PLA2G10 (phospholipase A2 group X) - Rat Genome Database
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Gene: PLA2G10 (phospholipase A2 group X) Homo sapiens
Analyze
Symbol: PLA2G10
Name: phospholipase A2 group X
RGD ID: 736427
HGNC Page HGNC
Description: Exhibits 1-alkyl-2-acetylglycerophosphocholine esterase activity and calcium-dependent phospholipase A2 activity. Involved in several processes, including glycerophospholipid metabolic process; low-density lipoprotein particle remodeling; and positive regulation of lipid localization. Localizes to extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: group 10 secretory phospholipase A2; group X secretory phospholipase A2; GX sPLA2; GXPLA2; GXSPLA2; MGC119918; MGC119919; MGC133367; phosphatidylcholine 2-acylhydrolase 10; phospholipase a2, group 10; phospholipase A2, group X; SPLA2; sPLA2-X
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1614,672,545 - 14,694,669 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh381614,672,548 - 14,694,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,264 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid metabolic process  (NAS)
arachidonic acid secretion  (IEA)
axon guidance  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
cholesterol homeostasis  (ISS)
defense response to virus  (IDA)
erythrocyte maturation  (ISO)
fertilization  (ISO)
hair follicle morphogenesis  (ISO)
intestinal stem cell homeostasis  (ISO)
lipid catabolic process  (IEA)
low-density lipoprotein particle remodeling  (IDA)
lysophospholipid transport  (IDA)
macrophage activation  (ISO)
negative regulation of cholesterol efflux  (ISS)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of DNA-binding transcription factor activity  (IBA,IDA)
negative regulation of inflammatory response  (ISO)
phosphatidic acid biosynthetic process  (TAS)
phosphatidic acid metabolic process  (IDA)
phosphatidylcholine acyl-chain remodeling  (TAS)
phosphatidylcholine catabolic process  (IDA)
phosphatidylcholine metabolic process  (IDA)
phosphatidylethanolamine acyl-chain remodeling  (TAS)
phosphatidylethanolamine metabolic process  (IDA)
phosphatidylglycerol acyl-chain remodeling  (TAS)
phosphatidylglycerol metabolic process  (IDA)
phosphatidylinositol acyl-chain remodeling  (TAS)
phosphatidylserine acyl-chain remodeling  (TAS)
phosphatidylserine metabolic process  (IDA)
phospholipid metabolic process  (IBA,IEA)
platelet activating factor catabolic process  (IDA)
positive regulation of acrosome reaction  (ISS)
positive regulation of arachidonic acid secretion  (ISS)
positive regulation of cellular protein metabolic process  (IMP)
positive regulation of lipid storage  (IMP)
positive regulation of macrophage derived foam cell differentiation  (IC)
positive regulation of prostaglandin secretion  (IMP)
production of molecular mediator involved in inflammatory response  (ISO)
prostaglandin biosynthetic process  (ISO)
regulation of macrophage activation  (IMP)

Cellular Component

References

Additional References at PubMed
PMID:8617505   PMID:9188469   PMID:9377118   PMID:9745929   PMID:10922494   PMID:11019817   PMID:11741884   PMID:12021277   PMID:12048163   PMID:12161451   PMID:12359733   PMID:12477932  
PMID:12664556   PMID:14501581   PMID:14962950   PMID:15007070   PMID:15489334   PMID:15781456   PMID:15927955   PMID:16146426   PMID:16169070   PMID:16341674   PMID:16438975   PMID:16962371  
PMID:17077289   PMID:17093191   PMID:18511424   PMID:18587072   PMID:19336475   PMID:19495570   PMID:20357262   PMID:20833395   PMID:20844270   PMID:20974857   PMID:21255140   PMID:21652694  
PMID:21805676   PMID:21873635   PMID:21878635   PMID:22494626   PMID:22967861   PMID:23349189   PMID:23614662   PMID:23859159   PMID:24070020   PMID:24508801   PMID:25286228   PMID:25583995  
PMID:25964585   PMID:26139511   PMID:26711221   PMID:26828067   PMID:28514442   PMID:28528433   PMID:32296183   PMID:32423798   PMID:32814053  


