RGD Reference Report - Assessment of the genetic component of hypertension. - Rat Genome Database

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Assessment of the genetic component of hypertension.

Authors: Yamada, Yoshiji  Matsuo, Hitoshi  Segawa, Tomonori  Watanabe, Sachiro  Kato, Kimihiko  Hibino, Takeshi  Yokoi, Kiyoshi  Ichihara, Sahoko  Metoki, Norifumi  Yoshida, Hidemi  Satoh, Kei  Nozawa, Yoshinori 
Citation: Yamada Y, etal., Am J Hypertens. 2006 Nov;19(11):1158-65. doi: 10.1016/j.amjhyper.2006.04.010.
RGD ID: 401959383
Pubmed: PMID:17070428   (View Abstract at PubMed)
DOI: DOI:10.1016/j.amjhyper.2006.04.010   (Journal Full-text)

BACKGROUND: Although genetic epidemiologic studies have suggested that several genetic variants increase the risk for hypertension, the genes that underlie genetic susceptibility to this condition remain to be identified definitively. We have now performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic component of hypertension.
METHODS: The study population comprised 4853 unrelated Japanese individuals, including 2818 subjects with hypertension (1677 men, 1141 women) and 2035 controls (1011 men, 1024 women). The genotypes for 150 polymorphisms of 128 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology.
RESULTS: Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking revealed that four polymorphisms (1648G-->A in ITGA2, -30G-->A in GCK, A-->G in SAH, and 1117C-->A in PTGIS) were significantly (P < .01) associated with hypertension. A stepwise forward selection procedure demonstrated that ITGA2, GCK, and PTGIS genotypes significantly affected the prevalence of hypertension. Combined genotype analysis of these polymorphisms yielded a lowest odds ratio of 0.47 for the genotypes of AA or AG for ITGA2, GA or AA for GCK, and CC for PTGIS, which were present in 1.1% and 2.0% of hypertensive and control individuals, respectively.
CONCLUSIONS: These results suggest that the genotypes for ITGA2, GCK, and PTGIS may prove reliable for the assessment of the genetic component of hypertension. Determination of the combined genotypes for these genes may contribute to personalized prevention of this condition.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanhypertension susceptibilityIAGP DNA:SNP:exon 8:g.1117C>A (rs6095558) (human)RGD 
PtgisRathypertension susceptibilityISOPTGIS (Homo sapiens)DNA:SNP:exon 8:g.1117C>A (rs6095558) (human)RGD 
PtgisMousehypertension susceptibilityISOPTGIS (Homo sapiens)DNA:SNP:exon 8:g.1117C>A (rs6095558) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGISHumanHypertension susceptibilityIAGP DNA:SNP:exon 8:g.1117C>A (rs6095558)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ptgis  (prostaglandin I2 synthase)

Genes (Mus musculus)
Ptgis  (prostaglandin I2 (prostacyclin) synthase)

Genes (Homo sapiens)
PTGIS  (prostaglandin I2 synthase)

Additional Information