Il13ra1 (interleukin 13 receptor subunit alpha 1)

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Gene: Il13ra1 (interleukin 13 receptor subunit alpha 1) Rattus norvegicus

Analyze

Symbol:

Il13ra1

Name:

interleukin 13 receptor subunit alpha 1

RGD ID:

628741

Description:

Enables interleukin-13 receptor activity. Involved in positive regulation of B cell proliferation and positive regulation of immunoglobulin production. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human IL13RA1 (interleukin 13 receptor subunit alpha 1); PARTICIPATES IN interleukin-4 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-amino-2-deoxy-D-glucopyranose.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1; MGC105309

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Related Pseudogenes:

Il13ra1-ps1

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	115,348,860 - 115,408,682 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	115,348,860 - 115,408,681 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	117,450,135 - 117,510,865 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,019,209 - 121,079,947 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	118,565,417 - 118,626,152 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	122,724,081 - 122,783,801 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	122,724,129 - 122,781,479 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	122,873,725 - 122,933,124 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	8,758,662 - 8,820,545 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	8,764,214 - 8,826,101 (-)	NCBI
Celera	X	114,585,012 - 114,644,379 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (ISO)

atopic dermatitis (ISO)

autistic disorder (ISO)

bronchiolitis obliterans (ISO)

chronic obstructive pulmonary disease (ISO)

genetic disease (ISO)

psoriasis (ISO)

pulmonary hypertension (ISO)

syndromic X-linked intellectual disability Cabezas type (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

systemic scleroderma (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

benzene (EXP)

benzo[a]pyrene (ISO)

beta-D-glucosamine (EXP)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bleomycin A2 (ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

Calcimycin (ISO)

cannabidiol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclophosphamide (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (ISO)

diclofenac (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

ferulic acid (ISO)

fipronil (EXP)

fluoranthene (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

heptachlor (EXP)

imiquimod (ISO)

irinotecan (EXP)

isotretinoin (ISO)

L-methionine (ISO)

lipopolysaccharide (ISO)

mercury dibromide (ISO)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylmercury(1+) (EXP)

mycotoxin (ISO)

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (ISO)

N-methyl-4-phenylpyridinium (ISO)

nefazodone (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (EXP,ISO)

protein kinase inhibitor (ISO)

SB 431542 (ISO)

senecionine (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

Soman (EXP)

succimer (ISO)

sulindac sulfide (ISO)

sunitinib (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

toluene (EXP)

topotecan (EXP)

torcetrapib (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cytokine-mediated signaling pathway (IBA)

interleukin-13-mediated signaling pathway (IEA)

positive regulation of B cell proliferation (IDA)

positive regulation of immunoglobulin production (IDA)

Cellular Component

external side of plasma membrane (IBA)

receptor complex (IBA)

Molecular Function

cytokine binding (IBA)

cytokine receptor activity (IBA)

interleukin-13 receptor activity (IPI)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cytokine mediated signaling pathway (IEA)

interleukin-4 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Novel polymorphism in the coding region of the IL-13 receptor alpha' gene: association study with atopic asthma in the Japanese population.	Ahmed S, etal., Exp Clin Immunogenet. 2000;17(1):18-22.
2.	Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease.	Beghe B, etal., Allergy. 2010 Apr;65(4):474-81. Epub 2009 Oct 1.
3.	IL-13 fusion cytotoxin ameliorates chronic fungal-induced allergic airway disease in mice.	Blease K, etal., J Immunol. 2001 Dec 1;167(11):6583-92.
4.	Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.	Broen JC, etal., J Rheumatol. 2012 Jan;39(1):112-8. doi: 10.3899/jrheum.110235. Epub 2011 Nov 1.
5.	Upregulation of interleukin-13 receptor chains in bronchial smooth muscle tissues of mouse experimental asthma.	Chiba Y, etal., J Smooth Muscle Res. 2010;46(1):49-55.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.	Graham BB, etal., Am J Pathol. 2010 Sep;177(3):1549-61. Epub 2010 Jul 29.
9.	IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome.	Keane MP, etal., J Immunol. 2007 Jan 1;178(1):511-9.
10.	Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma.	Kim HB, etal., J Hum Genet. 2006;51(12):1055-62. Epub 2006 Sep 28.
11.	Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy.	Konstantinidis AK, etal., Eur Respir J. 2007 Jul;30(1):40-7. Epub 2007 Mar 28.
12.	Analysis of polymorphisms in olive pollen allergy: IL13, IL4RA, IL5 and ADRB2 genes.	Llanes E, etal., Int Arch Allergy Immunol. 2009;148(3):228-38. doi: 10.1159/000161583. Epub 2008 Oct 10.
13.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
14.	Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.	Munitz A, etal., Proc Natl Acad Sci U S A. 2008 May 20;105(20):7240-5. Epub 2008 May 14.
15.	Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.	Pendergrass SA, etal., PLoS One. 2010 Aug 17;5(8):e12106.
16.	Expression of a functional IL-13Ralpha1 by rat B cells.	Pierrot C, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):969-76.
17.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
18.	GOA pipeline	RGD automated data pipeline
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis.	Wongpiyabovorn J, etal., J Dermatol Sci. 2003 Oct;33(1):31-40.

