LOC110259864 (group 10 secretory phospholipase A2-like) - Rat Genome Database

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Gene: LOC110259864 (group 10 secretory phospholipase A2-like) Sus scrofa
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Symbol: LOC110259864
Name: group 10 secretory phospholipase A2-like
RGD ID: 14147985
Description: ENCODES a protein that exhibits phospholipase A2 activity (ortholog); phospholipase activity (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); cholesterol homeostasis (ortholog); FOUND IN acrosomal vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid secretion  (IEA)
axon guidance  (IEA,ISO)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISO)
defense response to virus  (IEA)
erythrocyte maturation  (ISO)
fertilization  (ISO)
hair follicle morphogenesis  (ISO)
intestinal stem cell homeostasis  (ISO)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
low-density lipoprotein particle remodeling  (IEA)
lysophospholipid transport  (IEA,ISO)
macrophage activation  (ISO)
negative regulation of cholesterol efflux  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of DNA-binding transcription factor activity  (IBA,IEA)
negative regulation of inflammatory response  (ISO)
phosphatidic acid metabolic process  (IEA)
phosphatidylcholine catabolic process  (IEA)
phosphatidylcholine metabolic process  (IEA)
phosphatidylethanolamine metabolic process  (IEA)
phosphatidylglycerol metabolic process  (IEA)
phosphatidylserine metabolic process  (IEA)
phospholipid metabolic process  (IBA,IEA,ISO)
platelet activating factor catabolic process  (IEA)
positive regulation of acrosome reaction  (ISO)
positive regulation of arachidonic acid secretion  (ISO)
positive regulation of lipid storage  (IEA)
positive regulation of prostaglandin secretion  (IEA)
positive regulation of protein metabolic process  (IEA)
production of molecular mediator involved in inflammatory response  (ISO)
prostaglandin biosynthetic process  (ISO)
regulation of macrophage activation  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBI
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBImm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2101,597,761 - 1,610,822 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl101,597,761 - 1,609,000 (-)Ensembl
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
PLA2G10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBI
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBI
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBI
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBI
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBI
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBI
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,870,940 - 3,887,426 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 21 2 3 3
Below cutoff 2

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021086183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000045533   ⟹   ENSSSCP00000048031
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)Ensembl
RefSeq Acc Id: XM_021086183   ⟹   XP_020941842
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.137,623,326 - 7,641,061 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020941842 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020941842   ⟸   XM_021086183
- Sequence:
RefSeq Acc Id: ENSSSCP00000048031   ⟸   ENSSSCT00000045533
Protein Domains
PA2c


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000040569 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000048031 ENTREZGENE
  ENSSSCP00000048031.2 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000045533 ENTREZGENE
  ENSSSCT00000045533.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/TrEMBL
NCBI Gene LOC110259864 ENTREZGENE
PANTHER PTHR11716 UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/TrEMBL
PRINTS PHPHLIPASEA2 UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/TrEMBL
  PA2_HIS UniProtKB/TrEMBL
SMART PA2c UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/TrEMBL
UniProt A0A287AV88_PIG UniProtKB/TrEMBL