RGD Reference Report - Expression of a functional IL-13Ralpha1 by rat B cells. - Rat Genome Database

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Expression of a functional IL-13Ralpha1 by rat B cells.

Authors: Pierrot, C  Beniguel, L  Begue, A  Khalife, J 
Citation: Pierrot C, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):969-76.
RGD ID: 633067
Pubmed: PMID:11573960   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5682   (Journal Full-text)

IL-13 mediates its effects through a complex receptor system including IL-4Ralpha and a functional IL-13Ralpha1. IL-13 has been reported to have no effects on mouse B cells due to a lack of receptor expression. However, on human B cells a functional IL-13Ralpha1 has been described. Here, we identified the rat IL-13Ralpha1 in order to analyze its expression and function in rat B cells. The expression of IL-13Ralpha1 has been shown by the presence of mRNA and the corresponding protein in purified rat B cells and in rat hybridoma B cell line. Rat B cells are able to bind IL-13 and to proliferate when cultured with CD40 ligand and IL-13. In vivo experiments showed that administration of IL-13 did enhance IgE production. These results suggest a direct interaction of rat B cells with IL-13 through a functional receptor with an increase of IgE production and provide a relevant model to further study the activity of IL-13 and to better understand its role in human diseases.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Il13Ratpositive regulation of B cell proliferation  IDA requires CD40 antigenRGD 
Il13ra1Ratpositive regulation of B cell proliferation  IDA requires CD40 antigenRGD 
Il13Ratpositive regulation of immunoglobulin production  IDA IgE production after infectionRGD 
Il13ra1Ratpositive regulation of immunoglobulin production  IDA IgE production after infectionRGD 

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Il13ra1Ratinterleukin-13 receptor activity  IPIIl13 (Rattus norvegicus) RGD 
Il13Ratinterleukin-13 receptor binding  IPIIl13ra1 (Rattus norvegicus) RGD 


Genes (Rattus norvegicus)
Il13  (interleukin 13) Il13ra1  (interleukin 13 receptor subunit alpha 1)

Gene Il13ra1 interleukin 13 receptor, alpha 1 Mus musculus