Polr2b (RNA polymerase II subunit B)

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Gene: Polr2b (RNA polymerase II subunit B) Rattus norvegicus

Analyze

Symbol:

Polr2b

Name:

RNA polymerase II subunit B

RGD ID:

1309477

Description:

Predicted to enable chromatin binding activity. Predicted to contribute to RNA polymerase II activity. Predicted to be involved in transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human POLR2B (RNA polymerase II subunit B); PARTICIPATES IN RNA polymerase II transcription pathway; Huntington's disease pathway; purine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

DNA directed RNA polymerase II polypeptide B; DNA-directed RNA polymerase II subunit RPB2; LOC289561; polymerase (RNA) II (DNA directed) polypeptide B; polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; polymerase (RNA) II subunit B; RpB2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POLR2B (RNA polymerase II subunit B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Polr2b (polymerase (RNA) II (DNA directed) polypeptide B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Polr2b (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POLR2B (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POLR2B (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Polr2b (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POLR2B (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POLR2B (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Polr2b (RNA polymerase II subunit B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POLR2B (RNA polymerase II subunit B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Polr2b (polymerase (RNA) II (DNA directed) polypeptide B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	polr2b (polymerase (RNA) II (DNA directed) polypeptide B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpb-2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPB2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpII140	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	polr2b	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	30,797,228 - 30,834,916 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	30,797,228 - 30,834,916 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	31,178,151 - 31,215,766 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,486,476 - 32,524,093 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	30,971,132 - 31,008,749 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	33,070,104 - 33,107,792 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,070,078 - 33,107,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	32,863,627 - 32,901,277 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	33,069,966 - 33,107,615 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	33,069,967 - 33,107,600 (-)	NCBI
Celera	14	30,116,602 - 30,154,129 (-)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Tracheoesophageal Fistula (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,6-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

afimoxifene (ISO)

aristolochic acid A (ISO)

atrazine (ISO)

benzene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP)

buspirone (EXP)

crocidolite asbestos (ISO)

decabromodiphenyl ether (ISO)

dicrotophos (ISO)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

geldanamycin (ISO)

gentamycin (EXP)

ivermectin (ISO)

leflunomide (ISO)

N-methyl-4-phenylpyridinium (ISO)

nickel atom (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

raloxifene (ISO)

resveratrol (ISO)

testosterone (ISO)

topotecan (EXP)

trichloroethene (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

transcription by RNA polymerase II (ISO)

Cellular Component

chromosome, telomeric region (ISO)

nucleoplasm (ISO)

nucleus (ISO)

RNA polymerase II, core complex (IBA,ISO)

Molecular Function

chromatin binding (ISO)

DNA binding (IEA)

metal ion binding (IEA)

protein binding (ISO)

ribonucleoside binding (IEA)

RNA polymerase II activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

Huntington's disease pathway (IEA)

purine metabolic pathway (IEA)

pyrimidine metabolic pathway (IEA)

RNA polymerase II transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	TFIIB-related factors in RNA polymerase I transcription.	Knutson BA and Hahn S, Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):265-73. doi: 10.1016/j.bbagrm.2012.08.003. Epub 2012 Aug 30.
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:9268387	PMID:9852112	PMID:19946888	PMID:22287103	PMID:22658674	PMID:22681889	PMID:24270157	PMID:25568312

Genomics

Comparative Map Data

Polr2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	14	30,797,228 - 30,834,916 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	30,797,228 - 30,834,916 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	31,178,151 - 31,215,766 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	14	32,486,476 - 32,524,093 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	14	30,971,132 - 31,008,749 (-)	NCBI	Rnor_WKY
Rnor_6.0	14	33,070,104 - 33,107,792 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	33,070,078 - 33,107,776 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	32,863,627 - 32,901,277 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	33,069,966 - 33,107,615 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	33,069,967 - 33,107,600 (-)	NCBI
Celera	14	30,116,602 - 30,154,129 (-)	NCBI		Celera
Cytogenetic Map	14	p11	NCBI

