Map3k11 (mitogen-activated protein kinase kinase kinase 11) - Rat Genome Database

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Gene: Map3k11 (mitogen-activated protein kinase kinase kinase 11) Mus musculus
Analyze
Symbol: Map3k11
Name: mitogen-activated protein kinase kinase kinase 11
RGD ID: 1557593
MGI Page MGI
Description: Predicted to enable several functions, including ATP binding activity; JUN kinase kinase kinase activity; and enzyme binding activity. Predicted to be involved in several processes, including JNK cascade; cell cycle G1/S phase transition; and positive regulation of MAPK cascade. Predicted to be located in microtubule. Predicted to be active in centrosome and cytoplasm. Is expressed in blood vessel; brain; and embryo. Orthologous to human MAP3K11 (mitogen-activated protein kinase kinase kinase 11).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610017K16Rik; mitogen activated protein kinase kinase kinase 11; mixed lineage kinase 3; Mlk; Mlk3; PTK1; SPRK
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,738,764 - 5,752,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,738,770 - 5,752,893 (+)EnsemblGRCm39 Ensembl
GRCm38195,688,411 - 5,702,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,688,742 - 5,702,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,689,131 - 5,702,865 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,689,131 - 5,702,865 (+)NCBIMGSCv36mm8
Celera195,559,170 - 5,572,916 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IBA,IEA,ISO)
cytoplasm  (IBA,IEA)
microtubule  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. MGD IEA MGD IEA
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region. Pan J, etal., Neuroscience. 2005;131(1):147-59.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family. Teramoto H, etal., J Biol Chem. 1996 Nov 1;271(44):27225-8.
14. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. Wang R, etal., J Neurochem. 2006 Dec;99(6):1543-54. Epub 2006 Oct 25.
Additional References at PubMed
PMID:8889548   PMID:9003777   PMID:9195998   PMID:9346925   PMID:10349636   PMID:10894943   PMID:11042159   PMID:11076861   PMID:11713255   PMID:12477932   PMID:12520002   PMID:12897243  
PMID:12944902   PMID:14504284   PMID:15489334   PMID:15767678   PMID:15782199   PMID:15831472   PMID:15878863   PMID:16141072   PMID:16141073   PMID:16142231   PMID:17377140   PMID:17679097  
PMID:17711861   PMID:18554416   PMID:18855897   PMID:19782705   PMID:19918265   PMID:20185156   PMID:20368287   PMID:20421299   PMID:20971179   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:21917142   PMID:21965325   PMID:21979919   PMID:22566623   PMID:22917630   PMID:23152823   PMID:23172226   PMID:23860122   PMID:23954791   PMID:23982205   PMID:24044867   PMID:24389043  
PMID:24790140   PMID:25204656   PMID:26138442   PMID:26406121   PMID:26947074   PMID:27504807   PMID:28262979   PMID:28930674   PMID:30362822   PMID:30840837   PMID:31654642   PMID:32209667  
PMID:32554809   PMID:32710001   PMID:34324442   PMID:35247112   PMID:35867711   PMID:36142785  


