Kcnh5 (potassium voltage-gated channel subfamily H member 5) - Rat Genome Database

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Gene: Kcnh5 (potassium voltage-gated channel subfamily H member 5) Rattus norvegicus
Analyze
Symbol: Kcnh5
Name: potassium voltage-gated channel subfamily H member 5
RGD ID: 621417
Description: Exhibits ion channel binding activity. Predicted to be involved in potassium ion transmembrane transport; regulation of G2/M transition of mitotic cell cycle; and regulation of membrane potential. Predicted to localize to cell surface and integral component of plasma membrane. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Eag2; ether-a-go-go potassium channel 2; potassium channel, voltage gated eag related subfamily H, member 5; potassium voltage-gated channel, subfamily H (eag-related), member 5; rEAG2; voltage-gated potassium channel subunit Kv10.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2693,615,174 - 93,908,107 (-)NCBI
Rnor_6.0 Ensembl697,872,831 - 98,157,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0697,872,831 - 98,157,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06107,294,666 - 107,578,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4697,484,188 - 97,772,082 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1697,487,643 - 97,775,538 (-)NCBI
Celera692,059,360 - 92,339,391 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:15706225   PMID:18063306   PMID:20662937   PMID:22855790   PMID:24495567  


Genomics

Comparative Map Data
Kcnh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2693,615,174 - 93,908,107 (-)NCBI
Rnor_6.0 Ensembl697,872,831 - 98,157,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0697,872,831 - 98,157,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06107,294,666 - 107,578,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4697,484,188 - 97,772,082 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1697,487,643 - 97,775,538 (-)NCBI
Celera692,059,360 - 92,339,391 (-)NCBICelera
Cytogenetic Map6q24NCBI
KCNH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1462,699,464 - 63,102,037 (-)EnsemblGRCh38hg38GRCh38
GRCh381462,699,464 - 63,045,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371463,166,182 - 63,512,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361462,243,698 - 62,638,337 (-)NCBINCBI36hg18NCBI36
Build 341462,248,710 - 62,638,337NCBI
Celera1443,224,258 - 43,619,167 (-)NCBI
Cytogenetic Map14q23.2NCBI
HuRef1443,338,760 - 43,678,420 (-)NCBIHuRef
CHM1_11463,112,492 - 63,451,134 (-)NCBICHM1_1
Kcnh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391274,943,991 - 75,224,625 (-)NCBIGRCm39mm39
GRCm39 Ensembl1274,943,994 - 75,224,106 (-)Ensembl
GRCm381274,897,217 - 75,177,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1274,897,220 - 75,177,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371275,998,204 - 76,278,319 (-)NCBIGRCm37mm9NCBIm37
MGSCv361275,816,060 - 76,096,172 (-)NCBImm8
Celera1275,988,289 - 76,268,710 (-)NCBICelera
Cytogenetic Map12C3NCBI
Kcnh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554666,704,364 - 7,040,734 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554666,704,431 - 7,042,727 (+)NCBIChiLan1.0ChiLan1.0
KCNH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11461,560,591 - 61,889,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1461,560,600 - 61,889,137 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01443,297,114 - 43,633,275 (-)NCBIMhudiblu_PPA_v0panPan3
KCNH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1837,429,677 - 37,710,409 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl837,434,922 - 37,710,330 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha837,191,479 - 37,467,676 (-)NCBI
ROS_Cfam_1.0837,663,234 - 37,937,001 (-)NCBI
UMICH_Zoey_3.1837,271,557 - 37,554,004 (-)NCBI
UNSW_CanFamBas_1.0837,357,200 - 37,633,582 (-)NCBI
UU_Cfam_GSD_1.0837,713,171 - 37,986,803 (-)NCBI
Kcnh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864067,223,309 - 67,517,223 (+)NCBI
SpeTri2.0NW_0049364956,685,220 - 6,967,921 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1194,965,730 - 195,262,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11194,965,696 - 195,264,046 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNH5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12439,856,837 - 40,206,607 (-)NCBI
Kcnh5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473437,990,840 - 38,387,580 (+)NCBI

