PLA2G10 (phospholipase A2 group X) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PLA2G10 (phospholipase A2 group X) Homo sapiens
Analyze
Symbol: PLA2G10
Name: phospholipase A2 group X
RGD ID: 736427
HGNC Page HGNC:9029
Description: Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity and calcium-dependent phospholipase A2 activity. Involved in several processes, including glycerophospholipid metabolic process; low-density lipoprotein particle remodeling; and positive regulation of lipid localization. Acts upstream of or within axon guidance and lysophospholipid transport. Located in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: collagen alpha-3(IX) chain-like; group 10 secretory phospholipase A2; group X secretory phospholipase A2; GX sPLA2; GXPLA2; GXSPLA2; LOC105371095; MGC119918; MGC119919; MGC133367; phosphatidylcholine 2-acylhydrolase 10; phospholipase a2, group 10; phospholipase A2, group X; SPLA2; sPLA2-X
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBICelera
Cytogenetic Map16p13.12-p13.11NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arachidonic acid metabolic process  (NAS)
arachidonic acid secretion  (IEA)
axon guidance  (IDA)
cellular response to leukemia inhibitory factor  (IEA,ISO)
cholesterol homeostasis  (IEA,ISS)
defense response to virus  (IDA)
erythrocyte maturation  (IEA,ISO)
fertilization  (IEA,ISO)
hair follicle morphogenesis  (IEA)
intestinal stem cell homeostasis  (IEA)
lipid catabolic process  (IEA)
lipid metabolic process  (IEA)
low-density lipoprotein particle remodeling  (IDA)
lysophospholipid transport  (IDA)
macrophage activation  (IEA,ISO)
negative regulation of cholesterol efflux  (IEA,ISS)
negative regulation of cytokine production involved in inflammatory response  (IEA,ISO)
negative regulation of inflammatory response  (IEA,ISO)
phosphatidic acid metabolic process  (IDA,IEA)
phosphatidylcholine catabolic process  (IDA)
phosphatidylcholine metabolic process  (IDA,IEA)
phosphatidylethanolamine metabolic process  (IDA,IEA)
phosphatidylglycerol metabolic process  (IDA,IEA)
phosphatidylserine metabolic process  (IDA,IEA)
phospholipid metabolic process  (IBA,IEA,ISO)
platelet activating factor catabolic process  (IDA)
positive regulation of acrosome reaction  (IEA,ISS)
positive regulation of arachidonic acid secretion  (IEA,ISS)
positive regulation of lipid storage  (IMP)
positive regulation of macrophage derived foam cell differentiation  (IC)
positive regulation of prostaglandin secretion  (IMP)
positive regulation of protein metabolic process  (IMP)
production of molecular mediator involved in inflammatory response  (IEA,ISO)
prostaglandin biosynthetic process  (IEA)
regulation of macrophage activation  (IMP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8617505   PMID:9188469   PMID:9377118   PMID:9745929   PMID:10922494   PMID:11019817   PMID:11741884   PMID:12021277   PMID:12048163   PMID:12161451   PMID:12359733   PMID:12477932  
PMID:12664556   PMID:14501581   PMID:14962950   PMID:15007070   PMID:15489334   PMID:15781456   PMID:15927955   PMID:16146426   PMID:16169070   PMID:16341674   PMID:16438975   PMID:16962371  
PMID:17077289   PMID:17093191   PMID:18511424   PMID:18587072   PMID:19336475   PMID:19495570   PMID:20357262   PMID:20833395   PMID:20844270   PMID:20974857   PMID:21255140   PMID:21652694  
PMID:21805676   PMID:21873635   PMID:21878635   PMID:22494626   PMID:22967861   PMID:23349189   PMID:23614662   PMID:23859159   PMID:24070020   PMID:24508801   PMID:25286228   PMID:25583995  
PMID:25964585   PMID:26139511   PMID:26711221   PMID:26828067   PMID:28514442   PMID:28528433   PMID:32296183   PMID:32423798   PMID:32814053   PMID:33961781   PMID:34373451   PMID:35231479  


Genomics

Comparative Map Data
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBICelera
Cytogenetic Map16p13.12-p13.11NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBIT2T-CHM13v2.0
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)EnsemblGRCm39 Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBIMGSCv36mm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,104,927 - 2,117,998 (-)NCBIGRCr8
mRatBN7.2101,597,761 - 1,610,822 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,597,761 - 1,609,000 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,294,586 - 6,305,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,260,010 - 34,271,250 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,612,004 - 1,623,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