Genomics

Comparative Map Data
Map3k11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39195,738,764 - 5,752,893 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl195,738,770 - 5,752,893 (+)EnsemblGRCm39 Ensembl
GRCm38195,688,411 - 5,702,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl195,688,742 - 5,702,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,689,131 - 5,702,865 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,689,131 - 5,702,865 (+)NCBIMGSCv36mm8
Celera195,559,170 - 5,572,916 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map194.34NCBI
MAP3K11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381165,597,757 - 65,614,221 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1165,597,756 - 65,615,382 (-)EnsemblGRCh38hg38GRCh38
GRCh371165,365,228 - 65,381,692 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,121,802 - 65,138,296 (-)NCBINCBI36Build 36hg18NCBI36
Build 341165,121,801 - 65,138,296NCBI
Celera1162,691,942 - 62,708,437 (-)NCBICelera
Cytogenetic Map11q13.1NCBI
HuRef1161,692,198 - 61,708,691 (-)NCBIHuRef
CHM1_11165,249,129 - 65,265,648 (-)NCBICHM1_1
T2T-CHM13v2.01165,591,917 - 65,608,380 (-)NCBIT2T-CHM13v2.0
Map3k11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,404,685 - 212,417,986 (+)NCBIGRCr8
mRatBN7.21202,975,353 - 202,988,655 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1202,975,353 - 202,988,652 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,327,935 - 211,341,229 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01218,420,755 - 218,434,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,111,801 - 211,125,100 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01221,043,119 - 221,056,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1221,043,119 - 221,056,417 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01227,978,441 - 227,991,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41208,312,955 - 208,326,289 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11208,466,407 - 208,479,739 (+)NCBI
Celera1200,511,102 - 200,524,400 (+)NCBICelera
Cytogenetic Map1q43NCBI
Map3k11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542219,651,372 - 19,667,924 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542219,651,371 - 19,666,468 (+)NCBIChiLan1.0ChiLan1.0
MAP3K11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2966,827,487 - 66,844,363 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,870,243 - 67,888,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01160,956,880 - 60,973,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11164,291,099 - 64,308,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1164,291,635 - 64,307,737 (-)Ensemblpanpan1.1panPan2
MAP3K11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11851,593,641 - 51,609,245 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1851,594,274 - 51,608,696 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1850,201,432 - 50,217,631 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01852,630,200 - 52,646,397 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1852,631,100 - 52,646,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11851,730,092 - 51,746,289 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01851,304,151 - 51,320,331 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01852,094,525 - 52,110,726 (+)NCBIUU_Cfam_GSD_1.0
Map3k11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049477,405,272 - 7,420,546 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365993,848,334 - 3,863,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365993,847,637 - 3,862,895 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl26,640,056 - 6,657,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.126,640,061 - 6,657,717 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.225,910,163 - 5,914,495 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.118,625,431 - 8,639,049 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl18,625,961 - 8,638,924 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038105,919,807 - 105,938,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476720,779,898 - 20,796,015 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476720,780,356 - 20,796,015 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k11
321 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:225
Interacting mature miRNAs:276
Transcripts:ENSMUST00000004156
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142302Nstr1_mnerve sheath tumor resistance QTL 1 (mouse)Not determined19122371338Mouse
1301271Datd_mdopamine transporter density (mouse)Not determined19132340234Mouse
1300923Bits4_mbitterness sensitivity 4 (mouse)Not determined19332321637323348Mouse
11039522Tbbr4_mTrypanosoma brucei brucei response 4 (mouse)19531332639313470Mouse
25394536Skmw86_mskeletal muscle weight 86, TA (mouse)1950648178957825Mouse
4142161Drinksac2_mdrink saccharin 2 (mouse)Not determined120695286Mouse
1357819Tgct2_mtesticular germ cell tumor 2 (mouse)Not determined19332855120539663Mouse
4142406Pbctlp1_mperipheral blood cytotoxic T lymphocyte percentage 1 (mouse)Not determined132875174Mouse
1300776Lfp3_mlong free running period 3 (mouse)Not determined19120328703Mouse
1300904Chab5_mcholesterol absorption 5 (mouse)Not determined19165376435653927Mouse
26884385Skwq14_mskull length QTL 14, 16 week (mouse)19325000035877400Mouse
1301800Faq10_mfluctuating asymmetry QTL 10 (mouse)Not determined19332321637323348Mouse
1300591Pas3_mpulmonary adenoma susceptibility 3 (mouse)Not determined19332321637323348Mouse
1302126Skull26_mskull morphology 26 (mouse)Not determined19332321637323348Mouse

Markers in Region
AI502630  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38195,702,669 - 5,702,848UniSTSGRCm38
MGSCv37195,702,669 - 5,702,848UniSTSGRCm37
Celera195,572,720 - 5,572,899UniSTS
Cytogenetic Map19B2UniSTS
Cytogenetic Map19AUniSTS
cM Map190.5UniSTS
PMC114715P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38195,695,295 - 5,695,792UniSTSGRCm38
MGSCv37195,695,295 - 5,695,792UniSTSGRCm37
Celera195,565,345 - 5,565,842UniSTS
Cytogenetic Map19AUniSTS
cM Map190.5UniSTS
PMC87148P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38195,690,288 - 5,690,451UniSTSGRCm38
MGSCv37195,690,288 - 5,690,451UniSTSGRCm37
Celera195,560,336 - 5,560,499UniSTS
Cytogenetic Map19AUniSTS
cM Map190.5UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001418343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001418344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001418345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030250952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161599 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC134563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF155142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK011440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK200347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC047152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC095963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000004156   ⟹   ENSMUSP00000004156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,739,065 - 5,752,893 (+)Ensembl
GRCm38.p6 Ensembl195,689,037 - 5,702,865 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235661   ⟹   ENSMUSP00000158271
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,742,923 - 5,745,579 (+)Ensembl
GRCm38.p6 Ensembl195,692,895 - 5,695,551 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235727
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,738,770 - 5,740,032 (+)Ensembl
GRCm38.p6 Ensembl195,688,742 - 5,690,004 (+)Ensembl
Ensembl Acc Id: ENSMUST00000235891   ⟹   ENSMUSP00000158463
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,740,525 - 5,752,885 (+)Ensembl
GRCm38.p6 Ensembl195,690,497 - 5,702,857 (+)Ensembl
Ensembl Acc Id: ENSMUST00000237032
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl195,739,162 - 5,740,007 (+)Ensembl
GRCm38.p6 Ensembl195,689,134 - 5,689,979 (+)Ensembl
RefSeq Acc Id: NM_001418343   ⟹   NP_001405272
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,770 - 5,752,893 (+)NCBI
RefSeq Acc Id: NM_001418344   ⟹   NP_001405273
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,770 - 5,752,893 (+)NCBI
RefSeq Acc Id: NM_001418345   ⟹   NP_001405274
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,770 - 5,752,893 (+)NCBI
RefSeq Acc Id: NM_022012   ⟹   NP_071295
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,770 - 5,752,893 (+)NCBI
GRCm38195,689,131 - 5,702,865 (+)NCBI
MGSCv37195,689,131 - 5,702,865 (+)RGD
Celera195,559,170 - 5,572,916 (+)RGD
cM Map19 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030250951   ⟹   XP_030106811
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,764 - 5,752,893 (+)NCBI
GRCm38195,688,747 - 5,702,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030250952   ⟹   XP_030106812
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,738,768 - 5,752,893 (+)NCBI
GRCm38195,688,740 - 5,702,865 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161599   ⟹   XP_036017492
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,739,142 - 5,752,893 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004940149
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39195,739,149 - 5,752,885 (+)NCBI
Sequence:
RefSeq Acc Id: NP_071295   ⟸   NM_022012
- Peptide Label: isoform 1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030106812   ⟸   XM_030250952
- Peptide Label: isoform X1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_030106811   ⟸   XM_030250951
- Peptide Label: isoform X1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSMUSP00000158271   ⟸   ENSMUST00000235661
Ensembl Acc Id: ENSMUSP00000158463   ⟸   ENSMUST00000235891
Ensembl Acc Id: ENSMUSP00000004156   ⟸   ENSMUST00000004156
RefSeq Acc Id: XP_036017492   ⟸   XM_036161599
- Peptide Label: isoform X1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001405272   ⟸   NM_001418343
- Peptide Label: isoform 1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001405274   ⟸   NM_001418345
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001405273   ⟸   NM_001418344
- Peptide Label: isoform 1
- UniProtKB: Q8K0M8 (UniProtKB/Swiss-Prot),   Q80XI6 (UniProtKB/Swiss-Prot),   Q9JJ15 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80XI6-F1-model_v2 AlphaFold Q80XI6 1-850 view protein structure

Promoters
RGD ID:6830282
Promoter ID:MM_KWN:26107
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Transcripts:NM_022012,   NM_144868,   OTTMUST00000083264,   OTTMUST00000083265,   OTTMUST00000083266
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,688,531 - 5,689,107 (-)MPROMDB
RGD ID:6830181
Promoter ID:MM_KWN:26108
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000004156
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,689,356 - 5,690,717 (+)MPROMDB
RGD ID:13678568
Promoter ID:EPDNEW_M23433
Type:multiple initiation site
Name:Map3k11_1
Description:Mus musculus mitogen-activated protein kinase kinase kinase 11, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38195,689,785 - 5,689,845EPDNEW
RGD ID:6847567
Promoter ID:MM_ACW:25864
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:MAP3K11.ESEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36195,692,091 - 5,693,067 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1346880 AgrOrtholog
Ensembl Genes ENSMUSG00000004054 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000004156 ENTREZGENE
  ENSMUST00000004156.10 UniProtKB/Swiss-Prot
  ENSMUST00000235661.2 UniProtKB/TrEMBL
  ENSMUST00000235891.2 UniProtKB/TrEMBL
Gene3D-CATH SH3 Domains UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MLK1-3_SH3 UniProtKB/Swiss-Prot
  MLK1-4 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser_Thr_protein_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
KEGG Report mmu:26403 UniProtKB/Swiss-Prot
MGD MGI:1346880 ENTREZGENE
NCBI Gene 26403 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE-THREONINE PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Map3k11 PhenoGen
PIRSF MAPKKK9_11 UniProtKB/Swiss-Prot
PRINTS SH3DOMAIN UniProtKB/Swiss-Prot
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A494BAX3_MOUSE UniProtKB/TrEMBL
  A0A494BBI0_MOUSE UniProtKB/TrEMBL
  M3K11_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K0M8 ENTREZGENE
  Q9JJ15 ENTREZGENE
UniProt Secondary Q8K0M8 UniProtKB/Swiss-Prot
  Q9JJ15 UniProtKB/Swiss-Prot