Homer2 (homer scaffold protein 2) - Rat Genome Database

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Gene: Homer2 (homer scaffold protein 2) Rattus norvegicus
Analyze
Symbol: Homer2
Name: homer scaffold protein 2
RGD ID: 620705
Description: Enables G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of calcineurin-NFAT signaling cascade; and negative regulation of interleukin-2 production. Predicted to act upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in dendrite; neuronal cell body; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cupidin; homer homolog 2; homer homolog 2 (Drosophila); homer protein homolog 2; homer scaffolding protein 2; homer, neuronal immediate early gene, 2; homer-2; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,968,207 - 145,069,022 (-)NCBIGRCr8
mRatBN7.21135,558,977 - 135,659,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,488,882 - 143,581,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,658,320 - 150,750,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,564,822 - 143,658,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,443,300 - 143,535,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,387,025 - 144,478,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,827,128 - 137,933,089 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,905,533 - 138,012,215 (-)NCBI
Celera1127,618,673 - 127,711,006 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
Homer2Ratamenorrhea  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
Homer2Ratautosomal dominant nonsyndromic deafness 68  ISOHOMER2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Homer2RatBloom syndrome  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
Homer2Ratcolorectal cancer  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
Homer2Ratgenetic disease  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
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Original Reference(s)
Homer2RatCocaine-Related Disorders  ISOHOMER2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15545022
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Original Reference(s)
Homer2Ratautosomal dominant nonsyndromic deafness 68  ISOHOMER2 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Homer2Rat(1->4)-beta-D-glucan multiple interactionsISOHomer2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of HOMER2 mRNACTDPMID:36331819
Homer2Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of HOMER2 proteinCTDPMID:17337753
Homer2Rat1,2-dichloroethane decreases expressionISOHomer2 (Mus musculus)6480464ethylene dichloride results in decreased expression of HOMER2 mRNACTDPMID:28189721 and PMID:28960355
Homer2Rat1,2-dimethylhydrazine affects expressionISOHomer2 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of HOMER2 mRNACTDPMID:22206623
Homer2Rat17alpha-ethynylestradiol increases expressionISOHomer2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of HOMER2 mRNACTDPMID:17942748
Homer2Rat17alpha-ethynylestradiol multiple interactionsISOHomer2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER2 mRNACTDPMID:17942748
Homer2Rat17beta-estradiol multiple interactionsISOHOMER2 (Homo sapiens)6480464[Estradiol binds to ESR2 protein] which results in increased expression of HOMER2 mRNACTDPMID:20404318
Homer2Rat17beta-estradiol decreases expressionISOHomer2 (Mus musculus)6480464Estradiol results in decreased expression of HOMER2 mRNACTDPMID:39298647
Homer2Rat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOHOMER2 (Homo sapiens)6480464Dihydrotestosterone results in increased expression of HOMER2 mRNACTDPMID:29581250
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HOMER2 mRNACTDPMID:32109520
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHomer2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HOMER2 mRNACTDPMID:26377647 and PMID:28922406
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of HOMER2 mRNACTDPMID:22298810
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOHomer2 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of HOMER2 mRNACTDPMID:16960034
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HOMER2 mRNACTDPMID:16960034
Homer2Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHomer2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HOMER2 mRNACTDPMID:17942748
Homer2Rat2-hydroxypropanoic acid decreases expressionISOHOMER2 (Homo sapiens)6480464Lactic Acid results in decreased expression of HOMER2 mRNACTDPMID:30851411
Homer2Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOHomer2 (Mus musculus)64804643 more ...CTDPMID:19467301
Homer2Rat4,4'-sulfonyldiphenol affects expressionISOHomer2 (Mus musculus)6480464bisphenol S affects the expression of HOMER2 mRNACTDPMID:39298647
Homer2Rat4,4'-sulfonyldiphenol affects methylationISOHomer2 (Mus musculus)6480464bisphenol S affects the methylation of HOMER2 geneCTDPMID:31683443
Homer2Rataflatoxin B1 affects expressionISOHOMER2 (Homo sapiens)6480464Aflatoxin B1 affects the expression of HOMER2 proteinCTDPMID:20106945

