LOC101960864 (group 10 secretory phospholipase A2)

Gene: LOC101960864 (group 10 secretory phospholipase A2) Ictidomys tridecemlineatus

Analyze

Symbol:

LOC101960864 (Ensembl: PLA2G10)

Name:

group 10 secretory phospholipase A2

RGD ID:

12689192

Description:

ENCODES a protein that exhibits phospholipase A2 activity (ortholog); INVOLVED IN axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); erythrocyte maturation (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN acrosomal vesicle (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

phospholipase A2 group X; Pla2g10

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	114,743,588 - 114,759,931 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	2,841,660 - 2,854,952 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	2,841,209 - 2,857,570 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

arachidonic acid secretion (IEA)

axon guidance (IEA,ISO)

cellular response to leukemia inhibitory factor (IEA,ISO)

cholesterol homeostasis (IEA)

defense response to virus (IEA)

erythrocyte maturation (IEA,ISO)

fertilization (IEA,ISO)

hair follicle morphogenesis (IEA)

intestinal stem cell homeostasis (IEA)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

low-density lipoprotein particle remodeling (IEA)

lysophospholipid transport (IEA,ISO)

macrophage activation (IEA,ISO)

negative regulation of cholesterol efflux (IEA)

negative regulation of cytokine production involved in inflammatory response (IEA,ISO)

negative regulation of inflammatory response (IEA,ISO)

phosphatidic acid metabolic process (IEA)

phosphatidylcholine catabolic process (IEA)

phosphatidylcholine metabolic process (IEA)

phosphatidylethanolamine metabolic process (IEA)

phosphatidylglycerol metabolic process (IEA)

phosphatidylserine metabolic process (IEA)

phospholipid metabolic process (IEA,ISO)

platelet activating factor catabolic process (IEA)

positive regulation of acrosome reaction (IEA)

positive regulation of arachidonic acid secretion (IEA)

positive regulation of lipid storage (IEA)

positive regulation of prostaglandin secretion (IEA)

positive regulation of protein metabolic process (IEA)

production of molecular mediator involved in inflammatory response (IEA,ISO)

prostaglandin biosynthetic process (IEA)

regulation of macrophage activation (IEA)

Cellular Component

acrosomal vesicle (IEA)

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

1-alkyl-2-acetylglycerophosphocholine esterase activity (IEA)

calcium ion binding (IEA)

calcium-dependent phospholipase A2 activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

phospholipase A2 activity (IEA,ISO)

phospholipase activity (IEA)

phospholipid binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	114,743,588 - 114,759,931 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936501	2,841,660 - 2,854,952 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936501	2,841,209 - 2,857,570 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLA2G10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	14,672,548 - 14,701,850 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	14,672,548 - 14,694,308 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	14,766,405 - 14,788,430 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	14,673,906 - 14,696,027 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	14,673,907 - 14,696,027	NCBI
Celera	16	14,943,182 - 14,965,293 (-)	NCBI		Celera
Cytogenetic Map	16	p13.12-p13.11	NCBI
HuRef	16	14,685,697 - 14,707,807 (-)	NCBI		HuRef
CHM1_1	16	14,766,236 - 14,788,360 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	14,710,083 - 14,732,094 (-)	NCBI		T2T-CHM13v2.0

Pla2g10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	13,532,921 - 13,548,863 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	13,532,921 - 13,548,847 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	13,715,057 - 13,731,094 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	13,715,057 - 13,730,983 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	13,715,155 - 13,730,678 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	13,628,640 - 13,644,163 (-)	NCBI		MGSCv36	mm8
Celera	16	14,319,504 - 14,335,040 (-)	NCBI		Celera
Cytogenetic Map	16	A1	NCBI
cM Map	16	9.5	NCBI

Pla2g10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	2,104,927 - 2,117,998 (-)	NCBI		GRCr8
mRatBN7.2	10	1,597,761 - 1,610,822 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	1,597,761 - 1,609,000 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	6,294,586 - 6,305,824 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	34,260,010 - 34,271,250 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	1,612,004 - 1,623,245 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	1,509,732 - 1,520,970 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	1,509,732 - 1,520,970 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	406,661 - 417,899 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	26,035 - 37,273 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	26,034 - 37,266 (-)	NCBI
Celera	10	658,651 - 669,889 (-)	NCBI		Celera
Cytogenetic Map	10	q11	NCBI

Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	4,208,575 - 4,225,834 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	4,208,497 - 4,225,893 (+)	NCBI	ChiLan1.0	ChiLan1.0

LOC100990946
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	15,204,875 - 15,232,910 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	18,987,730 - 19,015,721 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	13,600,152 - 13,622,629 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	15,021,025 - 15,043,782 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

