Ghrh (growth hormone releasing hormone) - Rat Genome Database

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Gene: Ghrh (growth hormone releasing hormone) Rattus norvegicus
Analyze
Symbol: Ghrh
Name: growth hormone releasing hormone
RGD ID: 61883
Description: Exhibits growth hormone-releasing hormone activity. Involved in several processes, including circadian sleep/wake cycle, non-REM sleep; growth hormone secretion; and positive regulation of cell communication. Localizes to axon terminus; extracellular space; and perikaryon. Used to study myocardial infarction and prostatic hypertrophy. Biomarker of sleep disorder. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome type 1; endometrial cancer; ovarian cancer; and renal cell carcinoma. Orthologous to human GHRH (growth hormone releasing hormone); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: GHRF; GRF; growth hormone-releasing factor; growth hormone-releasing hormone; somatoliberin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23145,992,762 - 146,012,528 (-)NCBI
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03153,449,124 - 153,468,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03158,251,824 - 158,270,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,027,235 - 148,046,352 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13147,933,144 - 147,952,261 (-)NCBI
Celera3144,698,178 - 144,717,216 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Ambati S, etal., Biofactors. 2007;31(2):133-44.
2. Asa SL, etal., Endocrinology. 1992 Nov;131(5):2083-9.
3. Bagnato A, etal., Endocrinology. 1992 Mar;130(3):1097-102.
4. Boulanger L, etal., Peptides 2002 Jan;23(1):43-50.
5. Brazeau P, etal., Proc Natl Acad Sci U S A. 1982 Dec;79(24):7909-13.
6. Cai R, etal., Peptides. 2014 Feb;52:104-12. doi: 10.1016/j.peptides.2013.12.010. Epub 2013 Dec 25.
7. Carbone DL, etal., Endocrinology. 2012 Jan;153(1):295-306. doi: 10.1210/en.2011-1601. Epub 2011 Nov 8.
8. Chatzistamou I, etal., J Cancer Res Clin Oncol. 2001 Nov;127(11):645-52.
9. Ciocca DR, etal., Breast Cancer Res Treat. 1990 May;15(3):175-84.
10. Cocco C, etal., Autoimmunity. 2012 Sep;45(6):485-94. doi: 10.3109/08916934.2012.680632. Epub 2012 May 18.
11. Cunha SR and Mayo KE, Endocrinology 2002 Dec;143(12):4570-82.
12. De A, etal., Brain Res. 2002 Sep 13;949(1-2):209-12.
13. Engel JB, etal., J Clin Endocrinol Metab. 2005 Jun;90(6):3614-21. Epub 2005 Mar 22.
14. Feng XW, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 Nov;21(4):414-7.
15. Feng XW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2006 Apr;29(4):230-2.
16. Friedman SD, etal., JAMA Neurol. 2013 Jul;70(7):883-90. doi: 10.1001/jamaneurol.2013.1425.
17. Frohman LA and Kineman RD, Minerva Endocrinol. 2002 Dec;27(4):277-85.
18. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. GOA data from the GO Consortium
20. Gonzalez-Crespo S and Boronat A, Proc Natl Acad Sci U S A 1991 Oct 1;88(19):8749-53.
21. Granata R, etal., Cardiovasc Res. 2009 Jul 15;83(2):303-12. Epub 2009 Mar 17.
22. Halmos G, etal., J Clin Endocrinol Metab. 2002 Oct;87(10):4707-14.
23. Halmos G, etal., Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10555-60.
24. Jaszberenyi M, etal., Aging (Albany NY). 2012 Nov;4(11):755-67.
25. Kahan Z, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):582-9.
26. Kanashiro-Takeuchi RM, etal., Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2604-9. Epub 2010 Jan 21.
27. Khorram O, etal., Fertil Steril. 2001 Jan;75(1):174-9.
28. Kunz D, etal., BMC Genomics. 2009 Feb 24;10:90.
29. Leggett J, etal., Endocrinology. 2013 Sep;154(9):3305-18. doi: 10.1210/en.2012-2175. Epub 2013 Jul 3.
30. Liao F, etal., J Neurosci. 2010 Mar 17;30(11):4151-9. doi: 10.1523/JNEUROSCI.6047-09.2010.
31. Ludwig B, etal., Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):5022-7. doi: 10.1073/pnas.1201868109. Epub 2012 Mar 5.
32. Madaschi L, etal., Neurochem Res. 2003 Jan;28(1):163-8.
33. Majeed N, etal., Oncogene. 2005 Jul 7;24(29):4736-40.
34. Mayo KE, etal., Nature. 1985 Apr 4-10;314(6010):464-7.
35. Merchenthaler I, etal., Endocrinology. 1984 Apr;114(4):1082-5.
36. MGD data from the GO Consortium
37. Morishita M, etal., J Mol Endocrinol. 2003 Dec;31(3):441-8.
38. Nair D, etal., J Neurochem. 2013 Nov;127(4):531-40. doi: 10.1111/jnc.12360. Epub 2013 Jul 19.
39. NCBI rat LocusLink and RefSeq merged data July 26, 2002
40. Negishi T, etal., Endocrinology. 1999 Dec;140(12):5691-7.
41. Pals K, etal., J Neuroendocrinol. 2008 May;20(5):535-48. Epub 2008 Mar 15.
42. Perez-Riba M, etal., FEBS Lett. 1997 Feb 3;402(2-3):273-6.
43. Peterfi Z, etal., Am J Physiol Regul Integr Comp Physiol. 2010 Jan;298(1):R147-56. Epub 2009 Nov 4.
44. Peterfi Z, etal., Brain Res. 2006 Sep 7;1108(1):133-46. Epub 2006 Jul 21.
45. RGD automated data pipeline
46. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. RGD automated import pipeline for gene-chemical interactions
48. RGD comprehensive gene curation
49. Rick FG, etal., J Urol. 2012 Apr;187(4):1498-504. doi: 10.1016/j.juro.2011.11.081. Epub 2012 Feb 17.
50. Rick FG, etal., Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3755-60. doi: 10.1073/pnas.1018086108. Epub 2011 Feb 14.
51. Shohreh R, etal., Endocrinology. 2011 Oct;152(10):3803-10. Epub 2011 Aug 16.
52. Srivastava CH, etal., Endocrinology. 1995 Apr;136(4):1502-8.
53. Szentirmai E, etal., Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R922-30. Epub 2007 May 30.
54. Tarasiuk A, etal., Eur Respir J. 2011 Oct;38(4):870-7. Epub 2011 Mar 15.
55. Wren AM, etal., Neuroendocrinology 2002 Nov;76(5):316-24.
Additional References at PubMed
PMID:1333056   PMID:1334535   PMID:2857452   PMID:3008329   PMID:6406907   PMID:7680413   PMID:7694848   PMID:7867561   PMID:7912976   PMID:7980597   PMID:8391647   PMID:8395283  
PMID:8421089   PMID:9348175   PMID:10537133   PMID:11773624   PMID:12867592   PMID:12876464   PMID:15070777   PMID:15146101   PMID:15538933   PMID:15985453   PMID:16246898   PMID:16513828  
PMID:16728494   PMID:18329818   PMID:18628614   PMID:19553459   PMID:20814072   PMID:23417421   PMID:26831066   PMID:27480202  


Genomics

Candidate Gene Status
Ghrh is a candidate Gene for QTL Slep7
Ghrh is a candidate Gene for QTL Bw94
Ghrh is a candidate Gene for QTL Scl63
Comparative Map Data
Ghrh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23145,992,762 - 146,012,528 (-)NCBI
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03153,449,124 - 153,468,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03158,251,824 - 158,270,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43148,027,235 - 148,046,352 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13147,933,144 - 147,952,261 (-)NCBI
Celera3144,698,178 - 144,717,216 (-)NCBICelera
Cytogenetic Map3q42NCBI
GHRH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2037,251,086 - 37,261,814 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2037,251,082 - 37,261,835 (-)EnsemblGRCh38hg38GRCh38
GRCh382037,251,086 - 37,261,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372035,879,489 - 35,890,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362035,312,903 - 35,318,706 (-)NCBINCBI36hg18NCBI36
Build 342035,312,902 - 35,318,706NCBI
Celera2032,586,769 - 32,592,579 (-)NCBI
Cytogenetic Map20q11.23NCBI
HuRef2032,615,081 - 32,620,891 (-)NCBIHuRef
CHM1_12035,782,445 - 35,788,267 (-)NCBICHM1_1
Ghrh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392157,171,416 - 157,190,645 (-)NCBIGRCm39mm39
GRCm39 Ensembl2157,171,417 - 157,189,426 (-)Ensembl
GRCm382157,329,496 - 157,348,725 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2157,329,497 - 157,347,506 (-)EnsemblGRCm38mm10GRCm38
MGSCv372157,155,232 - 157,172,391 (-)NCBIGRCm37mm9NCBIm37
MGSCv362157,020,942 - 157,038,038 (-)NCBImm8
Celera2163,265,842 - 163,283,112 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map278.25NCBI
Ghrh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542224,481,246 - 24,490,529 (+)NCBIChiLan1.0ChiLan1.0
GHRH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12034,687,587 - 34,693,258 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2034,687,587 - 34,693,240 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02033,573,001 - 33,583,699 (-)NCBIMhudiblu_PPA_v0panPan3
GHRH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12425,893,224 - 25,902,095 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2425,893,225 - 25,897,712 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2425,542,127 - 25,546,302 (-)NCBI
ROS_Cfam_1.02426,590,708 - 26,594,898 (-)NCBI
UMICH_Zoey_3.12425,867,994 - 25,872,168 (-)NCBI
UNSW_CanFamBas_1.02425,973,219 - 25,977,394 (-)NCBI
UU_Cfam_GSD_1.02426,462,493 - 26,466,667 (-)NCBI
Ghrh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640174,794,985 - 174,803,395 (-)NCBI
SpeTri2.0NW_0049365613,946,256 - 3,954,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHRH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1740,387,344 - 40,397,857 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11740,386,725 - 40,398,312 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21745,876,581 - 45,887,302 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GHRH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1226,482,734 - 26,493,761 (+)NCBI
ChlSab1.1 Ensembl226,487,973 - 26,493,499 (+)Ensembl
Ghrh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046251465,484 - 8,763 (-)NCBI

