Advanced Search (OLGA)

Gene: Map3k11 (mitogen-activated protein kinase kinase kinase 11) Rattus norvegicus

Analyze

Symbol:

Map3k11

Name:

mitogen-activated protein kinase kinase kinase 11

RGD ID:

1359261

Description:

Enables ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Involved in several processes, including JNK cascade; positive regulation of JNK cascade; and protein autophosphorylation. Predicted to be located in microtubule. Predicted to be active in centrosome and cytoplasm. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; Reelin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

mixed lineage kinase 3; Mlk-3; Mlk3; RHOE

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	212,404,685 - 212,417,986 (+)	NCBI		GRCr8
mRatBN7.2	1	202,975,353 - 202,988,655 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	202,975,353 - 202,988,652 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	211,327,935 - 211,341,229 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	218,420,755 - 218,434,054 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,111,801 - 211,125,100 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	221,043,119 - 221,056,420 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,043,119 - 221,056,417 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	227,978,441 - 227,991,742 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	208,312,955 - 208,326,289 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	208,466,407 - 208,479,739 (+)	NCBI
Celera	1	200,511,102 - 200,524,400 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

Bardet-Biedl syndrome (ISO)

glycogen storage disease V (ISO)

immunodeficiency 90 (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diazinon (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

nitrates (ISO)

NSC 23766 (ISO)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

poly(I:C) (ISO)

raloxifene (ISO)

selenomethionine (ISO)

sodium arsenite (ISO)

sulfates (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

urethane (ISO)

valproic acid (ISO)

zinc oxide (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell cycle G1/S phase transition (IEA,ISO)

JNK cascade (IBA,IDA,IEA,ISO)

MAPK cascade (IEA,ISO)

microtubule-based process (IBA,IEA,ISO)

positive regulation of apoptotic process (IBA,IMP)

positive regulation of JNK cascade (IDA,IEA,ISO)

positive regulation of JUN kinase activity (ISO)

positive regulation of neuron apoptotic process (IMP)

protein autophosphorylation (IDA,ISO)

protein phosphorylation (IDA,ISO)

Cellular Component

centrosome (IBA,IEA,ISO)

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

microtubule (IEA,ISO)

Molecular Function

ATP binding (IDA,IEA)

identical protein binding (IEA,ISO)

JUN kinase kinase kinase activity (IBA,IDA,IEA,ISO)

kinase activity (IEA)

MAP kinase kinase kinase activity (IDA,IEA,ISO)

mitogen-activated protein kinase kinase binding (IPI)

mitogen-activated protein kinase kinase kinase binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (IPI,ISO)

protein homodimerization activity (IEA,ISO)

protein kinase activity (IEA)

protein serine kinase activity (IEA)

protein serine/threonine kinase activity (IDA,IEA,ISO)

small GTPase binding (IPI)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (IDA,ISO)

mitogen activated protein kinase signaling pathway (IEA)

p38 MAPK signaling pathway (ISO)

Reelin signaling pathway (ISO)

type II interferon signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Mechanisms and functions of p38 MAPK signalling.	Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.	Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
4.	Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells.	Kim KY, etal., J Biol Chem 2004 Jul 9;279(28):29478-84. Epub 2004 Apr 6.
5.	Evidence for a role of mixed lineage kinases in neuronal apoptosis.	Mota M, etal., J Neurosci. 2001 Jul 15;21(14):4949-57.
6.	The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region.	Pan J, etal., Neuroscience. 2005;131(1):147-59.
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9.	GOA pipeline	RGD automated data pipeline
10.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
12.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13.	Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family.	Teramoto H, etal., J Biol Chem. 1996 Nov 1;271(44):27225-8.
14.	Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats.	Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
15.	The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis.	Xu Z, etal., Mol Cell Biol. 2001 Jul;21(14):4713-24.
16.	Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats.	Zhang Q, etal., Life Sci. 2003 Nov 21;74(1):37-45.
17.	Crosstalk between PSD-95 and JIP1-mediated signaling modules: the mechanism of MLK3 activation in cerebral ischemia.	Zhang QX, etal., Biochemistry. 2007 Apr 3;46(13):4006-16. Epub 2007 Mar 10.
18.	Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus.	Zhao J, etal., Cell Signal. 2007 Apr;19(4):831-43. Epub 2006 Dec 8.
19.	SUMOylation of the kainate receptor subunit GluK2 contributes to the activation of the MLK3-JNK3 pathway following kainate stimulation.	Zhu QJ, etal., FEBS Lett. 2012 May 7;586(9):1259-64. doi: 10.1016/j.febslet.2012.03.048. Epub 2012 Mar 31.

Additional References at PubMed

PMID:8195146	PMID:9829970	PMID:11053428	PMID:12529434	PMID:14690535	PMID:15258589	PMID:15489334	PMID:15797868	PMID:16154687	PMID:17584736	PMID:17711861	PMID:18307989
PMID:19368836	PMID:19449206	PMID:19546888	PMID:19946888	PMID:21726169	PMID:22123824	PMID:27280801	PMID:29864954

Genomics

Comparative Map Data

Map3k11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	212,404,685 - 212,417,986 (+)	NCBI		GRCr8
mRatBN7.2	1	202,975,353 - 202,988,655 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	202,975,353 - 202,988,652 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	211,327,935 - 211,341,229 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	218,420,755 - 218,434,054 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	211,111,801 - 211,125,100 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	221,043,119 - 221,056,420 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	221,043,119 - 221,056,417 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	227,978,441 - 227,991,742 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	208,312,955 - 208,326,289 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	208,466,407 - 208,479,739 (+)	NCBI
Celera	1	200,511,102 - 200,524,400 (+)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

MAP3K11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	65,597,757 - 65,614,221 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	65,597,756 - 65,615,382 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	65,365,228 - 65,381,692 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	65,121,802 - 65,138,296 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	65,121,801 - 65,138,296	NCBI
Celera	11	62,691,942 - 62,708,437 (-)	NCBI		Celera
Cytogenetic Map	11	q13.1	NCBI
HuRef	11	61,692,198 - 61,708,691 (-)	NCBI		HuRef
CHM1_1	11	65,249,129 - 65,265,648 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	65,591,917 - 65,608,380 (-)	NCBI		T2T-CHM13v2.0

Map3k11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	5,738,764 - 5,752,893 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	5,738,770 - 5,752,893 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	5,688,411 - 5,702,865 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	5,688,742 - 5,702,865 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	5,689,131 - 5,702,865 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	5,689,131 - 5,702,865 (+)	NCBI		MGSCv36	mm8
Celera	19	5,559,170 - 5,572,916 (+)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	4.34	NCBI

Map3k11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	19,651,372 - 19,667,924 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	19,651,371 - 19,666,468 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAP3K11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	66,827,487 - 66,844,363 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	67,870,243 - 67,888,664 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	60,956,880 - 60,973,972 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	64,291,099 - 64,308,711 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	64,291,635 - 64,307,737 (-)	Ensembl	panpan1.1		panPan2

MAP3K11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	51,593,641 - 51,609,245 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	51,594,274 - 51,608,696 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	50,201,432 - 50,217,631 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	52,630,200 - 52,646,397 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	52,631,100 - 52,646,392 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	51,730,092 - 51,746,289 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	51,304,151 - 51,320,331 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	52,094,525 - 52,110,726 (+)	NCBI		UU_Cfam_GSD_1.0

Map3k11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	7,405,272 - 7,420,546 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936599	3,848,334 - 3,863,005 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936599	3,847,637 - 3,862,895 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAP3K11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	6,640,056 - 6,657,713 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	6,640,061 - 6,657,717 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	5,910,163 - 5,914,495 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAP3K11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	8,625,431 - 8,639,049 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	8,625,961 - 8,638,924 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	105,919,807 - 105,938,227 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Map3k11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	20,779,898 - 20,796,015 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	20,780,356 - 20,796,015 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Map3k11
27 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	81
Interacting mature miRNAs:	101
Transcripts:	ENSRNOT00000028185
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	150700247	252085048	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	151162512	256448636	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	197814409	242814409	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2302375	Bw83	Body weight QTL 83	4.87	0.0002	body mass (VT:0001259)	body weight (CMO:0000012)	1	197697768	242697768	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	177227632	256448636	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	201554356	246554356	Rat
2302378	Insul11	Insulin level QTL 11	3.25		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	1	144267353	251128347	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	167909849	212909849	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	171629477	216629477	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	171629477	216629477	Rat
1302787	Stl25	Serum triglyceride level QTL 25	2.7	0.0073	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	1	180359209	210702199	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	172609619	217609619	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	174133260	219133260	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	179567751	260522016	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	195804352	257091168	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	177227632	256448636	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
1558658	Bw59	Body weight QTL 59	3.5	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	1	178784622	223784622	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	184550676	229550676	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	153136852	260522016	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	171629477	216629477	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	195804352	257091168	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	201554356	246554356	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	143506580	212458660	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	169537671	214537671	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	150700247	252085048	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	171629477	216629477	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	185145134	221264292	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	158633083	203633083	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	183970203	243914901	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	191019702	246062233	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	173108781	218108781	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	149448574	221264292	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	201554356	246554356	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	171629477	216629477	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	144267353	222987745	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	151162766	225824951	Rat
737977	Bp160	Blood pressure QTL 160		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	181133855	226133855	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	171629477	216629477	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	201554356	246554356	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	197814409	242814409	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	150700142	252085212	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	171629477	216629477	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	193113876	238113876	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	156677124	256448636	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	196248093	241248093	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	197814409	242814409	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	199050459	259647894	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	182623426	219932796	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	171310381	216310381	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	181759564	214537555	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	156677124	218753816	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	176869060	221869060	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
619613	Bp77	Blood pressure QTL 77		0.01	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	164747424	209747424	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	185356336	231689108	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	178810256	240830002	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	199368955	224569684	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	169537671	214537671	Rat
1331790	Bp201	Blood pressure QTL 201	3.127		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	198211513	225126682	Rat
10059587	Bw173	Body weight QTL 173	3.23	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	1	202069611	247069611	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	213533942	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	164310393	243914901	Rat
10059590	Kidm44	Kidney mass QTL 44	3.42	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	191033875	236033875	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	197697768	238755659	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	196248093	241248093	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	176550523	221550523	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	151162512	256448636	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	188377360	224054420	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	183970203	243914901	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	193422268	214537671	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	180359209	218108781	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	197670404	242670404	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	181829673	224569684	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	176426412	257976495	Rat
1358191	Ept10	Estrogen-induced pituitary tumorigenesis QTL 10	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	192825253	243914732	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	201554356	246554356	Rat

Markers in Region

AI502630

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,988,457 - 202,988,638 (+)	MAPPER	mRatBN7.2
mRatBN7.2	4	132,277,197 - 132,277,459 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	132,086,377 - 132,086,638	NCBI	Rnor6.0
Rnor_6.0	1	221,056,223 - 221,056,403	NCBI	Rnor6.0
Rnor_5.0	4	196,577,927 - 196,578,188	UniSTS	Rnor5.0
Rnor_5.0	1	227,991,545 - 227,991,725	UniSTS	Rnor5.0
RGSC_v3.4	1	208,326,092 - 208,326,272	UniSTS	RGSC3.4
RGSC_v3.4	4	134,489,579 - 134,489,840	UniSTS	RGSC3.4
Celera	4	121,136,822 - 121,137,083	UniSTS
Celera	1	200,524,203 - 200,524,383	UniSTS
RH 3.4 Map	4	808.61	UniSTS
Cytogenetic Map	4	q34	UniSTS
Cytogenetic Map	1	q43	UniSTS

PMC87148P2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,975,828 - 202,975,992 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	221,043,595 - 221,043,758	NCBI	Rnor6.0
Rnor_5.0	1	227,978,917 - 227,979,080	UniSTS	Rnor5.0
RGSC_v3.4	1	208,313,431 - 208,313,594	UniSTS	RGSC3.4
Celera	1	200,511,578 - 200,511,741	UniSTS
Cytogenetic Map	1	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001013150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC134224	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY240868	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028185 ⟹ ENSRNOP00000028185