PLA2G10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	28,573,239 - 28,591,714 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	28,574,387 - 28,591,703 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	29,936,319 - 29,954,796 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	28,736,378 - 28,754,847 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	28,539,400 - 28,557,862 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	28,427,844 - 28,446,114 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	28,835,005 - 28,853,467 (+)	NCBI		UU_Cfam_GSD_1.0

LOC110259864
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	7,623,312 - 7,642,002 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	7,623,326 - 7,641,061 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

Pla2g10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624782	3,870,940 - 3,887,426 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624782	3,871,034 - 3,887,476 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005323688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000007572 ⟹ ENSSTOP00000006769

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936501	2,841,660 - 2,854,952 (-)	Ensembl

RefSeq Acc Id:

XM_005323688 ⟹ XP_005323745

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	114,743,588 - 114,759,931 (-)	NCBI
SpeTri2.0	NW_004936501	2,841,209 - 2,857,570 (-)	NCBI

Sequence:

show sequence

ATGGGTCTGCTACCTCCGTGCTCCCCAATAATGCTGCTACTCTTGCTGCTGCTGCTGCTGGGAC
CTGGCCCCGGACCCAGCGTGGCATCTAGGAGGTCACATGTGCGCCGGCGTGGGATCCTGGAACT
GGCAGGGACTTTGAACTGTGTCGGAACCCGAACCCCTATGGCCTACATGAACTACGGCTGCTAC
TGTGGCCTGGGTGGCCATGGCCAGCCCCAGGATGCCATCGACTGGTGCTGCTATCACCATGACT
GCTGCTACACTCGCGCAGAGGAGGCTGGCTGCAGACCCAAGTTGGAGCGCTACTCCTGGCAGTG
TGACAACCAGCGCATCCTGTGTGGATCCACGGATGATGAATGCCAGAAGCTCCTGTGTAAGTGT
GACAAGGAGATTGCTTACTGCCTAGCCGGTACCAAGTACAACTTTAAGTACCTCTTCTACCCCC
AGTCTTTGTGTGAGGAGGACTCACCCAAGTGTGACTGACTCCGTGTTCATTTGCAAAAGGAAAT
AAAGCTCCCTTTCATTAATGAACAACAGAATTCAGTTTCTGGAGGAGGCAACTGAGGCCAAGTG
ATAAAGCCACATGAGCCTTGTGTTTGCCTTCCGGCCTGGAACTCAGATTGAGTCTGTTCAGCTT
CCAGTTTGATGAAGGTCAAAAGTCCCATTCCTATTTTATAAAACCATGACTGTGTTGAGCTTGG
TATCGTTTTCTGTGGTTAGTTCGACTTTTTTGAAAAGGTGGGTTTTGTCTTCTCACTTGCTGCT
GATGACTGGTGGTCAAATGAGCGCGGATACCTGCCGGGCACTTGGCCATGTTGTAGGCTCAGTG
TCCGCAATAAAGAAGACATACAGGGGACACTCGCCCTTGTGAAATTCAAGTTTCATAGCTGTTT
GAAACCTTTAACAGTTTCCTGGGGAGGACAAACCCTAGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005323745	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000006769.3
GenBank Protein	KAG3259365	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005323745 ⟸ XM_005323688
- UniProtKB:	I3MA02 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGLLPPCSPIMLLLLLLLLLGPGPGPSVASRRSHVRRRGILELAGTLNCVGTRTPMAYMNYGCY CGLGGHGQPQDAIDWCCYHHDCCYTRAEEAGCRPKLERYSWQCDNQRILCGSTDDECQKLLCKC DKEIAYCLAGTKYNFKYLFYPQSLCEEDSPKCD hide sequence

RefSeq Acc Id:

ENSSTOP00000006769 ⟸ ENSSTOT00000007572

Protein Domains

Phospholipase A2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000007582	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000007572.3	UniProtKB/TrEMBL
Gene3D-CATH	1.20.90.10	UniProtKB/TrEMBL
InterPro	PLipase_A2	UniProtKB/TrEMBL
	PLipase_A2_Asp_AS	UniProtKB/TrEMBL
	PLipase_A2_dom	UniProtKB/TrEMBL
	PLipase_A2_dom_sf	UniProtKB/TrEMBL
	PLipase_A2_His_AS	UniProtKB/TrEMBL
NCBI Gene	Pla2g10	ENTREZGENE
PANTHER	GROUP 10 SECRETORY PHOSPHOLIPASE A2	UniProtKB/TrEMBL
	PTHR11716	UniProtKB/TrEMBL
Pfam	Phospholip_A2_1	UniProtKB/TrEMBL
PRINTS	PHPHLIPASEA2	UniProtKB/TrEMBL
PROSITE	PA2_ASP	UniProtKB/TrEMBL
	PA2_HIS	UniProtKB/TrEMBL
SMART	PA2c	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48619	UniProtKB/TrEMBL
UniProt	I3MA02	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-07-13	LOC101960864	group 10 secretory phospholipase A2	Pla2g10	phospholipase A2 group X	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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