (IEA)

glutamate signaling pathway (IEA)

glycerophospholipid metabolic pathway (IEA)

gonadotropin-releasing hormone signaling pathway (IEA)

linoleic acid metabolic pathway (IEA)

long term depression (IEA)

mitogen activated protein kinase signaling pathway (IEA)

toxoplasmosis pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
4.	Expression and location of mRNAs encoding multiple forms of secretory phospholipase A2 in the rat retina.	Kolko M, etal., J Neurosci Res 2004 Aug 15;77(4):517-24.
5.	Neuronal expression and neuritogenic action of group X secreted phospholipase A2.	Masuda S, etal., J Biol Chem. 2005 Jun 17;280(24):23203-14. Epub 2005 Mar 21.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12.	On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes.	Valentin E, etal., J Biol Chem 1999 Oct 29;274(44):31195-202.

Additional References at PubMed

PMID:15927955	PMID:18511424	PMID:20439489	PMID:20844270	PMID:21805676

Genomics

Comparative Map Data

Pla2g10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	1,597,761 - 1,610,822 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	1,597,761 - 1,609,000 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	6,294,586 - 6,305,824 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	10	34,260,010 - 34,271,250 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	10	1,612,004 - 1,623,245 (-)	NCBI	Rnor_WKY
Rnor_6.0	10	1,509,732 - 1,520,970 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	1,509,732 - 1,520,970 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	406,661 - 417,899 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	26,035 - 37,273 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	26,034 - 37,266 (-)	NCBI
Celera	10	658,651 - 669,889 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

PLA2G10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	14,672,548 - 14,701,850 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	14,672,548 - 14,694,308 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	14,766,405 - 14,788,430 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	14,673,906 - 14,696,027 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	14,673,907 - 14,696,027	NCBI
Celera	16	14,943,182 - 14,965,293 (-)	NCBI		Celera
Cytogenetic Map	16	p13.12	NCBI
HuRef	16	14,685,697 - 14,707,807 (-)	NCBI		HuRef
CHM1_1	16	14,766,236 - 14,788,360 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	14,710,083 - 14,732,094 (-)	NCBI		T2T-CHM13v2.0

Pla2g10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	13,532,921 - 13,548,863 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	13,532,921 - 13,548,847 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	13,715,057 - 13,731,094 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	13,715,057 - 13,730,983 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	13,715,155 - 13,730,678 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	13,628,640 - 13,644,163 (-)	NCBI		MGSCv36	mm8
Celera	16	14,319,504 - 14,335,040 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	9.5	NCBI

Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	4,208,575 - 4,225,834 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	4,208,497 - 4,225,893 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	15,021,025 - 15,043,782 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	16	13,600,152 - 13,622,629 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

PLA2G10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	28,573,239 - 28,591,714 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	28,574,387 - 28,591,703 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	29,936,319 - 29,954,796 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	28,736,378 - 28,754,847 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	28,539,400 - 28,557,862 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	28,427,844 - 28,446,114 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	28,835,005 - 28,853,467 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	114,743,588 - 114,759,931 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	2,841,660 - 2,854,952 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936501	2,841,209 - 2,857,570 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC110259864
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	7,623,312 - 7,642,002 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	7,623,326 - 7,641,061 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Pla2g10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	3,870,940 - 3,887,426 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	3,871,034 - 3,887,476 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pla2g10
34 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	48
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000004237
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	1	24158324	Rat
2293680	Bss40	Bone structure and strength QTL 40	5.66	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	10	1	35225947	Rat
634327	Hc4	Hypercalciuria QTL 4	2.4		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	10	1	38328221	Rat
7411611	Foco17	Food consumption QTL 17	18.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	1	42315980	Rat
70223	Bp57	Blood pressure QTL 57	5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1	80676123	Rat
10401803	Kidm50	Kidney mass QTL 50			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	10	418344	45418344	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	743364	63851208	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3										7
Low									3	29	23	3
Below cutoff		6	26	12	16	12	5	6	16	4	11	8	5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085716	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085722	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085724	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085727	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085729	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085731	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF166100	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY651029	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474017	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000217	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000004237 ⟹ ENSRNOP00000004237

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	1,597,761 - 1,609,000 (-)	Ensembl
Rnor_6.0 Ensembl	10	1,509,732 - 1,520,970 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000101842 ⟹ ENSRNOP00000092711

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	1,597,761 - 1,606,701 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103030 ⟹ ENSRNOP00000080329

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	1,598,246 - 1,609,000 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114578 ⟹ ENSRNOP00000093943

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	1,597,761 - 1,607,200 (-)	Ensembl

RefSeq Acc Id:

NM_017176 ⟹ NP_058872

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,000 (-)	NCBI
Rnor_6.0	10	1,509,732 - 1,520,970 (-)	NCBI
Rnor_5.0	10	406,661 - 417,899 (-)	NCBI
RGSC_v3.4	10	26,035 - 37,273 (-)	RGD
Celera	10	658,651 - 669,889 (-)	RGD

Sequence:

show sequence

CACGAGGCACGCTCCTATGTGTGGGCCACCTCTGTGACGGGCTATAATGCTGCTGCTACTGCTG
CTGTTGCTACTGGGACCTGGATCCTGTCTCAGCGAAGCAACCAGGAGGTCACATGTGTACAAGC
GTGGACTCCTGGAACTGGCAGGGACCTTGGATTGTGTTGGTCCTCGATCGCCGATGGCTTACAT
GAACTATGGTTGTTATTGTGGCCTTGGTGGCCACGGAGAGCCACGTGATGCCATTGACTGGTGC
TGCTACTACCATGACTGCTGCTACTCTCAGGCTCAGGATGCCGGCTGCAGCCCCAAGCTATACC
GATACCCGTGGAAGTGCATGGACCATCGCATCCTGTGTGGACCGGCAGAGAACAAATGCCAAGA
ACTCCTATGCAGGTGTGATGAGACGCTCGCATACTGCCTGGCAGACACAGAGTACCACCTGAAA
TACCTCTTCTTCCCCTCGGTTTTATGTGAGAAGGACTCACCCAAGTGCAACTAATAGGCTGAAA
TGTCCCTTTGCACATGGAAATGAAGTTCGCTTTCAGTGATGAACAACAGCCTTCGATTTGCGCA
GGAGTCCCTGGAGGCCAAGTGATGAAGCCTGGGTTTGCTTTCTCCCTCCATTCGTGAACTCAGG
ACTATGAGCCTGTGGAGCTGCCAGTTTGATGAAGGTTGAGAGTCCTGGGCCTGTTTTATACAAC
TGCAACTGTGTTGGGCTTGATATAATTTTTGAAGTCCAACTTTACAAAAAGCTTTACTACTGTG
TAACCTGCTGCAGAGGGTTGGTGGTCAAATGAACACCTGCTTAGGCTTGCTTGTGGTAATAACA
TTGCCACGATACATCTAGGAATTGTTAGTGTAATAAAGCATGTTCCCTACCTGTCAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039085716 ⟹ XP_038941644

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085717 ⟹ XP_038941645

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,821 (-)	NCBI

RefSeq Acc Id:

XM_039085718 ⟹ XP_038941646

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,245 (-)	NCBI

RefSeq Acc Id:

XM_039085719 ⟹ XP_038941647

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085720 ⟹ XP_038941648

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085721 ⟹ XP_038941649

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085722 ⟹ XP_038941650

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085723 ⟹ XP_038941651

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,821 (-)	NCBI

RefSeq Acc Id:

XM_039085724 ⟹ XP_038941652

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,032 (-)	NCBI

RefSeq Acc Id:

XM_039085726 ⟹ XP_038941654

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,040 (-)	NCBI

RefSeq Acc Id:

XM_039085727 ⟹ XP_038941655

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,821 (-)	NCBI

RefSeq Acc Id:

XM_039085728 ⟹ XP_038941656

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,529 (-)	NCBI

RefSeq Acc Id:

XM_039085729 ⟹ XP_038941657

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,821 (-)	NCBI

RefSeq Acc Id:

XM_039085730 ⟹ XP_038941658

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,821 (-)	NCBI

RefSeq Acc Id:

XM_039085731 ⟹ XP_038941659

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,609,021 (-)	NCBI

RefSeq Acc Id:

XM_039085732 ⟹ XP_038941660

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	1,597,761 - 1,610,822 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_058872	(Get FASTA)	NCBI Sequence Viewer
	XP_038941644	(Get FASTA)	NCBI Sequence Viewer
	XP_038941645	(Get FASTA)	NCBI Sequence Viewer
	XP_038941646	(Get FASTA)	NCBI Sequence Viewer
	XP_038941647	(Get FASTA)	NCBI Sequence Viewer
	XP_038941648	(Get FASTA)	NCBI Sequence Viewer
	XP_038941649	(Get FASTA)	NCBI Sequence Viewer
	XP_038941650	(Get FASTA)	NCBI Sequence Viewer
	XP_038941651	(Get FASTA)	NCBI Sequence Viewer
	XP_038941652	(Get FASTA)	NCBI Sequence Viewer
	XP_038941654	(Get FASTA)	NCBI Sequence Viewer
	XP_038941655	(Get FASTA)	NCBI Sequence Viewer
	XP_038941656	(Get FASTA)	NCBI Sequence Viewer
	XP_038941657	(Get FASTA)	NCBI Sequence Viewer
	XP_038941658	(Get FASTA)	NCBI Sequence Viewer
	XP_038941659	(Get FASTA)	NCBI Sequence Viewer
	XP_038941660	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF04501	(Get FASTA)	NCBI Sequence Viewer
	AAT68715	(Get FASTA)	NCBI Sequence Viewer
	EDL96169	(Get FASTA)	NCBI Sequence Viewer
	EDL96170	(Get FASTA)	NCBI Sequence Viewer
	Q9QZT3	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_058872 ⟸ NM_017176
- Peptide Label:	precursor
- UniProtKB:	Q9QZT3 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLLLLLLLLLGPGSCLSEATRRSHVYKRGLLELAGTLDCVGPRSPMAYMNYGCYCGLGGHGEPR DAIDWCCYYHDCCYSQAQDAGCSPKLYRYPWKCMDHRILCGPAENKCQELLCRCDETLAYCLAD TEYHLKYLFFPSVLCEKDSPKCN hide sequence

RefSeq Acc Id:

ENSRNOP00000004237 ⟸ ENSRNOT00000004237

RefSeq Acc Id:	XP_038941660 ⟸ XM_039085732
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941651 ⟸ XM_039085723
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941657 ⟸ XM_039085729
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941658 ⟸ XM_039085730
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941655 ⟸ XM_039085727
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941645 ⟸ XM_039085717
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941647 ⟸ XM_039085719
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941656 ⟸ XM_039085728
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941649 ⟸ XM_039085721
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941650 ⟸ XM_039085722
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941648 ⟸ XM_039085720
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941644 ⟸ XM_039085716
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941646 ⟸ XM_039085718
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941654 ⟸ XM_039085726
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941652 ⟸ XM_039085724
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038941659 ⟸ XM_039085731
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000092711 ⟸ ENSRNOT00000101842

RefSeq Acc Id:

ENSRNOP00000080329 ⟸ ENSRNOT00000103030

RefSeq Acc Id:

ENSRNOP00000093943 ⟸ ENSRNOT00000114578

Protein Domains

PA2c

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QZT3-F1-model_v2	AlphaFold	Q9QZT3	1-151	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696926

Promoter ID:

EPDNEW_R7451

Type:

multiple initiation site

Name:

Pla2g10_1

Description:

phospholipase A2, group X

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	10	1,520,977 - 1,521,037	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61935	AgrOrtholog
BioCyc Gene	G2FUF-26223	BioCyc
Ensembl Genes	ENSRNOG00000003164	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000004237	ENTREZGENE
	ENSRNOP00000004237.1	UniProtKB/TrEMBL
	ENSRNOP00000080329.1	UniProtKB/TrEMBL
	ENSRNOP00000092711.1	UniProtKB/TrEMBL
	ENSRNOP00000093943.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004237	ENTREZGENE
	ENSRNOT00000004237.3	UniProtKB/TrEMBL
	ENSRNOT00000101842.1	UniProtKB/TrEMBL
	ENSRNOT00000103030.1	UniProtKB/TrEMBL
	ENSRNOT00000114578.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	PLipase_A2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_Asp_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29359	UniProtKB/Swiss-Prot
NCBI Gene	29359	ENTREZGENE
PANTHER	PTHR11716	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Pla2g10	PhenoGen
PRINTS	PHPHLIPASEA2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PA2_ASP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PA2_HIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PA2c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC202847
UniProt	A0A8I6ALE8_RAT	UniProtKB/TrEMBL
	A0A8I6AW05_RAT	UniProtKB/TrEMBL
	A0A8I6G4E1_RAT	UniProtKB/TrEMBL
	G3V6E2_RAT	UniProtKB/TrEMBL
	PA2GX_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Pla2g10	phospholipase A2, group X		phospholipase A2, group 10	Name updated	1299863	APPROVED
2002-06-10	Pla2g10	phospholipase A2, group 10			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)