Position Markers
D6Mit8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2693,701,310 - 93,701,509 (+)MAPPER
Rnor_6.0697,949,772 - 97,949,970NCBIRnor6.0
Rnor_5.06107,370,981 - 107,371,179UniSTSRnor5.0
RGSC_v3.4697,561,873 - 97,562,072RGDRGSC3.4
RGSC_v3.4697,561,874 - 97,562,072UniSTSRGSC3.4
RGSC_v3.1697,565,330 - 97,565,528RGD
Celera692,136,112 - 92,136,316UniSTS
RH 3.4 Map6656.3UniSTS
RH 3.4 Map6656.3RGD
RH 2.0 Map6861.5RGD
SHRSP x BN Map655.6199RGD
Cytogenetic Map6q24UniSTS
D6Arb20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2693,641,596 - 93,641,736 (+)MAPPER
Rnor_6.0697,889,897 - 97,890,036NCBIRnor6.0
Rnor_5.06107,311,732 - 107,311,871UniSTSRnor5.0
RGSC_v3.4697,501,257 - 97,501,397RGDRGSC3.4
RGSC_v3.4697,501,258 - 97,501,397UniSTSRGSC3.4
RGSC_v3.1697,504,714 - 97,504,853RGD
Celera692,076,427 - 92,076,566UniSTS
RH 3.4 Map6657.3UniSTS
RH 3.4 Map6657.3RGD
RH 2.0 Map6859.3RGD
SHRSP x BN Map655.6199RGD
Cytogenetic Map6q24UniSTS
31.MMHAP7FLC4.seq  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2693,662,006 - 93,662,159 (+)MAPPER
Rnor_6.0697,910,305 - 97,910,457NCBIRnor6.0
Rnor_5.06107,332,140 - 107,332,292UniSTSRnor5.0
RGSC_v3.4697,521,666 - 97,521,818UniSTSRGSC3.4
Celera692,096,848 - 92,097,000UniSTS
Cytogenetic Map6q24UniSTS
WI-15244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,580,885 - 201,580,992 (-)MAPPER
mRatBN7.2693,811,478 - 93,811,583 (+)MAPPER
Rnor_6.0698,061,305 - 98,061,409NCBIRnor6.0
Rnor_5.06107,482,459 - 107,482,563UniSTSRnor5.0
RGSC_v3.4697,675,459 - 97,675,563UniSTSRGSC3.4
Celera692,242,925 - 92,243,029UniSTS
Cytogenetic Map6q24UniSTS
Kcnh5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2693,820,999 - 93,821,092 (+)MAPPER
Rnor_6.0698,070,824 - 98,070,916NCBIRnor6.0
Rnor_5.06107,491,978 - 107,492,070UniSTSRnor5.0
RGSC_v3.4697,684,985 - 97,685,077UniSTSRGSC3.4
Celera692,252,427 - 92,252,519UniSTS
Cytogenetic Map6q24UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)67009971115379601Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)648432758108268790Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)660606431108154445Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)660606431108154445Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)662263348107263348Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)666129520111129520Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)668781170147991367Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)671206251116206251Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)675449871120449871Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)675623277120276465Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)675623277120623277Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)675623277136143011Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)675623277136426962Rat
1581550Pur8Proteinuria QTL 8total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)675623393136142742Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)675623393136142742Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)676902247114203334Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)684763275108464097Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)686422697115379601Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)687418448111129520Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)688507712133507712Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)688996335139410483Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)689631358134631358Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)689631358134631358Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)691703409136703409Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (VE) (CMO:0000132)692879510137879510Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)693706176111134673Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)697949772133849286Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:123
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000013275
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8
Low 1 3 3 50 10
Below cutoff 2 10 22 9 15 9 7 8 16 18 24 11 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000013275   ⟹   ENSRNOP00000013275
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl697,872,831 - 98,157,087 (-)Ensembl
RefSeq Acc Id: NM_133610   ⟹   NP_598294
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2693,624,529 - 93,908,107 (-)NCBI
Rnor_6.0697,872,831 - 98,157,087 (-)NCBI
Rnor_5.06107,294,666 - 107,578,241 (-)NCBI
RGSC_v3.4697,484,188 - 97,772,082 (-)RGD
Celera692,059,360 - 92,339,391 (-)RGD
Sequence:
RefSeq Acc Id: XM_039111744   ⟹   XP_038967672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2693,615,174 - 93,848,207 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_598294   ⟸   NM_133610
- UniProtKB: Q9EPI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013275   ⟸   ENSRNOT00000013275
RefSeq Acc Id: XP_038967672   ⟸   XM_039111744
- Peptide Label: isoform X1
Protein Domains
PAC   PAS

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621417 AgrOrtholog
Ensembl Genes ENSRNOG00000009542 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000013275 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013275 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.120.350 UniProtKB/Swiss-Prot
  2.60.120.10 UniProtKB/Swiss-Prot
InterPro cNMP-bd-like UniProtKB/Swiss-Prot
  cNMP-bd_dom UniProtKB/Swiss-Prot
  EAG2 UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG UniProtKB/Swiss-Prot
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
  PAS UniProtKB/Swiss-Prot
  PAS-assoc_C UniProtKB/Swiss-Prot
  PAS-like_dom_sf UniProtKB/Swiss-Prot
  RmlC-like_jellyroll UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:171146 UniProtKB/Swiss-Prot
NCBI Gene 171146 ENTREZGENE
PANTHER PTHR10217:SF533 UniProtKB/Swiss-Prot
Pfam cNMP_binding UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  PAS_9 UniProtKB/Swiss-Prot
PhenoGen Kcnh5 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot
  EAGCHANNEL UniProtKB/Swiss-Prot
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
SMART cNMP UniProtKB/Swiss-Prot
  PAC UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot
  SSF55785 UniProtKB/Swiss-Prot
TIGRFAMs sensory_box UniProtKB/Swiss-Prot
UniProt KCNH5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88893 UniProtKB/Swiss-Prot
  Q9QXT2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnh5  potassium voltage-gated channel subfamily H member 5  Kcnh5  potassium channel, voltage gated eag related subfamily H, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnh5  potassium channel, voltage gated eag related subfamily H, member 5  Kcnh5  potassium voltage-gated channel, subfamily H (eag-related), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Kcnh5  potassium voltage-gated channel, subfamily H (eag-related), member 5      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kcnh5  potassium voltage-gated channel, subfamily H (eag-related), member 5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference