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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3438
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgis
Name: prostaglandin I2 synthase
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgisincreases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of PTGIS mRNAPMID:12075121
Ptgismultiple interactionsISOPtgis (Mus musculus)6480464CTD[Ibuprofen co-treated with hydroxyibuprofen co-treated with Diclofenac co-treated with Ethinyl Estradiol] results in decreased expression of PTGIS mRNAPMID:37844793
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