RGD Reference Report - Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients. - Rat Genome Database

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Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients.

Authors: Yi, Xingyang  Ming, Bing  Wang, Chun  Chen, Hong  Ma, Chun 
Citation: Yi X, etal., J Stroke Cerebrovasc Dis. 2017 May;26(5):1128-1135. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.032. Epub 2017 Jan 17.
RGD ID: 401959400
Pubmed: PMID:28108096   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jstrokecerebrovasdis.2016.12.032   (Journal Full-text)


BACKGROUND: Eicosanoids may play a role in ischemic stroke (IS). However, the association of variants in eicosanoid genes with symptomatic carotid artery or intracranial arterial stenosis and neurologic deterioration (ND) is not fully understood. The aim of the present study was to investigate the association of 11 variants in eicosanoid genes with symptomatic carotid artery or intracranial arterial stenosis and ND.
METHODS: Eleven variants in eicosanoid genes were examined using mass spectrometry method in 297 IS patients. The symptomatic carotid artery or intracranial arterial stenosis was assessed by computed tomographic angiography. Platelet aggregation and platelet-leukocyte aggregates were measured. The primary outcome was ND within 10 days of admission. ND was defined as an increase of 2 or more points in National Institutes of Health Stroke Scale score.
RESULTS: Among 297 IS patients, 182 (61.3%) cases had symptomatic carotid artery or intracranial arterial stenosis, and 88 (29.6%) patients experienced ND within 10 days after admission. Symptomatic carotid artery or intracranial arterial stenosis was significantly associated with higher ND (Pā€‰<ā€‰.001). Rs20417CC, rs41708TT, and rs5629CC were independent risk factors for symptomatic carotid artery or intracranial arterial stenosis and ND, and associated with higher platelet aggregation and platelet-leukocyte aggregates.
CONCLUSIONS: Symptomatic carotid artery or intracranial arterial stenosis was associated with higher ND. Rs20417CC, rs41708TT, and rs5629CC were not only independent risk factors for symptomatic carotid artery or intracranial arterial stenosis, but also independent risk predictors for ND.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanArterial Occlusive Diseases exacerbatesIAGP associated with cerebral infarction more ...RGD 
PtgisRatArterial Occlusive Diseases exacerbatesISOPTGIS (Homo sapiens)associated with cerebral infarction more ...RGD 
PtgisMouseArterial Occlusive Diseases exacerbatesISOPTGIS (Homo sapiens)associated with cerebral infarction more ...RGD 
PTGISHumancerebral infarction exacerbatesIAGP DNA:SNPs:exon more ...RGD 
PtgisRatcerebral infarction exacerbatesISOPTGIS (Homo sapiens)DNA:SNPs:exon more ...RGD 
PtgisMousecerebral infarction exacerbatesISOPTGIS (Homo sapiens)DNA:SNPs:exon more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanArterial stenosis exacerbatesIAGP associated with cerebral infarction more ...RGD 
PTGISHumanIschemic stroke exacerbatesIAGP DNA:SNPs:exon more ...RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ptgis  (prostaglandin I2 synthase)

Genes (Mus musculus)
Ptgis  (prostaglandin I2 (prostacyclin) synthase)

Genes (Homo sapiens)
PTGIS  (prostaglandin I2 synthase)


Additional Information