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	202,975,353 - 202,988,652 (+)	Ensembl
Rnor_6.0 Ensembl	1	221,043,119 - 221,056,417 (+)	Ensembl

RefSeq Acc Id:

NM_001013150 ⟹ NP_001013168

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	212,404,685 - 212,417,986 (+)	NCBI
mRatBN7.2	1	202,975,353 - 202,988,655 (+)	NCBI
Rnor_6.0	1	221,043,119 - 221,056,420 (+)	NCBI
Rnor_5.0	1	227,978,441 - 227,991,742 (+)	NCBI
RGSC_v3.4	1	208,312,955 - 208,326,289 (+)	RGD
Celera	1	200,511,102 - 200,524,400 (+)	RGD

Sequence:

show sequence

CCCGAGAAGAGGTAGCTTCGGCTCTATTGGAGACTTTCTCTTACCTCTTGTATCTCAAGACAAC
AACCAGAGTCCAGGCGCCGACCCTGGCAGGCCCCACCTTACAGTAGGCGGGCGCTGGAGCCAGG
TTCCCAGGACTACTTCGGGACCGAGGGACTCACTGCCGCTCCAATTCAGCCATGGTGAGGCGCC
GGAGGCCAGTGGGCCCCACCCCTCCAGCCTGACCACACTGCCCTCGGTGCCCTCCTCCAGAAGC
CCGAGATGCGGGGGGCCGGGAGGCGACACTCCTGGCTCCCCAGAGAGGCGTGGGTCTGGGGCTG
AGGGCCAGGGCCCGGATGCCCAGGTTCCGGCACTAGGGCCTCACAAGCCACCGGGGGTGGATAC
CACGGGCACCCGAAGAAGGTCCCCCACACATTCCAACGCCGGCTCCCTGCCATGGAGCCCTTGA
AGAACCTCTTCCTCAAGAGCCCGCTGGGGTCATGGAACGGCAGTGGCAGTGGGGGCGGTGGGGG
TTCTGGTGGAGTCCGGCCAGAGGGGTCCCCGAAGGCAACAGCAGCTTATGCCAACCCTGTCTGG
ACAGCCCTGTTCGACTATGAGCCCAATGGGCAGGACGAACTAGCCCTGAGGAAGGGCGACCGTG
TGGAGGTGCTGTCCAGGGATGCAGCCATCTCAGGAGATGAAGGCTGGTGGGCGGGCCAGGTGGG
TGGCCAGGTGGGCATTTTTCCATCCAACTATGTATCTCGGGGTGGAGGCCCACCCCCCTGTGAG
GTGGCCAGCTTCCAGGAGCTGCGACTGGAGGAGGTGATCGGCATCGGTGGCTTCGGCAAGGTCT
ACCGTGGCAGCTGGCGAGGGGAGCTGGTGGCTGTGAAAGCAGCTCGACAGGATCCTGATGAGGA
CATCAGTGTAACAGCTGAGAGTGTTCGACAGGAGGCCCGGCTTTTTGCCATGCTGGCACATCCC
AACATCATTGCCCTCAAAGCTGTGTGCCTGGAGGAGCCAAACCTATGCCTGGTGATGGAGTATG
CAGCTGGTGGACCTCTTAGCCGTGCCCTGGCTGGTCGGCGGGTGCCCCCCCATGTGCTGGTCAA
CTGGGCTGTGCAGATTGCCCGAGGGATGCACTACCTGCACTGTGAGGCTCTAGTGCCTGTGATA
CACCGAGACCTGAAGTCCAACAACATTCTGCTGCTGCAGCCCATTGAAGGTGACGACATGGAGC
ACAAGACCCTAAAGATTACTGACTTTGGCCTCGCCCGAGAGTGGCACAAAACCACACAGATGAG
TGCTGCGGGGACCTATGCGTGGATGGCTCCTGAGGTTATCAAGGCATCTACCTTCTCCAAGGGC
AGCGATGTCTGGAGCTTTGGGGTGCTGCTGTGGGAACTGCTGACTGGGGAGGTACCCTACCGTG
GTATCGACTGTCTTGCGGTAGCCTATGGTGTGGCTGTAAACAAGTTAACATTACCCATCCCATC
CACTTGCCCTGAGCCCTTCGCACAACTCATGGCTGACTGCTGGGCACAGGACCCCCACCGCAGG
CCCGACTTCGCCTCCATCCTGCAGCAGTTGGAAGCTCTAGAGGCTCAGGTGCTGAGGGAGATGC
CACGGGACTCCTTCCATTCCATGCAGGAGGGCTGGAAACGCGAGATCCAGGGCCTTTTTGATGA
GCTGCGGGCCAAGGAAAAGGAACTACTGAGCCGCGAGGAGGAACTGACGCGCGCAGCACGCGAG
CAGCGGTCCCAGGCAGAGCAGCTGCGACGGCGCGAGCACCTGCTGGCGCAGTGGGAGCTGGAGG
TGTTCGAGCGCGAGCTGACACTGCTGCTACAGCAGGTGGACCGAGAACGGCCACACGTGCGCCG
CCGACGCGGCACCTTCAAGCGGAGCAAGCTCCGAGCGAGGGATGGCGGAGAACGCATCAGCATG
CCCCTGGACTTCAAACATCGCATCACTGTGCAGGCCTCTCCAGGACTTGACCGGAGGAGAAATG
TGTTCGAGGTTGGGGCTGGGGACTCGCCCACCTTCCCTCGGTTCCGAGCTATCCAGTTGGAACC
TGCAGAATCAGGCCAGACTTGGGGTCGCCAGTCCCCTAGACGTCTTGACGATTCAAGCAATGGA
GAGAGGCGTGCTTGCTGGGCCTGGGGTCCCAGTTCCCCCAAGCCTGGGGAGGCCCAGAATGGGA
GGAGAAGGTCCCGCATGGATGAAGCCACGTGGTACCTAGATTCAGATGACTCATCCCCATTAGG
GTCTCCTTCTACTCCCCCAGCACTCAACGGTAATCCTCCAAGGCCTAGCCCTGAGCCAGAGGAG
CCACGGCGGTCTGGGCCCACAGAACGGGGCAATAGCTCTGGGACGCCTAAACTGATCCAACGTG
CATTGCTCCGGGGGACCGCTCTGCTGGCTTCCCTAGGCCTTGGCCGAGACCTGCAGCCTCCAGG
AGGCCTGAGCCGTGAACGTGGAGAGTCCCCGACAGCACCACCCCCTGCACAGATGGCTTCACCC
TGTCCACCTGACCTGCCCTCCACCCCGCTCATCCACCTCTCACAAGCAACACCTGATGCCCGTG
GACCACTCACCCCTGCACCCTTATTGCTGGACCTAGGTGTTTCCTCTGGCCAGCCATCAGCCAA
GAGCCCTCGGCGGGAAGAGACACGTGGAAGAACTGTTTCACCTCCACCAGGAATATCACGCTCT
GCTCCTGGCACCCCTGGAACCCCTCGCTCACCACCTTTGGGCCTCATCAGCCGACCTCGGCCAT
CACCACTCCGTAACCGTATTGACCCATGGAGCTTCGTGTCAGCTGGGCCACGGCCTTCACCCCT
GCCCTCTCCACAGCCTGCACCCCGACGGGCACCATGGACCTTATTCCCAGACTCAGATCCCTTC
TGGGACTCCCCACCTGCCAACCCCTTCCGGGGAGGCTCCCAGGACTGCAGGACGCAGACCAAAG
ATGTGGGTGCTCAGGCGCCATGGGCACCAGAAGCAGGGCCCTGAGTGGGCCAGACCATACCCCC
TGCGCTCCAGCTGCCTCAGAGGAGGCATAGCATACACTGGAAGAGGAGCCAGGAAGGCCTCTGT
GGCTGCCTTGGTTTCCCCCAGGGACCCTGACCCTTTGGCGGTCAGGAACACTACACTGCACAGA
AAGCCTTCACACTGGATGGGGGCTACACCCCACATGCCTACAAACTGTAGGTCCCCCTGATTTA
CCTGCCCCACTGGGGCCTGACACTGTACCTAGCTGGTTAGGAGGACCAGAGCCTGTCTCAGGGA
ATTGCCCCCCAAGGAGTGGTGCAGGGAGGGGGTCCAGGGGAAAGGGGCTGACCTCAGGTGTCAC
CAGCACTTTTGACCAAGTCCTGTTACTGTGGCCCCTGTCTCCAAGGCCTAGTTCCTGGACCCCC
TACCCTGGAGGTTATTGGAGCCGGGGCTCTCTGGGTGCCTTTCTACTGCCCCAGCCAAGGTTGG
AGCCTTGGCCTGGGGAGCCAATGAAGCCAAATAAACTTGTAAGCTGTCTCCCCAAAAAAAAAAA
AAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001013168	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81952	(Get FASTA)	NCBI Sequence Viewer
	AAO91627	(Get FASTA)	NCBI Sequence Viewer
	EDM12519	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028185.4
	ENSRNOP00000105161
GenBank Protein	Q66HA1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001013168 ⟸ NM_001013150

- UniProtKB:

Q80YF1 (UniProtKB/Swiss-Prot), Q66HA1 (UniProtKB/Swiss-Prot), A6HZ88 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEPLKNLFLKSPLGSWNGSGSGGGGGSGGVRPEGSPKATAAYANPVWTALFDYEPNGQDELALR
KGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLEEVIGIGG
FGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCL
VMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIEG
DDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGE
VPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEALEAQV
LREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQ
WELEVFERELTLLLQQVDRERPHVRRRRGTFKRSKLRARDGGERISMPLDFKHRITVQASPGLD
RRRNVFEVGAGDSPTFPRFRAIQLEPAESGQTWGRQSPRRLDDSSNGERRACWAWGPSSPKPGE
AQNGRRRSRMDEATWYLDSDDSSPLGSPSTPPALNGNPPRPSPEPEEPRRSGPTERGNSSGTPK
LIQRALLRGTALLASLGLGRDLQPPGGLSRERGESPTAPPPAQMASPCPPDLPSTPLIHLSQAT
PDARGPLTPAPLLLDLGVSSGQPSAKSPRREETRGRTVSPPPGISRSAPGTPGTPRSPPLGLIS
RPRPSPLRNRIDPWSFVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFRGGSQDCR
TQTKDVGAQAPWAPEAGP

hide sequence

Ensembl Acc Id:

ENSRNOP00000028185 ⟸ ENSRNOT00000028185

Protein Domains

Protein kinase SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q66HA1-F1-model_v2	AlphaFold	Q66HA1	1-850	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690667

Promoter ID:

EPDNEW_R1192

Type:

multiple initiation site

Name:

Map3k11_1

Description:

mitogen-activated protein kinase kinase kinase 11

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	221,043,093 - 221,043,153	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359261	AgrOrtholog
BioCyc Gene	G2FUF-56662	BioCyc
Ensembl Genes	ENSRNOG00000020773	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000028185.6	UniProtKB/Swiss-Prot
	ENSRNOT00000157493	ENTREZGENE
Gene3D-CATH	Phosphorylase Kinase, domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7122664	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MLK1-3_SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MLK1-4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser/Thr_Kinases-Pseudokinases	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:309168	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94039	IMAGE-MGC_LOAD
NCBI Gene	309168	ENTREZGENE
PANTHER	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	SH3_9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Map3k11	PhenoGen
PIRSF	MAPKKK9_11	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	SH3DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000020773	RatGTEx
SMART	S_TKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SH3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Protein kinase-like (PK-like)	UniProtKB/TrEMBL
	SH3-domain	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	SSF56112	UniProtKB/Swiss-Prot
UniProt	A6HZ88	ENTREZGENE, UniProtKB/TrEMBL
	M3K11_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q80YF1	ENTREZGENE
UniProt Secondary	Q80YF1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-29	Map3k11	mitogen-activated protein kinase kinase kinase 11			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Send us a Message

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)