POLR2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	56,978,896 - 57,031,158 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	56,977,722 - 57,031,158 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	57,845,062 - 57,897,324 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	57,539,866 - 57,592,091 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	57,686,036 - 57,738,262	NCBI
Celera	4	55,351,060 - 55,402,358 (+)	NCBI		Celera
Cytogenetic Map	4	q12	NCBI
HuRef	4	53,798,541 - 53,850,908 (+)	NCBI		HuRef
CHM1_1	4	57,880,501 - 57,933,190 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	60,470,344 - 60,522,595 (+)	NCBI		T2T-CHM13v2.0

Polr2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	77,458,331 - 77,497,175 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	77,457,994 - 77,497,171 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	77,310,484 - 77,349,328 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	77,310,147 - 77,349,324 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	77,739,509 - 77,778,353 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	78,385,273 - 78,424,099 (+)	NCBI		MGSCv36	mm8
Celera	5	74,577,709 - 74,617,045 (+)	NCBI		Celera
Cytogenetic Map	5	C3.3	NCBI

Polr2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955447	14,110,182 - 14,150,556 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955447	14,110,182 - 14,150,556 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	4	72,949,670 - 73,003,185 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	66,888,215 - 66,940,702 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	73,462,000 - 73,514,985 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	73,462,000 - 73,514,985 (-)	Ensembl	panpan1.1		panPan2

POLR2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	49,091,458 - 49,138,413 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	49,090,863 - 49,138,487 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	48,982,054 - 49,028,661 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	49,705,912 - 49,752,974 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	49,705,467 - 49,752,975 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	49,378,679 - 49,425,490 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	48,907,935 - 48,954,761 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	49,852,758 - 49,900,240 (+)	NCBI		UU_Cfam_GSD_1.0

Polr2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	27,179,024 - 27,225,143 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936482	19,073,124 - 19,119,421 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936482	19,073,125 - 19,119,424 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	56,231,789 - 56,285,011 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	56,232,730 - 56,283,367 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	59,014,262 - 59,064,755 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	11,694,446 - 11,736,215 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	11,694,619 - 11,736,611 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666066	12,273,518 - 12,305,507 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	12,387,553 - 12,430,871 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	12,387,553 - 12,430,211 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Polr2b
154 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	13
Count of miRNA genes:	10
Interacting mature miRNAs:	13
Transcripts:	ENSRNOT00000039252
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	17593761	42336881	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17622561	42337007	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18631345	42337007	Rat
10755459	Coatc15	Coat color QTL 15		0.01681	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	14	19836944	64836944	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30320092	80829842	Rat
2324617	Coatc2	Coat color QTL 2		0.001	coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	14	30767025	39153750	Rat

Markers in Region

RH139215

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	30,802,323 - 30,803,044 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	33,075,200 - 33,075,920	NCBI	Rnor6.0
Rnor_5.0	14	32,868,685 - 32,869,405	UniSTS	Rnor5.0
RGSC_v3.4	14	33,075,023 - 33,075,743	UniSTS	RGSC3.4
Celera	14	30,121,639 - 30,122,359	UniSTS
RH 3.4 Map	14	397.4	UniSTS
Cytogenetic Map	14	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC103462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EF536011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000039252 ⟹ ENSRNOP00000030781

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	30,797,228 - 30,834,916 (-)	Ensembl
Rnor_6.0 Ensembl	14	33,070,078 - 33,107,776 (-)	Ensembl

RefSeq Acc Id:

NM_001106002 ⟹ NP_001099472

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	14	30,797,228 - 30,834,916 (-)	NCBI
Rnor_6.0	14	33,070,104 - 33,107,792 (-)	NCBI
Rnor_5.0	14	32,863,627 - 32,901,277 (-)	NCBI
RGSC_v3.4	14	33,069,966 - 33,107,615 (-)	RGD
Celera	14	30,116,602 - 30,154,129 (-)	RGD

