HOMER2 (homer scaffold protein 2) - Rat Genome Database

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Gene: HOMER2 (homer scaffold protein 2) Chlorocebus sabaeus
Analyze
Symbol: HOMER2
Name: homer scaffold protein 2
RGD ID: 18633663
Description: ENCODES a protein that exhibits glutamate receptor binding (ortholog); identical protein binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN behavioral response to cocaine (inferred); calcium-mediated signaling (inferred); G protein-coupled glutamate receptor signaling pathway (inferred); ASSOCIATED WITH amenorrhea (ortholog); autosomal dominant nonsyndromic deafness 68 (ortholog); Bloom syndrome (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: homer protein homolog 2; homer scaffolding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1292,667,718 - 2,810,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl292,706,134 - 2,803,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605944,281,540 - 44,425,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green Monkeyamenorrhea  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary amenorrheaClinVarPMID:21681106
HOMER2Green Monkeyautosomal dominant nonsyndromic deafness 68  ISOHOMER2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
HOMER2Green MonkeyBloom syndrome  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Bloom syndromeClinVarPMID:28492532
HOMER2Green Monkeycolorectal cancer  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial colorectal cancerClinVarPMID:28492532
HOMER2Green Monkeygenetic disease  ISOHOMER2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green MonkeyCocaine-Related Disorders  ISOHOMER2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:15545022
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green Monkeyautosomal dominant nonsyndromic deafness 68  ISOHOMER2 (Homo sapiens)7240710 OMIM 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green Monkeybehavioral response to cocaine acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeycalcium-mediated signaling acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green MonkeyG protein-coupled glutamate receptor signaling pathway involved_inIEAInterPro:IPR044100150520179 InterProGO_REF:0000002
HOMER2Green Monkeynegative regulation of calcineurin-NFAT signaling cascade involved_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP00000407634150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeynegative regulation of interleukin-2 production involved_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP00000407634150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeyregulation of G protein-coupled receptor signaling pathway acts_upstream_of_or_withinIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeysensory perception of sound involved_inIEAUniProtKB:Q9NSB8 more ...150520179 EnsemblGO_REF:0000107

Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green Monkeyapical part of cell located_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeycytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
HOMER2Green Monkeycytoplasm located_inIEAUniProtKB:Q9NSB8 more ...150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeycytosol located_inIEAUniProtKB:Q9NSB8 and ensembl:ENSP00000407634150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeydendrite  ISOHomer2 (Rattus norvegicus)9068941 RGDPMID:15944415 and REF_RGD_ID:2302220
HOMER2Green Monkeyglutamatergic synapse is_active_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeyneuronal cell body  ISOHomer2 (Rattus norvegicus)9068941 RGDPMID:15944415 and REF_RGD_ID:2302220
HOMER2Green Monkeyplasma membrane located_inISOHomer2 (Rattus norvegicus)9068941PMID:17584991UniProtPMID:17584991 and REF_RGD_ID:25671399
HOMER2Green Monkeypostsynaptic density located_inIEAUniProtKB-SubCell:SL-0297150520179 UniProtGO_REF:0000044
HOMER2Green Monkeypostsynaptic density is_active_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeystereocilium tip located_inIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green Monkeysynapse located_inIEAUniProtKB-KW:KW-0770150520179 UniProtGO_REF:0000043
1 to 12 of 12 rows

Molecular Function
1 to 13 of 13 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
HOMER2Green Monkeyactin binding enablesIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
HOMER2Green MonkeyG protein-coupled glutamate receptor binding enablesIEAInterPro:IPR044100 and InterPro:IPR045027150520179 InterProGO_REF:0000002
HOMER2Green Monkeyglutamate receptor binding  ISOGrm1 (Rattus norvegicus) and Grm5 (Rattus norvegicus)9068941 RGDPMID:9727012 and REF_RGD_ID:632975
HOMER2Green Monkeyidentical protein binding  ISOHomer2 (Rattus norvegicus)9068941homodimerizationRGDPMID:9727012 and REF_RGD_ID:632975
HOMER2Green Monkeyprotein binding  ISOUbxn1 (Rattus norvegicus)9068941 RGDPMID:15944415 and REF_RGD_ID:2302220
HOMER2Green Monkeyprotein binding enablesISOPR:P977729068941 PMID:10493740 and PMID:9808458MGIPMID:10493740 and PMID:9808458
HOMER2Green Monkeyprotein binding enablesISOUniProtKB:Q9BRK4 and UniProtKB:Q9H4P49068941 PMID:25416956IntActPMID:25416956
HOMER2Green Monkeyprotein binding enablesISOUniProtKB:Q8WX93-2 and UniProtKB:Q9P2A49068941 PMID:32296183IntActPMID:32296183
HOMER2Green Monkeyprotein binding enablesISOUniProtKB:O95644 more ...9068941 PMID:18218901UniProtPMID:18218901
HOMER2Green Monkeyprotein binding enablesISOUniProtKB:Q6WQJ19068941PMID:17584991UniProtPMID:17584991 and REF_RGD_ID:25671399
HOMER2Green Monkeyprotein domain specific binding  ISOHomer2 (Rattus norvegicus)9068941CC and UBX domainsRGDPMID:15944415 and REF_RGD_ID:2302220
HOMER2Green Monkeyprotein-containing complex binding  ISOHomer1 (Rattus norvegicus)9068941heterodimerizationRGDPMID:9727012 and REF_RGD_ID:632975
HOMER2Green Monkeysynaptic receptor adaptor activity enablesIEAUniProtKB:Q9QWW1 and ensembl:ENSMUSP00000146787150520179 EnsemblGO_REF:0000107
1 to 13 of 13 rows

PMID:22301074   PMID:30032202  



HOMER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1292,667,718 - 2,810,238 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl292,706,134 - 2,803,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605944,281,540 - 44,425,488 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
HOMER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381582,834,661 - 82,986,157 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1582,836,946 - 82,986,153 (-)EnsemblGRCh38hg38GRCh38
GRCh371583,517,735 - 83,621,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361581,314,789 - 81,412,477 (-)NCBINCBI36Build 36hg18NCBI36
Build 341581,314,788 - 81,412,477NCBI
Celera1560,965,171 - 61,062,906 (+)NCBICelera
Cytogenetic Map15q25.2NCBI
HuRef1559,787,302 - 59,884,988 (-)NCBIHuRef
CHM1_11583,259,957 - 83,363,087 (-)NCBICHM1_1
T2T-CHM13v2.01580,701,241 - 80,850,554 (-)NCBIT2T-CHM13v2.0
Homer2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39781,250,229 - 81,356,673 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl781,250,229 - 81,357,275 (-)EnsemblGRCm39 Ensembl
GRCm38781,600,481 - 81,706,925 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl781,600,481 - 81,707,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv37788,745,367 - 88,851,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36781,483,228 - 81,580,639 (-)NCBIMGSCv36mm8
Celera779,009,788 - 79,104,812 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.71NCBI
Homer2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,968,207 - 145,069,022 (-)NCBIGRCr8
mRatBN7.21135,558,977 - 135,659,780 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,567,414 - 135,659,772 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1143,488,882 - 143,581,178 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01150,658,320 - 150,750,396 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01143,564,822 - 143,658,186 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01143,443,300 - 143,535,579 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1143,443,300 - 143,535,583 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01144,387,025 - 144,478,034 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41137,827,128 - 137,933,089 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11137,905,533 - 138,012,215 (-)NCBI
Celera1127,618,673 - 127,711,006 (-)NCBICelera
Cytogenetic Map1q31NCBI
Homer2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541613,741,161 - 13,818,060 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541613,671,115 - 13,828,413 (+)NCBIChiLan1.0ChiLan1.0
HOMER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21672,906,093 - 73,051,976 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11577,066,987 - 77,212,497 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01562,617,905 - 62,762,903 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11580,731,863 - 80,876,442 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1580,737,570 - 80,784,729 (-)Ensemblpanpan1.1panPan2
Homer2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640128,699,719 - 128,836,080 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648317,507,533 - 17,539,105 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648317,500,962 - 17,634,804 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HOMER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,001,579 - 52,096,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1752,001,253 - 52,104,426 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2757,489,011 - 57,584,450 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Homer2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476818,635,283 - 18,721,984 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476818,626,353 - 18,751,279 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in HOMER2
3008 total Variants



ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20



Ensembl Acc Id: ENSCSAT00000015387   ⟹   ENSCSAP00000013328
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl292,706,134 - 2,803,372 (+)Ensembl
RefSeq Acc Id: XM_007990232   ⟹   XP_007988423
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1292,667,718 - 2,804,068 (+)NCBI
Vero_WHO_p1.0NW_02366605944,289,228 - 44,425,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990233   ⟹   XP_007988424
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1292,667,718 - 2,810,238 (+)NCBI
Vero_WHO_p1.0NW_02366605944,281,540 - 44,425,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990234   ⟹   XP_007988425
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1292,667,718 - 2,804,068 (+)NCBI
Vero_WHO_p1.0NW_02366605944,289,227 - 44,425,468 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990236   ⟹   XP_007988427
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1292,706,037 - 2,804,074 (+)NCBI
Vero_WHO_p1.0NW_02366605944,289,228 - 44,388,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007990237   ⟹   XP_007988428
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1292,706,037 - 2,804,068 (+)NCBI
Vero_WHO_p1.0NW_02366605944,289,228 - 44,388,449 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037987783   ⟹   XP_037843711
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605944,284,118 - 44,425,488 (-)NCBI
RefSeq Acc Id: XM_037987784   ⟹   XP_037843712
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366605944,289,227 - 44,388,251 (-)NCBI
RefSeq Acc Id: XP_007988424   ⟸   XM_007990233
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007988423   ⟸   XM_007990232
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007988425   ⟸   XM_007990234
- Peptide Label: isoform X2
RefSeq Acc Id: XP_007988427   ⟸   XM_007990236
- Peptide Label: isoform X4
RefSeq Acc Id: XP_007988428   ⟸   XM_007990237
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RXI9 (UniProtKB/TrEMBL)



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCSAG00000017295 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015387.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1700 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro Homer UniProtKB/TrEMBL
  Homer_EVH1 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  WH1/EVH1_dom UniProtKB/TrEMBL
NCBI Gene HOMER2 ENTREZGENE
PANTHER PTHR10918 UniProtKB/TrEMBL
Pfam WH1 UniProtKB/TrEMBL
PROSITE WH1 UniProtKB/TrEMBL
SMART WH1 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt A0A0D9RXI9 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows