PLA2G10 (phospholipase A2 group X) - Rat Genome Database

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Gene: PLA2G10 (phospholipase A2 group X) Canis lupus familiaris
Analyze
Symbol: PLA2G10
Name: phospholipase A2 group X
RGD ID: 12424095
Description: ENCODES a protein that exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity (ortholog); phospholipase A2 activity (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); defense response to virus (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: group 10 secretory phospholipase A2; LOC489997; phospholipase A2, group X
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,736,238 - 28,754,865 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonate secretion  (IEA)
axon guidance  (ISO)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cholesterol homeostasis  (IEA)
defense response to virus  (ISO)
erythrocyte maturation  (IEA,ISO)
fertilization  (IEA,ISO)
hair follicle morphogenesis  (IEA)
intestinal stem cell homeostasis  (IEA)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
low-density lipoprotein particle remodeling  (ISO)
lysophospholipid transport  (ISO)
macrophage activation  (IEA,ISO)
negative regulation of cholesterol efflux  (IEA)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
phosphatidic acid metabolic process  (IEA)
phosphatidylcholine catabolic process  (ISO)
phosphatidylcholine metabolic process  (IEA)
phosphatidylethanolamine metabolic process  (IEA)
phosphatidylglycerol metabolic process  (IEA)
phosphatidylserine metabolic process  (IEA)
phospholipid metabolic process  (IEA,ISO)
platelet activating factor catabolic process  (ISO)
positive regulation of acrosome reaction  (IEA)
positive regulation of arachidonate secretion  (IEA)
positive regulation of lipid storage  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein metabolic process  (ISO)
production of molecular mediator involved in inflammatory response  (IEA,ISO)
prostaglandin biosynthetic process  (IEA)
regulation of macrophage activation  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl628,736,238 - 28,754,865 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBIUU_Cfam_GSD_1.0
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBICelera
Cytogenetic Map16p13.12-p13.11NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBIT2T-CHM13v2.0
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)EnsemblGRCm39 Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBIMGSCv36mm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,104,927 - 2,117,998 (-)NCBIGRCr8
mRatBN7.2101,597,761 - 1,610,822 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,597,761 - 1,609,000 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,294,586 - 6,305,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,260,010 - 34,271,250 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,612,004 - 1,623,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
LOC100990946
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,204,875 - 15,232,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,987,730 - 19,015,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,841,660 - 2,854,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,870,940 - 3,887,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G10
247 total Variants

Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 5 6 10 1 4 1 2 8 7 2 6 9

Sequence


Ensembl Acc Id: ENSCAFT00000029821   ⟹   ENSCAFP00000027715
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845018712   ⟹   ENSCAFP00845014607
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl628,736,238 - 28,754,865 (+)Ensembl
RefSeq Acc Id: XM_005622075   ⟹   XP_005622132
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1628,573,239 - 28,591,714 (+)NCBI
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038480411   ⟹   XP_038336339
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
RefSeq Acc Id: XM_038538871   ⟹   XP_038394799
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
RefSeq Acc Id: XM_038602997   ⟹   XP_038458925
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
RefSeq Acc Id: XM_038667703   ⟹   XP_038523631
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
RefSeq Acc Id: XP_005622132   ⟸   XM_005622075
- UniProtKB: A0A8C0R701 (UniProtKB/TrEMBL),   A0A8I3N529 (UniProtKB/TrEMBL),   A0A8P0SMN4 (UniProtKB/TrEMBL),   A0A8C0NLP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000027715   ⟸   ENSCAFT00000029821
RefSeq Acc Id: XP_038336339   ⟸   XM_038480411
RefSeq Acc Id: XP_038458925   ⟸   XM_038602997
RefSeq Acc Id: XP_038523631   ⟸   XM_038667703
- UniProtKB: A0A8C0R701 (UniProtKB/TrEMBL),   A0A8I3N529 (UniProtKB/TrEMBL),   A0A8P0SMN4 (UniProtKB/TrEMBL),   A0A8C0NLP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038394799   ⟸   XM_038538871
- UniProtKB: A0A8C0NLP2 (UniProtKB/TrEMBL),   A0A8C0R701 (UniProtKB/TrEMBL),   A0A8I3N529 (UniProtKB/TrEMBL),   A0A8P0SMN4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845014607   ⟸   ENSCAFT00845018712
Protein Domains
Phospholipase A2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018788 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030015068 UniProtKB/TrEMBL
  ENSCAFG00040003118 UniProtKB/TrEMBL
  ENSCAFG00845010583 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029821.5 UniProtKB/TrEMBL
  ENSCAFT00030027836.1 UniProtKB/TrEMBL
  ENSCAFT00040005929.1 UniProtKB/TrEMBL
  ENSCAFT00845018712 ENTREZGENE
  ENSCAFT00845018712.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
NCBI Gene LOC489997 ENTREZGENE
PANTHER GROUP 10 SECRETORY PHOSPHOLIPASE A2 UniProtKB/TrEMBL
  PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A8C0NLP2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0R701 ENTREZGENE
  A0A8I3N529 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SMN4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54056 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-10 PLA2G10  phospholipase A2 group X  LOC489997  group 10 secretory phospholipase A2  Symbol and/or name change 5135510 APPROVED