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Biological Process
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Original Reference(s)
Homer2Ratbehavioral response to cocaine acts_upstream_of_or_withinISOHomer2 (Mus musculus)1624291MGI:3526530 PMID:15294147RGDPMID:15294147
Homer2Ratbehavioral response to cocaine acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratcalcium-mediated signaling acts_upstream_of_or_withinISOHomer2 (Mus musculus)1624291MGI:3526530 PMID:12860966RGDPMID:12860966
Homer2Ratcalcium-mediated signaling acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2RatG protein-coupled glutamate receptor signaling pathway involved_inIEAInterPro:IPR0441001600115GO_REF:0000002InterProGO_REF:0000002
Homer2RatG protein-coupled glutamate receptor signaling pathway involved_inIBAPANTHER:PTN000857479 and Homer1 (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
Homer2Ratnegative regulation of calcineurin-NFAT signaling cascade involved_inISSUniProtKB:Q9NSB81600115GO_REF:0000024UniProtGO_REF:0000024
Homer2Ratnegative regulation of calcineurin-NFAT signaling cascade involved_inISOHOMER2 (Homo sapiens)1624291 PMID:18218901RGDPMID:18218901
Homer2Ratnegative regulation of calcineurin-NFAT signaling cascade involved_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP000004076341600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratnegative regulation of interleukin-2 production involved_inISOHOMER2 (Homo sapiens)1624291 PMID:18218901RGDPMID:18218901
Homer2Ratnegative regulation of interleukin-2 production involved_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP000004076341600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratnegative regulation of interleukin-2 production involved_inISSUniProtKB:Q9NSB81600115GO_REF:0000024UniProtGO_REF:0000024
Homer2Ratregulation of G protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOHomer2 (Mus musculus)1624291 PMID:12860966RGDPMID:12860966
Homer2Ratregulation of G protein-coupled receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratregulation of store-operated calcium entry involved_inIBAMGI:1347345 and PANTHER:PTN0008574791600115GO_REF:0000033GO_CentralGO_REF:0000033
Homer2Ratsensory perception of sound involved_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP000004076341600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratsensory perception of sound involved_inISOHOMER2 (Homo sapiens)1624291 PMID:25816005RGDPMID:25816005
Homer2Ratsensory perception of sound involved_inISSUniProtKB:Q9QWW11600115GO_REF:0000024UniProtGO_REF:0000024
Homer2Ratsensory perception of sound involved_inISOHomer2 (Mus musculus)1624291 PMID:25816005RGDPMID:25816005
Homer2Ratsensory perception of sound involved_inIEAUniProtKB-KW:KW-10091600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Original Reference(s)
Homer2Ratapical part of cell located_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratapical part of cell located_inISOHomer2 (Mus musculus)1624291 PMID:12860966RGDPMID:12860966
Homer2Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Homer2Ratcytoplasm located_inISOHOMER2 (Homo sapiens)1624291 PMID:25816005RGDPMID:25816005
Homer2Ratcytoplasm located_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP000004076341600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratcytoplasm located_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Homer2Ratcytoplasm located_inISOHomer2 (Mus musculus)1624291MGI:3526530 PMID:10493740RGDPMID:10493740
Homer2Ratcytoplasm is_active_inIBAFB:FBgn0025777 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Homer2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Homer2Ratcytosol located_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP000004076341600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratcytosol located_inISOHOMER2 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Homer2Ratdendrite  IDA 2302220 RGD 
Homer2Ratdendrite is_active_inIBAPANTHER:PTN000099620 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Homer2Ratglutamatergic synapse is_active_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratglutamatergic synapse is_active_inISOHomer2 (Mus musculus)1624291 PMID:24530450RGDPMID:24530450
Homer2Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Homer2Ratneuronal cell body  IDA 2302220 RGD 
Homer2Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Homer2Ratplasma membrane is_active_inIBAMGI:1347345 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Object Symbol
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Original Reference(s)
Homer2Ratactin binding enablesIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratactin binding enablesISOHomer2 (Mus musculus)1624291 PMID:10493740RGDPMID:10493740
Homer2RatG protein-coupled glutamate receptor binding enablesIEAInterPro:IPR044100 and InterPro:IPR0450271600115GO_REF:0000002InterProGO_REF:0000002
Homer2RatG protein-coupled glutamate receptor binding enablesIBAPANTHER:PTN000857479 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Homer2RatG protein-coupled glutamate receptor binding enablesIPIUniProtKB:P314248554618PMID:15758184UniProt 
Homer2Ratglutamate receptor binding  IPIGrm1 (Rattus norvegicus) and Grm5 (Rattus norvegicus)632975 RGD 
Homer2Ratidentical protein binding  IPIHomer2 (Rattus norvegicus)632975homodimerizationRGD 
Homer2Ratprotein binding enablesIPIUniProtKB:Q6WQJ125671399PMID:17584991UniProt 
Homer2Ratprotein binding  IPIUbxn1 (Rattus norvegicus)2302220 RGD 
Homer2Ratprotein binding enablesISOHomer2 (Mus musculus)1624291PR:P97772 PMID:10493740 and PMID:9808458RGDPMID:10493740 and PMID:9808458
Homer2Ratprotein binding enablesISOHOMER2 (Homo sapiens) and UniProtKB:Q9NSB8-21624291UniProtKB:Q8WX93-2 more ...RGDPMID:32296183
Homer2Ratprotein binding enablesISOHOMER2 (Homo sapiens)1624291UniProtKB:O95644 more ...RGDPMID:18218901 and PMID:25416956
Homer2Ratprotein domain specific binding  IMP 2302220CC and UBX domainsRGD 
Homer2Ratprotein-containing complex binding  IPIHomer1 (Rattus norvegicus)632975heterodimerizationRGD 
Homer2Ratsynaptic receptor adaptor activity enablesIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP000001467871600115GO_REF:0000107EnsemblGO_REF:0000107
Homer2Ratsynaptic receptor adaptor activity enablesISOHomer2 (Mus musculus)1624291 PMID:10493740RGDPMID:10493740
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Homer2Ratglutamate signaling pathway  IEA 6907045 KEGGrno:04724

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
3. A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. Ishibashi T, etal., J Biochem. 2005 May;137(5):617-23.
4. A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. Jung KM, etal., Mol Pharmacol. 2007 Sep;72(3):612-21. doi: 10.1124/mol.107.037796. Epub 2007 Jun 21.
5. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors. Kato A, etal., J Biol Chem 1998 Sep 11;273(37):23969-75.
6. The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons. Mao L, etal., J Neurosci. 2005 Mar 9;25(10):2741-52.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:9808458   PMID:9808459   PMID:10493740   PMID:12860966   PMID:14528310   PMID:15294147   PMID:18218901   PMID:19709672   PMID:23076792   PMID:24530450   PMID:25816005   PMID:26254965  



Homer2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,968,207 - 145,069,022 (-)NCBIGRCr8
mRatBN7.21135,558,977 - 135,659,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,488,882 - 143,581,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,658,320 - 150,750,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,564,822 - 143,658,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,443,300 - 143,535,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,387,025 - 144,478,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,827,128 - 137,933,089 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,905,533 - 138,012,215 (-)NCBI
Celera1127,618,673 - 127,711,006 (-)NCBICelera
Cytogenetic Map1q31NCBI
HOMER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381582,834,661 - 82,986,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1582,836,946 - 82,986,153 (-)EnsemblGRCh38hg38GRCh38
GRCh371583,517,735 - 83,621,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361581,314,789 - 81,412,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 341581,314,788 - 81,412,477NCBI
Celera1560,965,171 - 61,062,906 (+)NCBICelera
Cytogenetic Map15q25.2NCBI
HuRef1559,787,302 - 59,884,988 (-)NCBIHuRef
CHM1_11583,259,957 - 83,363,087 (-)NCBICHM1_1
T2T-CHM13v2.01580,701,241 - 80,850,554 (-)NCBIT2T-CHM13v2.0
Homer2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39781,250,229 - 81,356,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl781,250,229 - 81,357,275 (-)EnsemblGRCm39 Ensembl
GRCm38781,600,481 - 81,706,925 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,600,481 - 81,707,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37788,745,367 - 88,851,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36781,483,228 - 81,580,639 (-)NCBIMGSCv36mm8
Celera779,009,788 - 79,104,812 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.71NCBI
Homer2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541613,741,161 - 13,818,060 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541613,671,115 - 13,828,413 (+)NCBIChiLan1.0ChiLan1.0
HOMER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21672,906,093 - 73,051,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11577,066,987 - 77,212,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01562,617,905 - 62,762,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11580,731,863 - 80,876,442 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1580,737,570 - 80,784,729 (-)Ensemblpanpan1.1panPan2
Homer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640128,699,719 - 128,836,080 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648317,507,533 - 17,539,105 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648317,500,962 - 17,634,804 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOMER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,001,579 - 52,096,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,001,253 - 52,104,426 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,489,011 - 57,584,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HOMER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1292,667,718 - 2,810,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl292,706,134 - 2,803,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605944,281,540 - 44,425,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Homer2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476818,635,283 - 18,721,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476818,626,353 - 18,751,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Homer2
742 total Variants

Predicted Target Of
Summary Value
Count of predictions:309
Count of miRNA genes:186
Interacting mature miRNAs:214
Transcripts:ENSRNOT00000026158
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 61 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat

1 to 10 of 61 rows
D1Mco51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,589,540 - 135,589,751 (+)MAPPERmRatBN7.2
Rnor_6.01143,465,134 - 143,465,344NCBIRnor6.0
Rnor_5.01144,408,859 - 144,409,069UniSTSRnor5.0
RGSC_v3.41137,848,962 - 137,849,172UniSTSRGSC3.4
Celera1127,640,507 - 127,640,717UniSTS
Cytogenetic Map1q31UniSTS
RH140724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,563,325 - 135,563,498 (+)MAPPERmRatBN7.2
Rnor_6.01143,438,923 - 143,439,095NCBIRnor6.0
Rnor_5.01144,382,648 - 144,382,820UniSTSRnor5.0
RGSC_v3.41137,875,004 - 137,875,176UniSTSRGSC3.4
RGSC_v3.41137,822,751 - 137,822,923UniSTSRGSC3.4
Celera1127,614,308 - 127,614,480UniSTS
RH 3.4 Map11087.3UniSTS
Cytogenetic Map1q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000087785   ⟹   ENSRNOP00000070858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)Ensembl
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094383   ⟹   ENSRNOP00000088957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,567,414 - 135,601,000 (-)Ensembl
RefSeq Acc Id: NM_053309   ⟹   NP_445761
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,976,642 - 145,068,997 (-)NCBI
mRatBN7.21135,567,414 - 135,659,772 (-)NCBI
Rnor_6.01143,443,300 - 143,535,579 (-)NCBI
Rnor_5.01144,387,025 - 144,478,034 (-)NCBI
RGSC_v3.41137,827,128 - 137,933,089 (-)RGD
Celera1127,618,673 - 127,711,006 (-)RGD
Sequence:
RefSeq Acc Id: XM_039109538   ⟹   XP_038965466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,968,207 - 145,069,022 (-)NCBI
mRatBN7.21135,558,977 - 135,659,772 (-)NCBI
RefSeq Acc Id: XM_039109542   ⟹   XP_038965470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,968,207 - 145,053,748 (-)NCBI
mRatBN7.21135,558,977 - 135,644,428 (-)NCBI
RefSeq Acc Id: XM_063287628   ⟹   XP_063143698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81144,968,207 - 145,033,967 (-)NCBI
RefSeq Acc Id: NP_445761   ⟸   NM_053309
- UniProtKB: O88802 (UniProtKB/Swiss-Prot),   O88801 (UniProtKB/Swiss-Prot),   A6JCH3 (UniProtKB/TrEMBL),   A0A8I6GHM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070858   ⟸   ENSRNOT00000087785
RefSeq Acc Id: XP_038965466   ⟸   XM_039109538
- Peptide Label: isoform X1
- UniProtKB: A6JCH2 (UniProtKB/TrEMBL),   A0A8I6GHM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965470   ⟸   XM_039109542
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GHM8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088957   ⟸   ENSRNOT00000094383
WH1

Name Modeler Protein Id AA Range Protein Structure
AF-O88801-F1-model_v2 AlphaFold O88801 1-354 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58693 BioCyc
Ensembl Genes ENSRNOG00000061450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087785 ENTREZGENE
  ENSRNOT00000087785.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.1700 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
InterPro Homer UniProtKB/Swiss-Prot
  Homer_EVH1 UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  WH1/EVH1_dom UniProtKB/Swiss-Prot
KEGG Report rno:29547 UniProtKB/Swiss-Prot
NCBI Gene 29547 ENTREZGENE
PANTHER PTHR10918 UniProtKB/Swiss-Prot
Pfam WH1 UniProtKB/Swiss-Prot
PhenoGen Homer2 PhenoGen
PROSITE WH1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000061450 RatGTEx
SMART WH1 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
UniProt A0A8I6GHM8 ENTREZGENE, UniProtKB/TrEMBL
  A6JCH0_RAT UniProtKB/TrEMBL
  A6JCH1_RAT UniProtKB/TrEMBL
  A6JCH2 ENTREZGENE, UniProtKB/TrEMBL
  A6JCH3 ENTREZGENE, UniProtKB/TrEMBL
  A6JCH4_RAT UniProtKB/TrEMBL
  A6JCH5_RAT UniProtKB/TrEMBL
  HOME2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O88802 ENTREZGENE
UniProt Secondary O88802 UniProtKB/Swiss-Prot
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-16 Homer2  homer scaffold protein 2  Homer2  homer scaffolding protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-02-25 Homer2  homer scaffolding protein 2  Homer2  homer homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Homer2  homer homolog 2 (Drosophila)    homer, neuronal immediate early gene, 2  Name updated 1299863 APPROVED
2002-08-07 Homer2  homer, neuronal immediate early gene, 2      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains contains N-terminal EVH1- and PDZ-like domains, C-terminal MCC (mutated in colorectal cancer)-like domain and leucine zipper 632975
gene_expression expression is increased 1.5 fold in SHR compared with WKY rats 1357414
gene_product member of the Vesl/Homer family of PDZ proteins 632975