Ptgis (prostaglandin I2 synthase) - Rat Genome Database

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Gene: Ptgis (prostaglandin I2 synthase) Rattus norvegicus
Symbol: Ptgis (Ensembl: AABR07054614.1)
Name: prostaglandin I2 synthase
RGD ID: 3438
Description: Enables prostaglandin-I synthase activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to tumor necrosis factor; and prostaglandin biosynthetic process. Predicted to be located in caveola; endoplasmic reticulum membrane; and nucleus. Used to study cerebral infarction; congestive heart failure; ischemia (multiple); and pulmonary hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN prostacyclin biosynthetic pathway; acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; INTERACTS WITH (R)-carnitine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: hydroperoxy icosatetraenoate dehydratase; PGIS; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83176,347,589 - 176,383,251 (-)NCBIGRCr8
mRatBN7.23155,928,564 - 155,964,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,730,001 - 159,765,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,228,974 - 168,264,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,970,684 - 166,006,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-carnitine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-oxoprostaglandin F1alpha  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bosentan  (EXP)
cadmium dichloride  (ISO)
calcitriol  (ISO)
candesartan  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carboxy-PTIO  (EXP)
CGP 52608  (ISO)
clofibrate  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diatomic oxygen  (EXP)
dibenz[a,h]anthracene  (ISO)
diethyl malate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
entinostat  (ISO)
ethanol  (ISO)
fluvastatin  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
inulin  (ISO)
Lasiocarpine  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methoxychlor  (EXP)
molsidomine  (EXP)
monocrotaline  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nitrofen  (EXP)
oxidised LDL  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propanal  (ISO)
raloxifene  (EXP)
resveratrol  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium fluoride  (ISO)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
triglyceride  (EXP)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (IEA,ISO,ISS)
cytoplasm  (ISO)
endoplasmic reticulum  (ISO,ISS)
endoplasmic reticulum membrane  (IEA,ISS)
nucleus  (IEA,ISO,ISS)


References - curated
# Reference Title Reference Citation
1. Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. Blumberg FC, etal., Cardiovasc Res. 2002 Jul;55(1):171-7. doi: 10.1016/s0008-6363(02)00318-8.
2. Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury. Cao Y, etal., Pflugers Arch. 2019 Apr;471(4):543-555. doi: 10.1007/s00424-018-2229-6. Epub 2018 Nov 9.
3. Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Choquet H, etal., Free Radic Biol Med. 2016 Mar;92:100-109. doi: 10.1016/j.freeradbiomed.2016.01.008. Epub 2016 Jan 19.
4. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, etal., Pediatrics. 2009 Apr;123(4):1116-23. doi: 10.1542/peds.2008-0313.
5. Altered expression of inflammation-related genes in human carotid atherosclerotic plaques. Di Taranto MD, etal., Atherosclerosis. 2012 Jan;220(1):93-101. doi: 10.1016/j.atherosclerosis.2011.10.022. Epub 2011 Oct 25.
6. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. Du X, etal., J Clin Invest. 2006 Apr;116(4):1071-80. doi: 10.1172/JCI23354. Epub 2006 Mar 9.
7. Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. Ebmeyer J, etal., Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.
8. Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion. Fang YC, etal., J Cereb Blood Flow Metab. 2006 Apr;26(4):491-501.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. Geraci MW, etal., J Clin Invest 1999 Jun;103(11):1509-15.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Prostacyclin synthase gene transfer inhibits neointimal formation in rat balloon-injured arteries without bleeding complications. Harada M, etal., Cardiovasc Res. 1999 Aug 1;43(2):481-91. doi: 10.1016/s0008-6363(99)00107-8.
13. Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Hiraoka K, etal., Circulation. 2003 Nov 25;108(21):2689-96. doi: 10.1161/01.CIR.0000093275.78676.F4. Epub 2003 Oct 20.
14. Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression. Imai H, etal., Atherosclerosis. 2007 Dec;195(2):322-32. doi: 10.1016/j.atherosclerosis.2007.01.010. Epub 2007 Feb 14.
15. Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia. Ishii M, etal., Atherosclerosis. 2009 Sep;206(1):109-18. doi: 10.1016/j.atherosclerosis.2009.02.023. Epub 2009 Mar 11.
16. Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Ito T, etal., Hypertension. 2007 Sep;50(3):531-6. doi: 10.1161/HYPERTENSIONAHA.107.091348. Epub 2007 Jul 16.
17. Effects of IL-1beta, TNF-alpha, and macrophage migration inhibitory factor on prostacyclin synthesis in rat pulmonary artery smooth muscle cells. Itoh A, etal., Respirology. 2003 Dec;8(4):467-72. doi: 10.1046/j.1440-1843.2003.00491.x.
18. Human prostacyclin synthase gene and hypertension : the Suita Study. Iwai N, etal., Circulation. 1999 Nov 30;100(22):2231-6. doi: 10.1161/01.cir.100.22.2231.
19. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
20. Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. Koike H, etal., FASEB J. 2003 Apr;17(6):779-81. doi: 10.1096/fj.02-0754fje. Epub 2003 Feb 5.
21. Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model. Leger PL, etal., Stroke. 2016 Dec;47(12):3048-3052. doi: 10.1161/STROKEAHA.116.015095. Epub 2016 Nov 10.
22. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
23. Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Lin H, etal., Circulation. 2002 Apr 23;105(16):1962-9. doi: 10.1161/01.cir.0000015365.49180.05.
24. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
25. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
26. Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. Myers SI, etal., Prostaglandins Leukot Essent Fatty Acids. 1996 Jun;54(6):403-9. doi: 10.1016/s0952-3278(96)90023-x.
27. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Nagaya N, etal., Circulation. 2000 Oct 17;102(16):2005-10. doi: 10.1161/01.cir.102.16.2005.
28. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. Nakayama T, etal., Am Heart J. 2002 May;143(5):797-801. doi: 10.1067/mhj.2002.122171.
29. Association of 5' upstream promoter region of prostacyclin synthase gene variant with cerebral infarction. Nakayama T, etal., Am J Hypertens. 2000 Dec;13(12):1263-7. doi: 10.1016/s0895-7061(00)01216-4.
30. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Nakayama T, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1135-9.
31. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
32. Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. Numaguchi Y, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):727-33. doi: 10.1161/01.atv.19.3.727.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. 17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Ospina JA, etal., Stroke. 2002 Feb;33(2):600-5. doi: 10.1161/hs0202.102732.
35. Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients. Ozen G, etal., Prostaglandins Leukot Essent Fatty Acids. 2020 Sep;160:102158. doi: 10.1016/j.plefa.2020.102158. Epub 2020 Jul 5.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. Poole EM, etal., Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):502-8. doi: 10.1158/1055-9965.EPI-05-0804.
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Russo A, etal., J Oncol. 2018 Nov 8;2018:6301980. doi: 10.1155/2018/6301980. eCollection 2018.
43. Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients. Safiah Mokhtar S, etal., Tohoku J Exp Med. 2013 Nov;231(3):217-22. doi: 10.1620/tjem.231.217.
44. Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. Sasaki Y, etal., Sci Rep. 2015 Nov 27;5:17376. doi: 10.1038/srep17376.
45. Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. Schroll S, etal., Scand J Clin Lab Invest. 2008;68(4):270-6. doi: 10.1080/00365510701673375.
46. PGI2 production by rat blood vessels: diminished prostacyclin formation in veins compared to arteries. Skidgel RA and Printz MP, Prostaglandins 1978 Jul;16(1):1-16.
47. Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide. Skogastierna C, etal., Heart Vessels. 2011 Nov;26(6):628-36. doi: 10.1007/s00380-010-0097-x. Epub 2011 Jan 7.
48. Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. Soler M, etal., J Infect Dis. 2001 Jan 1;183(1):105-12. doi: 10.1086/317639. Epub 2000 Nov 10.
49. Imidazolineoxyl N-oxide prevents the impairment of vascular contraction caused by interleukin-1beta through several mechanisms. Soler M, etal., J Infect Dis. 2003 Sep 15;188(6):927-37. doi: 10.1086/377586. Epub 2003 Sep 4.
50. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Stearman RS, etal., Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. doi: 10.1164/rccm.201309-1697OC.
51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
52. Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. Suhara H, etal., J Thorac Cardiovasc Surg. 2002 May;123(5):855-61. doi: 10.1067/mtc.2002.118687.
53. Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Tahara N, etal., Hum Gene Ther. 2004 Dec;15(12):1270-8.
54. Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Tang EH and Vanhoutte PM, Physiol Genomics. 2008 Feb 19;32(3):409-18. doi: 10.1152/physiolgenomics.00136.2007. Epub 2007 Dec 4.
55. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Todaka T, etal., Stroke. 1999 Feb;30(2):419-26. doi: 10.1161/01.str.30.2.419.
56. Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. Tsai MJ, etal., Oxid Med Cell Longev. 2013;2013:649809. doi: 10.1155/2013/649809. Epub 2013 Apr 3.
57. Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension. Wang XJ, etal., JAMA Cardiol. 2020 Jun 1;5(6):677-684. doi: 10.1001/jamacardio.2020.0479.
58. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. Xie X, etal., Clin Chem Lab Med. 2009;47(3):347-52. doi: 10.1515/CCLM.2009.078.
59. [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China]. Xie X, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Jun;29(6):598-603.
60. Assessment of the genetic component of hypertension. Yamada Y, etal., Am J Hypertens. 2006 Nov;19(11):1158-65. doi: 10.1016/j.amjhyper.2006.04.010.
61. Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations. Yi X, etal., J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1773-1780. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.005. Epub 2017 May 3.
62. Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients. Yi X, etal., J Stroke Cerebrovasc Dis. 2017 May;26(5):1128-1135. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.032. Epub 2017 Jan 17.
63. Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. Yi X, etal., PLoS One. 2017 Jul 12;12(7):e0180704. doi: 10.1371/journal.pone.0180704. eCollection 2017.
64. Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits. Zhou L, etal., Circulation. 2013 Aug 27;128(9):982-94. doi: 10.1161/CIRCULATIONAHA.113.003139. Epub 2013 Jul 10.
65. Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI2 pathway. Zhou R, etal., Biomed Pharmacother. 2016 Dec;84:1359-1366. doi: 10.1016/j.biopha.2016.10.070. Epub 2016 Oct 29.
66. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Zou MH, etal., Diabetes. 2002 Jan;51(1):198-203. doi: 10.2337/diabetes.51.1.198.
Additional References at PubMed
PMID:8185632   PMID:10385625   PMID:11551955   PMID:15115769   PMID:15489334   PMID:17020766   PMID:17825254   PMID:17951541   PMID:18032380   PMID:20122998   PMID:20159982   PMID:20925195  
PMID:21035466   PMID:21296955   PMID:24141169   PMID:27923787   PMID:31505169  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83176,347,589 - 176,383,251 (-)NCBIGRCr8
mRatBN7.23155,928,564 - 155,964,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,730,001 - 159,765,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,228,974 - 168,264,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,970,684 - 166,006,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,503,874 - 49,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
T2T-CHM13v2.02051,273,490 - 51,337,709 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392167,045,114 - 167,095,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,033,725 - 167,082,524 (-)EnsemblGRCm39 Ensembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBIMGSCv36mm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554458,623,430 - 8,677,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,624,228 - 8,663,385 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22155,244,765 - 55,309,216 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,237,848 - 55,302,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,841,238 - 45,905,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,909,010 - 46,952,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,905,665 - 46,971,612 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12436,129,091 - 36,162,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,132,173 - 36,162,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,371,271 - 35,411,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,836,800 - 36,873,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,821,516 - 36,873,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,074,715 - 36,114,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,208,769 - 36,248,925 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,750,911 - 36,791,264 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640189,336,652 - 189,360,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,791,031 - 4,812,027 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,775,884 - 4,814,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1214,420,318 - 14,484,667 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,441,983 - 14,488,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,907,161 - 62,972,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptgis
171 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:41
Interacting mature miRNAs:43
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3112681431157681431Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3121056165157309487Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3130193298161695983Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141339013162184794Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145956084157309487Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3145956084161299569Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,951,423 - 155,951,573 (+)MAPPERmRatBN7.2
Rnor_6.03163,973,327 - 163,973,476NCBIRnor6.0
Rnor_5.03170,131,080 - 170,131,229UniSTSRnor5.0
Celera3154,532,212 - 154,532,361UniSTS
RH 3.4 Map31441.6RGD
RH 3.4 Map31441.6UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,943,587 - 155,943,756 (+)MAPPERmRatBN7.2
Rnor_6.03163,965,193 - 163,965,361NCBIRnor6.0
Rnor_5.03170,124,593 - 170,124,761UniSTSRnor5.0
Celera3154,524,558 - 154,524,726UniSTS
RH 3.4 Map31442.4UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,928,598 - 155,928,784 (-)MAPPERmRatBN7.2
mRatBN7.23155,928,598 - 155,928,784 (+)MAPPERmRatBN7.2
mRatBN7.21152,245,400 - 52,245,586 (-)MAPPERmRatBN7.2
mRatBN7.21152,245,400 - 52,245,586 (+)MAPPERmRatBN7.2
Rnor_6.01154,830,061 - 54,830,246NCBIRnor6.0
Rnor_6.03163,950,781 - 163,950,966NCBIRnor6.0
Rnor_5.03170,109,352 - 170,109,537UniSTSRnor5.0
Rnor_5.01157,988,636 - 57,988,821UniSTSRnor5.0
RGSC_v3.43158,356,913 - 158,357,098UniSTSRGSC3.4
RGSC_v3.41153,492,284 - 53,492,469UniSTSRGSC3.4
Celera1151,841,764 - 51,841,949UniSTS
Celera3154,508,808 - 154,508,993UniSTS
RH 3.4 Map2755.19UniSTS
Cytogenetic Map11q21UniSTS
Cytogenetic Map3q42UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23155,931,041 - 155,931,252 (+)MAPPERmRatBN7.2
Rnor_6.03163,953,224 - 163,953,434NCBIRnor6.0
Rnor_5.03170,111,795 - 170,112,005UniSTSRnor5.0
Celera3154,511,251 - 154,511,461UniSTS
RH 3.4 Map31441.5UniSTS
Cytogenetic Map3q42UniSTS



RefSeq Acc Id: ENSRNOT00000010891   ⟹   ENSRNOP00000010891
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,928,564 - 155,951,645 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082474   ⟹   ENSRNOP00000074093
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,928,564 - 155,953,292 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103286   ⟹   ENSRNOP00000088713
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105814   ⟹   ENSRNOP00000077774
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,925,619 - 155,964,267 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115486   ⟹   ENSRNOP00000087709
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3155,928,570 - 155,965,451 (-)Ensembl
RefSeq Acc Id: NM_031557   ⟹   NP_113745
Rat AssemblyChrPosition (strand)Source
GRCr83176,347,589 - 176,383,251 (-)NCBI
mRatBN7.23155,928,564 - 155,964,228 (-)NCBI
Rnor_6.03163,950,746 - 163,986,129 (-)NCBI
Rnor_5.03170,109,317 - 170,143,882 (-)NCBI
RGSC_v3.43158,356,878 - 158,387,984 (-)RGD
Celera3154,508,773 - 154,544,997 (-)RGD
RefSeq Acc Id: XM_039104378   ⟹   XP_038960306
Rat AssemblyChrPosition (strand)Source
GRCr83176,347,589 - 176,371,870 (-)NCBI
mRatBN7.23155,928,564 - 155,952,790 (-)NCBI
RefSeq Acc Id: NP_113745   ⟸   NM_031557
- UniProtKB: Q62969 (UniProtKB/Swiss-Prot),   A6JXJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038960306   ⟸   XM_039104378
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K776 (UniProtKB/TrEMBL),   F1LP67 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000087709   ⟸   ENSRNOT00000115486
RefSeq Acc Id: ENSRNOP00000074093   ⟸   ENSRNOT00000082474
RefSeq Acc Id: ENSRNOP00000010891   ⟸   ENSRNOT00000010891
RefSeq Acc Id: ENSRNOP00000077774   ⟸   ENSRNOT00000105814
RefSeq Acc Id: ENSRNOP00000088713   ⟸   ENSRNOT00000103286

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K776-F1-model_v2 AlphaFold A0A0G2K776 1-500 view protein structure
AF-Q62969-F1-model_v2 AlphaFold Q62969 1-501 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3438 AgrOrtholog
BioCyc Gene G2FUF-46744 BioCyc
BioCyc Pathway PWY66-374 [C20 prostanoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-374 BioCyc
Ensembl Genes ENSRNOG00000008245 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004622 UniProtKB/Swiss-Prot
  ENSRNOG00060001060 UniProtKB/Swiss-Prot
  ENSRNOG00065013008 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010891.7 UniProtKB/TrEMBL
  ENSRNOT00000082474.2 UniProtKB/TrEMBL
  ENSRNOT00000103286.1 UniProtKB/TrEMBL
  ENSRNOT00000105814.1 UniProtKB/TrEMBL
  ENSRNOT00000115486.1 UniProtKB/Swiss-Prot
  ENSRNOT00055007342 UniProtKB/Swiss-Prot
  ENSRNOT00060001442 UniProtKB/Swiss-Prot
  ENSRNOT00065021309 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25527 UniProtKB/Swiss-Prot
PANTHER PTHR24306 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24306:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptgis PhenoGen
PIRSF Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008245 RatGTEx
  ENSRNOG00055004622 RatGTEx
  ENSRNOG00060001060 RatGTEx
  ENSRNOG00065013008 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-09-21 Ptgis  prostaglandin I2 synthase  Ptgis  prostaglandin I2 (prostacyclin) synthase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ptgis  prostaglandin I2 (prostacyclin) synthase    prostaglandin I2 synthase   Name updated 1299863 APPROVED
2003-04-09 Ptgis  prostaglandin I2 synthase     Prostaglandin I2 (prostacyclin) synthase  Name updated 629478 APPROVED
2002-06-10 Ptgis  Prostaglandin I2 (prostacyclin) synthase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mutations_overexpression overexpression in transgenic mice provides protection against severe pulmonary hypertension 727270