Position Markers
D3Got116  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03153,469,939 - 153,470,103NCBIRnor6.0
Rnor_5.03158,249,942 - 158,250,106UniSTSRnor5.0
RGSC_v3.43148,048,069 - 148,048,234RGDRGSC3.4
RGSC_v3.43148,048,070 - 148,048,234UniSTSRGSC3.4
RGSC_v3.13147,953,978 - 147,954,143RGD
Celera3144,718,934 - 144,719,098UniSTS
RH 3.4 Map31351.2RGD
RH 3.4 Map31351.2UniSTS
RH 2.0 Map3910.9RGD
Cytogenetic Map3q42UniSTS
D3Got118  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03153,469,939 - 153,470,081NCBIRnor6.0
Rnor_5.03158,249,964 - 158,250,106UniSTSRnor5.0
RGSC_v3.43148,048,069 - 148,048,212RGDRGSC3.4
RGSC_v3.43148,048,070 - 148,048,212UniSTSRGSC3.4
RGSC_v3.13147,953,979 - 147,954,121RGD
Celera3144,718,934 - 144,719,076UniSTS
RH 3.4 Map31355.2RGD
RH 3.4 Map31355.2UniSTS
RH 2.0 Map3917.7RGD
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3138374177177699992Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3138374177177699992Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3139578365177699992Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3146232777177699992Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3147072047154807958Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3148034701177699992Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3148348517171467264Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3148348739163640325Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3150368003177699992Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153381237174632112Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3153381237174632112Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3153381237174632112Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3153381237174632112Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3153381237174632112Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3153381237174632112Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3153381237174632112Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3153412455165355668Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)3153412455170534769Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3153412455177699992Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000010298, ENSRNOT00000010443
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 6 31 15 18 15 5 5 62 9 13 10 5
Below cutoff 1 18 9 9 1 9 3 3 8 14 22 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U10156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U41183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z34092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000010298   ⟹   ENSRNOP00000010298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3153,450,086 - 153,454,160 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000010443   ⟹   ENSRNOP00000010444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3153,449,125 - 153,468,221 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082145   ⟹   ENSRNOP00000072891
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3153,449,125 - 153,468,794 (-)Ensembl
RefSeq Acc Id: NM_031577   ⟹   NP_113765
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23145,992,762 - 146,011,889 (-)NCBI
Rnor_6.03153,449,124 - 153,468,221 (-)NCBI
Rnor_5.03158,251,824 - 158,270,812 (+)NCBI
RGSC_v3.43148,027,235 - 148,046,352 (-)RGD
Celera3144,698,178 - 144,717,216 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762304   ⟹   XP_008760526
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23145,992,762 - 146,012,528 (-)NCBI
Rnor_6.03153,449,124 - 153,468,794 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113765   ⟸   NM_031577
- Peptide Label: precursor
- UniProtKB: P09916 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008760526   ⟸   XM_008762304
- Peptide Label: isoform X1
- UniProtKB: P09916 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072891   ⟸   ENSRNOT00000082145
RefSeq Acc Id: ENSRNOP00000010444   ⟸   ENSRNOT00000010443
RefSeq Acc Id: ENSRNOP00000010298   ⟸   ENSRNOT00000010298
Protein Domains
GLUCAGON

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61883 AgrOrtholog
Ensembl Genes ENSRNOG00000007782 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010298 UniProtKB/TrEMBL
  ENSRNOP00000010444 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072891 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010298 UniProtKB/TrEMBL
  ENSRNOT00000010443 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000082145 UniProtKB/Swiss-Prot
InterPro Glucagon_GIP_secretin_VIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29446 UniProtKB/Swiss-Prot
NCBI Gene 29446 ENTREZGENE
Pfam Hormone_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ghrh PhenoGen
PROSITE GLUCAGON UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART GLUCA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt P09916 ENTREZGENE
  P97567_RAT UniProtKB/TrEMBL
  SLIB_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ghrh  growth hormone releasing hormone      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference