Gene: Ptgis (prostaglandin I2 synthase) Rattus norvegicus
Symbol: Ptgis
Name: prostaglandin I2 synthase
Description: ENCODES a protein that exhibits prostaglandin-I synthase activity; heme binding (ortholog); INVOLVED IN prostaglandin biosynthetic process; response to hypoxia; apoptotic signaling pathway (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH brain ischemia; pulmonary hypertension; Abortion, Spontaneous (ortholog); FOUND IN extracellular space; caveola (ortholog); cytoplasm (ortholog); INTERACTS WITH (R)-carnitine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol
Type: protein-coding
Also known as: PGIS; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase
Homo sapiens (human) : PTGIS (prostaglandin I2 synthase)  HGNC  Alliance
Mus musculus (house mouse) : Ptgis (prostaglandin I2 (prostacyclin) synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgis (prostaglandin I2 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGIS (prostaglandin I2 synthase)
Canis lupus familiaris (dog) : PTGIS (prostaglandin I2 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgis (prostaglandin I2 synthase)
Sus scrofa (pig) : PTGIS (prostaglandin I2 synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ptgis
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3438
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE