Enables serotonin-gated monoatomic cation channel activity. Involved in several processes, including behavioral response to ethanol; positive regulation of ion transmembrane transporter activity; and response to cocaine. Located in axon and neuronal cell body. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-bromopropane; 6-propyl-2-thiouracil.
[Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein and [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] and 1-Butanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]
[Dexamethasone co-treated with Metoclopramide] results in decreased activity of HTR3A protein and [Dexamethasone co-treated with ramosetron] results in decreased activity of HTR3A protein
Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3A protein] and Dopamine binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA
Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] and Ethanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein] and Ondansetron binds to and results in decreased activity of HTR3A protein
1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3A protein]] and 1-Propanol promotes the reaction [Serotonin binds to and results in increased activity of [HTR3A protein binds to HTR3B protein]]
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HTR3A mRNA
Ondansetron affects the reaction [vortioxetine binds to and affects the activity of HTR3A protein] and vortioxetine binds to and affects the activity of HTR3A protein
Association and interaction analyses of 5-HT3 receptor and serotonin transporter genes with alcohol, cocaine, and nicotine dependence using the SAGE data.
Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers.
may play an important role in synaptic activation in neocortical VIP/CCK in GABAergic interneurons by serotonergic afferent fibres from brainstem raphe nuclei