LOC100990946
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,204,875 - 15,232,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,987,730 - 19,015,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBIUU_Cfam_GSD_1.0
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,841,660 - 2,854,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,870,940 - 3,887,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLA2G10
4 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16p13.12-13.11(chr16:14668382-16678513)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051357]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051357]|See cases [RCV000051357] Chr16:14668382..16678513 [GRCh38]
Chr16:14762239..16772370 [GRCh37]
Chr16:14669740..16679871 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-12.3(chr16:14609647-18765817)x3 copy number gain See cases [RCV000051353] Chr16:14609647..18765817 [GRCh38]
Chr16:14703504..18777139 [GRCh37]
Chr16:14611005..18684640 [NCBI36]
Chr16:16p13.12-12.3
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14639096-16431491)x3 copy number gain See cases [RCV000051354] Chr16:14639096..16431491 [GRCh38]
Chr16:14732953..16525348 [GRCh37]
Chr16:14640454..16432849 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14668182-16493213)x3 copy number gain See cases [RCV000051355] Chr16:14668182..16493213 [GRCh38]
Chr16:14762039..16587070 [GRCh37]
Chr16:14669540..16494571 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.12-13.11(chr16:14668382-16100721)x3 copy number gain See cases [RCV000051356] Chr16:14668382..16100721 [GRCh38]
Chr16:14762239..16194578 [GRCh37]
Chr16:14669740..16102079 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.13-13.11(chr16:11967831-15162888)x1 copy number loss See cases [RCV000052484] Chr16:11967831..15162888 [GRCh38]
Chr16:12061688..15256745 [GRCh37]
Chr16:11969189..15164246 [NCBI36]
Chr16:16p13.13-13.11
pathogenic
GRCh38/hg38 16p13.3-11.2(chr16:4644892-29170820)x3 copy number gain See cases [RCV000133809] Chr16:4644892..29170820 [GRCh38]
Chr16:4694893..29182141 [GRCh37]
Chr16:4634894..29089642 [NCBI36]
Chr16:16p13.3-11.2
pathogenic
GRCh38/hg38 16p13.13-13.11(chr16:11952467-15186199)x1 copy number loss See cases [RCV000137596] Chr16:11952467..15186199 [GRCh38]
Chr16:12046324..15280056 [GRCh37]
Chr16:11953825..15187557 [NCBI36]
Chr16:16p13.13-13.11
likely pathogenic
GRCh38/hg38 16p13.12(chr16:14140498-14686337)x3 copy number gain See cases [RCV000137490] Chr16:14140498..14686337 [GRCh38]
Chr16:14234355..14780194 [GRCh37]
Chr16:14141856..14687695 [NCBI36]
Chr16:16p13.12
likely benign
GRCh38/hg38 16p13.12-13.11(chr16:14686278-16431491)x3 copy number gain See cases [RCV000140727] Chr16:14686278..16431491 [GRCh38]
Chr16:14780135..16525348 [GRCh37]
Chr16:14687636..16432849 [NCBI36]
Chr16:16p13.12-13.11
uncertain significance
GRCh38/hg38 16p13.3-13.11(chr16:666662-15743104)x3 copy number gain See cases [RCV000143710] Chr16:666662..15743104 [GRCh38]
Chr16:716662..15836961 [GRCh37]
Chr16:656663..15744462 [NCBI36]
Chr16:16p13.3-13.11
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:102839-28327676)x3 copy number gain See cases [RCV000203445] Chr16:102839..28327676 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:1279324-31926800)x3 copy number gain Ductal breast carcinoma [RCV000207053] Chr16:1279324..31926800 [GRCh37]
Chr16:16p13.3-11.2
uncertain significance
GRCh37/hg19 16p13.3-12.3(chr16:1274615-19073133)x3 copy number gain Ductal breast carcinoma [RCV000207326] Chr16:1274615..19073133 [GRCh37]
Chr16:16p13.3-12.3
uncertain significance
Single allele deletion 16p13.11 recurrent microdeletion syndrome [RCV003221320] Chr16:14692101..16527136 [GRCh38]
Chr16:16p13.12-13.11
likely pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
maternal UPD(16p) complex Hemimegalencephaly [RCV000494707] Chr16:1280042..33710558 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-12.2(chr16:85880-22442007)x3 copy number gain See cases [RCV000511360] Chr16:85880..22442007 [GRCh37]
Chr16:16p13.3-12.2
pathogenic
GRCh37/hg19 16p13.3-12.3(chr16:85880-19806921)x3 copy number gain See cases [RCV000512194] Chr16:85880..19806921 [GRCh37]
Chr16:16p13.3-12.3
pathogenic
GRCh37/hg19 16p13.12-12.3(chr16:14780543-16855348)x1 copy number loss not provided [RCV000683767] Chr16:14780543..16855348 [GRCh37]
Chr16:16p13.12-12.3
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14780641-16498084)x1 copy number loss not provided [RCV000683768] Chr16:14780641..16498084 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.13-13.12(chr16:12007434-14781381)x1 copy number loss not provided [RCV000683763] Chr16:12007434..14781381 [GRCh37]
Chr16:16p13.13-13.12
uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14759219-16419494)x1 copy number loss not provided [RCV000739062] Chr16:14759219..16419494 [GRCh37]
Chr16:16p13.12-13.11
likely benign
GRCh37/hg19 16p13.12-13.11(chr16:14766480-16286694) copy number gain not provided [RCV000767573] Chr16:14766480..16286694 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
NM_003561.3(PLA2G10):c.360G>A (p.Pro120=) single nucleotide variant not provided [RCV000969969] Chr16:14672745 [GRCh38]
Chr16:14766602 [GRCh37]
Chr16:16p13.12
likely benign
GRCh37/hg19 16p13.12-13.11(chr16:14770672-16458408)x1 copy number loss not provided [RCV001006769] Chr16:14770672..16458408 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14770672-16388343)x1 copy number loss not provided [RCV001006768] Chr16:14770672..16388343 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14780543-16391045)x1 copy number loss not provided [RCV001006770] Chr16:14780543..16391045 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:5805001-34230001) copy number gain Microcephaly [RCV001252948] Chr16:5805001..34230001 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:2959279-30190593)x3 copy number gain See cases [RCV001263169] Chr16:2959279..30190593 [GRCh37]
Chr16:16p13.3-11.2
pathogenic|likely pathogenic
GRCh37/hg19 16p13.3-11.2(chr16:4380767-30445350)x3 copy number gain not provided [RCV002472599] Chr16:4380767..30445350 [GRCh37]
Chr16:16p13.3-11.2
pathogenic
GRCh37/hg19 16p13.12-12.3(chr16:14365745-17052798)x3 copy number gain not provided [RCV002473916] Chr16:14365745..17052798 [GRCh37]
Chr16:16p13.12-12.3
likely pathogenic
GRCh37/hg19 16p13.12-13.11(chr16:14780544-16330627)x1 copy number loss not provided [RCV002473940] Chr16:14780544..16330627 [GRCh37]
Chr16:16p13.12-13.11
pathogenic
NM_003561.3(PLA2G10):c.387G>C (p.Leu129Phe) single nucleotide variant Inborn genetic diseases [RCV002757848] Chr16:14672718 [GRCh38]
Chr16:14766575 [GRCh37]
Chr16:16p13.12
uncertain significance
NC_000016.10:g.14683149_16205174dup duplication not specified [RCV003225664] Chr16:14683149..16205174 [GRCh38]
Chr16:16p13.12-13.11
uncertain significance
NM_003561.3(PLA2G10):c.346G>A (p.Val116Ile) single nucleotide variant Inborn genetic diseases [RCV003183877] Chr16:14688174 [GRCh38]
Chr16:14782031 [GRCh37]
Chr16:16p13.12
likely benign
GRCh37/hg19 16p13.12-13.11(chr16:14643928-14725823)x1 copy number loss Dyskeratosis congenita, autosomal recessive 6 [RCV003228701] Chr16:14643928..14725823 [GRCh37]
Chr16:16p13.12-13.11
not provided
NM_003561.3(PLA2G10):c.359C>T (p.Pro120Leu) single nucleotide variant Inborn genetic diseases [RCV003369562] Chr16:14672746 [GRCh38]
Chr16:14766603 [GRCh37]
Chr16:16p13.12
uncertain significance
GRCh37/hg19 16p13.12(chr16:14423662-14777432)x3 copy number gain not provided [RCV003485097] Chr16:14423662..14777432 [GRCh37]
Chr16:16p13.12
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:261
Interacting mature miRNAs:268
Transcripts:ENST00000438167, ENST00000567462
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D16S312  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371614,787,112 - 14,787,279UniSTSGRCh37
GRCh371614,826,229 - 14,826,402UniSTSGRCh37
Build 361614,694,613 - 14,694,780RGDNCBI36
Celera1614,963,878 - 14,964,051RGD
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map16p13.1-p12UniSTS
HuRef1614,706,392 - 14,706,565UniSTS
RH65989  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371614,766,461 - 14,766,592UniSTSGRCh37
Build 361614,673,962 - 14,674,093RGDNCBI36
Celera1614,943,238 - 14,943,369RGD
Cytogenetic Map16p12.2UniSTS
Cytogenetic Map16p13.1-p12UniSTS
HuRef1614,685,753 - 14,685,884UniSTS
GeneMap99-GB4 RH Map16167.28UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 199 7 5 2 6 6 19 65
Low 768 19 66 32 478 32 222 28 326 103 719 719 10 6 31 3
Below cutoff 1271 1871 1187 401 850 274 3376 1687 2986 235 628 669 129 956 2278 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_003561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_133651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011522698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047434757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054329142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC243753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC069539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC106732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC111804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM739473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HF583722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000438167   ⟹   ENSP00000393847
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1614,672,548 - 14,694,308 (-)Ensembl
RefSeq Acc Id: ENST00000567462   ⟹   ENSP00000456433
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1614,672,681 - 14,694,276 (-)Ensembl
RefSeq Acc Id: NM_003561   ⟹   NP_003552
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,672,548 - 14,694,308 (-)NCBI
GRCh371614,766,405 - 14,788,526 (-)ENTREZGENE
Build 361614,673,906 - 14,696,027 (-)NCBI Archive
HuRef1614,685,697 - 14,707,807 (-)ENTREZGENE
CHM1_11614,766,236 - 14,788,264 (-)NCBI
T2T-CHM13v2.01614,710,083 - 14,731,829 (-)NCBI
Sequence:
RefSeq Acc Id: NR_133651
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,672,548 - 14,694,573 (-)NCBI
CHM1_11614,766,236 - 14,788,264 (-)NCBI
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522695   ⟹   XP_011520997
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,678,794 - 14,701,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522696   ⟹   XP_011520998
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,683,458 - 14,701,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522697   ⟹   XP_011520999
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,678,699 - 14,701,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011522698   ⟹   XP_011521000
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,683,666 - 14,701,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047434757   ⟹   XP_047290713
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381614,672,548 - 14,701,850 (-)NCBI
RefSeq Acc Id: NP_003552   ⟸   NM_003561
- Peptide Label: preproprotein
- UniProtKB: Q14DU3 (UniProtKB/Swiss-Prot),   Q6NT23 (UniProtKB/Swiss-Prot),   O15496 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011520999   ⟸   XM_011522697
- Peptide Label: isoform X4
- UniProtKB: H3BRW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011520997   ⟸   XM_011522695
- Peptide Label: isoform X2
- UniProtKB: H3BRW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011520998   ⟸   XM_011522696
- Peptide Label: isoform X3
- UniProtKB: H3BRW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011521000   ⟸   XM_011522698
- Peptide Label: isoform X5
- UniProtKB: H3BRW4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000393847   ⟸   ENST00000438167
RefSeq Acc Id: ENSP00000456433   ⟸   ENST00000567462
RefSeq Acc Id: XP_047290713   ⟸   XM_047434757
- Peptide Label: isoform X1
- UniProtKB: Q14DU3 (UniProtKB/Swiss-Prot),   O15496 (UniProtKB/Swiss-Prot),   Q6NT23 (UniProtKB/Swiss-Prot)
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O15496-F1-model_v2 AlphaFold O15496 1-165 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9029 AgrOrtholog
COSMIC PLA2G10 COSMIC
Ensembl Genes ENSG00000069764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSG00000276870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000438167 ENTREZGENE
  ENST00000438167.8 UniProtKB/Swiss-Prot
  ENST00000567462 ENTREZGENE
  ENST00000567462.1 UniProtKB/TrEMBL
  ENST00000621727.2 UniProtKB/Swiss-Prot
  ENST00000634009.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000069764 GTEx
  ENSG00000276870 GTEx
HGNC ID HGNC:9029 ENTREZGENE
Human Proteome Map PLA2G10 Human Proteome Map
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8399 UniProtKB/Swiss-Prot
NCBI Gene 8399 ENTREZGENE
OMIM 603603 OMIM
PANTHER GROUP 10 SECRETORY PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33360 PharmGKB
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BRW4 ENTREZGENE, UniProtKB/TrEMBL
  L8E7V2_HUMAN UniProtKB/TrEMBL
  O15496 ENTREZGENE, UniProtKB/Swiss-Prot
  Q14DU3 ENTREZGENE
  Q6NT23 ENTREZGENE
UniProt Secondary Q14DU3 UniProtKB/Swiss-Prot
  Q6NT23 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-14 PLA2G10  phospholipase A2 group X  LOC105371095  collagen alpha-3(IX) chain-like  Data merged from RGD:38606216 737654 PROVISIONAL
2015-11-24 PLA2G10  phospholipase A2 group X    phospholipase A2, group X  Symbol and/or name change 5135510 APPROVED