Pla2g10 (phospholipase A2, group X) - Rat Genome Database

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Gene: Pla2g10 (phospholipase A2, group X) Mus musculus
Analyze
Symbol: Pla2g10
Name: phospholipase A2, group X
RGD ID: 62228
MGI Page MGI
Description: Enables calcium-dependent phospholipase A2 activity. Involved in several processes, including cholesterol homeostasis; glycerophospholipid metabolic process; and regulation of lipid transport. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; erythrocyte maturation; and negative regulation of cytokine production involved in inflammatory response. Located in acrosomal vesicle. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Orthologous to human PLA2G10 (phospholipase A2 group X).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: group 10 secretory phospholipase A2; group X secretory phospholipase A2; GX sPLA2; mGXs; mGXsPLA2; phosphatidylcholine 2-acylhydrolase 10; PLA; PLA2GX; sPLA2-X
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)EnsemblGRCm39 Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBIMGSCv36mm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. On the diversity of secreted phospholipases A(2). Cloning, tissue distribution, and functional expression of two novel mouse group II enzymes. Valentin E, etal., J Biol Chem 1999 Oct 29;274(44):31195-202.
Additional References at PubMed
PMID:9188469   PMID:10349636   PMID:11019817   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11741598   PMID:12021277   PMID:12050136   PMID:12359733   PMID:12477932   PMID:14610273  
PMID:14681479   PMID:15781456   PMID:15789617   PMID:15927955   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17008322   PMID:17403936   PMID:18506007   PMID:18511424   PMID:18539905  
PMID:18799693   PMID:20421306   PMID:20424323   PMID:20424324   PMID:20432503   PMID:20439489   PMID:20585029   PMID:20833395   PMID:20844270   PMID:21266581   PMID:21266583   PMID:21267068  
PMID:21622863   PMID:21652694   PMID:21677750   PMID:21792918   PMID:21873635   PMID:21984544   PMID:23349189   PMID:23624557   PMID:24194600   PMID:24204651   PMID:24287291   PMID:24725934  
PMID:25122761   PMID:26655718   PMID:26828067   PMID:27226632   PMID:27292189   PMID:27626380   PMID:29093264   PMID:32341057  


Genomics

Comparative Map Data
Pla2g10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391613,532,921 - 13,548,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1613,532,921 - 13,548,847 (-)EnsemblGRCm39 Ensembl
GRCm381613,715,057 - 13,731,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1613,715,057 - 13,730,983 (-)EnsemblGRCm38mm10GRCm38
MGSCv371613,715,155 - 13,730,678 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361613,628,640 - 13,644,163 (-)NCBIMGSCv36mm8
Celera1614,319,504 - 14,335,040 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map169.5NCBI
PLA2G10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381614,672,548 - 14,701,850 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1614,672,548 - 14,694,308 (-)EnsemblGRCh38hg38GRCh38
GRCh371614,766,405 - 14,788,430 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361614,673,906 - 14,696,027 (-)NCBINCBI36Build 36hg18NCBI36
Build 341614,673,907 - 14,696,027NCBI
Celera1614,943,182 - 14,965,293 (-)NCBICelera
Cytogenetic Map16p13.12-p13.11NCBI
HuRef1614,685,697 - 14,707,807 (-)NCBIHuRef
CHM1_11614,766,236 - 14,788,360 (-)NCBICHM1_1
T2T-CHM13v2.01614,710,083 - 14,732,094 (-)NCBIT2T-CHM13v2.0
Pla2g10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8102,104,927 - 2,117,998 (-)NCBIGRCr8
mRatBN7.2101,597,761 - 1,610,822 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl101,597,761 - 1,609,000 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx106,294,586 - 6,305,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01034,260,010 - 34,271,250 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0101,612,004 - 1,623,245 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0101,509,732 - 1,520,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl101,509,732 - 1,520,970 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010406,661 - 417,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41026,035 - 37,273 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11026,034 - 37,266 (-)NCBI
Celera10658,651 - 669,889 (-)NCBICelera
Cytogenetic Map10q11NCBI
Pla2g10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554424,208,575 - 4,225,834 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554424,208,497 - 4,225,893 (+)NCBIChiLan1.0ChiLan1.0
LOC100990946
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21815,204,875 - 15,232,910 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11618,987,730 - 19,015,721 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01613,600,152 - 13,622,629 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11615,021,025 - 15,043,782 (-)NCBIpanpan1.1PanPan1.1panPan2
PLA2G10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1628,573,239 - 28,591,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl628,574,387 - 28,591,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha629,936,319 - 29,954,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0628,736,378 - 28,754,847 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1628,539,400 - 28,557,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0628,427,844 - 28,446,114 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0628,835,005 - 28,853,467 (+)NCBIUU_Cfam_GSD_1.0
LOC101960864
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344114,743,588 - 114,759,931 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365012,841,660 - 2,854,952 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365012,841,209 - 2,857,570 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259864
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl37,623,312 - 7,642,002 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.137,623,326 - 7,641,061 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pla2g10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247823,870,940 - 3,887,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247823,871,034 - 3,887,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pla2g10
667 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:523
Count of miRNA genes:316
Interacting mature miRNAs:336
Transcripts:ENSMUST00000023364, ENSMUST00000115807, ENSMUST00000127780, ENSMUST00000156504
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120780888Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122500574Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122520318Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16122897739Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124263853Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124263853Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128434358Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129674200Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130066977Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130814572Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16378077915731053Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16647700935021216Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16713690629225471Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse

Markers in Region
Pla2g10  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A1UniSTS
cM Map163.4UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000023364   ⟹   ENSMUSP00000023364
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1613,532,923 - 13,548,847 (-)Ensembl
GRCm38.p6 Ensembl1613,715,059 - 13,730,983 (-)Ensembl
RefSeq Acc Id: ENSMUST00000115807   ⟹   ENSMUSP00000111474
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1613,532,921 - 13,548,307 (-)Ensembl
GRCm38.p6 Ensembl1613,715,057 - 13,730,443 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127780
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1613,533,258 - 13,548,583 (-)Ensembl
GRCm38.p6 Ensembl1613,715,394 - 13,730,719 (-)Ensembl
RefSeq Acc Id: ENSMUST00000156504
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1613,543,015 - 13,548,543 (-)Ensembl
GRCm38.p6 Ensembl1613,725,151 - 13,730,679 (-)Ensembl
RefSeq Acc Id: NM_001291009   ⟹   NP_001277938
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391613,532,921 - 13,548,348 (-)NCBI
GRCm381613,715,057 - 13,730,484 (-)NCBI
Celera1614,319,499 - 14,335,438 (-)NCBI
Sequence:
RefSeq Acc Id: NM_011987   ⟹   NP_036117
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391613,532,921 - 13,548,348 (-)NCBI
GRCm381613,715,057 - 13,730,484 (-)NCBI
MGSCv371613,715,155 - 13,730,678 (-)RGD
Celera1614,319,499 - 14,335,438 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_110990
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391613,532,921 - 13,548,348 (-)NCBI
GRCm381613,715,057 - 13,730,484 (-)NCBI
Celera1614,319,499 - 14,335,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017316987   ⟹   XP_017172476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391613,532,921 - 13,548,863 (-)NCBI
GRCm381613,715,057 - 13,731,094 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036117   ⟸   NM_011987
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q9EQK6 (UniProtKB/Swiss-Prot),   Q9QXX3 (UniProtKB/Swiss-Prot),   Q8C5Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277938   ⟸   NM_001291009
- Peptide Label: isoform 2 preproprotein
- UniProtKB: Q8K130 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017172476   ⟸   XM_017316987
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000111474   ⟸   ENSMUST00000115807
RefSeq Acc Id: ENSMUSP00000023364   ⟸   ENSMUST00000023364
Protein Domains
Phospholipase A2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXX3-F1-model_v2 AlphaFold Q9QXX3 1-151 view protein structure

Promoters
RGD ID:8685498
Promoter ID:EPDNEW_M20780
Type:initiation region
Name:Pla2g10_1
Description:Mus musculus phospholipase A2, group X , transcript variant 2,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381613,730,464 - 13,730,524EPDNEW
RGD ID:6827357
Promoter ID:MM_KWN:20171
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000065065,   OTTMUST00000065066,   OTTMUST00000065067,   OTTMUST00000065068
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361613,730,886 - 13,731,386 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1347522 AgrOrtholog
Ensembl Genes ENSMUSG00000022683 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023364 ENTREZGENE
  ENSMUST00000023364.7 UniProtKB/Swiss-Prot
  ENSMUST00000115807 ENTREZGENE
  ENSMUST00000115807.9 UniProtKB/TrEMBL
Gene3D-CATH 1.20.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PLipase_A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_Asp_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_A2_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:26565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1347522 ENTREZGENE
NCBI Gene 26565 ENTREZGENE
PANTHER GROUP 10 SECRETORY PHOSPHOLIPASE A2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phospholip_A2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pla2g10 PhenoGen
PRINTS PHPHLIPASEA2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PA2_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PA2_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PA2c UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48619 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt PA2GX_MOUSE UniProtKB/Swiss-Prot
  Q8C5Y6 ENTREZGENE, UniProtKB/TrEMBL
  Q8K130 ENTREZGENE, UniProtKB/TrEMBL
  Q9EQK6 ENTREZGENE
  Q9QXX3 ENTREZGENE
  S4W5N8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9EQK6 UniProtKB/Swiss-Prot