Htr3a (5-hydroxytryptamine receptor 3A) - Rat Genome Database

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Gene: Htr3a (5-hydroxytryptamine receptor 3A) Rattus norvegicus
Analyze
Symbol: Htr3a
Name: 5-hydroxytryptamine receptor 3A
RGD ID: 61818
Description: Enables serotonin-gated cation-selective channel activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; response to cocaine; and response to ethanol. Located in several cellular components, including axon; neuronal cell body; and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A); INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 1-bromopropane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-HT-3; 5-HT3; 5-HT3 receptor; 5-HT3-A; 5-HT3A; 5-HT3R; 5-hydroxytryptamine (serotonin) receptor 3a; 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic; 5-hydroxytryptamine receptor 3; 5HT3; 5HT3 receptor; Htr3; serotonin receptor 3A; serotonin-gated ion channel receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,242,018 - 49,254,475 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl849,242,020 - 49,254,389 (-)Ensembl
Rnor_6.0853,211,436 - 53,223,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,211,438 - 53,223,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,803,895 - 51,816,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,161,147 - 52,173,514 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,180,200 - 52,192,425 (-)NCBI
Celera848,799,808 - 48,812,052 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloroethane  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-bromopropane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-methylserotonin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
alfentanil  (ISO)
ammonium chloride  (EXP)
atrazine  (ISO)
benzamides  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
capsaicin  (ISO)
carvacrol  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
citronellol  (ISO)
clozapine  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
dexamethasone  (ISO)
diazinon  (EXP)
dieldrin  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-aminobutyric acid  (EXP)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
GR 65630  (ISO)
hydromorphone  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
m-Chlorophenylbiguanide  (EXP)
methamphetamine  (ISO)
metoclopramide  (EXP,ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
nickel atom  (EXP)
nitrates  (EXP)
O-methyleugenol  (ISO)
Ondansetron  (EXP,ISO)
paracetamol  (EXP)
Polygodial  (ISO)
potassium dichromate  (ISO)
propan-1-ol  (ISO)
pyridines  (EXP)
raloxifene  (ISO)
Ramosetron hydrochloride  (EXP,ISO)
remifentanil  (ISO)
SB 431542  (ISO)
serotonin  (EXP,ISO)
sodium arsenite  (ISO)
sufentanil  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
toluene  (ISO)
trichloroethene  (EXP,ISO)
valproic acid  (ISO)
vortioxetine  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Induction by cocaine of the serotonergic 5-HT3 receptor in rat cerebellum. Arpin-Bott MP, etal., Ann N Y Acad Sci. 2006 Aug;1074:382-9.
2. Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. Carvalho F, etal., Horm Metab Res 2002 Feb;34(2):55-61.
3. Immunolabelling of the 5-HT 3B receptor subunit in the central and peripheral nervous systems in rodents. Doucet E, etal., Eur J Neurosci. 2007 Jul;26(2):355-66.
4. 5-HT3 receptors mediate serotonergic fast synaptic excitation of neocortical vasoactive intestinal peptide/cholecystokinin interneurons. Ferezou I, etal., J Neurosci 2002 Sep 1;22(17):7389-97.
5. Ligand-induced 5-HT3 receptor internalization in enteric neurons in rat ileum. Freeman SL, etal., Gastroenterology. 2006 Jul;131(1):97-107.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Localization of 5-HT2A, 5-HT3, 5-HT5A and 5-HT7 receptor-like immunoreactivity in the rat cerebellum. Geurts FJ, etal., J Chem Neuroanat 2002 Jun;24(1):65-74.
8. Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. Hanna MC, etal., J Neurochem 2000 Jul;75(1):240-7.
9. The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome. Kilpatrick LA, etal., Gastroenterology. 2011 Jun;140(7):1943-51. Epub 2011 Mar 21.
10. Characterisation of axon terminals in the rat dorsal horn that are immunoreactive for serotonin 5-HT3A receptor subunits. Maxwell DJ, etal., Exp Brain Res. 2003 Mar;149(1):114-24. doi: 10.1007/s00221-002-1339-7. Epub 2003 Jan 11.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Differential subcellular localization of the 5-HT3-As receptor subunit in the rat central nervous system. Miquel MC, etal., Eur J Neurosci. 2002 Feb;15(3):449-57.
13. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species. Miyake A, etal., Mol Pharmacol 1995 Sep;48(3):407-16.
14. Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. Morales M and Wang SD, J Neurosci 2002 Aug 1;22(15):6732-41.
15. Serotonin receptor 3A polymorphism c.-42C > T is associated with severe dyspepsia. Mujakovic S, etal., BMC Med Genet. 2011 Oct 20;12:140. doi: 10.1186/1471-2350-12-140.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Identification of neurotransmitter receptor genes involved in alcohol self-administration in the rat prefrontal cortex, hippocampus and amygdala. Pickering C, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):53-64. Epub 2006 Jul 28.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Identification of critical residues in loop E in the 5-HT3ASR binding site. Venkataraman P, etal., BMC Biochem 2002 Jun 13;3(1):15.
