RGD Reference Report - Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke. - Rat Genome Database

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Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke.

Authors: Lemaitre, RN  Rice, K  Marciante, K  Bis, JC  Lumley, TS  Wiggins, KL  Smith, NL  Heckbert, SR  Psaty, BM 
Citation: Lemaitre RN, etal., Atherosclerosis. 2009 Jun;204(2):e58-63. Epub 2008 Nov 1.
RGD ID: 2313891
Pubmed: PMID:19046748   (View Abstract at PubMed)
PMCID: PMC2753183   (View Article at PubMed Central)
DOI: DOI:10.1016/j.atherosclerosis.2008.10.011   (Journal Full-text)

OBJECTIVES: Eicosanoids are lipid mediators that may play a role in atherosclerosis. We investigated the association of common genetic variation in prostaglandin H synthase 1 (PTGS1), prostaglandin H synthase 2 (PTGS2), thromboxane A2 synthase (TBXAS1), prostacyclin synthase (PTGIS), prostaglandin E synthase (PTGES), 5-lipoxygenase activating protein (ALOX5AP), 12-lipoxygenase (ALOX12) and 15-lipoxygenase (ALOX15) with the risks of myocardial infarction (MI) and ischemic stroke. A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC). METHODS: We conducted a case-control study in a large Health Maintenance Organization. Cases were men and women, aged 30-79 years with incident non-fatal myocardial infarction (n=1063) or ischemic stroke (n=469) between January 1995 and December 2004. Controls (n=3462) were randomly selected and frequency matched to cases on age, sex, hypertension and calendar year. RESULTS: Common variation in TBXAS1 and PTGIS was associated with MI risk (p-value for global Chi-square test, 0.01 and 0.03, respectively). Common variation in ALOX5AP, ALOX12, ALOX15, PTGS1, PTGS2 and PTGES was not associated with risks of MI and ischemic stroke. We replicated the observation of the Atherosclerosis Risk in Communities Study and observed an interaction of rs20417 with aspirin use on myocardial infarction risk (p for interaction=0.03). CONCLUSIONS: Study results suggest that variation in TBXAS1 and PTGIS may influence MI risk, and carriers of rs20417C allele might derive greater benefits from aspirin use in primary prevention.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ALOX5APHumanmyocardial infarction no_associationIAGP DNA:snps:multiple (human)RGD 
Alox5apRatmyocardial infarction no_associationISOALOX5AP (Homo sapiens)DNA:snps:multiple (human)RGD 
Alox5apMousemyocardial infarction no_associationISOALOX5AP (Homo sapiens)DNA:snps:multiple (human)RGD 
PTGISHumanmyocardial infarction susceptibilityIAGP DNA:SNP:CDS: (rs5629) (human)RGD 
PtgisRatmyocardial infarction susceptibilityISOPTGIS (Homo sapiens)DNA:SNP:CDS: (rs5629) (human)RGD 
PtgisMousemyocardial infarction susceptibilityISOPTGIS (Homo sapiens)DNA:SNP:CDS: (rs5629) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanMyocardial infarction susceptibilityIAGP DNA:SNP:CDS: (rs5629)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Alox5ap  (arachidonate 5-lipoxygenase activating protein)
Ptgis  (prostaglandin I2 synthase)

Genes (Mus musculus)
Alox5ap  (arachidonate 5-lipoxygenase activating protein)
Ptgis  (prostaglandin I2 (prostacyclin) synthase)

Genes (Homo sapiens)
ALOX5AP  (arachidonate 5-lipoxygenase activating protein)
PTGIS  (prostaglandin I2 synthase)


Additional Information