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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3438
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgis
Name: prostaglandin I2 synthase
Acc ID: CHEBI:63634
Term: valdecoxib
Definition: A member of the class of isoxazoles that is isoxazole which is substituted at positions 3, 4 and 5 by phenyl, p-sulfamoylphenyl and methyl groups, respectively. A selective cyclooxygenase 2-inhibitor, it used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of arthritis from 2001 until 2005, when it was withdrawn following concerns of an associated increased risk of heart attack and stroke.
Chemical ID: MESH:C406224
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgisdecreases expressionEXP 6480464CTDvaldecoxib results in decreased expression of PTGIS mRNAPMID:24136188
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