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Gene: Ptgis (prostaglandin I2 (prostacyclin) synthase) Mus musculus
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Symbol: Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
Description: Predicted to have heme binding activity and prostaglandin-I synthase activity. Involved in decidualization and embryo implantation. Localizes to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and musculoskeletal system. Orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cyp8; Cyp8a1; Pgis; prostacyclin synthase
Orthologs:
Homo sapiens (human) : PTGIS (prostaglandin I2 synthase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptgis (prostaglandin I2 synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgis (prostaglandin I2 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGIS (prostaglandin I2 synthase)
Canis lupus familiaris (dog) : PTGIS (prostaglandin I2 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgis (prostaglandin I2 synthase)
Sus scrofa (pig) : PTGIS (prostaglandin I2 synthase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBImm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2 H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ptgis
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11183
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.