Homer2 (homer scaffold protein 2) - Rat Genome Database

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Gene: Homer2 (homer scaffold protein 2) Rattus norvegicus
Analyze
Symbol: Homer2
Name: homer scaffold protein 2
RGD ID: 620705
Description: Enables G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of interleukin-2 production. Predicted to act upstream of or within behavioral response to cocaine; calcium-mediated signaling using intracellular calcium source; and regulation of G protein-coupled receptor signaling pathway. Located in dendrite; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cupidin; homer homolog 2; homer homolog 2 (Drosophila); homer protein homolog 2; homer scaffolding protein 2; homer, neuronal immediate early gene, 2; homer-2; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21135,558,977 - 135,659,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,488,882 - 143,581,178 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01150,658,320 - 150,750,396 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01143,564,822 - 143,658,186 (-)NCBIRnor_WKY
Rnor_6.01143,443,300 - 143,535,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,387,025 - 144,478,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,827,128 - 137,933,089 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,905,533 - 138,012,215 (-)NCBI
Celera1127,618,673 - 127,711,006 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
3. A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. Ishibashi T, etal., J Biochem. 2005 May;137(5):617-23.
4. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Jung KM, etal., Mol Pharmacol. 2007 Sep;72(3):612-21. doi: 10.1124/mol.107.037796. Epub 2007 Jun 21.
5. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. Kato A, etal., J Biol Chem 1998 Sep 11;273(37):23969-75.
6. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Mao L, etal., J Neurosci. 2005 Mar 9;25(10):2741-52.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9808458   PMID:9808459   PMID:10493740   PMID:12860966   PMID:14528310   PMID:15294147   PMID:18218901   PMID:19709672   PMID:23076792   PMID:24530450   PMID:25816005   PMID:26254965  


Genomics

Comparative Map Data
Homer2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21135,558,977 - 135,659,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,488,882 - 143,581,178 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01150,658,320 - 150,750,396 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01143,564,822 - 143,658,186 (-)NCBIRnor_WKY
Rnor_6.01143,443,300 - 143,535,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,387,025 - 144,478,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,827,128 - 137,933,089 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,905,533 - 138,012,215 (-)NCBI
Celera1127,618,673 - 127,711,006 (-)NCBICelera
Cytogenetic Map1q31NCBI
HOMER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381582,834,661 - 82,986,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1582,836,946 - 82,986,153 (-)EnsemblGRCh38hg38GRCh38
GRCh371583,517,735 - 83,621,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361581,314,789 - 81,412,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 341581,314,788 - 81,412,477NCBI
Celera1560,965,171 - 61,062,906 (+)NCBICelera
Cytogenetic Map15q25.2NCBI
HuRef1559,787,302 - 59,884,988 (-)NCBIHuRef
CHM1_11583,259,957 - 83,363,087 (-)NCBICHM1_1
T2T-CHM13v2.01580,713,263 - 80,817,090 (-)NCBIT2T-CHM13v2.0
Homer2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39781,250,229 - 81,356,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl781,250,229 - 81,357,275 (-)EnsemblGRCm39 Ensembl
GRCm38781,600,481 - 81,706,925 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,600,481 - 81,707,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37788,745,367 - 88,851,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36781,483,228 - 81,580,639 (-)NCBIMGSCv36mm8
Celera779,009,788 - 79,104,812 (-)NCBICelera
Cytogenetic Map7D3NCBI
Homer2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541613,741,161 - 13,818,060 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541613,671,115 - 13,828,413 (+)NCBIChiLan1.0ChiLan1.0
HOMER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11580,731,863 - 80,876,442 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1580,737,570 - 80,784,729 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01562,617,905 - 62,762,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Homer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640128,699,719 - 128,836,080 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648317,507,533 - 17,539,105 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648317,500,962 - 17,634,804 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOMER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,001,579 - 52,096,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,001,253 - 52,104,426 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,489,011 - 57,584,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HOMER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1292,667,718 - 2,810,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl292,706,134 - 2,803,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605944,281,540 - 44,425,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Homer2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476818,635,283 - 18,721,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476818,626,353 - 18,751,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Homer2
621 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:309
Count of miRNA genes:186
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000026158
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat

Markers in Region
D1Mco51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,589,540 - 135,589,751 (+)MAPPERmRatBN7.2
Rnor_6.01143,465,134 - 143,465,344NCBIRnor6.0
Rnor_5.01144,408,859 - 144,409,069UniSTSRnor5.0
RGSC_v3.41137,848,962 - 137,849,172UniSTSRGSC3.4
Celera1127,640,507 - 127,640,717UniSTS
Cytogenetic Map1q31UniSTS
RH140724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,563,325 - 135,563,498 (+)MAPPERmRatBN7.2
Rnor_6.01143,438,923 - 143,439,095NCBIRnor6.0
Rnor_5.01144,382,648 - 144,382,820UniSTSRnor5.0
RGSC_v3.41137,875,004 - 137,875,176UniSTSRGSC3.4
RGSC_v3.41137,822,751 - 137,822,923UniSTSRGSC3.4
Celera1127,614,308 - 127,614,480UniSTS
RH 3.4 Map11087.3UniSTS
Cytogenetic Map1q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 35 11 10 1 10 7 8 63 29 27 7
Low 2 8 46 31 18 31 1 3 11 6 14 11 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087785   ⟹   ENSRNOP00000070858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)Ensembl
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094383   ⟹   ENSRNOP00000088957
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,567,414 - 135,601,000 (-)Ensembl
RefSeq Acc Id: NM_053309   ⟹   NP_445761
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21135,567,414 - 135,659,772 (-)NCBI
Rnor_6.01143,443,300 - 143,535,579 (-)NCBI
Rnor_5.01144,387,025 - 144,478,034 (-)NCBI
RGSC_v3.41137,827,128 - 137,933,089 (-)RGD
Celera1127,618,673 - 127,711,006 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109538   ⟹   XP_038965466
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21135,558,977 - 135,659,772 (-)NCBI
RefSeq Acc Id: XM_039109542   ⟹   XP_038965470
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21135,558,977 - 135,644,428 (-)NCBI
RefSeq Acc Id: XM_039109546   ⟹   XP_038965474
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21135,558,977 - 135,659,780 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_445761   ⟸   NM_053309
- UniProtKB: O88802 (UniProtKB/Swiss-Prot),   O88801 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070858   ⟸   ENSRNOT00000087785
RefSeq Acc Id: XP_038965474   ⟸   XM_039109546
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038965466   ⟸   XM_039109538
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038965470   ⟸   XM_039109542
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000088957   ⟸   ENSRNOT00000094383
Protein Domains
WH1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88801-F1-model_v2 AlphaFold O88801 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620705 AgrOrtholog
BioCyc Gene G2FUF-58693 BioCyc
Ensembl Genes ENSRNOG00000061450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070858 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000088957.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087785 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000094383.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Homer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homer_EVH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29547 UniProtKB/Swiss-Prot
NCBI Gene 29547 ENTREZGENE
PANTHER PTHR10918 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Homer2 PhenoGen
PROSITE WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WH1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GHM8_RAT UniProtKB/TrEMBL
  HOME2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O88802 ENTREZGENE
UniProt Secondary O88802 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Homer2  homer scaffold protein 2  Homer2  homer scaffolding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Homer2  homer scaffolding protein 2  Homer2  homer homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Homer2  homer homolog 2 (Drosophila)    homer, neuronal immediate early gene, 2  Name updated 1299863 APPROVED
2002-08-07 Homer2  homer, neuronal immediate early gene, 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains N-terminal EVH1- and PDZ-like domains, C-terminal MCC (mutated in colorectal cancer)-like domain and leucine zipper 632975
gene_expression expression is increased 1.5 fold in SHR compared with WKY rats 1357414
gene_product member of the Vesl/Homer family of PDZ proteins 632975