Additional References at PubMed

PMID:12477932

Genomics

Comparative Map Data

Il13ra1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	115,348,860 - 115,408,682 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	115,348,860 - 115,408,681 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	117,450,135 - 117,510,865 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	X	121,019,209 - 121,079,947 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	X	118,565,417 - 118,626,152 (+)	NCBI	Rnor_WKY
Rnor_6.0	X	122,724,081 - 122,783,801 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	122,724,129 - 122,781,479 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	122,873,725 - 122,933,124 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	8,758,662 - 8,820,545 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	8,764,214 - 8,826,101 (-)	NCBI
Celera	X	114,585,012 - 114,644,379 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

IL13RA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	118,727,606 - 118,805,228 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	X	118,727,133 - 118,794,535 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	117,861,569 - 117,928,496 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	117,745,587 - 117,812,524 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	117,643,440 - 117,710,378	NCBI
Celera	X	118,316,317 - 118,383,340 (+)	NCBI		Celera
Cytogenetic Map	X	q24	NCBI
HuRef	X	107,355,737 - 107,421,582 (+)	NCBI		HuRef
CHM1_1	X	117,772,468 - 117,839,397 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	117,105,336 - 117,182,975 (+)	NCBI		T2T-CHM13v2.0

Il13ra1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	35,375,761 - 35,434,915 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	35,375,763 - 35,434,912 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	36,112,108 - 36,171,262 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	36,112,110 - 36,171,259 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	33,652,134 - 33,711,257 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	32,543,584 - 32,602,707 (+)	NCBI		MGSCv36	mm8
Celera	X	22,841,197 - 22,900,025 (+)	NCBI		Celera
Cytogenetic Map	X	A3.3	NCBI
cM Map	X	20.49	NCBI

Il13ra1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955534	1,160,340 - 1,204,911 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955534	1,157,758 - 1,205,158 (-)	NCBI	ChiLan1.0	ChiLan1.0

IL13RA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	X	118,089,492 - 118,167,836 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	107,735,233 - 107,813,282 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	118,195,828 - 118,269,449 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	118,202,285 - 118,266,770 (+)	Ensembl	panpan1.1		panPan2

IL13RA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	90,925,497 - 90,981,855 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	90,924,801 - 90,979,963 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	77,001,059 - 77,055,772 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	92,665,536 - 92,720,247 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	92,665,506 - 92,720,247 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	90,118,717 - 90,173,430 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	91,877,457 - 91,932,160 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	91,605,785 - 91,660,491 (+)	NCBI		UU_Cfam_GSD_1.0

Il13ra1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	89,878,479 - 89,937,244 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	11,050,249 - 11,108,909 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936479	11,052,077 - 11,108,915 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL13RA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	97,300,466 - 97,356,133 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	97,300,960 - 97,353,754 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	114,333,596 - 114,386,429 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

IL13RA1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	31,471,060 - 31,545,965 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il13ra1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624895	2,706,043 - 2,763,798 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624895	2,706,225 - 2,763,489 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Il13ra1
104 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	825
Count of miRNA genes:	309
Interacting mature miRNAs:	421
Transcripts:	ENSRNOT00000017746
Prediction methods:	Microtar, Miranda, Pita, Pita,Targetscan, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	112934952	138400867	Rat
5685004	Bss104	Bone structure and strength QTL 104	3.9		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	X	113805422	126975220	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_145789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC093615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000455	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_145789 ⟹ NP_665732

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	115,348,860 - 115,408,682 (+)	NCBI
Rnor_6.0	X	122,724,081 - 122,783,801 (+)	NCBI
Rnor_5.0	X	122,873,725 - 122,933,124 (+)	NCBI
RGSC_v3.4	X	8,758,662 - 8,820,545 (-)	RGD
Celera	X	114,585,012 - 114,644,379 (+)	RGD

Sequence:

show sequence

GAGACTGCCGCGGCTCCAGCCGGGCCGGGCTCGGAGGCGAGGGGCTGCATGGCGCGGCCAGCGT
GGCTGGGCGAGCTGTTGGTGCTGCTGCTTTTTGCCGCCTCCCTGGACCAAGTTGCCCTGGCCAC
AGAAGTTCAGCCACCTGTAACGAATTTGAGTGTCTCTGTCGAAAATCTCTGCACAATAGTGTGG
ACATGGAGTCCTCCTGAGGGAGCCAGTCCAAATTGCAGTCTCAGATATTTTAGTCATTTTGATG
ACCAACAGGATAAGAAAATTGCTCCTGAAACTCGTCGTAAAAAGGAATTACCCCTAAATGAGAA
AATCTGTCTGCAAGTGGGGTCCCAGTGTAGCACCAATGAAAGTGAGAAGCCTAGCCCTTTGGTG
AAAAAGTGCATCTCACCCCCCGAAGGGGATCCTGAGTCTGCTGTGACCGAACTGCAGTGCATTT
GGCACAACCTGAGCTATATGAAGTGTTCCTGGCTCCCTGGAAAGAATACAAGCCCGGACACCAA
CTATACTCTTTACTATTGGTACAGCAGCCTGGGGAAAAGTCTTCAATGTGAAAACATCCACAGA
GAAGGTCAACACATTGGTTGTTCCTTTAAATTGACTAAAGTGGAATCTAATTATGAACATCATA
ACATTCAGATAATGGTCAAGGATAATGCTGGGAAAATTAGGCCATCCTACAAAATAGTGTCCTT
CACTTCCAATGTGAAACCCGGTCCTCCACATATTAAACATCTTTTCCTCAAAAATGGTGCCTTA
TTCGTGCAGTGGAAGAACCCACAGAATTTCAGTAGCAGATGTTTGTCTTATGAAGTAGAAGTCA
ATAGCACTCAAACTGACAGCTATAATTCTAACTCTTTAGAGGTTGAAGAGGACAAATGCCAGAA
TTCTGAATTTGATAGAAACATGGAGGGTGCAAGTTGTTTCATATCTCCCGGTGTTCTTGCCAAC
ACTGTCTACACAGTCAGAGTAAGAGTCAAAACAAACAAGTTATGCTTTGATGACAACGACCTGT
GGAGTAATTGGAGCGAAGCGCTGAGTATAGGTAAGGAGCCGAATTCCACCTTCTACACCACCAT
GTTACTCATCATTCCAGTCTTTGTCGCAGTGGTAATCATAATTCTCCTTTTTTACCTGAAAAGG
CTTAAGATCATTATATTTCCTCCAATTCCTGATCCTGGCAAGATTTTTAAAGAAATGTTTGGAG
ACCAGAATGATGATACCCTGCACTGGAAAAAGTATGACATCTATGAGAAACAATCGAAAGAAGA
AACCGACTCTGTAGTGCTGATAGAAAACCTGAAGAAAGCGGCTCCATGATGGGGACTCGAGATT
TCTTTTTTGCCTTTAATGTGACCCTGTGAAGATTTATTGCATTCTCCATTTGTTATCTGGGGAC
TCGTTAAATAGAAACTGAAACTACTCTTGAAAAACAGGCAGCTCCTAAGAGCCTCAGGTCTTGA
TGTGACTCTTGCACCAAAAATCCAAACTAAAGGAGCTCTTCAAGAAAAGCAGAGTTCTTCTCAT
TCTTGCTCAATCCTAAAAGCAGATGTCCTTTGCAAAATCTCCAAACTAGAGGACAAAGAAAAGG
GAGCAATGACCATGAATTCATCTTATCAGGAATTGTGACGGCTTCCTAAGGAATCTCTGCTTGC
TCTGTATTCTTTGTGTGGAATAAGATCAAGAAATGTTTCTTGAGAGGAATTTCATTTGGGGTGT
GTACACTAATGTTGTACTTACCACAGAACATCTAGCAAACAAAACTGATAGAATCTGCTGCCTA
TTGTTCAGGAACCCACTGAGTAATATTTGTAGCTTTTAAACTACAATATCATTATCTACTTCAA
TAGCATTTTCCTCTGATTGGAAATTCCCAGAAATCATCTTGGACCATGGTAATGACACGTAGAG
AAAAGGCATAGGCAACTTTTCCACCAAGGCTGATTTATGTCATTGCTTGTCTTTTAGGACAGTG
GAGGCAGAATGAGGTAGTCTCTAATGATGGATGCTTACCTTTCATTTCTGCTACTCAAGTCAAG
TATAGACTATGTATCTAGCTTGTGCCAAACCTTTAAGTATGAGGAGGGATGGGACCTCCCACCC