Sequence:

show sequence

GCTTTGACGCCGAGGATTCTGGGAACGCCGGAGACGGAAATTACTTCGTCTGGCGCTCAGAGTT
TGCTGCAGCGCTTTTCAACTCTAGTTTTGTGATTTCGAGTTAAGAGCTCCAGAAACCTTTGGCC
AAGATGTATGACGCCGACGAGGATATGCAATATGATGAAGATGATGATGAAATCACTCCAGATT
TGTGGCAGGAAGCATGCTGGATCGTGATCAGTTCTTATTTTGATGAAAAAGGCTTGGTCAGACA
GCAGCTGGATTCCTTTGACGAGTTTATTCAGATGTCTGTTCAAAGAATTGTGGAAGATGCACCA
CCGATTGACCTGCAGGCTGAAGCCCAGCACGCTAGTGGGGAGGTTGAAGAGCCGCCAAGATATT
TACTGAAGTTTGAACAAATTTACCTCTCCAAACCTACTCATTGGGAAAGAGATGGTGCCCCTTC
ACCAATGATGCCAAATGAAGCCAGGTTAAGAAATCTCACGTACTCCGCCCCGCTTTACGTGGAC
ATAACGAAGACGGTCATTAAAGAGGGTGAAGAGCAGCTGCAGACTCAGCACCAGAAAACCTTCA
TCGGGAAAATCCCCATTATGCTGCGCTCCACGTATTGCTTGTTGAATGGCTTAACAGACCGTGA
CTTGTGTGAGCTGAATGAGTGTCCTTTGGATCCTGGTGGCTATTTTATTATTAATGGATCAGAA
AAGGTTCTGATAGCTCAAGAGAAAATGGCAACAAACACAGTCTATGTGTTTGCCAAAAAGGATT
CCAAGTATGCCTATACAGGAGAATGCCGCTCATGCCTAGAGAATTCTTCCCGACCCACCAGTAC
TATATGGGTTAGCATGCTGGCCAGAGGAGGACAGGGTGCAAAGAAGAGTGCAATTGGCCAGCGC
ATCGTGGCGACATTACCATATATCAAGCAAGAAGTTCCCATCATAATTGTGTTCAGAGCATTAG
GCTTTGTGTCTGATAGAGATATTTTAGAGCACATCATTTATGACTTCGAAGACCCAGAGATGAT
GGAAATGGTTAAACCATCTCTCGATGAAGCATTTGTCATCCAAGAGCAGAATGTTGCCTTAAAC
TTCATTGGTTCAAGAGGGGCGAAGCCTGGTGTTACTAAGGAGAAAAGAATTAAATATGCAAAAG
AAGTCTTACAGAAAGAGATGCTTCCGCATGTCGGTGTCAGTGATTTCTGTGAGACCAAAAAGGC
CTATTTCTTGGGGTACATGGTTCATAGGTTACTTCTAGCAGCCTTGGGTAGAAGAGAACTAGAT
GACAGAGATCACTATGGCAACAAGAGATTGGATCTTGCTGGGCCTCTGCTTGCGTTCTTATTTA
GAGGCATGTTTAAGAATTTGCTGAAAGAAGTACGGATCTATGCACAGAAGTTTATTGACCGCGG
AAAGGACTTTAACCTAGAGTTGGCAATTAAGACAAGGATCATATCCGATGGGCTAAAATACTCT
TTAGCCACTGGGAACTGGGGTGACCAGAAGAAAGCTCACCAAGCCAGAGCTGGAGTGTCGCAGG
TACTGAACCGCCTGACTTTTGCGTCTACTCTTTCTCACCTGCGTCGTTTAAACTCTCCTATTGG
CAGAGATGGCAAGCTAGCAAAGCCGAGACAGTTGCATAATACATTGTGGGGGATGGTGTGTCCT
GCTGAAACTCCAGAGGGCCATGCTGTAGGACTTGTGAAGAATTTAGCCCTGATGGCTTATATTT
CAGTTGGATCTCAACCTTCTCCAATTTTGGAATTTTTGGAAGAATGGAGCATGGAAAACTTAGA
GGAAATTTCCCCTGCAGCTATTGCCGATGCAACCAAGATTTTTGTTAATGGCTGCTGGGTTGGA
ATCCATAAAGACCCGGAACAACTCATGAACACACTCAGGAAATTACGGCGTCAGATGGACATCA
TTGTATCCGAAGTTTCTATGATCAGAGATATCCGCGAGCGTGAGATTCGGATCTATACAGACGC
AGGCCGTATTTGTAGACCACTTCTAATTGTGGAAAAGCAAAAGCTTCTTTTGAAGAAGAGACAC
ATTGACCAGTTGAAAGAGAGAGAATATAACAACTACAGTTGGCAGGATCTGGTAGCCAGTGGGG
TAGTAGAGTATATTGATACCCTGGAAGAAGAAACCGTGATGCTTGCAATGACTCCAGATGATTT
GCAGGAGAAAGAAGTAGCTTATTGCTCCACCTATACCCACTGTGAGATTCACCCATCAATGATT
CTTGGCGTCTGTGCATCTATTATTCCTTTTCCTGATCATAACCAGTCCCCTAGAAACACGTACC
AGTCTGCTATGGGCAAGCAGGCTATGGGAGTTTATATCACCAACTTCCACGTTCGGATGGACAC
CTTGGCGCACGTTCTCTACTATCCTCAGAAGCCCCTTGTGACTACACGGTCTATGGAGTATCTC
CGGTTTAGAGAACTGCCAGCAGGAATCAACTCAATTGTGGCCATTGCATCATACACGGGCTATA
ATCAAGAAGACTCTGTTATCATGAATCGTTCAGCTGTGGATCGAGGCTTTTTCAGGTCTGTTTT
CTACCGATCATACAAAGAACAAGAGTCTAAAAAAGGATTTGATCAAGAAGAAGTGTTCGAGAAG
CCTACACGTGAAACATGTCAGGGCATGAGGCATGCCATTTATGACAAGTTGGACGATGATGGCT
TGATAGCGCCAGGGGTCCGAGTGTCGGGAGACGATGTTATTATAGGCAAAACGGTCACCCTCCC
TGAGAACGAGGATGAGCTGGAGAGCACCAACAGGCGCTACACCAAGAGGGACTGCAGCACCTTC
CTCAGAACCAGTGAGACAGGCATTGTGGACCAGGTCATGGTCACTCTCAACCAGGAAGGATATA
AATTTTGTAAAATAAGGGTACGCTCTGTTAGAATTCCGCAGATCGGAGACAAATTTGCTAGCCG
ACATGGTCAGAAGGGTACTTGTGGTATTCAGTATAGACAAGAGGACATGCCGTTCACTTGTGAA
GGCATAACTCCTGACATCATCATAAACCCCCACGCCATCCCCTCTCGGATGACGATTGGTCACT
TGATTGAATGTCTCCAAGGGAAGGTCTCTGCGAACAAGGGTGAAATTGGTGATGCTACTCCGTT
TAATGATGCTGTCAATGTGCAGAAGATTTCTAATCTTTTATCTGACTACGGCTACCATCTCAGA
GGAAATGAGGTGCTCTACAATGGATTCACTGGTCGCAAAATCACATCGCAGATTTTTATTGGCC
CCACTTACTACCAGCGTTTGAAGCATATGGTGGATGACAAAATTCATTCTCGTGCTCGGGGGCC
CATTCAGATTCTTAACAGACAGCCCATGGAGGGCAGATCGCGTGATGGTGGCCTGCGCTTTGGA
GAAATGGAGCGAGACTGTCAGATCGCACATGGTGCAGCACAGTTCTTAAGAGAAAGGCTGTTTG
AAGCATCAGATCCGTATCAGGTTCACGTTTGTAATCTTTGTGGAATAATGGCAATTGCTAACAC
CAGGACTCACACATACGAATGCAGGGGATGCCGCAATAAGACCCAGATCTCCTTGGTGCGAATG
CCGTATGCGTGCAAGCTGTTGTTCCAGGAGCTCATGTCCATGAGCATCGCACCACGGATGATGA
GTGTTTAGTGGTCAGAAGTTCATGGTCCGATACTGTGAGCAGCAGTATCTTGTTTCGGTGACTG
TCGTTTTTAAAAAAAAAAATGACAAAATTTCCTGTTGTAATAAGAATTTTATTTGTTTTGTTTA
AAGCTCTGCATGCTTTTTCTGTAAATAAACAATAAACTTTTGTAGATAGTCTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099472	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABX80211	(Get FASTA)	NCBI Sequence Viewer
	EDL89872	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001099472 ⟸ NM_001106002

