PLA2G10 (phospholipase A2 group X) - Rat Genome Database

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Gene: PLA2G10 (phospholipase A2 group X) Canis lupus familiaris
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Symbol: PLA2G10
Name: phospholipase A2 group X
RGD ID: 12424095
Description: ENCODES a protein that exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity (ortholog); phospholipase A2 activity (ortholog); phospholipase activity (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); cholesterol homeostasis (ortholog); FOUND IN acrosomal vesicle (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: group 10 secretory phospholipase A2; LOC489997; phospholipase A2, group X
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid secretion  (IEA)
axon guidance  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISO)
defense response to virus  (ISO)
erythrocyte maturation  (ISO)
fertilization  (ISO)
hair follicle morphogenesis  (ISO)
intestinal stem cell homeostasis  (ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
low-density lipoprotein particle remodeling  (ISO)
lysophospholipid transport  (ISO)
macrophage activation  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of DNA-binding transcription factor activity  (IBA)
negative regulation of inflammatory response  (ISO)
phosphatidic acid metabolic process  (ISO)
phosphatidylcholine catabolic process  (ISO)
phosphatidylcholine metabolic process  (ISO)
phosphatidylethanolamine metabolic process  (ISO)
phosphatidylglycerol metabolic process  (ISO)
phosphatidylserine metabolic process  (ISO)
phospholipid metabolic process  (IBA,IEA,ISO)
platelet activating factor catabolic process  (ISO)
positive regulation of acrosome reaction  (ISO)
positive regulation of arachidonic acid secretion  (ISO)
positive regulation of lipid storage  (ISO)
positive regulation of prostaglandin secretion  (ISO)
positive regulation of protein metabolic process  (ISO)
production of molecular mediator involved in inflammatory response  (ISO)
prostaglandin biosynthetic process  (ISO)
regulation of macrophage activation  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBI
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBImm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,597,761 - 1,610,822 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl101,597,761 - 1,609,000 (-)Ensembl
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
PLA2G10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0panPan3
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBI
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,870,940 - 3,887,426 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system nervous system reproductive system respiratory system
High
Medium 1
Low 1 1 4
Below cutoff 2 5 1 4 1 1 2 6 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000029821   ⟹   ENSCAFP00000027715
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)Ensembl
RefSeq Acc Id: XM_005622075   ⟹   XP_005622132
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1628,573,239 - 28,591,714 (+)NCBI
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038480411   ⟹   XP_038336339
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
RefSeq Acc Id: XM_038538871   ⟹   XP_038394799
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
RefSeq Acc Id: XM_038602997   ⟹   XP_038458925
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
RefSeq Acc Id: XM_038667703   ⟹   XP_038523631
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005622132   ⟸   XM_005622075
- Sequence:
RefSeq Acc Id: ENSCAFP00000027715   ⟸   ENSCAFT00000029821
RefSeq Acc Id: XP_038336339   ⟸   XM_038480411
RefSeq Acc Id: XP_038458925   ⟸   XM_038602997
RefSeq Acc Id: XP_038523631   ⟸   XM_038667703
RefSeq Acc Id: XP_038394799   ⟸   XM_038538871
Protein Domains
PA2c

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
6 28576290 28576291 G A snv Dachshund (DH098), Whippet (WH083), Rhodesian Ridgeback (RR098)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018788 Ensembl
  ENSCAFG00030015068 UniProtKB/TrEMBL
  ENSCAFG00040003118 UniProtKB/TrEMBL
  ENSCAFG00845010583 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030024293.1 UniProtKB/TrEMBL
  ENSCAFP00040005115 UniProtKB/TrEMBL
  ENSCAFP00845014607 ENTREZGENE
  ENSCAFP00845014607.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030027836.1 UniProtKB/TrEMBL
  ENSCAFT00040005929 UniProtKB/TrEMBL
  ENSCAFT00845018712 ENTREZGENE
  ENSCAFT00845018712.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
NCBI Gene LOC489997 ENTREZGENE
PANTHER PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A8C0NLP2_CANLF UniProtKB/TrEMBL
  A0A8I3N529_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54056 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-10 PLA2G10  phospholipase A2 group X  LOC489997  group 10 secretory phospholipase A2  Symbol and/or name change 5135510 APPROVED