Il7r (interleukin 7 receptor) - Rat Genome Database

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Gene: Il7r (interleukin 7 receptor) Rattus norvegicus
Analyze
Symbol: Il7r
Name: interleukin 7 receptor
RGD ID: 1309776
Description: Predicted to enable interleukin-7 receptor activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; interleukin-7-mediated signaling pathway; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to act upstream of or within several processes, including lymph node development; lymphocyte homeostasis; and positive regulation of T cell differentiation in thymus. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in external side of plasma membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in colon cancer; lung non-small cell carcinoma; primary immunodeficiency disease; severe combined immunodeficiency; and stomach cancer. Orthologous to human IL7R (interleukin 7 receptor); PARTICIPATES IN cytokine mediated signaling pathway; Jak-Stat signaling pathway; primary immunodeficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: interleukin-7 receptor subunit alpha; LOC294797
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,179,561 - 60,204,937 (-)NCBIGRCr8
mRatBN7.2258,452,393 - 58,477,757 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,454,217 - 58,477,757 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx265,533,615 - 65,557,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,655,666 - 63,679,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,656,991 - 58,680,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4259,103,992 - 59,128,004NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1259,033,898 - 59,056,163NCBI
Celera254,059,389 - 54,082,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
afimoxifene  (ISO)
aluminium hydroxide  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astemizole  (EXP)
Azoxymethane  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cobalt(2+) sulfate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dichloromethane  (EXP)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
diuron  (ISO)
doxorubicin  (ISO)
ethylbenzene  (EXP)
eugenol  (ISO)
ferroheme b  (ISO)
ferulic acid  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fragrance  (ISO)
geraniol  (ISO)
heme b  (ISO)
imiquimod  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
Nonylphenol  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
pemetrexed  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Mahajan R, etal., Jpn J Clin Oncol. 2008 Sep;38(9):626-33. doi: 10.1093/jjco/hyn075. Epub 2008 Aug 7.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. [The expressions of IL-7 and IL-7R and the relationship between them with lymph node metastasis and prognosis in non-small cell lung cancer]. MING J, etal., Zhongguo Fei Ai Za Zhi. 2010 Dec;13(12):1101-6. doi: 10.3779/j.issn.1009-3419.2010.12.04.
6. Identification of copy number alterations in colon cancer from analysis of amplicon-based next generation sequencing data. Oliveira DM, etal., Oncotarget. 2018 Apr 17;9(29):20409-20425. doi: 10.18632/oncotarget.24912. eCollection 2018 Apr 17.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. Puel A, etal., Nat Genet. 1998 Dec;20(4):394-7.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. The tumoral and stromal immune microenvironment in malignant pleural mesothelioma: A comprehensive analysis reveals prognostic immune markers. Ujiie H, etal., Oncoimmunology. 2015 Mar 19;4(6):e1009285. doi: 10.1080/2162402X.2015.1009285. eCollection 2015 Jun.
14. Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. Van Dyke AL, etal., Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1829-40.
15. Increased expression of thymic stromal lymphopoietin receptor in a rat model of middle cerebral artery occlusion. Yu X, etal., Neuroreport. 2019 Feb 6;30(3):182-187. doi: 10.1097/WNR.0000000000001181.
Additional References at PubMed
PMID:9215624   PMID:9215626   PMID:11418668   PMID:12714519   PMID:12732660   PMID:15294943   PMID:15909309   PMID:18958875   PMID:19934022  


Genomics

Comparative Map Data
Il7r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8260,179,561 - 60,204,937 (-)NCBIGRCr8
mRatBN7.2258,452,393 - 58,477,757 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl258,454,217 - 58,477,757 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx265,533,615 - 65,557,174 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0263,655,666 - 63,679,222 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0258,656,991 - 58,680,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
RGSC_v3.4259,103,992 - 59,128,004NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1259,033,898 - 59,056,163NCBI
Celera254,059,389 - 54,082,658 (-)NCBICelera
Cytogenetic Map2q16NCBI
IL7R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38535,856,891 - 35,879,603 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl535,852,695 - 35,879,603 (+)EnsemblGRCh38hg38GRCh38
GRCh37535,856,993 - 35,879,705 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36535,892,748 - 35,912,681 (+)NCBINCBI36Build 36hg18NCBI36
Build 34535,892,747 - 35,912,678NCBI
Celera535,746,654 - 35,762,626 (+)NCBICelera
Cytogenetic Map5p13.2NCBI
HuRef535,806,996 - 35,829,599 (+)NCBIHuRef
CHM1_1535,859,671 - 35,882,400 (+)NCBICHM1_1
T2T-CHM13v2.0536,105,155 - 36,127,873 (+)NCBIT2T-CHM13v2.0
Il7r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39159,505,880 - 9,530,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl159,505,874 - 9,530,262 (-)EnsemblGRCm39 Ensembl
GRCm38159,506,159 - 9,529,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl159,505,788 - 9,530,176 (-)EnsemblGRCm38mm10GRCm38
MGSCv37159,435,914 - 9,459,631 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36159,450,884 - 9,474,583 (-)NCBIMGSCv36mm8
Celera159,305,599 - 9,329,318 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map154.16NCBI
Il7r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542620,787,471 - 20,818,577 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542620,785,896 - 20,818,512 (+)NCBIChiLan1.0ChiLan1.0
IL7R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2474,455,530 - 74,479,659 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1572,609,162 - 72,633,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0574,489,188 - 74,516,330 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1579,769,859 - 79,792,566 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl579,769,859 - 79,792,612 (-)Ensemblpanpan1.1panPan2
IL7R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1472,633,528 - 72,668,242 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl472,636,325 - 72,668,300 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha472,241,264 - 72,278,318 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0473,138,660 - 73,173,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl473,141,707 - 73,173,377 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1472,886,268 - 72,921,029 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0473,010,018 - 73,044,745 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0473,540,714 - 73,577,774 (-)NCBIUU_Cfam_GSD_1.0
Il7r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213225,529,223 - 225,555,932 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365185,815,820 - 5,842,571 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL7R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1621,300,111 - 21,329,585 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11621,300,141 - 21,330,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21622,278,413 - 22,314,409 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IL7R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1434,701,724 - 34,724,241 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl434,701,531 - 34,721,361 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607125,018,055 - 25,040,613 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il7r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475919,067,856 - 19,098,859 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475919,067,933 - 19,103,007 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il7r
109 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6480225Gdil1Gastrointestinal dilation QTL 1enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)25666087974786777Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
1579916Bp270Blood pressure QTL 2700.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)25653191259324719Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
631208Bw1Body weight QTL15.09mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)24317101783575226Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)24280460760653831Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354592Rf50Renal function QTL 503.5urine output (VT:0003620)timed urine volume (CMO:0000260)25382274774786777Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
1582246Cm60Cardiac mass QTL 605.8heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)25760561276539510Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat

Markers in Region
RH131549  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4259,103,992 - 59,104,211UniSTSRGSC3.4
Celera254,059,389 - 54,059,608UniSTS
Cytogenetic Map2q16UniSTS
RH139982  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4259,104,473 - 59,104,682UniSTSRGSC3.4
Celera254,059,870 - 54,060,079UniSTS
Cytogenetic Map2q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 42 113 91 90 59 25 59 6 210 89 93 45 53 31

Sequence


Ensembl Acc Id: ENSRNOT00000113073   ⟹   ENSRNOP00000093429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl258,454,217 - 58,477,757 (-)Ensembl
RefSeq Acc Id: NM_001106418   ⟹   NP_001099888
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,181,382 - 60,204,917 (-)NCBI
mRatBN7.2258,454,217 - 58,477,757 (-)NCBI
Rnor_5.0279,669,913 - 79,690,427 (+)NCBI
RGSC_v3.4259,103,992 - 59,128,004 (-)RGD
Celera254,059,389 - 54,082,658 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257699   ⟹   XP_006257761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,179,561 - 60,200,484 (-)NCBI
mRatBN7.2258,452,393 - 58,473,215 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281523   ⟹   XP_063137593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8260,183,918 - 60,204,937 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099888 (Get FASTA)   NCBI Sequence Viewer  
  XP_006257761 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137593 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL75666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000093429.1
RefSeq Acc Id: NP_001099888   ⟸   NM_001106418
- Peptide Label: precursor
- UniProtKB: D4A3X8 (UniProtKB/TrEMBL),   A6KGJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257761   ⟸   XM_006257699
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000093429   ⟸   ENSRNOT00000113073
RefSeq Acc Id: XP_063137593   ⟸   XM_063281523
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3X8-F1-model_v2 AlphaFold D4A3X8 1-457 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309776 AgrOrtholog
BioCyc Gene G2FUF-54097 BioCyc
Ensembl Genes ENSRNOG00000065741 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000113073.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.1870 UniProtKB/TrEMBL
InterPro FN3_7 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  FN_III UniProtKB/TrEMBL
  Hempt_rcpt_S_F1_CS UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
KEGG Report rno:294797 UniProtKB/TrEMBL
NCBI Gene 294797 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-7 RECEPTOR SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam FN3_7 UniProtKB/TrEMBL
PhenoGen Il7r PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
  HEMATOPO_REC_S_F1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000065741 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt A6KGJ9 ENTREZGENE, UniProtKB/TrEMBL
  D4A3X8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Il7r  interleukin 7 receptor   Il7r_predicted  interleukin 7 receptor (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Il7r_predicted  interleukin 7 receptor (predicted)      Symbol and Name status set to approved 70820 APPROVED