ATGGGTTTACATATATTTGGGGCTCCTTATTTTTCATCACCTTCTTTATCCCCCAGATAGGCAT
TTCCGGACTTTTGAACTTCCCATCTTCTGTTTATGCCCCCATTGTGCCTACTCCCCCATCCTCT
TTCTTGTAACCTTTTCACTCAGTGGAATTGAGGAGACAATTTTGCTTAGACTACCTAGTGGAGC
AGGAAATACTCTGCATCTCAGGTAAAAAAAATGAGTAGACTGAACAACAATATGTAATTCATGC
ATATTTTACAACTTCCCTGTGAGCCTGCAATTTGAGATTTTCAAGCAATTGGTGTTTCTGTGTG
TTTTCTAAATAGAGATGACGTCTTTTTTTTCCACTTAGAATTTAGCCCTATTTGCTTGAGAGGG
GGAAAAAATAAGATTCATATCTGTTTCTCTTTGTTTGCAAAATAAGCCGTACAATGGCTGTTTT
CTATGCTGTAAGTGGTCCTGTCAATTCTGTATTTTACTGAGAGGGAGGCAAGTGGAGCTCCAAC
TATGTGCTTGCTTTTTGCATATATTAGGTTTCCAATTCTATTCCCACAATATATGTTCATGTAC
ATCCCCCCATTCTGACCATTTCCTGAAAATTTAAAACAGTGAGAGTTACACCCCCTTCTCTTTC
TCCTACAGATCACTAGCCAGGACTGAAGCATTTGATATCAAAATTTTCCAGGCATGTATCAGTT
CCTGTTAATAAAACGATACCAGTTGCATCTCTTGTTCTTAAGCAGGGCAGATAAGAGACCCCTG
CTCTCCACAGGTTGGGACCACGGGGAACCTTGCTTGCCTGGTAGTGGAGGAGCATTGTGCCTGG
AATTTCAGGAAATAGGGGAACATGGCACAATTGATGCCATTTCCTCCTGGCACTTTTTGGTATC
AGATTGTGGCTGGGATACAGGCATTCTGGGTGTTGCAGTCTCCTATTAGTCAGTAGAAACAAGA
CTTCGCTTTCTTGCATAAGTGTGAAATACTCCTTCCCCGGGGTATCATAGTTCTGAGAAGGAAA
GCATCGTAAATGCCTTGTACAGAGCCATTGTTTACTACTGGCCTGTGTTGATGGAGCTGAAGAG
CATGTTTTGAAATGCTCTGGAAACCGTCAATGCTGACAGTCTTACAGCATGGAAACAAAGACAT
CCTATTTTGCTTCAAATTCTCATTCAGAAGTACAGTAGCAGGGGGGAAGGGGACAGACAGCAAA
TAGGAGTACCTTTGTTTTAACAGACAAAAGTAATCTCCAGGCCTTAAGAACTCTTCATGATATC
AGTACATTGCTTATTGGTAACTTGTAAGTTCATATATTGACGAAGGTATATAGATTTTTCCCCA
CTTACATACGTAAATCCAACATAAAGCGGACATTCCTACATTCCTTTCCTTTCATTCAGATGAT
GTTTCTGAATCTGGGCACTGAAGGGATGGCATACAATAATGTTAATGTTTTCAGTAATGTCTTC
AACTAGGAGGCTTTCTGTTGAACTACTTATACAGAAGTAAAATAAATATTGTCTTTTTGTATGT
CAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_665732	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH93615	(Get FASTA)	NCBI Sequence Viewer
	EDM10800	(Get FASTA)	NCBI Sequence Viewer
	EDM10801	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_665732 ⟸ NM_145789
- Peptide Label:	precursor
- UniProtKB:	Q561K3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARPAWLGELLVLLLFAASLDQVALATEVQPPVTNLSVSVENLCTIVWTWSPPEGASPNCSLRY FSHFDDQQDKKIAPETRRKKELPLNEKICLQVGSQCSTNESEKPSPLVKKCISPPEGDPESAVT ELQCIWHNLSYMKCSWLPGKNTSPDTNYTLYYWYSSLGKSLQCENIHREGQHIGCSFKLTKVES NYEHHNIQIMVKDNAGKIRPSYKIVSFTSNVKPGPPHIKHLFLKNGALFVQWKNPQNFSSRCLS YEVEVNSTQTDSYNSNSLEVEEDKCQNSEFDRNMEGASCFISPGVLANTVYTVRVRVKTNKLCF DDNDLWSNWSEALSIGKEPNSTFYTTMLLIIPVFVAVVIIILLFYLKRLKIIIFPPIPDPGKIF KEMFGDQNDDTLHWKKYDIYEKQSKEETDSVVLIENLKKAAP hide sequence

