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Gene: Nek7 (NIMA-related kinase 7) Rattus norvegicus
Analyze
Symbol:
Nek7
Name:
NIMA-related kinase 7
RGD ID:
1311160
Description:
Exhibits protein serine/threonine kinase activity. Predicted to be involved in positive regulation of DNA metabolic process and protein phosphorylation. Predicted to localize to cytoplasm and nucleoplasm. Orthologous to human NEK7 (NIMA related kinase 7); INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; aflatoxin B1.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC360850; never in mitosis A-related kinase 7; NIMA (never in mitosis gene a)-related expressed kinase 7; NIMA (never in mitosis gene a)-related kinase 7; nimA-related protein kinase 7; serine/threonine-protein kinase Nek7
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NEK7 (NIMA related kinase 7)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):
Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7)
HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nek7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NEK7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NEK7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nek7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NEK7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
NEK7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Nek7 (NIMA related kinase 7)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
NEK7 (NIMA related kinase 7)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Nek7 (NIMA (never in mitosis gene a)-related expressed kinase 7)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
nek7 (NIMA-related kinase 7)
Alliance
DIOPT (PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
nekl-3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 13 50,022,212 - 50,149,374 (-) NCBI Rnor_6.0 Ensembl 13 55,488,531 - 55,561,750 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 13 55,485,759 - 55,617,534 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 13 60,515,259 - 60,641,914 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 13 51,679,191 - 51,942,636 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 13 51,696,338 - 51,802,947 (-) NCBI Celera 13 50,308,775 - 50,377,141 (-) NCBI Celera Cytogenetic Map 13 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Disease Annotations - CTD
1,2-dimethylhydrazine multiple interactions ISO RGD:1322472 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NEK7 mRNA CTD PMID:22206623 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1322472 6480464 Tetrachlorodibenzodioxin results in decreased expression of NEK7 mRNA CTD PMID:19770486 , PMID:25270620 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1322472 6480464 Tetrachlorodibenzodioxin affects the expression of NEK7 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1322472 6480464 Tetrachlorodibenzodioxin results in increased expression of NEK7 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1322472 6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NEK7 mRNA] CTD PMID:15034205 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of NEK7 mRNA CTD PMID:21346803 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of NEK7 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of NEK7 mRNA CTD PMID:23630614 aflatoxin B1 decreases methylation ISO RGD:1322471 6480464 Aflatoxin B1 results in decreased methylation of NEK7 gene CTD PMID:27153756 Aroclor 1254 decreases expression ISO RGD:1322472 6480464 Chlorodiphenyl 54% Chlorine results in decreased expression of NEK7 mRNA CTD PMID:23650126 arsenous acid increases expression ISO RGD:1322471 6480464 Arsenic Trioxide results in increased expression of NEK7 mRNA CTD PMID:22521957 benzo[a]pyrene increases mutagenesis ISO RGD:1322471 6480464 Benzoapyrene results in increased mutagenesis of NEK7 gene CTD PMID:25435355 benzo[a]pyrene increases methylation ISO RGD:1322471 6480464 Benzoapyrene results in increased methylation of NEK7 3' UTR CTD PMID:27901495 benzo[a]pyrene increases methylation ISO RGD:1322472 6480464 Benzoapyrene results in increased methylation of NEK7 intron CTD PMID:27901495 benzo[a]pyrene affects methylation ISO RGD:1322471 6480464 Benzoapyrene affects the methylation of NEK7 5' UTR CTD PMID:27901495 benzo[a]pyrene increases expression ISO RGD:1322472 6480464 Benzoapyrene results in increased expression of NEK7 mRNA CTD PMID:15034205 benzo[a]pyrene multiple interactions ISO RGD:1322472 6480464 AHR protein inhibits the reaction [Benzoapyrene results in increased expression of NEK7 mRNA] CTD PMID:15034205 benzo[a]pyrene decreases expression ISO RGD:1322472 6480464 Benzoapyrene results in decreased expression of NEK7 mRNA CTD PMID:19770486 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1322471 6480464 7 more ... CTD PMID:19150397 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of NEK7 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:1322471 6480464 bisphenol A results in decreased expression of NEK7 mRNA CTD PMID:29275510 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of NEK7 mRNA CTD PMID:25181051 carbon nanotube decreases expression ISO RGD:1322472 6480464 Nanotubes, Carbon analog results in decreased expression of NEK7 mRNA CTD PMID:25554681 carbon nanotube increases expression ISO RGD:1322472 6480464 Nanotubes, Carbon analog results in increased expression of NEK7 mRNA CTD PMID:25620056 cisplatin decreases expression ISO RGD:1322471 6480464 Cisplatin results in decreased expression of NEK7 mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1322471 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of NEK7 mRNA CTD PMID:27392435 cobalt dichloride increases expression ISO RGD:1322471 6480464 cobaltous chloride results in increased expression of NEK7 mRNA CTD PMID:19376846 crocidolite asbestos decreases expression ISO RGD:1322472 6480464 Asbestos, Crocidolite results in decreased expression of NEK7 mRNA CTD PMID:29279043 cyclosporin A decreases expression ISO RGD:1322472 6480464 Cyclosporine results in decreased expression of NEK7 mRNA CTD PMID:19770486 diarsenic trioxide increases expression ISO RGD:1322471 6480464 Arsenic Trioxide results in increased expression of NEK7 mRNA CTD PMID:22521957 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of NEK7 mRNA CTD PMID:21266533 dicrotophos decreases expression ISO RGD:1322471 6480464 dicrotophos results in decreased expression of NEK7 mRNA CTD PMID:28302478 ethanol multiple interactions ISO RGD:1322472 6480464 Ethanol affects the expression of and affects the splicing of NEK7 mRNA CTD PMID:30319688 finasteride increases expression EXP 6480464 Finasteride results in increased expression of NEK7 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of NEK7 mRNA CTD PMID:24136188 folic acid decreases expression ISO RGD:1322472 6480464 Folic Acid results in decreased expression of NEK7 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:1322472 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of NEK7 mRNA CTD PMID:22206623 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NEK7 mRNA CTD PMID:22061828 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of NEK7 mRNA CTD PMID:22061828 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of NEK7 mRNA CTD PMID:30467583 nickel atom decreases expression ISO RGD:1322471 6480464 Nickel results in decreased expression of NEK7 mRNA CTD PMID:23195993 paracetamol affects expression ISO RGD:1322472 6480464 Acetaminophen affects the expression of NEK7 mRNA CTD PMID:17562736 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1322471 6480464 perfluorooctane sulfonic acid results in decreased expression of NEK7 mRNA CTD PMID:27153767 phenobarbital affects expression ISO RGD:1322472 6480464 Phenobarbital affects the expression of NEK7 mRNA CTD PMID:23091169 pirinixic acid increases expression ISO RGD:1322472 6480464 pirinixic acid results in increased expression of NEK7 mRNA CTD PMID:18301758 , PMID:18445702 propiconazole decreases expression ISO RGD:1322472 6480464 propiconazole results in decreased expression of NEK7 mRNA CTD PMID:21278054 raloxifene affects expression ISO RGD:1322471 6480464 Raloxifene Hydrochloride affects the expression of NEK7 mRNA CTD PMID:14699072 rimonabant multiple interactions ISO RGD:1322472 6480464 Rimonabant inhibits the reaction [Dietary Fats results in increased expression of NEK7 mRNA] CTD PMID:19030233 rimonabant affects expression ISO RGD:1322472 6480464 Rimonabant affects the expression of NEK7 mRNA CTD PMID:19030233 silicon dioxide increases expression ISO RGD:1322471 6480464 Silicon Dioxide analog results in increased expression of NEK7 mRNA CTD PMID:25895662 sulindac decreases expression EXP 6480464 Sulindac results in decreased expression of NEK7 mRNA CTD PMID:24136188 tamoxifen multiple interactions ISO RGD:1322471 6480464 ESR1 protein affects the reaction [Tamoxifen results in decreased expression of NEK7 mRNA] CTD PMID:14699072 tamoxifen affects expression ISO RGD:1322471 6480464 Tamoxifen affects the expression of NEK7 mRNA CTD PMID:14699072 testosterone multiple interactions EXP 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of NEK7 mRNA CTD PMID:26496021 urethane increases expression ISO RGD:1322471 6480464 Urethane results in increased expression of NEK7 mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:1322471 6480464 Valproic Acid results in decreased methylation of NEK7 gene CTD PMID:29154799 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of NEK7 mRNA CTD PMID:20566332 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of NEK7 mRNA CTD PMID:19015723 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of NEK7 mRNA CTD PMID:23034163
Biological Process
positive regulation of telomerase activity ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomerase activity involved_in ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomerase activity involved_in IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomerase activity IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomere capping ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomere capping involved_in ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomere capping involved_in IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomere capping IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomere maintenance via telomerase ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomere maintenance via telomerase involved_in ISO RGD:1322471 1624291 PMID:21531765 RGD PMID:21531765 positive regulation of telomere maintenance via telomerase involved_in IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of telomere maintenance via telomerase IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation IEA UniProtKB:Q8TDX7 , ensembl:ENSP000003563551600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein phosphorylation involved_in ISO RGD:1322471 1624291 PMID:12840024 , PMID:31409757 RGD PMID:12840024 , PMID:31409757 protein phosphorylation involved_in ISS UniProtKB:Q8TDX7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein phosphorylation ISS UniProtKB:Q8TDX7 1600115 GO_REF:0000024 UniProt GO_REF:0000024 protein phosphorylation ISO RGD:1322471 1624291 PMID:12840024 , PMID:31409757 RGD PMID:12840024 , PMID:31409757
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 1 107975663 Rat 1354666 Bp244 Blood pressure QTL 244 4.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 1 107975663 Rat 1581554 Pur11 Proteinuria QTL 11 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581573 Uae36 Urinary albumin excretion QTL 36 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 13 9016906 82995569 Rat 1581570 Eae17 Experimental allergic encephalomyelitis QTL 17 4.1 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 12193394 108478121 Rat 9589141 Insul28 Insulin level QTL 28 10.82 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 13 14096330 59096330 Rat 7411662 Foco29 Food consumption QTL 29 20.8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 13 14096330 59096330 Rat 2317040 Aia21 Adjuvant induced arthritis QTL 21 2.75 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 2317046 Aia8 Adjuvant induced arthritis QTL 8 3.9700000286102295 joint integrity trait (VT:0010548) left rear ankle joint diameter (CMO:0002149) 13 14624631 59624631 Rat 631645 Bp121 Blood pressure QTL 121 3.3 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 19810814 64810814 Rat 9589164 Gluco66 Glucose level QTL 66 6.67 0.001 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 13 20052477 65052477 Rat 1331784 Bp222 Blood pressure QTL 222 2.944 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 21482481 58537177 Rat 7207885 Glom27 Glomerulus QTL 27 3.9 kidney glomerulus integrity trait (VT:0010546) kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139) 13 24502279 108770533 Rat 61391 Bp5 Blood pressure QTL 5 5.6 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 28008338 73008338 Rat 70170 Eae14 Experimental allergic encephalomyelitis QTL 14 0.0024 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046) 13 28584452 73584452 Rat 1558644 Cm45 Cardiac mass QTL 45 3.6 0.002 heart mass (VT:0007028) heart wet weight (CMO:0000069) 13 29076934 74076934 Rat 6893338 Cm76 Cardiac mass QTL 76 0 0.99 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 29076934 74076934 Rat 1354621 Rf47 Renal function QTL 47 3.7 kidney renin amount (VT:0010559) kidney renin level (CMO:0002166) 13 35301263 107975663 Rat 2301962 Cm72 Cardiac mass QTL 72 4.12 heart left ventricle mass (VT:0007031) heart left ventricle weight (CMO:0000776) 13 36147533 64868393 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 36147533 99968921 Rat 70181 BpQTLcluster11 Blood pressure QTL cluster 11 6.922 arterial blood pressure trait (VT:2000000) absolute change in mean arterial blood pressure (CMO:0000533) 13 36147533 99968921 Rat 2303563 Bw89 Body weight QTL 89 6 body mass (VT:0001259) body weight (CMO:0000012) 13 37346348 82346348 Rat 61340 Bp25 Blood pressure QTL 25 4.2 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39372927 84372927 Rat 10755495 Bp387 Blood pressure QTL 387 3.78 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 39501300 93652524 Rat 4889861 Pur29 Proteinuria QTL 29 13.8 0.005 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 13 42310744 86833540 Rat 1331750 Bp220 Blood pressure QTL 220 2.98 arterial blood pressure trait (VT:2000000) diastolic blood pressure (CMO:0000005) 13 42310744 87310744 Rat 70220 Bp55 Blood pressure QTL 55 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 61349 Bp31 Blood pressure QTL 31 5.75 arterial blood pressure trait (VT:2000000) blood pressure measurement (CMO:0000003) 13 42508345 87508345 Rat 1549897 Stresp12 Stress response QTL 12 3.35 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 13 43575717 88575717 Rat 619615 Bp80 Blood pressure QTL 80 0.0354 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 45676629 90676629 Rat 6893344 Cm79 Cardiac mass QTL 79 1.5 0.04 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 13 49058507 67207219 Rat 12879441 Bp396 Blood pressure QTL 396 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 13 51080989 96080989 Rat 1298066 Bp159 Blood pressure QTL 159 0.004 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 13 51569248 96569248 Rat 71119 Thym2 Thymus enlargement QTL 2 3.8 thymus mass (VT:0004954) thymus weight to body weight ratio (CMO:0000612) 13 51577824 90675199 Rat