PTGIS (prostaglandin I2 synthase) - Rat Genome Database

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Gene: PTGIS (prostaglandin I2 synthase) Sus scrofa
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Symbol: PTGIS
Name: prostaglandin I2 synthase
RGD ID: 13912408
Description: ENCODES a protein that exhibits prostaglandin-I synthase activity (ortholog); INVOLVED IN vasodilation; cellular response to estradiol stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Arterial Occlusive Diseases (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: CYP8A1; cytochrome P450 8A1; prostacyclin synthase; prostaglandin I2 (prostacyclin) synthase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:19410579   PMID:20693398   PMID:22301074   PMID:23043950   PMID:26069941   PMID:30032202  


Genomics

Comparative Map Data
PTGIS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGIS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,503,874 - 49,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
T2T-CHM13v2.02051,273,490 - 51,337,709 (-)NCBIT2T-CHM13v2.0
Ptgis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,045,114 - 167,095,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,033,725 - 167,082,524 (-)EnsemblGRCm39 Ensembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBIMGSCv36mm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
Ptgis
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,347,589 - 176,383,251 (-)NCBIGRCr8
mRatBN7.23155,928,564 - 155,964,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,730,001 - 159,765,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,228,974 - 168,264,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,970,684 - 166,006,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ptgis
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,623,430 - 8,677,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,624,228 - 8,663,385 (+)NCBIChiLan1.0ChiLan1.0
PTGIS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,244,765 - 55,309,216 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,237,848 - 55,302,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,841,238 - 45,905,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,909,010 - 46,952,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,905,665 - 46,971,612 (-)Ensemblpanpan1.1panPan2
PTGIS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,129,091 - 36,162,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,132,173 - 36,162,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,371,271 - 35,411,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,836,800 - 36,873,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,821,516 - 36,873,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,074,715 - 36,114,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,208,769 - 36,248,925 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,750,911 - 36,791,264 (-)NCBIUU_Cfam_GSD_1.0
Ptgis
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,336,652 - 189,360,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,791,031 - 4,812,027 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,775,884 - 4,814,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGIS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,420,318 - 14,484,667 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,441,983 - 14,488,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,907,161 - 62,972,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgis
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGIS
1978 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 1 1 2
Low 8 3 2 4 2 11 2 1 1
Below cutoff 1 12

Sequence


RefSeq Acc Id: ENSSSCT00000008167   ⟹   ENSSSCP00000007951
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000075928   ⟹   ENSSSCP00000068086
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1751,153,154 - 51,190,583 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084443   ⟹   ENSSSCP00000068241
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1751,153,669 - 51,200,262 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000084513   ⟹   ENSSSCP00000064428
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1751,155,552 - 51,200,204 (-)Ensembl
RefSeq Acc Id: XM_005654247   ⟹   XP_005654304
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005654248   ⟹   XP_005654305
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11751,153,151 - 51,200,322 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005654304   ⟸   XM_005654247
- Peptide Label: isoform X1
- UniProtKB: A0A8D0ZAZ2 (UniProtKB/TrEMBL),   A0A480J0J0 (UniProtKB/TrEMBL),   A0A480M2M6 (UniProtKB/TrEMBL),   A0A4X1UJZ0 (UniProtKB/TrEMBL),   A0A8D2CGZ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005654305   ⟸   XM_005654248
- Peptide Label: isoform X2
- UniProtKB: A0A5G2QTI8 (UniProtKB/TrEMBL),   A0A8D1GIA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000068086   ⟸   ENSSSCT00000075928
RefSeq Acc Id: ENSSSCP00000068241   ⟸   ENSSSCT00000084443
RefSeq Acc Id: ENSSSCP00000064428   ⟸   ENSSSCT00000084513
RefSeq Acc Id: ENSSSCP00000007951   ⟸   ENSSSCT00000008167


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000007463 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00015002561 UniProtKB/TrEMBL
  ENSSSCG00025076422 UniProtKB/TrEMBL
  ENSSSCG00030004165 UniProtKB/TrEMBL
  ENSSSCG00035025183 UniProtKB/TrEMBL
  ENSSSCG00040073457 UniProtKB/TrEMBL
  ENSSSCG00045003681 UniProtKB/TrEMBL
  ENSSSCG00050012637 UniProtKB/TrEMBL
  ENSSSCG00055024961 UniProtKB/TrEMBL
  ENSSSCG00060008642 UniProtKB/TrEMBL
  ENSSSCG00065073607 UniProtKB/TrEMBL
  ENSSSCG00070017381 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000008167 ENTREZGENE
  ENSSSCT00000008167.5 UniProtKB/TrEMBL
  ENSSSCT00000075928.1 UniProtKB/TrEMBL
  ENSSSCT00000084443 ENTREZGENE
  ENSSSCT00000084443.2 UniProtKB/TrEMBL
  ENSSSCT00000084513.2 UniProtKB/TrEMBL
  ENSSSCT00015003188.1 UniProtKB/TrEMBL
  ENSSSCT00015003206.1 UniProtKB/TrEMBL
  ENSSSCT00015003227.1 UniProtKB/TrEMBL
  ENSSSCT00025105871.1 UniProtKB/TrEMBL
  ENSSSCT00030005508.1 UniProtKB/TrEMBL
  ENSSSCT00030005522.1 UniProtKB/TrEMBL
  ENSSSCT00030005528.1 UniProtKB/TrEMBL
  ENSSSCT00035033138.1 UniProtKB/TrEMBL
  ENSSSCT00035033143.1 UniProtKB/TrEMBL
  ENSSSCT00035033145.1 UniProtKB/TrEMBL
  ENSSSCT00040101403.1 UniProtKB/TrEMBL
  ENSSSCT00040101472.1 UniProtKB/TrEMBL
  ENSSSCT00040101518.1 UniProtKB/TrEMBL
  ENSSSCT00040101561.1 UniProtKB/TrEMBL
  ENSSSCT00045006080.1 UniProtKB/TrEMBL
  ENSSSCT00045006087.1 UniProtKB/TrEMBL
  ENSSSCT00045006094.1 UniProtKB/TrEMBL
  ENSSSCT00045006099.1 UniProtKB/TrEMBL
  ENSSSCT00050017038.1 UniProtKB/TrEMBL
  ENSSSCT00050017048.1 UniProtKB/TrEMBL
  ENSSSCT00055049404.1 UniProtKB/TrEMBL
  ENSSSCT00055049481.1 UniProtKB/TrEMBL
  ENSSSCT00055049562.1 UniProtKB/TrEMBL
  ENSSSCT00060011070.1 UniProtKB/TrEMBL
  ENSSSCT00060011073.1 UniProtKB/TrEMBL
  ENSSSCT00065101357.1 UniProtKB/TrEMBL
  ENSSSCT00065101405.1 UniProtKB/TrEMBL
  ENSSSCT00070034313.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  PTGIS UniProtKB/TrEMBL
KEGG Report ssc:100126284 UniProtKB/TrEMBL
NCBI Gene PTGIS ENTREZGENE
PANTHER PTHR24306 UniProtKB/TrEMBL
  PTHR24306:SF4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PIRSF Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
  PTGIS UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A480J0J0 ENTREZGENE, UniProtKB/TrEMBL
  A0A480M2M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1UJZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2QT35_PIG UniProtKB/TrEMBL
  A0A5G2QTI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A5G2R1M5_PIG UniProtKB/TrEMBL
  A0A8D0MBH7_PIG UniProtKB/TrEMBL
  A0A8D0MDH5_PIG UniProtKB/TrEMBL
  A0A8D0MDV5_PIG UniProtKB/TrEMBL
  A0A8D0V8G5_PIG UniProtKB/TrEMBL
  A0A8D0V8H5_PIG UniProtKB/TrEMBL
  A0A8D0V8S0_PIG UniProtKB/TrEMBL
  A0A8D0Z8T2_PIG UniProtKB/TrEMBL
  A0A8D0ZAZ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1CQC6_PIG UniProtKB/TrEMBL
  A0A8D1G3Z2_PIG UniProtKB/TrEMBL
  A0A8D1G984_PIG UniProtKB/TrEMBL
  A0A8D1GGG0_PIG UniProtKB/TrEMBL
  A0A8D1GIA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1RPJ4_PIG UniProtKB/TrEMBL
  A0A8D1RVZ6_PIG UniProtKB/TrEMBL
  A0A8D1SPY0_PIG UniProtKB/TrEMBL
  A0A8D2CGZ3 ENTREZGENE, UniProtKB/TrEMBL
  F1SBE5_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96515 ENTREZGENE