Il7r (interleukin 7 receptor) - Rat Genome Database

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Gene: Il7r (interleukin 7 receptor) Rattus norvegicus
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Symbol: Il7r
Name: interleukin 7 receptor
RGD ID: 1309776
Description: ENCODES a protein that exhibits cytokine receptor activity (ortholog); INVOLVED IN B cell proliferation (ortholog); cell morphogenesis (ortholog); defense response to Gram-positive bacterium (ortholog); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; primary immunodeficiency pathway; ASSOCIATED WITH Acute Lymphoblastic Leukemia, with Lymphomatous Features (ortholog); COVID-19 (ortholog); endometriosis (ortholog); FOUND IN cytosol (ortholog); external side of plasma membrane (ortholog); nucleoplasm (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: interleukin-7 receptor subunit alpha; LOC294797
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2258,452,393 - 58,477,757 (-)NCBI
RGSC_v3.4259,103,992 - 59,128,004NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1259,033,898 - 59,056,163NCBI
Celera254,059,389 - 54,082,658 (-)NCBICelera
Cytogenetic Map2q16NCBI


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
astemizole  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dichloromethane  (EXP)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
ethylbenzene  (EXP)
eugenol  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
geraniol  (ISO)
heme b  (ISO)
imiquimod  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tamibarotene  (ISO)
testosterone  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:9215624   PMID:9215626   PMID:11418668   PMID:12714519   PMID:12732660   PMID:15294943   PMID:15909309   PMID:18958875   PMID:19934022  


Genomics

Comparative Map Data
Il7r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2258,452,393 - 58,477,757 (-)NCBI
RGSC_v3.4259,103,992 - 59,128,004NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1259,033,898 - 59,056,163NCBI
Celera254,059,389 - 54,082,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
IL7R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl535,852,695 - 35,879,603 (+)EnsemblGRCh38hg38GRCh38
GRCh38535,856,891 - 35,879,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37535,856,993 - 35,879,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,892,748 - 35,912,681 (+)NCBINCBI36hg18NCBI36
Build 34535,892,747 - 35,912,678NCBI
Celera535,746,654 - 35,762,626 (+)NCBI
Cytogenetic Map5p13.2NCBI
HuRef535,806,996 - 35,829,599 (+)NCBIHuRef
CHM1_1535,859,671 - 35,882,400 (+)NCBICHM1_1
Il7r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,505,880 - 9,530,270 (-)NCBIGRCm39mm39
GRCm39 Ensembl159,505,874 - 9,530,262 (-)Ensembl
GRCm38159,506,159 - 9,529,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,505,788 - 9,530,176 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,435,914 - 9,459,631 (-)NCBIGRCm37mm9NCBIm37
MGSCv36159,450,884 - 9,474,583 (-)NCBImm8
Celera159,305,599 - 9,329,318 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map154.16NCBI
Il7r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,787,471 - 20,818,577 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542620,785,896 - 20,818,512 (+)NCBIChiLan1.0ChiLan1.0
IL7R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1579,769,859 - 79,792,566 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl579,769,859 - 79,792,612 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0574,489,188 - 74,516,330 (-)NCBIMhudiblu_PPA_v0panPan3
IL7R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,633,528 - 72,668,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,636,325 - 72,668,300 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha472,241,264 - 72,278,318 (-)NCBI
ROS_Cfam_1.0473,138,660 - 73,173,398 (-)NCBI
UMICH_Zoey_3.1472,886,268 - 72,921,029 (-)NCBI
UNSW_CanFamBas_1.0473,010,018 - 73,044,745 (-)NCBI
UU_Cfam_GSD_1.0473,540,714 - 73,577,774 (-)NCBI
Il7r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,529,223 - 225,555,932 (+)NCBI
SpeTri2.0NW_0049365185,815,820 - 5,842,571 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL7R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,300,111 - 21,329,585 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11621,300,141 - 21,330,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,278,413 - 22,314,409 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL7R
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1434,701,724 - 34,724,241 (+)NCBI
ChlSab1.1 Ensembl434,701,531 - 34,721,361 (+)Ensembl
Il7r
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475919,067,933 - 19,103,007 (-)NCBI

Position Markers
RH131549  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4259,103,992 - 59,104,211UniSTSRGSC3.4
Celera254,059,389 - 54,059,608UniSTS
Cytogenetic Map2q16UniSTS
RH139982  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4259,104,473 - 59,104,682UniSTSRGSC3.4
Celera254,059,870 - 54,060,079UniSTS
Cytogenetic Map2q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 19 9
Low 1 12 45 37 37 8 8 37 17 14 2 8
Below cutoff 24 4 4 4 2 37 18 21

Sequence


Reference Sequences
RefSeq Acc Id: NM_001106418   ⟹   NP_001099888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2258,454,217 - 58,477,757 (-)NCBI
Rnor_5.0279,669,913 - 79,690,427 (+)NCBI
RGSC_v3.4259,103,992 - 59,128,004 (-)RGD
Celera254,059,389 - 54,082,658 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257699   ⟹   XP_006257761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2258,452,393 - 58,473,215 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099888 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257761 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75666 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099888   ⟸   NM_001106418
- Peptide Label: precursor
- UniProtKB: D4A3X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257761   ⟸   XM_006257699
- Peptide Label: isoform X1
- Sequence:
Protein Domains
Fibronectin type-III

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000058446 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070236 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090309 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro FN3_7 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:294797 UniProtKB/TrEMBL
NCBI Gene 294797 ENTREZGENE
Pfam fn3 UniProtKB/TrEMBL
  FN3_7 UniProtKB/TrEMBL
PhenoGen Il7r PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt D4A3X8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Il7r  interleukin 7 receptor   Il7r_predicted  interleukin 7 receptor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il7r_predicted  interleukin 7 receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED