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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:stattic
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Accession:CHEBI:86989 term browser browse the term
Definition:A member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma.
Synonyms:exact_synonym: 6-nitro-1H-1-benzothiophene-1,1-dione
 related_synonym: 6-nitro-1-benzothiophene 1,1-dioxide;   CHEMBL1337170;   Formula=C8H5NO4S;   InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H;   InChIKey=ZRRGOUHITGRLBA-UHFFFAOYSA-N;   SMILES=[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1;   STAT3 Inhibitor V
 xref_mesh: MESH:C517409
 xref: PMID:17114005;   PMID:25425624;   PMID:25492480;   Reaxys:11410


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stattic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of AKT1 protein] CTD PMID:23255093 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO stattic results in decreased expression of BCL2 protein CTD PMID:24627483, PMID:25611565 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BCL2L1 mRNA] CTD PMID:19153190 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO stattic inhibits the reaction [glycine-extended gastrin 17 results in increased expression of BIRC5 mRNA] CTD PMID:19153190 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN2 mRNA]
CTD PMID:25740948 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein] CTD PMID:30670587 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cish cytokine inducible SH2-containing protein multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA] CTD PMID:26297436 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of COL1A1 mRNA]
CTD PMID:25740948 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of CCND1 protein]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Egf epidermal growth factor multiple interactions ISO stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein] CTD PMID:24627483 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions ISO stattic inhibits the reaction [Arsenicals results in increased phosphorylation of EZH2 protein] CTD PMID:23255093 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO stattic inhibits the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of GPT protein] CTD PMID:28887131 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein] CTD PMID:29341321 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO stattic inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein] CTD PMID:29329563 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il12a interleukin 12A multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA] CTD PMID:26297436 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of IL1B mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] CTD PMID:22454431 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of APPA mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CCN2 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of CISH mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of COL1A1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of HIF1A protein]; stattic inhibits the reaction [IL6 protein results in increased expression of IL12A mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1A mRNA]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [27-hydroxycholesterol results in increased secretion of IL6 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]
CTD PMID:22454431, PMID:25740948, PMID:26297436, PMID:28739487, PMID:29341321 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of JAK2 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of JAK2 mRNA] CTD PMID:22454431 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of MAPK9 protein] CTD PMID:24434654 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mir21 microRNA 21 affects expression
multiple interactions
ISO stattic affects the expression of MIR21 mRNA
stattic affects the reaction [arsenic trichloride affects the expression of MIR21 mRNA]
CTD PMID:24434654 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO stattic results in decreased expression of MMP10 mRNA CTD PMID:22285823 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:25740948 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 decreases expression ISO stattic results in decreased expression of PSMB1 mRNA; stattic results in decreased expression of PSMB1 protein CTD PMID:24627483 NCBI chr 1:57,470,878...57,491,359
Ensembl chr 1:57,470,632...57,489,727
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO stattic results in decreased expression of PSMB2 mRNA; stattic results in decreased expression of PSMB2 protein CTD PMID:24627483 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 decreases expression ISO stattic results in decreased expression of PSMB3 mRNA; stattic results in decreased expression of PSMB3 protein CTD PMID:24627483 NCBI chr10:85,646,646...85,653,729
Ensembl chr10:85,646,633...85,653,729
JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression ISO stattic results in decreased expression of PSMB4 mRNA; stattic results in decreased expression of PSMB4 protein CTD PMID:24627483 NCBI chr 2:196,043,546...196,046,320
Ensembl chr 2:196,043,618...196,046,311
JBrowse link
G Psmb5 proteasome 20S subunit beta 5 decreases expression
multiple interactions
ISO stattic results in decreased expression of PSMB5 mRNA; stattic results in decreased expression of PSMB5 protein
stattic inhibits the reaction [EGF protein results in increased expression of PSMB5 protein]
CTD PMID:24627483 NCBI chr15:33,259,039...33,263,634
Ensembl chr15:33,259,043...33,263,659
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 decreases expression ISO stattic results in decreased expression of PSMB6 mRNA; stattic results in decreased expression of PSMB6 protein CTD PMID:24627483 NCBI chr10:57,131,339...57,133,685
Ensembl chr10:57,131,386...57,133,637
JBrowse link
G Psmb7 proteasome 20S subunit beta 7 decreases expression ISO stattic results in decreased expression of PSMB7 mRNA; stattic results in decreased expression of PSMB7 protein CTD PMID:24627483 NCBI chr 3:22,890,072...22,951,718
Ensembl chr 3:22,871,105...22,952,063
JBrowse link
G Riox2 ribosomal oxygenase 2 multiple interactions ISO stattic inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]; stattic inhibits the reaction [arsenic trichloride results in increased phosphorylation of RIOX2 protein] CTD PMID:24434654 NCBI chr11:43,006,190...43,028,722
Ensembl chr11:43,006,757...43,022,565
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions EXP stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 mRNA]; stattic inhibits the reaction [EDN1 protein results in increased expression of SKP2 protein] CTD PMID:30670587 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO [stattic co-treated with IL6 protein] results in increased expression of SOCS3 protein CTD PMID:25740948 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT1 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT1 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT1 protein] CTD PMID:22454431 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO
EXP
stattic affects the reaction [Arsenicals affects the phosphorylation of STAT3 protein]; stattic affects the reaction [IL6 protein affects the phosphorylation of STAT3 protein]; stattic inhibits the reaction [EGF protein results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [zoniporide results in increased phosphorylation of STAT3 protein]
stattic inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [deoxynivalenol results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [deoxynivalenol results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [T-2 Toxin results in increased expression of STAT3 mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased phosphorylation of STAT3 protein]; stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]
stattic results in decreased phosphorylation of STAT3 protein
CTD PMID:20942815, PMID:22454431, PMID:23255093, PMID:24627483, PMID:25740948, PMID:28739487, PMID:29341321 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO stattic inhibits the reaction [IL6 protein results in increased activity of TGFB1 protein]; stattic inhibits the reaction [IL6 protein results in increased expression of TGFB1 mRNA]
stattic inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TGFB1 mRNA]
CTD PMID:25740948 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO stattic inhibits the reaction [deoxynivalenol results in increased expression of TNF mRNA]; stattic inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA] CTD PMID:22454431 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        inhibitor 18223
          STAT3 inhibitor 36
            stattic 36
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzothiophenes 902
                                        1-benzothiophenes 902
                                          stattic 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.