Ptgis (prostaglandin I2 synthase) - Rat Genome Database

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Gene: Ptgis (prostaglandin I2 synthase) Heterocephalus glaber
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Symbol: Ptgis
Name: prostaglandin I2 synthase
RGD ID: 18899608
Description: ENCODES a protein that exhibits prostaglandin-I synthase activity (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cellular response to estradiol stimulus (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH Arterial Occlusive Diseases (ortholog); atherosclerosis (ortholog); autism spectrum disorder (ortholog); FOUND IN caveola (ortholog); cytoplasm (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Prostacyclin synthase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptgis
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PTGIS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382049,503,874 - 49,568,137 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2049,503,874 - 49,568,137 (-)EnsemblGRCh38hg38GRCh38
GRCh372048,120,411 - 48,184,674 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362047,553,818 - 47,618,114 (-)NCBINCBI36Build 36hg18NCBI36
Build 342047,553,820 - 47,618,114NCBI
Celera2044,825,044 - 44,889,311 (-)NCBICelera
Cytogenetic Map20q13.13NCBI
HuRef2044,868,991 - 44,933,099 (-)NCBIHuRef
CHM1_12048,024,824 - 48,089,470 (-)NCBICHM1_1
T2T-CHM13v2.02051,273,490 - 51,337,709 (-)NCBIT2T-CHM13v2.0
Ptgis
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392167,045,114 - 167,095,069 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2167,033,725 - 167,082,524 (-)EnsemblGRCm39 Ensembl
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBIMGSCv36mm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
cM Map287.22NCBI
Ptgis
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83176,347,589 - 176,383,251 (-)NCBIGRCr8
mRatBN7.23155,928,564 - 155,964,228 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3155,916,412 - 155,965,451 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3159,730,001 - 159,765,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03168,228,974 - 168,264,675 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03165,970,684 - 166,006,385 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03163,950,746 - 163,986,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03170,109,317 - 170,143,882 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43158,356,878 - 158,387,984 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13158,262,914 - 158,294,020 (-)NCBI
Celera3154,508,773 - 154,544,997 (-)NCBICelera
Cytogenetic Map3q42NCBI
Ptgis
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554458,623,430 - 8,677,658 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554458,624,228 - 8,663,385 (+)NCBIChiLan1.0ChiLan1.0
PTGIS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,244,765 - 55,309,216 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12055,237,848 - 55,302,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02045,841,238 - 45,905,641 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12046,909,010 - 46,952,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2046,905,665 - 46,971,612 (-)Ensemblpanpan1.1panPan2
PTGIS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12436,129,091 - 36,162,525 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2436,132,173 - 36,162,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2435,371,271 - 35,411,412 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02436,836,800 - 36,873,631 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2436,821,516 - 36,873,620 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12436,074,715 - 36,114,829 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02436,208,769 - 36,248,925 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02436,750,911 - 36,791,264 (-)NCBIUU_Cfam_GSD_1.0
Ptgis
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640189,336,652 - 189,360,405 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365144,791,031 - 4,812,027 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365144,775,884 - 4,814,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGIS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1751,153,154 - 51,200,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11751,153,151 - 51,200,515 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21757,474,357 - 57,521,683 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGIS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,420,318 - 14,484,667 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,441,983 - 14,488,264 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605062,907,161 - 62,972,792 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Sequence


Ensembl Acc Id: ENSHGLT00000009980   ⟹   ENSHGLP00000009871
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247905,850,810 - 5,886,014 (+)Ensembl
RefSeq Acc Id: XM_013077192   ⟹   XP_012932646
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247905,850,647 - 5,885,754 (+)NCBI
RefSeq Acc Id: XM_021239050   ⟹   XP_021094709
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247905,861,239 - 5,885,754 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012932646 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094709 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB04133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009871
GenBank Protein JAO02796 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012932646   ⟸   XM_013077192
- Peptide Label: isoform X1
- UniProtKB: G5B4C2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094709   ⟸   XM_021239050
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JED3 (UniProtKB/TrEMBL),   G5B4C2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000009871   ⟸   ENSHGLT00000009980


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000007083 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000009980 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CYP7A1-type UniProtKB/TrEMBL
  Cyt_P450_E_grp-IV UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene Ptgis ENTREZGENE
PANTHER PTHR24306 UniProtKB/TrEMBL
  PTHR24306:SF4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PIRSF Cytochrome_CYPVIIA1 UniProtKB/TrEMBL
PRINTS EP450IV UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0P6JED3 ENTREZGENE, UniProtKB/TrEMBL
  G5B4C2 ENTREZGENE, UniProtKB/TrEMBL