Protein Domains

Interleukin-13 receptor subunit alpha-1 Ig-like Type I cytokine receptor cytokine-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q561K3-F1-model_v2	AlphaFold	Q561K3	1-426	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701978

Promoter ID:

EPDNEW_R12501

Type:

initiation region

Name:

Il13ra1_1

Description:

interleukin 13 receptor subunit alpha 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	122,724,066 - 122,724,126	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628741	AgrOrtholog
BioCyc Gene	G2FUF-1324	BioCyc
Ensembl Genes	ENSRNOG00000001713	UniProtKB/TrEMBL
	ENSRNOG00000013170	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017746	ENTREZGENE
	ENSRNOP00000017746.5	UniProtKB/TrEMBL
	ENSRNOP00000070979.1	UniProtKB/TrEMBL
	ENSRNOP00000087106.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002330.6	UniProtKB/TrEMBL
	ENSRNOT00000017746	ENTREZGENE
	ENSRNOT00000017746.7	UniProtKB/TrEMBL
	ENSRNOT00000112175.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7310384	IMAGE-MGC_LOAD
InterPro	FN3_sf	UniProtKB/TrEMBL
	FN_III	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	Il13Ra_Ig	UniProtKB/TrEMBL
	IL6_recept_bd	UniProtKB/TrEMBL
	Short_hematopoietin_rcpt_2_CS	UniProtKB/TrEMBL
KEGG Report	rno:100360218	UniProtKB/TrEMBL
	rno:252963	UniProtKB/TrEMBL
MGC_CLONE	MGC:105309	IMAGE-MGC_LOAD
NCBI Gene	252963	ENTREZGENE
PANTHER	CYTOKINE RECEPTOR	UniProtKB/TrEMBL
	PTHR23037:SF35	UniProtKB/TrEMBL
Pfam	Il13Ra_Ig	UniProtKB/TrEMBL
	IL6Ra-bind	UniProtKB/TrEMBL
PhenoGen	Il13ra1	PhenoGen
PROSITE	HEMATOPO_REC_S_F2	UniProtKB/TrEMBL
Superfamily-SCOP	FN_III-like	UniProtKB/TrEMBL
UniProt	A0A8I6A7D4_RAT	UniProtKB/TrEMBL
	Q561K3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-16	Il13ra1	interleukin 13 receptor subunit alpha 1	Il13ra1	interleukin 13 receptor, alpha 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Il13ra1	interleukin 13 receptor, alpha 1			Symbol and Name status set to approved	1299863	APPROVED
2003-02-27	Il13ra1	interleukin 13 receptor, alpha 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	short intracellular domain with a proline rich motif and two conserved tyrosine residues	633067
gene_expression	mRNA and protein is expressed in rat B cells	633067
gene_homology	cDNA is 86.8% similar to mouse and 72.4% similar to the human gene	633067

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)