Additional References at PubMed
PMID:7509203   PMID:7616200   PMID:9950429   PMID:12411518   PMID:12411529   PMID:12611954   PMID:12617944   PMID:12937671   PMID:14499437   PMID:14648680   PMID:15135935   PMID:15905216  
PMID:15975728   PMID:16407231   PMID:17150309   PMID:17161536   PMID:17467903   PMID:18063656   PMID:18313044   PMID:18357529   PMID:18931259   PMID:19026634   PMID:19077442   PMID:19154775  
PMID:19247214   PMID:19556691   PMID:19558425   PMID:19799413   PMID:19944698   PMID:20023641   PMID:20359130   PMID:20682192   PMID:20691988   PMID:20817619   PMID:21186576   PMID:21291881  
PMID:21514668   PMID:22289689   PMID:22358093   PMID:22528232   PMID:22845622   PMID:23035083   PMID:23399761   PMID:24949809   PMID:25119048   PMID:25913635   PMID:26724993   PMID:27904941  
PMID:28115218   PMID:28761086   PMID:28795477   PMID:32537854   PMID:33160048  


Genomics

Comparative Map Data
Htr3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2849,242,018 - 49,254,475 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl849,242,020 - 49,254,389 (-)Ensembl
Rnor_6.0853,211,436 - 53,223,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,211,438 - 53,223,804 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0851,803,895 - 51,816,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,161,147 - 52,173,514 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1852,180,200 - 52,192,425 (-)NCBI
Celera848,799,808 - 48,812,052 (-)NCBICelera
Cytogenetic Map8q23NCBI
HTR3A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,975,108 - 113,990,313 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11113,975,075 - 113,990,313 (+)EnsemblGRCh38hg38GRCh38
GRCh3711113,845,830 - 113,861,035 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611113,351,120 - 113,366,245 (+)NCBINCBI36hg18NCBI36
Build 3411113,351,119 - 113,366,242NCBI
Celera11110,998,666 - 111,013,897 (+)NCBI
Cytogenetic Map11q23.2NCBI
HuRef11109,774,553 - 109,789,782 (+)NCBIHuRef
CHM1_111113,729,890 - 113,745,126 (+)NCBICHM1_1
T2T-CHM13v2.011113,985,458 - 114,000,652 (+)NCBI
Htr3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39948,810,513 - 48,822,451 (-)NCBIGRCm39mm39
GRCm39 Ensembl948,810,513 - 48,822,399 (-)Ensembl
GRCm38948,899,213 - 48,911,152 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl948,899,213 - 48,911,099 (-)EnsemblGRCm38mm10GRCm38
MGSCv37948,707,318 - 48,719,204 (-)NCBIGRCm37mm9NCBIm37
MGSCv36948,651,146 - 48,662,968 (-)NCBImm8
Celera946,196,535 - 46,208,676 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
Htr3a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,589,117 - 15,602,211 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,589,117 - 15,602,211 (+)NCBIChiLan1.0ChiLan1.0
HTR3A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111112,696,271 - 112,711,507 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,695,891 - 112,711,695 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011108,851,954 - 108,869,119 (+)NCBIMhudiblu_PPA_v0panPan3
HTR3A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,324,087 - 19,338,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,324,444 - 19,338,294 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,248,270 - 19,261,807 (-)NCBI
ROS_Cfam_1.0519,345,236 - 19,358,844 (-)NCBI
ROS_Cfam_1.0 Ensembl519,345,236 - 19,359,053 (-)Ensembl
UMICH_Zoey_3.1519,409,269 - 19,422,833 (-)NCBI
UNSW_CanFamBas_1.0519,311,211 - 19,324,318 (-)NCBI
UU_Cfam_GSD_1.0519,357,640 - 19,371,211 (-)NCBI
HTR3A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl941,576,796 - 41,589,538 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1941,575,085 - 41,589,083 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2946,389,414 - 46,403,415 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR3A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11105,359,139 - 105,375,217 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1105,359,730 - 105,374,664 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604320,649,879 - 20,665,225 (-)NCBIVero_WHO_p1.0
Htr3a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247849,470,344 - 9,483,595 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247849,470,440 - 9,483,132 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:134
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000008965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low 3 12 74 2 17
Below cutoff 15 16 4 6 4 18 18 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008965   ⟹   ENSRNOP00000008965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,242,033 - 49,254,389 (-)Ensembl
Rnor_6.0 Ensembl853,211,438 - 53,223,804 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105962   ⟹   ENSRNOP00000092870
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,242,020 - 49,252,411 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000114957   ⟹   ENSRNOP00000091167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,242,020 - 49,253,005 (-)Ensembl
RefSeq Acc Id: NM_024394   ⟹   NP_077370
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,020 - 49,254,389 (-)NCBI
Rnor_6.0853,211,438 - 53,223,804 (-)NCBI
Rnor_5.0851,803,895 - 51,816,278 (-)NCBI
RGSC_v3.4852,161,147 - 52,173,514 (-)RGD
Celera848,799,808 - 48,812,052 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243021   ⟹   XP_006243083
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,018 - 49,254,471 (-)NCBI
Rnor_6.0853,211,436 - 53,223,877 (-)NCBI
Rnor_5.0851,803,895 - 51,816,278 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595928   ⟹   XP_017451417
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,018 - 49,254,475 (-)NCBI
Rnor_6.0853,211,436 - 53,223,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039082195   ⟹   XP_038938123
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,018 - 49,249,675 (-)NCBI
RefSeq Acc Id: XM_039082196   ⟹   XP_038938124
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,018 - 49,251,949 (-)NCBI
RefSeq Acc Id: XM_039082197   ⟹   XP_038938125
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2849,242,018 - 49,251,946 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_077370   ⟸   NM_024394
- Peptide Label: precursor
- UniProtKB: P35563 (UniProtKB/Swiss-Prot),   Q62999 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243083   ⟸   XM_006243021
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017451417   ⟸   XM_017595928
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000008965   ⟸   ENSRNOT00000008965
RefSeq Acc Id: XP_038938124   ⟸   XM_039082196
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038938125   ⟸   XM_039082197
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038938123   ⟸   XM_039082195
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000092870   ⟸   ENSRNOT00000105962
RefSeq Acc Id: ENSRNOP00000091167   ⟸   ENSRNOT00000114957
Protein Domains
Neur_chan_LBD   Neur_chan_memb

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35563-F1-model_v2 AlphaFold P35563 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 51809587 51809588 C A snv KFRS3B/Kyo (KyushuU), RCS/Kyo (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61818 AgrOrtholog
BioCyc Gene G2FUF-30594 BioCyc
Ensembl Genes ENSRNOG00000006595 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008965 ENTREZGENE
  ENSRNOP00000008965.5 UniProtKB/TrEMBL
  ENSRNOP00000091167.1 UniProtKB/TrEMBL
  ENSRNOP00000092870 ENTREZGENE
  ENSRNOP00000092870.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008965 ENTREZGENE
  ENSRNOT00000008965.5 UniProtKB/TrEMBL
  ENSRNOT00000105962 ENTREZGENE
  ENSRNOT00000105962.1 UniProtKB/TrEMBL
  ENSRNOT00000114957.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.390 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.70.170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 5HT3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT3_rcpt_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_lig-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro-gated_channel_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neuro_actylchol_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotrans-gated_channel_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neurotransmitter_ion_chnl_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79246 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 79246 ENTREZGENE
PANTHER PTHR18945 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Neur_chan_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Neur_chan_memb UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HTR3A RGD
PhenoGen Htr3a PhenoGen
PRINTS 5HT3ARECEPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  5HT3RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NRIONCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NEUROTR_ION_CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF63712 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs LIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt 5HT3A_RAT UniProtKB/Swiss-Prot
  A0A8I6AD80_RAT UniProtKB/TrEMBL
  A0A8I6AHF0_RAT UniProtKB/TrEMBL
  A0A8L2Q4R5_RAT UniProtKB/TrEMBL
  P35563 ENTREZGENE
  Q62999 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Htr3a  5-hydroxytryptamine receptor 3A  Htr3a  5-hydroxytryptamine (serotonin) receptor 3A, ionotropic  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-17 Htr3a  5-hydroxytryptamine (serotonin) receptor 3A, ionotropic  Htr3a  5-hydroxytryptamine (serotonin) receptor 3a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Htr3a  5-hydroxytryptamine (serotonin) receptor 3a      Name updated 70584 APPROVED
2001-05-08 Htr3  5-Hydroxytryptamine (serotonin) receptor 3A      Symbol inconsistent with Human and Mouse 62408 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs HT3R antagonist tropisetron blocks fast membrane potential depolarizations induced by serotonin 625727
gene_expression expressed in central and peripheral neurons 625727
gene_expression expressed in the cerebellum 727384
gene_expression expressed in a subset of GABAergic interneurons 625727
gene_function ligand-gated ion channel receptor for serotonin 625727
gene_function cation-selective ligand-gated ion channel 625614
gene_other dendrites and somata of 5HT3R secreting neurons placed in close apposition of serotonergic fibres indicating possible synaptic contacts 625727
gene_other dendrites and somata of 5HT3R secreting neurons are placed in close apposition of serotonergic fibres indicating possible synaptic contacts 625727
gene_process may play an important role in synaptic activation in neocortical VIP/CCK in GABAergic interneurons by serotonergic afferent fibres from brainstem raphe nuclei 625727
gene_process may be involved in mediating fast synaptic transmission in neocortex region of brain 625614
gene_process mediates visceral afferent information and visceral reflexes, nociception and cognition 625727