Ptgis (prostaglandin I2 (prostacyclin) synthase) - Rat Genome Database

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Gene: Ptgis (prostaglandin I2 (prostacyclin) synthase) Mus musculus
Symbol: Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
RGD ID: 11183
Description: Predicted to enable heme binding activity and prostaglandin-I synthase activity. Acts upstream of or within decidualization and embryo implantation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); colorectal adenoma; limb ischemia; and primary pulmonary hypertension. Orthologous to human PTGIS (prostaglandin I2 synthase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cyp8; Cyp8a1; hydroperoxy icosatetraenoate dehydratase; P; Pg; Pgis; prostacyclin synthase
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392167,045,114 - 167,095,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,033,725 - 167,082,524 (-)EnsemblGRCm39 Ensembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBIMGSCv36mm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-carnitine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
Ammothamnine  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
asbestos  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
candesartan  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
carboxy-PTIO  (ISO)
CGP 52608  (ISO)
clofibrate  (EXP)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diatomic oxygen  (ISO)
dibenz[a,h]anthracene  (EXP)
diclofenac  (EXP)
diethyl malate  (EXP)
dioxygen  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fluvastatin  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
glucose  (ISO)
ibuprofen  (EXP)
inulin  (EXP)
Lasiocarpine  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
molsidomine  (ISO)
monocrotaline  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nitrofen  (ISO)
oxidised LDL  (ISO)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propanal  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
T-2 toxin  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (EXP)
triglyceride  (ISO)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
caveola  (ISO)
cytoplasm  (IDA)
endoplasmic reticulum  (ISO)
membrane  (IEA)
nucleus  (IDA,ISO)


References - curated
# Reference Title Reference Citation
1. Increased pulmonary prostacyclin synthesis in rats with chronic hypoxic pulmonary hypertension. Blumberg FC, etal., Cardiovasc Res. 2002 Jul;55(1):171-7. doi: 10.1016/s0008-6363(02)00318-8.
2. Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury. Cao Y, etal., Pflugers Arch. 2019 Apr;471(4):543-555. doi: 10.1007/s00424-018-2229-6. Epub 2018 Nov 9.
3. Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1. Choquet H, etal., Free Radic Biol Med. 2016 Mar;92:100-109. doi: 10.1016/j.freeradbiomed.2016.01.008. Epub 2016 Jan 19.
4. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Dagle JM, etal., Pediatrics. 2009 Apr;123(4):1116-23. doi: 10.1542/peds.2008-0313.
5. Altered expression of inflammation-related genes in human carotid atherosclerotic plaques. Di Taranto MD, etal., Atherosclerosis. 2012 Jan;220(1):93-101. doi: 10.1016/j.atherosclerosis.2011.10.022. Epub 2011 Oct 25.
6. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. Du X, etal., J Clin Invest. 2006 Apr;116(4):1071-80. doi: 10.1172/JCI23354. Epub 2006 Mar 9.
7. Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. Ebmeyer J, etal., Chem Biol Interact. 2019 Jan 25;298:104-111. doi: 10.1016/j.cbi.2018.11.007. Epub 2018 Nov 19.
8. Induction of prostacyclin/PGI2 synthase expression after cerebral ischemia-reperfusion. Fang YC, etal., J Cereb Blood Flow Metab. 2006 Apr;26(4):491-501.
9. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. Geraci MW, etal., J Clin Invest 1999 Jun;103(11):1509-15.
10. Prostacyclin synthase gene transfer inhibits neointimal formation in rat balloon-injured arteries without bleeding complications. Harada M, etal., Cardiovasc Res. 1999 Aug 1;43(2):481-91. doi: 10.1016/s0008-6363(99)00107-8.
11. Enhanced therapeutic angiogenesis by cotransfection of prostacyclin synthase gene or optimization of intramuscular injection of naked plasmid DNA. Hiraoka K, etal., Circulation. 2003 Nov 25;108(21):2689-96. doi: 10.1161/01.CIR.0000093275.78676.F4. Epub 2003 Oct 20.
12. Prostacyclin synthase gene transfer inhibits neointimal formation by suppressing PPAR delta expression. Imai H, etal., Atherosclerosis. 2007 Dec;195(2):322-32. doi: 10.1016/j.atherosclerosis.2007.01.010. Epub 2007 Feb 14.
13. Mesenchymal stem cell-based gene therapy with prostacyclin synthase enhanced neovascularization in hindlimb ischemia. Ishii M, etal., Atherosclerosis. 2009 Sep;206(1):109-18. doi: 10.1016/j.atherosclerosis.2009.02.023. Epub 2009 Mar 11.
14. Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. Ito T, etal., Hypertension. 2007 Sep;50(3):531-6. doi: 10.1161/HYPERTENSIONAHA.107.091348. Epub 2007 Jul 16.
15. Human prostacyclin synthase gene and hypertension : the Suita Study. Iwai N, etal., Circulation. 1999 Nov 30;100(22):2231-6. doi: 10.1161/01.cir.100.22.2231.
16. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
17. Enhanced angiogenesis and improvement of neuropathy by cotransfection of human hepatocyte growth factor and prostacyclin synthase gene. Koike H, etal., FASEB J. 2003 Apr;17(6):779-81. doi: 10.1096/fj.02-0754fje. Epub 2003 Feb 5.
18. Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model. Leger PL, etal., Stroke. 2016 Dec;47(12):3048-3052. doi: 10.1161/STROKEAHA.116.015095. Epub 2016 Nov 10.
19. Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
20. Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction. Lin H, etal., Circulation. 2002 Apr 23;105(16):1962-9. doi: 10.1161/01.cir.0000015365.49180.05.
21. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Majed BH and Khalil RA, Pharmacol Rev. 2012 Jul;64(3):540-82. doi: 10.1124/pr.111.004770. Epub 2012 Jun 7.
22. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
23. MGDs mouse GO annotations MGD data from the GO Consortium
25. Estrogen increases male rat aortic endothelial cell (RAEC) PGI2 release. Myers SI, etal., Prostaglandins Leukot Essent Fatty Acids. 1996 Jun;54(6):403-9. doi: 10.1016/s0952-3278(96)90023-x.
26. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Nagaya N, etal., Circulation. 2000 Oct 17;102(16):2005-10. doi: 10.1161/01.cir.102.16.2005.
27. Association of a novel single nucleotide polymorphism of the prostacyclin synthase gene with myocardial infarction. Nakayama T, etal., Am Heart J. 2002 May;143(5):797-801. doi: 10.1067/mhj.2002.122171.
28. Association of 5' upstream promoter region of prostacyclin synthase gene variant with cerebral infarction. Nakayama T, etal., Am J Hypertens. 2000 Dec;13(12):1263-7. doi: 10.1016/s0895-7061(00)01216-4.
29. Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Nakayama T, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1135-9.
30. Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Neidhardt L, etal., Mech Dev 2000 Nov;98(1-2):77-94.
31. Prostacyclin synthase gene transfer accelerates reendothelialization and inhibits neointimal formation in rat carotid arteries after balloon injury. Numaguchi Y, etal., Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):727-33. doi: 10.1161/01.atv.19.3.727.
32. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. 17beta-estradiol increases rat cerebrovascular prostacyclin synthesis by elevating cyclooxygenase-1 and prostacyclin synthase. Ospina JA, etal., Stroke. 2002 Feb;33(2):600-5. doi: 10.1161/hs0202.102732.
35. Downregulation of PGI2 pathway in Pulmonary Hypertension Group-III patients. Ozen G, etal., Prostaglandins Leukot Essent Fatty Acids. 2020 Sep;160:102158. doi: 10.1016/j.plefa.2020.102158. Epub 2020 Jul 5.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
38. Prostacyclin synthase and arachidonate 5-lipoxygenase polymorphisms and risk of colorectal polyps. Poole EM, etal., Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):502-8. doi: 10.1158/1055-9965.EPI-05-0804.
39. Mouse MP Annotation Import Pipeline RGD automated import pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma. Russo A, etal., J Oncol. 2018 Nov 8;2018:6301980. doi: 10.1155/2018/6301980. eCollection 2018.
43. Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients. Safiah Mokhtar S, etal., Tohoku J Exp Med. 2013 Nov;231(3):217-22. doi: 10.1620/tjem.231.217.
44. Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1. Sasaki Y, etal., Sci Rep. 2015 Nov 27;5:17376. doi: 10.1038/srep17376.
45. Effects of selective and unselective endothelin-receptor antagonists on prostacyclin synthase gene expression in experimental pulmonary hypertension. Schroll S, etal., Scand J Clin Lab Invest. 2008;68(4):270-6. doi: 10.1080/00365510701673375.
46. Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide. Skogastierna C, etal., Heart Vessels. 2011 Nov;26(6):628-36. doi: 10.1007/s00380-010-0097-x. Epub 2011 Jan 7.
47. Effect of an imidazolineoxyl nitric oxide on prostaglandin synthesis in experimental shock: possible role of nitrogen dioxide in prostacyclin synthase inactivation. Soler M, etal., J Infect Dis. 2001 Jan 1;183(1):105-12. doi: 10.1086/317639. Epub 2000 Nov 10.
48. Imidazolineoxyl N-oxide prevents the impairment of vascular contraction caused by interleukin-1beta through several mechanisms. Soler M, etal., J Infect Dis. 2003 Sep 15;188(6):927-37. doi: 10.1086/377586. Epub 2003 Sep 4.
49. Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension. Stearman RS, etal., Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. doi: 10.1164/rccm.201309-1697OC.
50. Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. Suhara H, etal., J Thorac Cardiovasc Surg. 2002 May;123(5):855-61. doi: 10.1067/mtc.2002.118687.
51. Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Tahara N, etal., Hum Gene Ther. 2004 Dec;15(12):1270-8.
52. Gene expression changes of prostanoid synthases in endothelial cells and prostanoid receptors in vascular smooth muscle cells caused by aging and hypertension. Tang EH and Vanhoutte PM, Physiol Genomics. 2008 Feb 19;32(3):409-18. doi: 10.1152/physiolgenomics.00136.2007. Epub 2007 Dec 4.
53. Gene transfer of human prostacyclin synthase prevents neointimal formation after carotid balloon injury in rats. Todaka T, etal., Stroke. 1999 Feb;30(2):419-26. doi: 10.1161/01.str.30.2.419.
54. Enhanced prostacyclin synthesis by adenoviral gene transfer reduced glial activation and ameliorated dopaminergic dysfunction in hemiparkinsonian rats. Tsai MJ, etal., Oxid Med Cell Longev. 2013;2013:649809. doi: 10.1155/2013/649809. Epub 2013 Apr 3.
55. Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension. Wang XJ, etal., JAMA Cardiol. 2020 Jun 1;5(6):677-684. doi: 10.1001/jamacardio.2020.0479.
56. Association of polymorphisms of PTGS2 and CYP8A1 with myocardial infarction. Xie X, etal., Clin Chem Lab Med. 2009;47(3):347-52. doi: 10.1515/CCLM.2009.078.
57. [Study on the association of cyclooxygenase-2 -765g>C and prostacyclin synthase C1117A polymorphisms and the risk of myocardial infarction in Uigur population of Xinjiang, China]. Xie X, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2008 Jun;29(6):598-603.
58. Assessment of the genetic component of hypertension. Yamada Y, etal., Am J Hypertens. 2006 Nov;19(11):1158-65. doi: 10.1016/j.amjhyper.2006.04.010.
59. Interactions among Variants in Eicosanoid Genes Increase Risk of Atherothrombotic Stroke in Chinese Populations. Yi X, etal., J Stroke Cerebrovasc Dis. 2017 Aug;26(8):1773-1780. doi: 10.1016/j.jstrokecerebrovasdis.2017.04.005. Epub 2017 May 3.
60. Variants in COX-2, PTGIS, and TBXAS1 Are Associated with Carotid Artery or Intracranial Arterial Stenosis and Neurologic Deterioration in Ischemic Stroke Patients. Yi X, etal., J Stroke Cerebrovasc Dis. 2017 May;26(5):1128-1135. doi: 10.1016/j.jstrokecerebrovasdis.2016.12.032. Epub 2017 Jan 17.
61. Genetic variants of PTGS2, TXA2R and TXAS1 are associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. Yi X, etal., PLoS One. 2017 Jul 12;12(7):e0180704. doi: 10.1371/journal.pone.0180704. eCollection 2017.
62. Endothelial-like progenitor cells engineered to produce prostacyclin rescue monocrotaline-induced pulmonary arterial hypertension and provide right ventricle benefits. Zhou L, etal., Circulation. 2013 Aug 27;128(9):982-94. doi: 10.1161/CIRCULATIONAHA.113.003139. Epub 2013 Jul 10.
63. Oxymatrine attenuated isoproterenol-induced heart failure in rats via regulation of COX-2/PGI2 pathway. Zhou R, etal., Biomed Pharmacother. 2016 Dec;84:1359-1366. doi: 10.1016/j.biopha.2016.10.070. Epub 2016 Oct 29.
64. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Zou MH, etal., Diabetes. 2002 Jan;51(1):198-203. doi: 10.2337/diabetes.51.1.198.
Additional References at PubMed
PMID:8889548   PMID:9202154   PMID:10349636   PMID:10385625   PMID:10922068   PMID:11042159   PMID:11072079   PMID:11076861   PMID:11782360   PMID:12403673   PMID:12477932   PMID:12664598  
PMID:12745259   PMID:14610273   PMID:14681479   PMID:15489334   PMID:16081819   PMID:16141072   PMID:16141073   PMID:16186418   PMID:16602821   PMID:17065353   PMID:17120018   PMID:17187424  
PMID:17328923   PMID:17652370   PMID:17947695   PMID:18514659   PMID:18790018   PMID:18799693   PMID:18973680   PMID:19138979   PMID:19906840   PMID:21267068   PMID:21873635   PMID:22865892  
PMID:23042236   PMID:23300697   PMID:26275053   PMID:28378742   PMID:33383181   PMID:33582554   PMID:34555210   PMID:37796199   PMID:38355793  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392167,045,114 - 167,095,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,033,725 - 167,082,524 (-)EnsemblGRCm39 Ensembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBIMGSCv36mm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,503,874 - 49,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
T2T-CHM13v2.02051,273,490 - 51,337,709 (-)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83176,347,589 - 176,383,251 (-)NCBIGRCr8
mRatBN7.23155,928,564 - 155,964,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,730,001 - 159,765,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,228,974 - 168,264,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,970,684 - 166,006,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554458,623,430 - 8,677,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,624,228 - 8,663,385 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v22155,244,765 - 55,309,216 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,237,848 - 55,302,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,841,238 - 45,905,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,909,010 - 46,952,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,905,665 - 46,971,612 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12436,129,091 - 36,162,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,132,173 - 36,162,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,371,271 - 35,411,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,836,800 - 36,873,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,821,516 - 36,873,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,074,715 - 36,114,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,208,769 - 36,248,925 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,750,911 - 36,791,264 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024408640189,336,652 - 189,360,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,791,031 - 4,812,027 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,775,884 - 4,814,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1214,420,318 - 14,484,667 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,441,983 - 14,488,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,907,161 - 62,972,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ptgis
1523 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:535
Count of miRNA genes:384
Interacting mature miRNAs:450
Transcripts:ENSMUST00000018113, ENSMUST00000088041, ENSMUST00000136271
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
1300688Nidd2k_mNidd2 on KK-A (mouse)Not determined2158078337178442452Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1301378Hpdty_mhindlimb polydactyly (mouse)Not determined2165664893168623678Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
12910800Pwgrq3_mpre-weaning growth rate QTL 3 (mouse)2160611165169794802Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1558991Tailq4_mtail length QTL 4 (mouse)Not determined2162736926178442452Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
12910810Pwbwq2_mpre-weaning body weight QTL 2 (mouse)2160611165169794802Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1357435Epfq2_mepididymal fat pad weight QTL 2 (mouse)Not determined2162736926178442452Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H3UniSTS
cM Map2 UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382167,221,335 - 167,221,528UniSTSGRCm38
MGSCv372167,046,835 - 167,047,028UniSTSGRCm37
Celera2173,161,471 - 173,161,664UniSTS
Cytogenetic Map2H3UniSTS



Nucleotide Sequences
RefSeq Transcripts NM_001420752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001420756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB001607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB040750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL591854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY285779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD742059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000018113   ⟹   ENSMUSP00000018113
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,044,827 - 167,082,524 (-)Ensembl
GRCm38.p6 Ensembl2167,202,907 - 167,240,604 (-)Ensembl
RefSeq Acc Id: ENSMUST00000088041   ⟹   ENSMUSP00000085357
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,033,725 - 167,082,509 (-)Ensembl
GRCm38.p6 Ensembl2167,191,805 - 167,240,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136271
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2167,048,442 - 167,050,336 (-)Ensembl
GRCm38.p6 Ensembl2167,206,522 - 167,208,416 (-)Ensembl
RefSeq Acc Id: NM_001420752   ⟹   NP_001407681
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,082,491 (-)NCBI
RefSeq Acc Id: NM_001420753   ⟹   NP_001407682
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,095,069 (-)NCBI
RefSeq Acc Id: NM_001420754   ⟹   NP_001407683
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,094,045 (-)NCBI
RefSeq Acc Id: NM_001420755   ⟹   NP_001407684
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,082,736 (-)NCBI
RefSeq Acc Id: NM_001420756   ⟹   NP_001407685
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,067,075 - 167,082,491 (-)NCBI
RefSeq Acc Id: NM_008968   ⟹   NP_032994
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm392167,045,114 - 167,082,491 (-)NCBI
GRCm382167,203,194 - 167,240,605 (-)NCBI
MGSCv372167,028,696 - 167,066,037 (-)RGD
Celera2173,143,332 - 173,180,671 (-)RGD
RefSeq Acc Id: NP_032994   ⟸   NM_008968
- Peptide Label: isoform a precursor
- UniProtKB: O35074 (UniProtKB/Swiss-Prot),   Q8BXC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000085357   ⟸   ENSMUST00000088041
RefSeq Acc Id: ENSMUSP00000018113   ⟸   ENSMUST00000018113
RefSeq Acc Id: NP_001407682   ⟸   NM_001420753
- Peptide Label: isoform c
RefSeq Acc Id: NP_001407683   ⟸   NM_001420754
- Peptide Label: isoform c
RefSeq Acc Id: NP_001407684   ⟸   NM_001420755
- Peptide Label: isoform c
RefSeq Acc Id: NP_001407681   ⟸   NM_001420752
- Peptide Label: isoform b precursor
- UniProtKB: Q8BXC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001407685   ⟸   NM_001420756
- Peptide Label: isoform d precursor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35074-F1-model_v2 AlphaFold O35074 1-501 view protein structure

RGD ID:6832213
Promoter ID:MM_KWN:33096
SO ACC ID:SO:0000170
Tissues & Cell Lines:Lung
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,033,771 - 167,034,271 (-)MPROMDB
RGD ID:6832214
Promoter ID:MM_KWN:33097
SO ACC ID:SO:0000170
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000002269,   OTTMUST00000038851
Mouse AssemblyChrPosition (strand)Source
MGSCv362167,065,886 - 167,066,387 (-)MPROMDB
RGD ID:6879798
Promoter ID:EPDNEW_M3350
Type:initiation region
Description:Mus musculus prostaglandin I2 synthase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm382167,240,571 - 167,240,631EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1097156 AgrOrtholog
Ensembl Genes ENSMUSG00000017969 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000018113 ENTREZGENE
  ENSMUST00000018113.8 UniProtKB/Swiss-Prot
  ENSMUST00000088041.11 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19223 UniProtKB/Swiss-Prot
PANTHER PTHR24306 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24306:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptgis PhenoGen
PIRSF Cytochrome_CYPVIIA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTGIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt O35074 ENTREZGENE, UniProtKB/Swiss-Prot