- UniProtKB:

G3V8Y5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPP
IDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDI
TKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEK
VLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRI
VATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNF
IGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDD
RDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSL
ATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPA
ETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGI
HKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHI
DQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMIL
GVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLR
FRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKP
TRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFL
RTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRG
NEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGE
MERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMP
YACKLLFQELMSMSIAPRMMSV

hide sequence

RefSeq Acc Id:

ENSRNOP00000030781 ⟸ ENSRNOT00000039252

Protein Domains

DNA-directed RNA polymerase subunit 2 hybrid- RNA polymerase beta subunit protrusion RNA polymerase Rpb2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V8Y5-F1-model_v2	AlphaFold	G3V8Y5	1-1174	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699266

Promoter ID:

EPDNEW_R9790

Type:

multiple initiation site

Name:

Polr2b_1

Description:

RNA polymerase II subunit B

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	33,107,750 - 33,107,810	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309477	AgrOrtholog
BioCyc Gene	G2FUF-15992	BioCyc
Ensembl Genes	ENSRNOG00000024779	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000030781	ENTREZGENE
	ENSRNOP00000030781.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000039252	ENTREZGENE
	ENSRNOT00000039252.6	UniProtKB/TrEMBL
Gene3D-CATH	2.40.270.10	UniProtKB/TrEMBL
	2.40.50.150	UniProtKB/TrEMBL
	3.90.1070.20	UniProtKB/TrEMBL
	3.90.1100.10	UniProtKB/TrEMBL
	3.90.1110.10	UniProtKB/TrEMBL
	RNA polymerase alpha subunit dimerisation domain	UniProtKB/TrEMBL
InterPro	DNA-dir_RNA_pol_su2	UniProtKB/TrEMBL
	DNA-dir_RNA_pol_su2_6	UniProtKB/TrEMBL
	DNA-dir_RNAP_su2_hyb_sf	UniProtKB/TrEMBL
	RNA_pol_bsu_CS	UniProtKB/TrEMBL
	RNA_pol_bsu_protrusion	UniProtKB/TrEMBL
	RNA_pol_Rpb2_2	UniProtKB/TrEMBL
	RNA_pol_Rpb2_2_sf	UniProtKB/TrEMBL
	RNA_pol_Rpb2_3	UniProtKB/TrEMBL
	RNA_pol_Rpb2_4	UniProtKB/TrEMBL
	RNA_pol_Rpb2_5	UniProtKB/TrEMBL
	RNA_pol_Rpb2_7	UniProtKB/TrEMBL
	RNA_pol_RPB2_OB-fold	UniProtKB/TrEMBL
KEGG Report	rno:289561	UniProtKB/TrEMBL
NCBI Gene	289561	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2	UniProtKB/TrEMBL
	RNA_pol_I_sub2	UniProtKB/TrEMBL
Pfam	RNA_pol_Rpb2_1	UniProtKB/TrEMBL
	RNA_pol_Rpb2_2	UniProtKB/TrEMBL
	RNA_pol_Rpb2_3	UniProtKB/TrEMBL
	RNA_pol_Rpb2_4	UniProtKB/TrEMBL
	RNA_pol_Rpb2_5	UniProtKB/TrEMBL
	RNA_pol_Rpb2_6	UniProtKB/TrEMBL
	RNA_pol_Rpb2_7	UniProtKB/TrEMBL
PhenoGen	Polr2b	PhenoGen
PROSITE	RNA_POL_BETA	UniProtKB/TrEMBL
Superfamily-SCOP	beta and beta-prime subunits of DNA dependent RNA-polymerase	UniProtKB/TrEMBL
UniProt	G3V8Y5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-07-21	Polr2b	RNA polymerase II subunit B	Polr2b	polymerase (RNA) II subunit B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-03-16	Polr2b	polymerase (RNA) II subunit B	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Polr2b	polymerase (RNA) II (DNA directed) polypeptide B	Polr2b_predicted	polymerase (RNA) II (DNA directed) polypeptide B (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Polr2b_predicted	polymerase (RNA) II (DNA directed) polypeptide B (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)