Ptgis (prostaglandin I2 (prostacyclin) synthase) - Rat Genome Database
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Gene: Ptgis (prostaglandin I2 (prostacyclin) synthase) Mus musculus
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Symbol: Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
RGD ID: 11183
MGI Page MGI
Description: Predicted to have heme binding activity and prostaglandin-I synthase activity. Involved in decidualization and embryo implantation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cyp8; Cyp8a1; hydroperoxy icosatetraenoate dehydratase; P; Pg; Pgis; prostacyclin synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,045,114 - 167,094,070 (-)NCBIGRCm39mm39
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBImm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-carnitine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
candesartan  (ISO)
carbon nanotube  (EXP)
clofibrate  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
dibenz[a,h]anthracene  (EXP)
diethyl malate  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
Lasiocarpine  (ISO)
methotrexate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
raloxifene  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium fluoride  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:8889548   PMID:9202154   PMID:10349636   PMID:10385625   PMID:10922068   PMID:11042159   PMID:11072079   PMID:11076861   PMID:11782360   PMID:12403673   PMID:12477932   PMID:12664598  
PMID:12745259   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16081819   PMID:16141072   PMID:16141073   PMID:16186418   PMID:16602821   PMID:17065353   PMID:17120018   PMID:17187424  
PMID:17328923   PMID:17652370   PMID:17947695   PMID:18514659   PMID:18790018   PMID:18799693   PMID:18973680   PMID:19138979   PMID:19906840   PMID:21267068   PMID:21873635   PMID:22865892  
PMID:23042236   PMID:23300697   PMID:26275053   PMID:26611322   PMID:28378742  


Genomics

Comparative Map Data
Ptgis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,045,114 - 167,094,070 (-)NCBIGRCm39mm39
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBImm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
PTGIS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2049,503,874 - 49,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,674 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh372048,120,411 - 48,184,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBI
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
Ptgis
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23155,928,564 - 155,964,228 (-)NCBI
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ptgis
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,623,430 - 8,677,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,624,228 - 8,663,385 (+)NCBIChiLan1.0ChiLan1.0
PTGIS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12046,909,010 - 46,952,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,905,665 - 46,971,612 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02045,841,238 - 45,905,641 (-)NCBIMhudiblu_PPA_v0panPan3
PTGIS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2436,132,173 - 36,162,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12436,129,091 - 36,162,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptgis
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365144,775,884 - 4,814,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGIS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGIS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,420,318 - 14,484,667 (+)NCBI
ChlSab1.1 Ensembl214,441,983 - 14,488,264 (+)Ensembl
Ptgis
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBI

Position Markers
Ptgis  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H3UniSTS
cM Map2 UniSTS
AW529446  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,221,335 - 167,221,528UniSTSGRCm38
MGSCv372167,046,835 - 167,047,028UniSTSGRCm37
Celera2173,161,471 - 173,161,664UniSTS
Cytogenetic Map2H3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133302991167303138Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133302991167303138Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135590624173607823Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135857301169857441Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135857301169857441Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135857301169857441Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135857301169857441Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2139124680173124809Mouse
11353826Bdln10_mbody length 10 (mouse)2140599562174599562Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142586427176586530Mouse
12801461Intim1_mintima modifier 1 (mouse)2142586427176586530Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142751556178800659Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143931525169276004Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144673941181254801Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145355029179355165Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145386799179386921Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145676855179677006Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148396284182113224Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148822973182113224Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149394987182113224Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2150146982182113224Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150370301182113224Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150370301182113224Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150370301182113224Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151867353174547331Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151936377182113224Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152487900182113224Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152857301169276004Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155982127182113224Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156354671182113224Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158236417178800659Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160769245169952882Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160769245169952882Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162791700182113224Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162895006178800659Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162895006178800659Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163844614182113224Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163844614182113224Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164873361182113224Mouse
1301378Hpdty_mhindlimb polydactyly (mouse)Not determined2165822973168781758Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:535
Count of miRNA genes:384
Interacting mature miRNAs:450
Transcripts:ENSMUST00000018113, ENSMUST00000088041, ENSMUST00000136271
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000018113   ⟹   ENSMUSP00000018113
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2167,202,907 - 167,240,604 (-)Ensembl
RefSeq Acc Id: ENSMUST00000088041   ⟹   ENSMUSP00000085357
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2167,191,805 - 167,240,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136271
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2167,206,522 - 167,208,416 (-)Ensembl
RefSeq Acc Id: NM_008968   ⟹   NP_032994
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,082,525 (-)NCBI
GRCm382167,203,194 - 167,240,605 (-)NCBI
MGSCv372167,028,696 - 167,066,037 (-)RGD
Celera2173,143,332 - 173,180,671 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030248627   ⟹   XP_030104487
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,094,070 (-)NCBI
GRCm382167,203,194 - 167,252,150 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032994   ⟸   NM_008968
- Peptide Label: precursor
- UniProtKB: O35074 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030104487   ⟸   XM_030248627
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000085357   ⟸   ENSMUST00000088041
RefSeq Acc Id: ENSMUSP00000018113   ⟸   ENSMUST00000018113

Promoters
RGD ID:6832213
Promoter ID:MM_KWN:33096
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000038852
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,033,771 - 167,034,271 (-)MPROMDB
RGD ID:6832214
Promoter ID:MM_KWN:33097
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000002269,   OTTMUST00000038851
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,065,886 - 167,066,387 (-)MPROMDB
RGD ID:6879798
Promoter ID:EPDNEW_M3350
Type:initiation region
Name:Ptgis_1
Description:Mus musculus prostaglandin I2 synthase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382167,240,571 - 167,240,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097156 AgrOrtholog
Ensembl Genes ENSMUSG00000017969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000018113 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000085357 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018113 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000088041 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19223 UniProtKB/Swiss-Prot
MGD MGI:1097156 ENTREZGENE
NCBI Gene 19223 ENTREZGENE
PANTHER PTHR24306:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PTGIS RGD
PhenoGen Ptgis PhenoGen
PIRSF Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O35074 ENTREZGENE, UniProtKB/Swiss-Prot
  Q7TSX2_MOUSE UniProtKB/TrEMBL
  Q8BXC0_MOUSE UniProtKB/TrEMBL