Genomics

Comparative Map Data
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1614,672,545 - 14,694,669 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh381614,672,548 - 14,694,662 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBI
Cytogenetic Map16p13.12NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,264 (-)NCBICHM1_1
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39mm39
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBImm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
PLA2G10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0panPan3
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,311 - 7,641,082 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBI

Position Markers
D16S312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371614,787,112 - 14,787,279UniSTSGRCh37
GRCh371614,826,229 - 14,826,402UniSTSGRCh37
Build 361614,694,613 - 14,694,780RGDNCBI36
Celera1614,963,878 - 14,964,051RGD
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map16p13.1-p12UniSTS
HuRef1614,706,392 - 14,706,565UniSTS
RH65989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371614,766,461 - 14,766,592UniSTSGRCh37
Build 361614,673,962 - 14,674,093RGDNCBI36
Celera1614,943,238 - 14,943,369RGD
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map16p13.1-p12UniSTS
HuRef1614,685,753 - 14,685,884UniSTS
GeneMap99-GB4 RH Map16167.28UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:261
Interacting mature miRNAs:268
Transcripts:ENST00000438167, ENST00000567462
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 199 7 5 2 6 6 19 65
Low 768 19 66 32 478 32 222 28 326 103 719 719 10 6 31 3
Below cutoff 1271 1871 1187 401 850 274 3376 1687 2986 235 628 669 129 956 2278 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_133651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC243753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM739473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000438167   ⟹   ENSP00000393847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1614,672,548 - 14,694,308 (-)Ensembl
RefSeq Acc Id: ENST00000567462   ⟹   ENSP00000456433
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1614,672,681 - 14,694,276 (-)Ensembl
RefSeq Acc Id: NM_003561   ⟹   NP_003552
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,672,548 - 14,694,308 (-)NCBI
GRCh371614,766,405 - 14,788,526 (-)ENTREZGENE
Build 361614,673,906 - 14,696,027 (-)NCBI Archive
HuRef1614,685,697 - 14,707,807 (-)ENTREZGENE
CHM1_11614,766,236 - 14,788,264 (-)NCBI
Sequence:
RefSeq Acc Id: NR_133651
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,672,548 - 14,694,573 (-)NCBI
CHM1_11614,766,236 - 14,788,264 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522695   ⟹   XP_011520997
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,678,795 - 14,694,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522696   ⟹   XP_011520998
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,683,458 - 14,694,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522697   ⟹   XP_011520999
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,678,699 - 14,694,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522698   ⟹   XP_011521000
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,683,666 - 14,694,662 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003552   ⟸   NM_003561
- Peptide Label: preproprotein
- UniProtKB: O15496 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011520999   ⟸   XM_011522697
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_011520997   ⟸   XM_011522695
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_011520998   ⟸   XM_011522696
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011521000   ⟸   XM_011522698
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSP00000393847   ⟸   ENST00000438167
RefSeq Acc Id: ENSP00000456433   ⟸   ENST00000567462
Protein Domains
PA2c


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.12-13.11(chr16:14668382-16678513)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051357]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051357]|See cases [RCV000051357] Chr16:14668382..16678513 [GRCh38]
Chr16:14762239..16772370 [GRCh37]
Chr16:14669740..16679871 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-12.3(chr16:14609647-18765817)x3 copy number gain See cases [RCV000051353] Chr16:14609647..18765817 [GRCh38]
Chr16:14703504..18777139 [GRCh37]
Chr16:14611005..18684640 [NCBI36]
Chr16:16p13.12-12.3
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14639096-16431491)x3 copy number gain See cases [RCV000051354] Chr16:14639096..16431491 [GRCh38]
Chr16:14732953..16525348 [GRCh37]
Chr16:14640454..16432849 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14668182-16493213)x3 copy number gain See cases [RCV000051355] Chr16:14668182..16493213 [GRCh38]
Chr16:14762039..16587070 [GRCh37]
Chr16:14669540..16494571 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14668382-16100721)x3 copy number gain See cases [RCV000051356] Chr16:14668382..16100721 [GRCh38]
Chr16:14762239..16194578 [GRCh37]
Chr16:14669740..16102079 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.13-13.11(chr16:11967831-15162888)x1 copy number loss See cases [RCV000052484] Chr16:11967831..15162888 [GRCh38]
Chr16:12061688..15256745 [GRCh37]
Chr16:11969189..15164246 [NCBI36]
Chr16:16p13.13-13.11
pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2
pathogenic
GRCh38/hg38 16p13.13-13.11(chr16:11952467-15186199)x1 copy number loss See cases [RCV000137596] Chr16:11952467..15186199 [GRCh38]
Chr16:12046324..15280056 [GRCh37]
Chr16:11953825..15187557 [NCBI36]
Chr16:16p13.13-13.11
likely pathogenic
GRCh38/hg38 16p13.12(chr16:14140498-14686337)x3 copy number gain See cases [RCV000137490] Chr16:14140498..14686337 [GRCh38]
Chr16:14234355..14780194 [GRCh37]
Chr16:14141856..14687695 [NCBI36]
Chr16:16p13.12
likely benign
GRCh38/hg38 16p13.12-13.11(chr16:14686278-16431491)x3 copy number gain See cases [RCV000140727] Chr16:14686278..16431491 [GRCh38]
Chr16:14780135..16525348 [GRCh37]
Chr16:14687636..16432849 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2
uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Ductal breast carcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2
pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3
pathogenic
GRCh37/hg19 16p13.12-12.3(chr16:14780543-16855348)x1 copy number loss not provided [RCV000683767] Chr16:14780543..16855348 [GRCh37]
Chr16:16p13.12-12.3
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14780641-16498084)x1 copy number loss not provided [RCV000683768] Chr16:14780641..16498084 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.13-13.12(chr16:12007434-14781381)x1 copy number loss not provided [RCV000683763] Chr16:12007434..14781381 [GRCh37]
Chr16:16p13.13-13.12
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14759219-16419494)x1 copy number loss not provided [RCV000739062] Chr16:14759219..16419494 [GRCh37]
Chr16:16p13.12-13.11
likely benign
GRCh37/hg19 16p13.12-13.11(chr16:14766480-16286694) copy number gain not provided [RCV000767573] Chr16:14766480..16286694 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
NM_003561.3(PLA2G10):c.360G>A (p.Pro120=) single nucleotide variant not provided [RCV000969969] Chr16:14672745 [GRCh38]
Chr16:14766602 [GRCh37]
Chr16:16p13.12
likely benign
GRCh37/hg19 16p13.12-13.11(chr16:14770672-16458408)x1 copy number loss not provided [RCV001006769] Chr16:14770672..16458408 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14770672-16388343)x1 copy number loss not provided [RCV001006768] Chr16:14770672..16388343 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14780543-16391045)x1 copy number loss not provided [RCV001006770] Chr16:14780543..16391045 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9029 AgrOrtholog
COSMIC PLA2G10 COSMIC
Ensembl Genes ENSG00000069764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000276870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000393847 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000456433 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000479397 UniProtKB/Swiss-Prot
  ENSP00000488697 UniProtKB/TrEMBL
Ensembl Transcript ENST00000438167 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000567462 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000621727 UniProtKB/Swiss-Prot
  ENST00000634009 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000069764 GTEx
  ENSG00000276870 GTEx
HGNC ID HGNC:9029 ENTREZGENE
Human Proteome Map PLA2G10 Human Proteome Map
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8399 UniProtKB/Swiss-Prot
NCBI Gene 8399 ENTREZGENE
OMIM 603603 OMIM
PANTHER PTHR11716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33360 PharmGKB
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BRW4_HUMAN UniProtKB/TrEMBL
  L8E7V2_HUMAN UniProtKB/TrEMBL
  O15496 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q14DU3 UniProtKB/Swiss-Prot
  Q6NT23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-24 PLA2G10  phospholipase A2 group X    phospholipase A2, group X  Symbol and/or name change 5135510 APPROVED