RGD Reference Report - Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide. - Rat Genome Database

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Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide.

Authors: Skogastierna, Cristine  Luksha, Leonid  Kublickiene, Karolina  Eliasson, Erik  Rane, Anders  Ekström, Lena 
Citation: Skogastierna C, etal., Heart Vessels. 2011 Nov;26(6):628-36. doi: 10.1007/s00380-010-0097-x. Epub 2011 Jan 7.
RGD ID: 401901154
Pubmed: PMID:21213109   (View Abstract at PubMed)
DOI: DOI:10.1007/s00380-010-0097-x   (Journal Full-text)

Statins are believed to exert beneficial effects against cardiovascular disease beyond correction of dyslipidemia. There are however still very sparse data on how individual statins interact with the production of vasoactive eicosanoids and nitric oxide (NO) in human vascular endothelial cells. Here we have determined how fluvastatin affects the mRNA expression of genes associated with vascular reactivity as well as the formation of two major vasodilators, prostacyclin (PGI2) and NO, in human endothelial cells. Also, the influence of fluvastatin on arterial resistance was assessed in isolated small arteries. We show that the promoter activity of prostacyclin synthase (PTGIS), the mRNA expression of PTGIS and endothelial nitric oxide synthase (eNOS), and the production of PGI2 and NO are significantly induced by fluvastatin. Also, strong rapid dilatation ex vivo was observed, with the equal contribution of PGI2 and NO. Our findings in cell culture experiments and in isolated human arteries indicate that fluvastatin-evoked endothelium-derived vasodilator production may confer protection of the endothelial cells via both acute and long-term effects of fluvastatin treatment. If these effects take place in vivo, we suggest a protective pleiotropic role of fluvastatin on the cardiovascular system, particularly at the level of the vascular endothelium, to ameliorate the process of atherogenesis and in the acute manner to reduce vascular tone.



Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanfluvastatin increases expression EXP Fluvastatin increases expression of PTGIS mRNA in umbilical vein endothelial cellsRGD 
PtgisRatfluvastatin increases expression ISOPTGIS (Homo sapiens)Fluvastatin increases expression of PTGIS mRNA in umbilical vein endothelial cellsRGD 
PtgisMousefluvastatin increases expression ISOPTGIS (Homo sapiens)Fluvastatin increases expression of PTGIS mRNA in umbilical vein endothelial cellsRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgis  (prostaglandin I2 synthase)

Genes (Mus musculus)
Ptgis  (prostaglandin I2 (prostacyclin) synthase)

Genes (Homo sapiens)
PTGIS  (prostaglandin I2 synthase)


Additional Information